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公开(公告)号：US20230320384A1
公开(公告)日：2023-10-12
申请号：US17981620
申请日：2022-11-07
申请人： Gelesis, LLC
IPC分类号： A23L2/52 , A21D2/14 , A21D2/18 , A23G9/34 , A23L2/68 , C08B13/00 , C08B15/00 , C08J3/075 , C08L1/32 , A23L29/288 , A23L7/10 , A23L7/109 , A23L7/122 , A23L7/126 , A23L33/00 , A23L33/24 , A21D13/80
CPC分类号： A23L2/52 , A21D2/145 , A21D2/18 , A21D2/188 , A23G9/34 , A23L2/68 , C08B13/00 , C08B15/005 , C08J3/075 , C08L1/32 , A23L29/288 , A23L7/10 , A23L7/109 , A23L7/122 , A23L7/126 , A23L33/30 , A23L33/24 , A21D13/80 , A23V2002/00 , C08J2301/02 , C08J2301/10 , A61K47/38
摘要： The present invention provides methods, compositions and modified foods and foodstuffs useful for weight management and glycemic control.
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公开(公告)号：US20190184020A1
公开(公告)日：2019-06-20
申请号：US16281700
申请日：2019-02-21
摘要： A process for making esterified cellulose ethers which have i) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, ii) a weight average molecular weight Mw of from 80,000 Dalton to 350,000 Dalton, iii) a Polydispersity Mw/Mn of from 1.3 to 4.1, and iv) a viscosity of up to 4.0 mPa·s, measured as a 2.0 wt % solution of the esterified cellulose ether in 0.43 wt % aqueous NaOH at 20° C., are useful as enteric polymers for pharmaceutical dosage forms.
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公开(公告)号：US20180327515A1
公开(公告)日：2018-11-15
申请号：US15531041
申请日：2016-01-11
发明人： Byung Ho JEON , Joon Soo LEE
IPC分类号： C08B13/00
摘要： Disclosed is a method of preparing an acetylated cellulose ether. The disclosed method of preparing acetylated cellulose ether includes converting a cellulose ether to an acetylated cellulose ether in the presence of an acid catalyst.
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公开(公告)号：US20180127516A1
公开(公告)日：2018-05-10
申请号：US15861733
申请日：2018-01-04
CPC分类号： C08B13/00 , A61K9/146 , A61K9/2866 , A61K9/4816 , C08B11/20 , C08L1/32
摘要： Esterified cellulose ethers which comprise (i) groups of the formula —C(O)—R—COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, which have a viscosity of up 50 mPa·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C., and a weight average molecular weight Mw of at least 220,000 Dalton, or which have a viscosity of up 100 mPa·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C., and a weight average molecular weight Mw of at least 310,000 Dalton are useful for preparing solid dispersions comprising drugs.
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公开(公告)号：US20180072818A1
公开(公告)日：2018-03-15
申请号：US15550094
申请日：2016-03-08
发明人： Oliver Petermann , Matthias Knarr
CPC分类号： C08B13/00 , A23P10/30 , A23P20/105 , A61K9/4816 , A61K9/4833 , A61K9/4866 , A61K47/38 , C08L1/32 , C09D101/32
摘要： 1. An esterified cellulose ether which i) comprises groups of the formula —C(O)—R—COOH or a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, wherein R is a divalent hydrocarbon group, ii) has a weight average molecular weight Mw of up to 70,000 Dalton, iii) has a degree of neutralization of the groups —C(O)—R—COOH of not more than 0.4, and iv) has a solubility in water of at least 2.0 weight percent at 2° C., is useful for preparing enteric capsules.
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6.发明申请公开(公告)号：US20180057612A1
公开(公告)日：2018-03-01
申请号：US15683222
申请日：2017-08-22
摘要： Provided is a method for producing HPMCAS capable of reducing the average particle size of HPMCAS particles to an intended range without a pulverization step. Specifically provided is a method for producing hypromellose acetate succinate, comprising an esterification step of reacting hypromellose with an esterification agent in the presence of a catalyst to obtain a reaction solution containing crude hypromellose acetate succinate, a precipitation step of mixing the reaction solution with water to precipitate the crude hypromellose acetate succinate, thereby obtaining a hypromellose acetate succinate suspension, a liquid removal step of removing a liquid from the hypromellose acetate succinate suspension with a centrifugal decanter to obtain liquid-removed hypromellose acetate succinate, and a drying step of drying the liquid-removed hypromellose acetate succinate.
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公开(公告)号：US09890221B2
公开(公告)日：2018-02-13
申请号：US14777838
申请日：2014-05-07
IPC分类号： C08B13/00 , A61K9/14 , A61K31/095 , A61K31/4166 , A61K47/38
CPC分类号： C08B13/00 , A61K9/146 , A61K31/095 , A61K31/4166 , A61K47/38
摘要： Esterified cellulose ethers comprising groups of formula —C(O)—CHR′—CHR″—COOA, wherein, R′ and R″ are hydrogen or (—S)m(—R1)n-R2, wherein R1 is a hydrocarbon group having 1 to 4 carbon atoms, R2 is an optionally substituted 5- or 6-membered cyclic group, m and n each independently are 0 or 1, and A is hydrogen or a cation, with the proviso that in each group CHR′—CHR″ one of R′ and R″ is hydrogen and the other one is (—S)m(—R1)n-R2, are useful as excipients for maintaining the concentration of poorly water-soluble drugs in aqueous liquids at supersaturation levels.
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8.发明申请公开(公告)号：US20180030158A1
公开(公告)日：2018-02-01
申请号：US15549877
申请日：2016-03-08
发明人： Oliver Petermann , Robert B. Appell
CPC分类号： C08B11/20 , A61K9/4816 , A61K47/38 , C08B13/00
摘要： A process for preparing an ester of a cellulose ether comprises the steps of reacting a cellulose ether with a dicarboxylic acid anhydride or with a combination of a dicarboxylic acid anhydride and an aliphatic monocarboxylic acid anhydride, wherein the esterification is conducted i) in the absence of an esterification catalyst or in the presence of no more than 0.1 mole of an esterification catalyst per mole of anhydroglucose units of cellulose ether, and ii) in the presence of an aliphatic carboxylic acid, wherein the molar ratio [aliphatic carboxylic acid/anhydroglucose units of cellulose ether] is up to 12/1.
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公开(公告)号：US20170283514A1
公开(公告)日：2017-10-05
申请号：US15471224
申请日：2017-03-28
IPC分类号： C08B13/00 , A61K9/28 , A61K31/525 , A61K9/50
CPC分类号： C08B13/00 , A61K9/2866 , A61K9/5042 , A61K9/5089 , A61K31/525 , A61K47/38
摘要： Provided are HPMCAS powder having high solubility when dissolved in a solvent and being capable of suppressing generation of undissolved materials; and a method for producing the powder. More specifically, provided is hypromellose acetate succinate powder having an average ratio of L to D of from 2.0 to 3.0, wherein L and D mean maximum and minimum diameters of each particle, respectively. Also provided is a method for producing a hypromellose acetate succinate, comprising the steps of: dissolving hypromellose powder in a solvent, esterifying the dissolved hypromellose with succinic anhydride and acetic anhydride in the presence of a catalyst to obtain a reaction mixture, and mixing the reaction mixture with water to precipitate hypromellose acetate succinate, wherein the reaction mixture just before being mixed with the water has a viscosity of from 100 to 200 Pa·s.
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公开(公告)号：US09745387B2
公开(公告)日：2017-08-29
申请号：US14420985
申请日：2013-08-15
发明人： Meinolf Brackhagen , Nicholas S. Grasman , Yongfu Li , David M. Meunier , Oliver Petermann , Matthias Sprehe
CPC分类号： C08B13/00 , A61K9/10 , A61K9/146 , A61K9/2866 , C08B11/20
摘要： A partially cross-linked esterified cellulose ether having A) groups of the formula —C(O)—R—COOA or a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, and B) having a molecular weight distribution such that [Wf(>100 k)−Wf(>100 k)XL]/Wf(>100 k)XL is at least 0.20, wherein Wf(>100 k) is the total weight fraction of the esterified cellulose ether that exceeds 100,000 g/mol, and Wf(>100 k)XL is the weight fraction that exceeds 100,000 g/mol of the methylated esterified cellulose ether is useful as enteric polymer for pharmaceutical dosage forms.
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