公开(公告)号：US20190210003A1

公开(公告)日：2019-07-11

申请号：US15520390

申请日：2015-10-01

Applicant: JNC CORPORATION

Inventor： Natuki OKANIWA ,  Tsuyoshi NAKAMA ,  Eri IWAMOTO ,  Shuji SASAKI ,  Takuo IKEDA

IPC: B01J20/24 ,  B01J20/28 ,  B01J20/285 ,  B01J20/30 ,  B01D15/36 ,  B01J41/16 ,  B01J41/07 ,  C08B15/00 ,  C08B15/06 ,  C08J9/28 ,  B01J20/281

CPC classification number: B01J20/24 ,  B01D15/361 ,  B01J20/28042 ,  B01J20/281 ,  B01J20/285 ,  B01J20/30 ,  B01J20/305 ,  B01J20/3085 ,  B01J41/05 ,  B01J41/07 ,  B01J41/16 ,  B01J2220/52 ,  C07K1/16 ,  C07K1/18 ,  C08B15/005 ,  C08B15/06 ,  C08J9/26 ,  C08J9/28 ,  C08J2201/026 ,  C08J2301/12 ,  G01N30/482 ,  G01N30/88 ,  G01N2030/484

Abstract: Provided is a manufacturing method for monolithic structure that is a porous body formed of polysaccharide being a naturally-occurring polymer, has continuous pores with an average pore diameter suitable for biomolecule separation, and allows formation into arbitrary shape. The polysaccharide monolithic structure is manufactured by a method including a first step of obtaining a polysaccharide solution by dissolving polysaccharide into a mixed solvent of a first component and a second component at temperature lower than a boiling point of the mixed solvent, and a second step of obtaining polysaccharide monolithic structure by cooling the polysaccharide solution, wherein the first component is a solvent selected from lactate, and the second component is a solvent selected from water, lower alcohol, and a combination thereof. The monolithic structure obtained is a porous body having continuous pores with an average pore diameter of 0.01 to 20.0 micrometers, and a thickness of 100 micrometers or more.

公开(公告)号：US20240316534A1

公开(公告)日：2024-09-26

申请号：US18577700

申请日：2022-04-15

Applicant: JNC CORPORATION

Inventor： Kenji KADOI ,  Eri IWAMOTO ,  Tsuyoshi NAKAMA

IPC: B01J20/285 ,  B01D15/26

CPC classification number: B01J20/285 ,  B01D15/265 ,  B01J2220/4825 ,  B01J2220/50

Abstract: A porous particle has a controlled 3D network skeleton and communicating pores that include the voids of the skeleton and penetrate from the particle surface to the inside, a method produces the same, and a filler for chromatography uses the same. The porous particle mainly includes cellulose acetate or cellulose, is spherical, and has a 3D network skeleton and communicating pores that include the voids of the skeleton and penetrate from the particle surface to the inside. The retention time of dextran with a molecular weight of 2 million at a flow rate of 0.4 ml/min in a column with an inner diameter of 0.78 cm and a length of 30 cm filled with the porous particles is 20 minutes or more.

公开(公告)号：US20130137850A1

公开(公告)日：2013-05-30

申请号：US13688988

申请日：2012-11-29

Applicant: Jnc Corporation

Inventor： Tomohiro YOSHIMURA ,  Tsuyoshi NAKAMA ,  Eri IWAMOTO

IPC: C08B37/08

CPC classification number: C08B37/0072 ,  C08B11/12 ,  C08B37/0021 ,  C08B37/0069 ,  C08B37/0075 ,  C08H1/00 ,  C08L1/286 ,  C08L5/00 ,  C08L5/02 ,  C08L5/08 ,  C08L5/10 ,  C08L89/00

Abstract: An objective of the invention is to provide an excellent biomaterial having a good operability and a high safety; the solution is a polymer having one or more peptide units represented by formula (1) as described below and one or more saccharide residues derived from polysaccharides: -(Pro-Y-Gly)n-  (1) wherein, Y represents Pro or Hyp and n is an integer of 1 or more; the invention provides a novel polymer having both various characteristics of a collagen-like polypeptide suitable for a biomaterial, and characteristics of polysaccharides, namely, a high hydrophilicity and enzymolytic degradation, and also having a high mechanical strength and water absorbing properties; furthermore, the water absorbing properties and enzymolysis properties of the resultant polymer can be controlled by changing an amount of charging the peptide oligomer and the polysaccharides in a condensation reaction.

Abstract translation: 本发明的目的是提供一种具有良好可操作性和高安全性的优异生物材料; 溶液是具有如下所述的由式（1）表示的一个或多个肽单元的聚合物和衍生自多糖的一种或多种糖残基： - （Pro-Y-Gly）n-（1）其中，Y表示Pro或Hyp n为1以上的整数， 本发明提供了具有适合于生物材料的胶原样多肽的各种特性以及多糖的特性，即高亲水性和酶解降解，还具有高机械强度和吸水性的新型聚合物。 此外，所得聚合物的吸水性和酶解性能可以通过在缩合反应中改变加入肽低聚物和多糖的量来控制。

公开(公告)号：US20140311984A1

公开(公告)日：2014-10-23

申请号：US14258456

申请日：2014-04-22

Applicant: JNC CORPORATION

Inventor： Tsuyoshi NAKAMA ,  Masami TODOKORO ,  Eri IWAMOTO

IPC: B01J20/285 ,  B29C44/04 ,  B01D15/08

CPC classification number: B01J20/285 ,  B01D15/08 ,  B01D15/361 ,  B01D15/3809 ,  B01D67/0009 ,  B01D71/10 ,  B01J20/24 ,  B01J20/265 ,  B01J20/267 ,  B01J20/28042 ,  B01J20/28078 ,  B01J20/286 ,  B01J20/3212 ,  B01J20/3248 ,  B01J2220/82 ,  B29C67/20 ,  C07K1/18 ,  C07K1/20 ,  C07K1/22 ,  C08J9/28 ,  C08J2201/052 ,  C08J2201/054 ,  C08J2301/12

Abstract: A problem is to provide a monolithic structure that is a porous body formed of a polysaccharide being a naturally-occurring polymer, and has continuous pores having an average pore diameter suitable for biomolecule separation to allow formation into an arbitrary shape, and a manufacturing method therefor. A solution is to manufacture the polysaccharide monolithic structure by a method including a first step for dissolving a polysaccharide into a mixed solvent including a solvent into which the polysaccharide is soluble and a solvent into which the polysaccharide is insoluble, at a temperature lower than a boiling point of the mixed solvent, to give a polysaccharide solution, and a second step for cooling the polysaccharide solution to give the polysaccharide monolithic structure. The polysaccharide monolithic structure obtained is a porous body having continuous pores having an average pore diameter of 0.01 to 20 micrometers and a thickness of 100 micrometers or more.

Abstract translation: 问题在于提供作为天然存在的聚合物的多糖形成的多孔体的整体结构，并且具有适于生物分子分离以使形成任意形状的平均孔径的连续孔及其制造方法 。 解决方案是通过包括第一步骤的方法来制造多糖整体结构，该方法包括将多糖溶解在包含多糖可溶性的溶剂的混合溶剂中，以及多糖不溶于其中的溶剂，在低于沸点 的混合溶剂，得到多糖溶液，第二步是冷却多糖溶液，得到多糖整体结构。 获得的多糖整体结构是具有平均孔径为0.01〜20微米，厚度为100微米以上的连续孔的多孔体。