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公开(公告)号：US20230320384A1
公开(公告)日：2023-10-12
申请号：US17981620
申请日：2022-11-07
申请人： Gelesis, LLC
IPC分类号： A23L2/52 , A21D2/14 , A21D2/18 , A23G9/34 , A23L2/68 , C08B13/00 , C08B15/00 , C08J3/075 , C08L1/32 , A23L29/288 , A23L7/10 , A23L7/109 , A23L7/122 , A23L7/126 , A23L33/00 , A23L33/24 , A21D13/80
CPC分类号： A23L2/52 , A21D2/145 , A21D2/18 , A21D2/188 , A23G9/34 , A23L2/68 , C08B13/00 , C08B15/005 , C08J3/075 , C08L1/32 , A23L29/288 , A23L7/10 , A23L7/109 , A23L7/122 , A23L7/126 , A23L33/30 , A23L33/24 , A21D13/80 , A23V2002/00 , C08J2301/02 , C08J2301/10 , A61K47/38
摘要： The present invention provides methods, compositions and modified foods and foodstuffs useful for weight management and glycemic control.
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公开(公告)号：US20210024656A1
公开(公告)日：2021-01-28
申请号：US17066543
申请日：2020-10-09
IPC分类号： C08B13/00 , A61K47/38 , A61K9/28 , A61K9/50 , A61K31/525
摘要： Provided are HPMCAS powder having high solubility when dissolved in a solvent and being capable of suppressing generation of undissolved materials; and a method for producing the powder. More specifically, provided is hypromellose acetate succinate powder having an average ratio of L to D of from 2.0 to 3.0, wherein L and D mean maximum and minimum diameters of each particle, respectively. Also provided is a method for producing a hypromellose acetate succinate, comprising the steps of: dissolving hypromellose powder in a solvent, esterifying the dissolved hypromellose with succinic anhydride and acetic anhydride in the presence of a catalyst to obtain a reaction mixture, and mixing the reaction mixture with water to precipitate hypromellose acetate succinate, wherein the reaction mixture just before being mixed with the water has a viscosity of from 100 to 200 Pa·s.
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公开(公告)号：US10730956B2
公开(公告)日：2020-08-04
申请号：US15541642
申请日：2016-01-04
发明人： Roland Bayer , Oliver Petermann
IPC分类号： C08B11/20 , C08B11/193 , C08B13/00
摘要： A process for producing a water-soluble cellulose derivative of a reduced content of water-insoluble particles comprises the steps of a) reacting cellulose with an alkaline material to produce alkali cellulose, b) reacting the produced alkali cellulose with one or more derivatizing agents to produce a water-soluble cellulose derivative, c) washing the produced cellulose derivative with an aqueous liquid once or several times to provide a moist cellulose derivative having a water content of 25 to 85 percent, based on the total weight of the moist cellulose derivative, d) subjecting the moist cellulose derivative to homogenization to form the moist cellulose derivative to a paste, and e) pressing the paste through a filter of a pore size of up to 200 μm.
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公开(公告)号：US20200181291A1
公开(公告)日：2020-06-11
申请号：US16789598
申请日：2020-02-13
IPC分类号： C08B13/00 , A61K31/525 , A61K9/50 , A61K9/28 , A61K47/38
摘要： Provided are HPMCAS powder having high solubility when dissolved in a solvent and being capable of suppressing generation of undissolved materials; and a method for producing the powder. More specifically, provided is hypromellose acetate succinate powder having an average ratio of L to D of from 2.0 to 3.0, wherein L and D mean maximum and minimum diameters of each particle, respectively. Also provided is a method for producing a hypromellose acetate succinate, comprising the steps of: dissolving hypromellose powder in a solvent, esterifying the dissolved hypromellose with succinic anhydride and acetic anhydride in the presence of a catalyst to obtain a reaction mixture, and mixing the reaction mixture with water to precipitate hypromellose acetate succinate, wherein the reaction mixture just before being mixed with the water has a viscosity of from 100 to 200 Pa·s.
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公开(公告)号：US10562983B2
公开(公告)日：2020-02-18
申请号：US15104561
申请日：2014-12-15
发明人： Sung Hwan Bang , Ju Hee Shin , Jin Ryul Son , Kyung Yeol Park , Jeong Hee Chun , Ji Seon Jeong , Sang Youb Lee
摘要： Disclosed are a method for preparing hydroxypropyl methylcellulose acetate succinate (HPMCAS) grains and HPMCAS grains. The disclosed method for preparing HPMCAS grains comprises: a step of esterifying hydroxypropyl methylcellulose (HPMC), acetic anhydride, and succinic anhydride in a reaction medium in the presence of a catalyst so as to obtain a reaction solution containing HPMCAS (esterification step); and a step of continuously or intermittently putting the reaction solution into water so as to form grains (granulating step).
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公开(公告)号：US10526421B2
公开(公告)日：2020-01-07
申请号：US15503600
申请日：2015-08-18
摘要： Esterified cellulose ethers which have i) as ester groups aliphatic monovalent acyl groups or groups of the formula —C(O)—R—COOA or a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, and ii) a content of not more than 0.85 weight percent acetone-insoluble esterified cellulose ether particles, when the esterified cellulose ether is present in a mixture of 12.5 weight parts of esterified cellulose ether and 87.5 weight parts of acetone at 21° C., the weight percent acetone-insoluble esterified cellulose ether particles being based on the total weight of the esterified cellulose ether, wherein iii) not more than 14 percent of the acetone-insoluble esterified cellulose ether particles have a particle size of more than 90 micrometers.
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公开(公告)号：US20190184020A1
公开(公告)日：2019-06-20
申请号：US16281700
申请日：2019-02-21
摘要： A process for making esterified cellulose ethers which have i) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, ii) a weight average molecular weight Mw of from 80,000 Dalton to 350,000 Dalton, iii) a Polydispersity Mw/Mn of from 1.3 to 4.1, and iv) a viscosity of up to 4.0 mPa·s, measured as a 2.0 wt % solution of the esterified cellulose ether in 0.43 wt % aqueous NaOH at 20° C., are useful as enteric polymers for pharmaceutical dosage forms.
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公开(公告)号：US20180327515A1
公开(公告)日：2018-11-15
申请号：US15531041
申请日：2016-01-11
发明人： Byung Ho JEON , Joon Soo LEE
IPC分类号： C08B13/00
摘要： Disclosed is a method of preparing an acetylated cellulose ether. The disclosed method of preparing acetylated cellulose ether includes converting a cellulose ether to an acetylated cellulose ether in the presence of an acid catalyst.
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公开(公告)号：US10106625B2
公开(公告)日：2018-10-23
申请号：US15216936
申请日：2016-07-22
发明人： Todd A. Brugel , Tuyen T. Nguyen
IPC分类号： C08B13/00 , A61K47/38 , C08L1/32 , A61K31/4418 , A61K31/397
摘要： The presently disclosed and claimed inventive concept(s) relates to a polymer for enhancing drug performance and improving processability. Specifically, the polymer comprises hydroxypropyl methyl cellulose acetate succinate (HPMC-AS). On the HPMC-AS, the percentage of total succinoyl degree of substitution is less than 12% at C6-OH position and greater than 53% at C3-OH, and the percentage of total acetyl degree of substitution is greater than 32% at C6-OH position.
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公开(公告)号：US20180127516A1
公开(公告)日：2018-05-10
申请号：US15861733
申请日：2018-01-04
CPC分类号： C08B13/00 , A61K9/146 , A61K9/2866 , A61K9/4816 , C08B11/20 , C08L1/32
摘要： Esterified cellulose ethers which comprise (i) groups of the formula —C(O)—R—COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, which have a viscosity of up 50 mPa·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C., and a weight average molecular weight Mw of at least 220,000 Dalton, or which have a viscosity of up 100 mPa·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C., and a weight average molecular weight Mw of at least 310,000 Dalton are useful for preparing solid dispersions comprising drugs.
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