-
公开(公告)号：US20240343934A1
公开(公告)日：2024-10-17
申请号：US18608596
申请日：2024-03-18
发明人： Yasuhisa MINAGAWA , Chiaki DOKAI
IPC分类号： C09D133/14 , C07K17/08 , G01N1/40
CPC分类号： C09D133/14 , C07K17/08 , G01N1/405
摘要： Provided is a polymer-coated glass substrate having a surface with controlled irregularity and a low elastic modulus. The polymer-coated glass substrate includes a glass substrate and two or more hydrophilic polymer layers on a surface of the glass substrate.
-
公开(公告)号：US20240302380A1
公开(公告)日：2024-09-12
申请号：US18493207
申请日：2023-10-24
发明人： Edward MARCOTTE , Eric V. ANSLYN , Andrew ELLINGTON , Jagannath SWAMINATHAN , Erik HERNANDEZ , Amber JOHNSON , Alexander BOULGAKOV , James L. BACHMAN , Helen SEIFERT
CPC分类号： G01N33/6824 , C07K17/08 , G01N33/582 , G01N33/58 , G01N33/6818 , G01N2570/00
摘要： Identifying proteins and peptides, and more specifically large-scale sequencing of single peptides in a mixture of diverse peptides at the single molecule level is an unmet challenge in the field of protein sequencing. Herein are methods for identifying amino acids in peptides, including peptides comprising unnatural amino acids. In one embodiment, the N-terminal amino acid is labeled with a first label and an internal amino acid is labeled with a second label. In some embodiments, the labels are fluorescent labels. In other embodiments, the internal amino acid is Lysine. In other embodiments, amino acids in peptides are identified based on the fluorescent signature for each peptide at the single molecule level.
-
公开(公告)号：US20240109979A1
公开(公告)日：2024-04-04
申请号：US18275893
申请日：2022-03-04
申请人： faCellitate GmbH
CPC分类号： C07K17/08 , C12N5/0068 , C12N2537/10
摘要： The present invention is concerned with materials and methods for mediating eukaryotic cell attachment to rigid surfaces. In particular, the invention is concerned with coatings for forming cell attachment surfaces, preferably for cell culture devices, microfluidic devices, biosensors or implants. The invention correspondingly provides polymer conjugates for such coatings, methods of polymer conjugate formation, methods of polymer conjugate application and uses of such polymer conjugates. The invention also provides surfaces and devices at least partly coated with such polymer conjugates.
-
公开(公告)号：US20240002547A1
公开(公告)日：2024-01-04
申请号：US18348229
申请日：2023-07-06
申请人： AEBI LTD.
发明人： llan MORAD , Hanan ITZHAKI
IPC分类号： C07K17/08 , C07K14/82 , A61K47/60 , A61P35/00 , C07K14/47 , C07K7/08 , A61K47/62 , A61K47/64 , C07K14/33 , C07K14/705
CPC分类号： C07K17/08 , C07K14/82 , A61K47/60 , A61P35/00 , C07K14/4748 , C07K7/08 , A61K47/62 , A61K47/6415 , C07K14/33 , C07K14/70532 , C07K2319/33 , C07K2319/00 , C07K2319/40 , C07K2319/55 , A61K38/00
摘要： The present invention provides constructs comprising a plurality of peptides capable of targeting at least two different extracellular tumor antigens and a toxin, optionally connected to an organic scaffold. Use of such constructs in treating cancer are provided as well. The invention also provides particular peptides binding certain extracellular tumor antigens as well as toxins having antitumor activity.
-
公开(公告)号：US09902784B2
公开(公告)日：2018-02-27
申请号：US15708736
申请日：2017-09-19
发明人： Yeon-Gyu Yu , Moon-Hee Sung
CPC分类号： C07K17/08 , C08G69/08 , C08G69/10 , C08K5/0008
摘要： A method of stabilizing a membrane protein includes forming a membrane protein-amphiphilic polymer complex by binding a membrane protein in an aqueous solution to the amphiphilic polymer represented by Formula 1. The amphiphilic polymer includes a large amount of hydrophilic structures and hydrophobic structures, and thereby effectively stabilizing a membrane protein having a hydrophobic surface in an aqueous solution.
-
公开(公告)号：US20180009909A1
公开(公告)日：2018-01-11
申请号：US15708736
申请日：2017-09-19
发明人： Yeon-Gyu YU , Moon-Hee SUNG
CPC分类号： C07K17/08 , C08G69/08 , C08G69/10 , C08K5/0008
摘要： A method of stabilizing a membrane protein includes forming a membrane protein-amphiphilic polymer complex by binding a membrane protein in an aqueous solution to the amphiphilic polymer represented by Formula 1. The amphiphilic polymer includes a large amount of hydrophilic structures and hydrophobic structures, and thereby effectively stabilizing a membrane protein having a hydrophobic surface in an aqueous solution.
-
公开(公告)号：US09821278B2
公开(公告)日：2017-11-21
申请号：US15506654
申请日：2015-08-25
发明人： Carlo David Montemagno , Jeffrey Germain , Kyle Minor , Sinoj Abraham , Hiofan Hoi , Yuan He
IPC分类号： B01D71/82 , C02F1/44 , C02F101/00 , C07K14/705 , C07K17/08 , C08G75/23 , C02F101/12 , C02F101/16 , C02F101/30 , C02F101/38
CPC分类号： B01D71/82 , C02F1/44 , C02F2101/12 , C02F2101/16 , C02F2101/306 , C02F2101/308 , C02F2101/38 , C02F2103/08 , C07B2200/11 , C07K14/47 , C07K14/705 , C07K17/00 , C07K17/08 , C07K17/12 , C08G75/23
摘要： Constructs having membrane proteins stabilized by functionalized beta-sheet peptides are provided. The constructs can be associated with or covalently linked to supports. The support can be a membrane. The membrane can be used to selectively move desired particles from one side of the membrane to the other while impeding passage of undesired particles through the membrane. Methods of making and using such constructs and membranes are provided.
-
公开(公告)号：US20170268032A1
公开(公告)日：2017-09-21
申请号：US15464043
申请日：2017-03-20
CPC分类号： C12Q1/18 , C07K5/0806 , C07K5/0812 , C07K17/06 , C07K17/08 , G01N2333/195 , G01N2500/10
摘要： A solid supported branched linker assay system, including an alpha compound and a beta compounds reversibly tethered to a solid support; a branched linker coupled to the solid support that tethers the alpha and beta compounds to the solid support; the branched linker having two cleavable linkers that are chemically distinct from one another, wherein a first chemically distinct linker tethers the β compound to the branched linker and a second chemically distinct linker tethers the α compound to the branched linker; and at least two means for cleaving the chemically distinct linkers, wherein a first cleavage means is configured to selectively cleave a first chemically distinct linker and a second cleavage means is configured to selectively cleave a second chemically distinct linker.
-
公开(公告)号：US09732367B2
公开(公告)日：2017-08-15
申请号：US14430542
申请日：2013-09-24
申请人： MEDIMMUNE LIMITED
发明人： Kenneth H. Grabstein , Michael Van Brunt , Marcello Marelli , William Brady , Jeffrey C. Johnson
IPC分类号： C12P21/02 , C07K16/40 , C12N15/85 , C07K16/46 , C07K17/08 , C07K16/32 , C07C271/12 , C07C271/20 , C07C271/22 , C07C233/49 , C07C233/56 , C07C247/04 , C07K16/24 , A61K47/48 , C07C235/74 , C07K14/435 , C07K16/28 , C12N9/00
CPC分类号： C12P21/02 , A61K47/6851 , C07C233/49 , C07C233/56 , C07C235/74 , C07C247/04 , C07C271/12 , C07C271/20 , C07C271/22 , C07K14/43595 , C07K16/244 , C07K16/248 , C07K16/2863 , C07K16/32 , C07K16/40 , C07K16/46 , C07K17/08 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/40 , C07K2317/51 , C12N9/93 , C12N15/85 , C12Y301/01025 , C12Y601/01 , C12Y601/01025
摘要： There is provided inter alia a process for stabilizing a eukaryotic cell line which expresses PylRS and tRNAPyl and which is suitable for incorporation of a gene encoding a target protein containing one or more non-natural amino acids encoded by a nonsense codon which comprises culturing said cell line under conditions in which the adverse effect of tRNAPyl expression on cell viability and/or cell growth is reduced or eliminated.
-
公开(公告)号：US09688777B2
公开(公告)日：2017-06-27
申请号：US14392208
申请日：2014-06-27
IPC分类号： C07K17/08 , C07K14/00 , G01N33/68 , C07K5/062 , C07K14/315 , C08G61/12 , C12N9/42 , C12N9/96 , G01N33/543
CPC分类号： C07K17/08 , C07K5/06034 , C07K14/00 , C07K14/315 , C08G61/128 , C08G2261/1426 , C08G2261/1432 , C08G2261/148 , C08G2261/94 , C12N9/2437 , C12N9/96 , C12Y302/01004 , G01N33/54306 , G01N33/68
摘要： Provided is a protein-polymer complex which is capable of detecting a target with good sensitivity. Specifically provided is a protein-polymer complex comprising a polymer having a glutamine (Gln) residue or a primary amine on a side chain, wherein either a protein having a primary amine is bound to the glutamine (Gln) residue, or a protein having a glutamine (Gln) residue is bound to the primary amine.
-
-
-
-
-
-
-
-
-
搜索结果
389 条记录 (耗时 0.029 秒)
