公开(公告)号：US20240326019A1

公开(公告)日：2024-10-03

申请号：US18739559

申请日：2024-06-11

申请人： Waters Technologies Corporation

发明人： Yeliz Tunc Sarisozen ,  Nicole L. Lawrence ,  Darryl W. Brousmiche ,  Andrew Wyatt Schmudlach ,  Matthew A. Lauber

IPC分类号： B01J20/289 ,  B01J20/10 ,  B01J20/26 ,  B01J20/28

CPC分类号： B01J20/289 ,  B01J20/103 ,  B01J20/262 ,  B01J20/265 ,  B01J20/28004 ,  B01J20/28011 ,  B01J20/28016 ,  B01J20/28052 ,  B01J20/28083 ,  B01J20/28085 ,  B01J2220/4806 ,  B01J2220/54 ,  B01J2220/58

摘要： The present disclosure is directed to stationary phase materials (e.g., porous inorganic-organic hybrid particles) for performing size exclusion chromatography. Embodiments of the present disclosure feature hydroxy-terminated polyethylene glycol surface modified stationary phase materials.

公开(公告)号：US11998890B2

公开(公告)日：2024-06-04

申请号：US17376567

申请日：2021-07-15

申请人： Puridify Ltd.

发明人： Marc Hummersone ,  Benjamin Wallis ,  Frederic Leroux ,  William Law

IPC分类号： B01D15/20 ,  B01D15/38 ,  B01J20/26 ,  B01J20/28 ,  B01J20/286 ,  B01J20/289 ,  B01J20/30 ,  B01J20/32 ,  C07K1/16

CPC分类号： B01J20/265 ,  B01D15/20 ,  B01D15/3809 ,  B01J20/28023 ,  B01J20/28038 ,  B01J20/28052 ,  B01J20/286 ,  B01J20/289 ,  B01J20/3085 ,  B01J20/3092 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3217 ,  B01J20/3219 ,  B01J20/3227 ,  B01J20/3248 ,  B01J20/3272 ,  B01J20/328 ,  B01J20/3293 ,  C07K1/16 ,  B01J2220/62

摘要： Functionalised polymeric chromatography medium, comprising: at least one non-woven sheet comprising one or more polymeric nanofibers having a mean diameter of 10-1000 nm; one or more polymer chains grafted onto the one or more polymeric nanofibers, wherein the polymer chains are poly-glycerol chains comprising glycidol monomer residues or wherein the polymer chains comprise divinylsulfone monomer residues; and at least one ligand group bonded to the one or more polymer chains.

公开(公告)号：US11951453B2

公开(公告)日：2024-04-09

申请号：US16961514

申请日：2019-01-11

申请人： RESTEK CORPORATION

发明人： Hanjiang Dong ,  Edward G. Franklin ,  Charles Vernon Bartlett

IPC分类号： B01J20/283 ,  B01J20/10 ,  B01J20/28 ,  B01J20/289 ,  B01J20/30 ,  B01J20/32

CPC分类号： B01J20/283 ,  B01J20/103 ,  B01J20/28011 ,  B01J20/28057 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/289 ,  B01J20/3057 ,  B01J20/3078 ,  B01J20/3257

摘要： Superficially porous particles are disclosed, each including a solid core and a layered porous shell. The layered porous shell includes a porous inner layer and at least one porous outer layer, a shell skeleton thickness greater than 1 nm, and constitutes from 10 vol % to 90 vol % of the plurality of superficially porous particles. The porous inner layer includes an inner layer thickness of less than 300 nm. The at least one porous outer layer includes a cumulative outer layer thickness ranging from 1 to 100 times the inner layer thickness, a predominately radial pore orientation, and an outer layer pore structure which is more organized than the inner layer pore structure. A layer-by-layer process for forming a plurality of superficially porous particles with layered structure is disclosed. A post-modification process for preparing a plurality of chromatographically enhanced superficially porous properties is also disclosed.

公开(公告)号：US20240050925A1

公开(公告)日：2024-02-15

申请号：US18258715

申请日：2021-12-21

申请人： METROHM AG

发明人： Alexandra ZATIRAKHA ,  Andrea AESCHLIMANN ,  Bastian BRAND ,  Brigitte LAMERS

IPC分类号： B01J20/289 ,  B01J20/26 ,  B01J20/32 ,  B01D15/36

CPC分类号： B01J20/289 ,  B01J20/267 ,  B01J20/3282 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3293 ,  B01D15/361 ,  B01J2220/54

摘要： A method for modifying a support material, in particular a polymeric support material, for use as a stationary phase in an analytical or preparative separation process. The method includes the steps of providing a support material, coating the support material with an oligoamine or polyamine and reacting the support material with a compound comprising a first functional group reactive with amines and/or hydroxy group and an ion-exchange group. Additionally a support material, a chromatography column, a method of chromatographic separation of analytes and the use of such support material.

公开(公告)号：US20240024851A1

公开(公告)日：2024-01-25

申请号：US17997042

申请日：2021-04-27

申请人： KANEKA CORPORATION

发明人： Takuma SUEOKA ,  Masakatsu NISHIHACHIJO ,  Hisako YAURA

IPC分类号： B01J20/28 ,  B01J20/289 ,  B01J20/32 ,  C07K17/08 ,  B01D15/38

CPC分类号： B01J20/28038 ,  B01J20/289 ,  B01J20/3212 ,  B01J20/3219 ,  C07K17/08 ,  B01D15/3804 ,  C07K2317/22

摘要： A structure includes a water-insoluble fiber, and a low-molecular-weight antibody connected to the water-insoluble fiber. A method of producing a structure includes connecting a water-insoluble fiber and a low-molecular-weight antibody to each other.

公开(公告)号：US20230365954A1

公开(公告)日：2023-11-16

申请号：US18201392

申请日：2023-05-24

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Brian Dwyer ,  Bohong Zhang ,  Jun Hu ,  Muthuraman Meiyappan ,  Thomas Miller ,  Paul McLean ,  Clark Pan

IPC分类号： C12N9/40 ,  B01J20/286 ,  B01J20/289 ,  B01J20/32

CPC分类号： C12N9/2465 ,  C12Y302/01022 ,  B01J20/286 ,  B01J20/289 ,  B01J20/3219 ,  B01J20/3253 ,  B01J20/3255

摘要： The invention relates to an affinity resin functionalized with small molecule inhibitors of glycoside-cleaving enzymes, e.g., α-galactosidase A (α-Gal A), glucocerebrosidase (GCB), β-galactosidase, and acid alpha-glucosidase (GAA), and a method for purifying glycoside-cleaving enzymes produced in a cell line using the small molecule inhibitor-functionalized affinity resin.

公开(公告)号：US20230234029A1

公开(公告)日：2023-07-27

申请号：US17927384

申请日：2021-07-01

申请人： ACADEMY OF NATIONAL FOOD AND STRATEGIC RESERVES ADMINISTRATION

发明人： Changpo SUN ,  Yangying HAN ,  Hujun LIU ,  Jun WANG ,  Xiaojiao CHANG ,  Jing SUN

IPC分类号： B01J20/26 ,  B01J20/20 ,  B01J20/10 ,  B01J20/289 ,  B01J20/28 ,  B01J20/32 ,  B01J20/30 ,  B01D15/20 ,  B01D15/18

CPC分类号： B01J20/268 ,  B01J20/205 ,  B01J20/103 ,  B01J20/289 ,  B01J20/28019 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3278 ,  B01J20/3021 ,  B01J20/3092 ,  B01D15/206 ,  B01D15/1807 ,  B01J2220/54

摘要： A zearalenone functionalized graphene surface molecularly imprinted material, a preparation method therefor and the use thereof, which belong to the technical field of molecularly imprinted materials. The zearalenone functionalized graphene surface molecularly imprinted material is prepared by using RGO as a carrier, CDHB as a template molecule, 1-ALPP as a functional monomer, TRIM as a cross-linking agent, AIBN as an initiator, and acetonitrile as a pore-forming agent.

公开(公告)号：US20190177342A1

公开(公告)日：2019-06-13

申请号：US16276907

申请日：2019-02-15

申请人： 3M INNOVATIVE PROPERTIES COMPANY

发明人： George W. Griesgraber ,  Robert T. Fitzsimons, JR. ,  Douglas A. Hanggi ,  Masayuki Nakamura ,  Jerald K. Rasmussen

IPC分类号： C07F7/18 ,  G01N1/40 ,  B01J20/286 ,  B01J20/28 ,  B01J20/32 ,  B01J20/10 ,  B01J20/22 ,  B01J20/289 ,  B01D24/00 ,  C12M1/12 ,  B01D15/00

CPC分类号： C07F7/1804 ,  B01D15/00 ,  B01D24/00 ,  B01J20/103 ,  B01J20/22 ,  B01J20/28004 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/286 ,  B01J20/289 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3244 ,  B01J20/3293 ,  B01J2220/80 ,  C07F7/1872 ,  C07F7/1892 ,  C12M25/16 ,  G01N1/405

摘要： Guanidine-functionalized particles and methods of making and using such particles.

公开(公告)号：US20180345249A1

公开(公告)日：2018-12-06

申请号：US15571269

申请日：2016-05-03

申请人： ELICITYL

发明人： Ludovic BASTIDE ,  Silvère BONNET ,  Benoit DARBLADE ,  Stéphane HAVET ,  Bernard MANDRAND ,  Mialy RANDRIANTSOA

IPC分类号： B01J20/289 ,  B01D15/38 ,  B01J20/288 ,  B01J20/22 ,  B01J20/24 ,  B01J20/32 ,  A61M1/36

CPC分类号： B01J20/289 ,  A61M1/3679 ,  A61M2202/0413 ,  B01D15/3804 ,  B01D15/3809 ,  B01J20/223 ,  B01J20/24 ,  B01J20/286 ,  B01J20/288 ,  B01J20/3208 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3244 ,  B01J20/3274 ,  B01J20/3278 ,  G01N33/491

摘要： The present invention provides a substrate for purifying a biological liquid comprising a solid phase onto which molecules of at least one oligosaccharide that is capable of binding to one or more antibodies are grafted by covalent bonding, said solid phase carrying free aldehyde functions —CHO, a method of producing such a substrate, the use of such a substrate to stabilize the antibody/oligosaccharide bond, as well as a method of purifying a biological liquid in which the biological liquid is brought into contact with at least one substrate of the invention, in a manner such as to obtain the capture of antibodies present in said biological liquid by binding with at least certain of the molecules of oligosaccharide(s) grafted onto the solid phase.

公开(公告)号：US20180345248A1

公开(公告)日：2018-12-06

申请号：US16058069

申请日：2018-08-08

申请人： Waters Technologies Corporation

发明人： Darryl W. Brousmiche ,  Jacob N. Fairchild ,  Jason F. Hill ,  Giorgis Isaac ,  Michael F. Morris ,  Kevin D. Wyndham

IPC分类号： B01J20/283 ,  C07F7/18 ,  B01J20/28 ,  B01D15/30 ,  B01D15/32 ,  B01D15/40 ,  B01D53/02 ,  B01J20/22 ,  B01J20/32 ,  B01J20/30 ,  B01J20/289 ,  B01J20/288 ,  B01D15/26 ,  B01J20/282 ,  B01J20/285 ,  B01J20/284

CPC分类号： B01J20/283 ,  B01D15/26 ,  B01D15/30 ,  B01D15/305 ,  B01D15/322 ,  B01D15/40 ,  B01D53/025 ,  B01J20/22 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28042 ,  B01J20/28057 ,  B01J20/28059 ,  B01J20/28061 ,  B01J20/28064 ,  B01J20/28066 ,  B01J20/28069 ,  B01J20/28071 ,  B01J20/28073 ,  B01J20/28076 ,  B01J20/28078 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/282 ,  B01J20/284 ,  B01J20/285 ,  B01J20/288 ,  B01J20/289 ,  B01J20/3085 ,  B01J20/32 ,  B01J20/3204 ,  B01J20/3206 ,  B01J20/3208 ,  B01J20/3234 ,  B01J20/3246 ,  B01J20/3285 ,  B01J20/3293 ,  B01J2220/54 ,  B01J2220/80 ,  C07F7/1804

摘要： The present disclosure relates to a method of separating a compound of interest, particularly unsaturated compound(s) of interest, from a mixture. The compound is separated using a column having a chromatographic stationary phase material for various different modes of chromatography containing a first substituent and a second substituent. The first substituent minimizes compound retention variation over time under chromatographic conditions. The second substituent chromatographically and selectively retains the compound by incorporating one or more aromatic, polyaromatic, heterocyclic aromatic, or polyheterocyclic aromatic hydrocarbon groups, each group being optionally substituted with an aliphatic group.