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公开(公告)号：US11992824B2
公开(公告)日：2024-05-28
申请号：US17353096
申请日：2021-06-21
发明人： Kevin D. Wyndham , Michael F. Morris , Darryl W. Brousmiche , Jason F. Hill , Jacob N. Fairchild
IPC分类号： B01J20/28 , B01D15/26 , B01D15/30 , B01D15/32 , B01D15/40 , B01D53/02 , B01J20/22 , B01J20/283 , B01J20/288 , B01J20/289 , B01J20/30 , B01J20/32 , C07F7/18 , B01J20/282 , B01J20/284 , B01J20/285
CPC分类号： B01J20/283 , B01D15/26 , B01D15/30 , B01D15/305 , B01D15/322 , B01D15/40 , B01D53/025 , B01J20/22 , B01J20/28004 , B01J20/28016 , B01J20/28042 , B01J20/28057 , B01J20/28059 , B01J20/28061 , B01J20/28064 , B01J20/28066 , B01J20/28069 , B01J20/28071 , B01J20/28073 , B01J20/28076 , B01J20/28078 , B01J20/28083 , B01J20/28085 , B01J20/288 , B01J20/289 , B01J20/3085 , B01J20/3204 , B01J20/3206 , B01J20/3208 , B01J20/3246 , B01J20/3285 , B01J20/3293 , C07F7/1804 , B01J20/282 , B01J20/284 , B01J20/285 , B01J20/32 , B01J20/3234 , B01J2220/54 , B01J2220/80
摘要： In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0.
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公开(公告)号：US20230294073A1
公开(公告)日：2023-09-21
申请号：US18311671
申请日：2023-05-03
IPC分类号： B01J20/283 , B01J20/22 , B01J20/28 , B01J20/285 , B01J20/286 , B01J20/32 , B01D15/20
CPC分类号： B01J20/283 , B01J20/22 , B01J20/28092 , B01J20/285 , B01J20/286 , B01J20/3204 , B01J20/3234 , B01J20/3257 , B01J20/3285 , B01J20/3289 , B01J20/3293 , B01J20/3295 , B01J20/28042 , B01J20/28016 , B01J20/28069 , B01J20/28095 , B01J20/28078 , B01J20/28057 , B01D15/206 , B01J20/28004 , B01J20/28009 , B01J20/28019 , B01J20/28059 , B01J20/28061 , B01J20/28064 , B01J20/28066 , B01J20/28071 , B01J20/28073 , B01J20/28083 , B01J20/28085 , B01J20/3236 , B01J20/324 , B01J20/3272 , B01J20/28076 , B01J20/28007 , B01J20/28097 , B01J20/32 , B01J20/3242 , B01J2220/46 , B01J2220/56 , B01J2220/82
摘要： The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are chromatographic materials comprising having a narrow particle size distribution.
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公开(公告)号：US11685764B2
公开(公告)日：2023-06-27
申请号：US17221438
申请日：2021-04-02
IPC分类号： A23J1/00 , C07K1/22 , B01D15/38 , B01J20/24 , B01J20/28 , B01J20/286 , B01J20/32 , C07K14/31 , C07K16/00 , C07K16/06 , C07K17/10
CPC分类号： C07K1/22 , B01D15/3809 , B01J20/24 , B01J20/286 , B01J20/28016 , B01J20/28078 , B01J20/3212 , B01J20/3274 , C07K14/31 , C07K16/00 , C07K16/065 , C07K17/10
摘要： The invention relates to a separation matrix comprising at least 11 mg/ml Fc-binding ligands covalently coupled to a porous support, wherein:
a) the ligands comprise multimers of alkali-stabilized Protein A domains, and
b) the porous support comprises cross-linked polymer particles having a volume-weighted median diameter (d50, v) of 56-70 micrometers and a dry solids weight of 55-80 mg/ml.-
公开(公告)号：US20230166019A1
公开(公告)日：2023-06-01
申请号：US17823120
申请日：2022-08-30
申请人： CytoSorbents, Inc.
IPC分类号： A61M1/36 , A61K9/16 , B01J20/28 , A61K31/765 , B01J20/26 , C08F299/00 , C08J9/26
CPC分类号： A61M1/3679 , A61K9/16 , B01J20/28078 , B01J20/28069 , A61K31/765 , B01J20/261 , C08F299/00 , C08J9/26 , A61M2202/0057 , A61M2202/0413 , A61M2202/0415 , A61M2202/0405 , A61M2202/0464 , A61M2202/0466 , A61M2202/0492 , A61M2202/0496 , A61M2202/049 , A61M2202/20 , A61M2202/203 , A61M2202/206 , A61M2202/0423 , C08J2201/0444 , C08J2207/10 , C08J2353/00
摘要： Provided herein are materials and methods of reducing contamination in a biological substance or treating contamination in a subject by one or more toxins comprising contacting the biological substance with an effective amount of a sorbent capable of sorbing the toxin, wherein the sorbent comprises a plurality of pores ranging from 50 Å to 40,000 Å with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and sorbing the toxin. Also provided are kits to reduce contamination by one or more toxins in a biological substance comprising a sorbent capable of sorbing a toxin, wherein the sorbent comprises a plurality of pores ranging from 50 Å to 40,000 Å with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and a vessel to store said sorbent when not in use together with packaging for same.
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公开(公告)号：US20230149898A1
公开(公告)日：2023-05-18
申请号：US17919273
申请日：2021-11-10
申请人： LG CHEM, LTD.
发明人： Seul Ah LEE , Yoon Jae MIN , Ui Seok CHUNG , Gicheul KIM
CPC分类号： B01J20/267 , B01J20/28078 , B01J20/3282 , B01J2220/68
摘要： The present disclosure relates to a preparation method of a super absorbent polymer. More specifically, it relates to a preparation method of a super absorbent polymer with improved permeability and anti-caking efficiency while having a high absorption rate by adding an additive having a specific structure to the hydrogel polymer polymerized in the presence of an encapsulated foaming agent, followed by coarse pulverization.
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公开(公告)号：US20190217273A1
公开(公告)日：2019-07-18
申请号：US16359328
申请日：2019-03-20
发明人： Kevin D. Wyndham , Michael F. Morris , Darryl W. Brousmiche , Jason F. Hill , Jacob N. Fairchild
IPC分类号： B01J20/283 , C07F7/18 , B01J20/28 , B01D15/26 , B01D15/30 , B01D15/32 , B01D15/40 , B01J20/288 , B01J20/32 , B01J20/289 , B01D53/02 , B01J20/22 , B01J20/30
CPC分类号： B01J20/283 , B01D15/26 , B01D15/30 , B01D15/305 , B01D15/322 , B01D15/40 , B01D53/025 , B01J20/22 , B01J20/28004 , B01J20/28016 , B01J20/28042 , B01J20/28057 , B01J20/28059 , B01J20/28061 , B01J20/28064 , B01J20/28066 , B01J20/28069 , B01J20/28071 , B01J20/28073 , B01J20/28076 , B01J20/28078 , B01J20/28083 , B01J20/28085 , B01J20/282 , B01J20/284 , B01J20/285 , B01J20/288 , B01J20/289 , B01J20/3085 , B01J20/32 , B01J20/3204 , B01J20/3206 , B01J20/3208 , B01J20/3234 , B01J20/3246 , B01J20/3285 , B01J20/3293 , B01J2220/54 , B01J2220/80 , C07F7/1804
摘要： In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0.
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公开(公告)号：US20180251623A1
公开(公告)日：2018-09-06
申请号：US15727301
申请日：2017-10-06
IPC分类号： C08J9/28 , C08G18/06 , B01J20/28 , C08G18/38 , C08G18/76 , C08G18/78 , C08G18/79 , C01B32/00 , C01B32/05 , B01J20/20 , B01J20/26 , C04B38/00 , C04B35/52 , B01J20/30 , C08G18/32 , C08G101/00
CPC分类号： C08J9/286 , B01J20/20 , B01J20/267 , B01J20/28011 , B01J20/28042 , B01J20/28047 , B01J20/28057 , B01J20/28078 , B01J20/3078 , C01B32/00 , C01B32/05 , C04B38/0032 , C08G18/06 , C08G18/3215 , C08G18/3872 , C08G18/7657 , C08G18/7664 , C08G18/7893 , C08G18/792 , C08G2101/0091 , C08J2201/04 , C08J2201/0502 , C08J2205/026 , C08J2205/042 , C08J2375/04 , Y10T428/1376 , Y10T428/21 , Y10T428/24149 , Y10T428/249953 , Y10T428/249978 , Y10T428/249986 , Y10T428/2982 , Y10T428/31547 , C04B35/52
摘要： Nanoporous three-dimensional networks of polyurethane particles, e.g., polyurethane aerogels, and methods of preparation are presented herein. Such nanoporous networks may include polyurethane particles made up of linked polyisocyanate and polyol monomers. In some cases, greater than about 95% of the linkages between the polyisocyanate monomers and the polyol monomers are urethane linkages. To prepare such networks, a mixture including polyisocyanate monomers (e.g., diisocyanates, triisocyanates), polyol monomers (diols, triols), and a solvent is provided. The polyisocyanate and polyol monomers may be aliphatic or aromatic. A polyurethane catalyst is added to the mixture causing formation of linkages between the polyisocyanate monomers and the polyol monomers. Phase separation of particles from the reaction medium can be controlled to enable formation of polyurethane networks with desirable nanomorphologies, specific surface area, and mechanical properties. Various properties of such networks of polyurethane particles (e.g., strength, stiffness, flexibility, thermal conductivity) may be tailored depending on which monomers are provided in the reaction.
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公开(公告)号：US20180229151A1
公开(公告)日：2018-08-16
申请号：US15515082
申请日：2015-09-29
申请人： Francois PARMENTIER
发明人： Francois PARMENTIER
IPC分类号： B01D15/22 , B01J20/291 , B01J20/292 , B01J20/285 , B01J20/28
CPC分类号： B01D15/22 , B01D53/025 , B01D2253/202 , B01D2253/308 , B01D2253/31 , B01J20/28042 , B01J20/28047 , B01J20/2805 , B01J20/28078 , B01J20/285 , B01J20/291 , B01J20/292 , B01J2220/84
摘要： The invention relates to a chromatography method in which a gaseous, liquid or supercritical mobile phase containing species to be separated is circulated through a packing, said packing comprising: —a plurality of capillary ducts extending in the packing between an upstream face through which the mobile phase enters the packing and a downstream face through which the mobile phase leaves the packing, and —a continuous medium permeable to molecular diffusion extending between said ducts, comprising a porous organic gel or an organic liquid and including at least one network of connected pores, the size of which is greater than two times the molecular diameter of at least one species to be separated and opening to the ducts, so as to give said at least one species a diffusive path between said ducts. The invention also relates to a packing for the implementation of such a method and a method for manufacturing such a packing.
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公开(公告)号：US10016743B2
公开(公告)日：2018-07-10
申请号：US15647587
申请日：2017-07-12
IPC分类号： B01J20/30 , B01J20/20 , B01J20/28 , C01B32/354 , C01B32/348 , C01B31/08 , C01B31/12
CPC分类号： B01J20/3078 , B01J20/20 , B01J20/28004 , B01J20/28011 , B01J20/28057 , B01J20/28069 , B01J20/28078 , B01J20/3021 , B01J20/3071 , B01J20/3085 , C01B32/348 , C01B32/354
摘要： The present invention provides activated carbon with which hydrophilicity is excellent and the amount of steam adsorbed is increased, and provides a method for producing this activated carbon. This activated carbon is characterized in that the amount of basic functional groups in the activated carbon is 0.470 meq/m2 or greater. Preferably the amount of basic groups per specific surface area of activated carbon is 0.200 μeq/m2 or greater and the ratio of the amount of basic functional groups and the amount of acidic functional groups (basic functional groups/acidic functional groups) is 1.00 or greater. This method for producing activated carbon is characterized in comprising a step for imparting basic functional groups by bringing the activated carbon into contact with a basic substance. According to a preferred embodiment, the method comprises a step for heating the resulting activated carbon in an insert atmosphere.
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10.发明申请公开(公告)号：US20180110801A1
公开(公告)日：2018-04-26
申请号：US15559196
申请日：2016-03-18
申请人： Dazhi YANG
发明人： Dazhi YANG
IPC分类号： A61K31/785 , C08G83/00 , A61P7/08 , C08G81/00 , C08B15/06 , C08J9/16 , B01J20/26 , B01J20/28
CPC分类号： A61K31/785 , A61K9/14 , A61K31/738 , A61P7/08 , B01J20/264 , B01J20/267 , B01J20/28004 , B01J20/28078 , B01J20/28085 , B01J20/3085 , C08B15/06 , C08F251/02 , C08G73/0206 , C08G81/00 , C08G83/002 , C08G2101/00 , C08G2210/00 , C08J9/16 , C08J2205/022 , C08J2207/10 , C08J2387/00 , C08L1/08 , C08L3/20 , C08L5/02 , C08L5/08
摘要： Disclosed is a pharmaceutical composition for treating hyperuricemia (HUA). The pharmaceutical composition includes a polysaccharide-polyamine copolymer and a pharmaceutically acceptable salt thereof as active ingredients. The polysaccharide-polyamine copolymer is formed by copolymerization of the following two parts: a selectively oxidized polysaccharide with 2,3-dialdehydo, and a polyamine with an amino functional group; the polyamine with an amino functional group and the selectively oxidized polysaccharide with 2,3-dialdehydo can form a net structure by means of covalent crosslinking, resulting in a hydrogel with an amino functional group or a granular polysaccharide-polyamine copolymer, wherein the amino functional group in the hydrogel with an amino functional group or the granular polysaccharide-polyamine copolymer can be protonated so as to form a cationic copolymer of a three-dimensional network structure having a protonated site, and the nitrogen content of the cationic copolymer and the nitrogen content of the polysaccharide-polyamine copolymer are above 12.3 wt %, and both the cationic copolymer and the polysaccharide-polyamine copolymer are water-insoluble.
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