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    Cellulose ether powders
    1.
    发明授权
    Cellulose ether powders 有权

    公开(公告)号：US10577432B2

    公开(公告)日：2020-03-03

    申请号：US15574497

    申请日：2016-05-26

    申请人： Dow Global Technologies LLC

    发明人： Roland Adden ,  Tirtha Chatterjee ,  Matthias Knarr ,  Meinolf Brackhagen

    IPC分类号： C08B11/20 ,  B01J2/04

    摘要： Provided is a method of making methylcellulose-type ether in powder form, said method comprising (a) providing a solution of said methylcellulose-type ether in water, and (b) then separating said methylcellulose-type ether from said water to produce dried methylcellulose-type ether, with the proviso that either (i) step (b) produces said methylcellulose-type ether in powder form, or (ii) after step (b), said method additionally comprises a step (c) of subjecting said dried methylcellulose-type ether to mechanical stress to produce said methylcellulose-type ether in powder form.

    DISPERSION COMPRISING A PARTIALLY NEUTRALIZED ESTERIFIED CELLULOSE ETHER
    3.
    发明申请
    DISPERSION COMPRISING A PARTIALLY NEUTRALIZED ESTERIFIED CELLULOSE ETHER 审中-公开

    公开(公告)号：US20170181977A1

    公开(公告)日：2017-06-29

    申请号：US15308792

    申请日：2015-04-28

    申请人： Dow Global Technologies LLC

    发明人： Jin Zhao ,  Roland Adden ,  Neal J. Fetner ,  David L. Malotky

    IPC分类号： A61K9/48 ,  B29C41/14

    CPC分类号： A61K9/4816 ,  B29C41/14

    摘要： An aqueous composition comprising at least 10 weight percent of a dispersed esterified cellulose ether, based on the total weight of the aqueous composition, wherein the esterified cellulose ether comprises (i) groups of the formula —C(O)—R—COOH or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, R being a divalent aliphatic or aromatic hydrocarbon group, and at least a part of the groups —C(O)—R—COOH are neutralized with an ammonium salt of carbonic acid, formic acid or acetic acid, and wherein d90 of the dispersed esterified cellulose ether particles is up to 10 micrometers, d90 being the diameter where 90 mass percent of the particles have a smaller equivalent diameter and the other 10 mass percent have a larger equivalent diameter, is useful for preparing coating dosage forms including tablets, capsules and others, or for the formation of capsules shells.

    Sustained release dosage forms
    5.
    发明授权
    Sustained release dosage forms 有权

    公开(公告)号：US09616036B2

    公开(公告)日：2017-04-11

    申请号：US14390046

    申请日：2013-04-08

    申请人： Dow Global Technologies LLC

    发明人： Meinolf Brackhagen ,  Roland Adden ,  Oliver Petermann ,  Robert L. Sammler ,  David E. Wallick

    IPC分类号： A61K31/167 ,  A61K9/20 ,  C08B11/08 ,  C08B11/193 ,  C08L1/28

    CPC分类号： A61K31/167 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2095 ,  C08B11/08 ,  C08B11/193 ,  C08L1/284

    摘要： A sustained release dosage form comprises an active ingredient blended with a polymeric matrix. At least a portion of the polymeric matrix is formed by a cellulose ether having an onset dissolution temperature of at least 40° C., having anhydroglucose units joined by 1-4 linkages and having methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl as substituents such that the cellulose ether has an MS (hydroxyalkyl) of 0.05 to 1.00, and hydroxyl groups of anhydroglucose units are substituted with methyl groups such that [s23/s26−0.2*MS(hydroxyalkyl)] is 0.31 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 3-positions of the anhydroglucose unit are substituted with a methyl group and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 6-positions of the anhydroglucose unit are substituted with a methyl group.

    NOVEL SUSTAINED RELEASE DOSAGE FORMS
    10.
    发明申请
    NOVEL SUSTAINED RELEASE DOSAGE FORMS 有权
    新的持续释放剂型

    公开(公告)号：US20150057358A1

    公开(公告)日：2015-02-26

    申请号：US14390046

    申请日：2013-04-08

    申请人： Dow Global Technologies LLC

    发明人： Meinolf Brackhagen ,  Roland Adden ,  Oliver Petermann ,  Robert L. Sammler ,  David E. Wallick

    IPC分类号： A61K31/167 ,  A61K9/20

    CPC分类号： A61K31/167 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2095 ,  C08B11/08 ,  C08B11/193 ,  C08L1/284

    摘要： A sustained release dosage form comprises an active ingredient blended with a polymeric matrix. At least a portion of the polymeric matrix is formed by a cellulose ether having an onset dissolution temperature of at least 40° C., having anhydroglucose units joined by 1-4 linkages and having methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl as substituents such that the cellulose ether has an MS (hydroxyalkyl) of 0.05 to 1.00, and hydroxyl groups of anhydrogluclose units are substituted with methyl groups such that [s23/s26−0.2*MS(hydroxyalkyl)] is 0.31 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 3-positions of the anhydroglucose unit are substituted with a methyl group and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 6-positions of the anhydroglucose unit are substituted with a methyl group.

    摘要翻译： 持续释放剂型包含与聚合物基质共混的活性成分。 聚合物基质的至少一部分由起始溶解温度为至少40℃的纤维素醚形成，其具有通过1-4键连接且具有甲基，羟基烷基和任选的烷基不同的脱水葡萄糖单元 由甲基作为取代基，使得纤维素醚具有0.05至1.00的MS（羟基烷基），并且脱甲羟基化单元的羟基被甲基取代，使得[s23 / s26-0.2 * MS（羟烷基）]为0.31以下， 其中s23是脱水葡萄糖单元的摩尔分数，其中只有脱水葡萄糖单元的2-和3-位上的两个羟基被甲基取代，并且其中s26是脱水葡萄糖单元的摩尔分数，其中只有两个羟基在 脱水葡萄糖单元的2-位和6-位被甲基取代。