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公开(公告)号：US10253345B2
公开(公告)日：2019-04-09
申请号：US15611116
申请日：2017-06-01
申请人： MEDIMMUNE LIMITED
发明人： Kenneth H. Grabstein , Michael Van Brunt , Marcello Marelli , William Brady , Jeffrey C. Johnson
IPC分类号： C12P21/02 , A61K47/68 , C07C271/12 , C07C271/20 , C07C271/22 , C07C233/49 , C07C233/56 , C07C247/04 , C07C17/08 , C07K16/24 , C07K16/32 , C07C235/74 , C07K16/46 , C07K17/08 , C07K14/435 , C07K16/28 , C07K16/40 , C12N9/00 , C12N15/85
摘要： There is provided inter alia a process for stabilizing a eukaryotic cell line which expresses PylRS and tRNAPyl and which is suitable for incorporation of a gene encoding a target protein containing one or more non-natural amino acids encoded by a nonsense codon which comprises culturing said cell line under conditions in which the adverse effect of tRNAPyl expression on cell viability and/or cell growth is reduced or eliminated.
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公开(公告)号：US09732367B2
公开(公告)日：2017-08-15
申请号：US14430542
申请日：2013-09-24
申请人： MEDIMMUNE LIMITED
发明人： Kenneth H. Grabstein , Michael Van Brunt , Marcello Marelli , William Brady , Jeffrey C. Johnson
IPC分类号： C12P21/02 , C07K16/40 , C12N15/85 , C07K16/46 , C07K17/08 , C07K16/32 , C07C271/12 , C07C271/20 , C07C271/22 , C07C233/49 , C07C233/56 , C07C247/04 , C07K16/24 , A61K47/48 , C07C235/74 , C07K14/435 , C07K16/28 , C12N9/00
CPC分类号： C12P21/02 , A61K47/6851 , C07C233/49 , C07C233/56 , C07C235/74 , C07C247/04 , C07C271/12 , C07C271/20 , C07C271/22 , C07K14/43595 , C07K16/244 , C07K16/248 , C07K16/2863 , C07K16/32 , C07K16/40 , C07K16/46 , C07K17/08 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/40 , C07K2317/51 , C12N9/93 , C12N15/85 , C12Y301/01025 , C12Y601/01 , C12Y601/01025
摘要： There is provided inter alia a process for stabilizing a eukaryotic cell line which expresses PylRS and tRNAPyl and which is suitable for incorporation of a gene encoding a target protein containing one or more non-natural amino acids encoded by a nonsense codon which comprises culturing said cell line under conditions in which the adverse effect of tRNAPyl expression on cell viability and/or cell growth is reduced or eliminated.
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公开(公告)号：US10131920B2
公开(公告)日：2018-11-20
申请号：US14775684
申请日：2014-03-14
申请人： MEDIMMUNE LIMITED
摘要： There is provided inter alia a DNA construct which comprises a tRNApyl coding sequence and a RNA polymerase III promoter sequence which is capable of acting to express functional tRNApyl sufficiently to support nonsense suppression in a eukaryotic expression system.
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公开(公告)号：US10214761B2
公开(公告)日：2019-02-26
申请号：US15610931
申请日：2017-06-01
申请人： MEDIMMUNE LIMITED
IPC分类号： C12P21/02 , A61K47/68 , C07C271/12 , C07C271/20 , C07C271/22 , C07C233/49 , C07C233/56 , C07C247/04 , C07C235/74 , C07K16/24 , C07K16/32 , C07K16/46 , C07K17/08 , C07K14/435 , C07K16/28 , C07K16/40 , C12N9/00 , C12N15/85
摘要： There are provided amino acid derivatives of formula V and VI as defined herein which are pyrrolysine analogs for use in bioconjugation processes.
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公开(公告)号：US09981908B2
公开(公告)日：2018-05-29
申请号：US14910107
申请日：2014-08-04
申请人： MedImmune Limited
IPC分类号： C07C323/58 , C07C271/12 , C07C271/16 , C07C271/20 , C07C271/22 , C07C275/10 , C07C275/14 , C07C275/16 , C07C235/06 , C07C247/04 , C07K16/32 , C07C275/20
CPC分类号： C07C323/58 , C07C235/06 , C07C247/04 , C07C271/12 , C07C271/16 , C07C271/20 , C07C271/22 , C07C275/10 , C07C275/14 , C07C275/16 , C07C275/20 , C07K16/32 , C07K2317/24 , C07K2317/40 , C07K2317/526
摘要： There are provided pyrrolysine analogs of the formulae (X), (I), (II), (V), (VI), (VII) and (VIII), in which the a, b, d, X, Y, Z, FG, R, R1, R2 and R3 are as defined in the claims, which are useful in bioconjugation processes and mutant proteins containing them.
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公开(公告)号：US20160176811A1
公开(公告)日：2016-06-23
申请号：US14910107
申请日：2014-08-04
申请人： MEDIMMUNE LIMITED
IPC分类号： C07C323/58 , C07C275/14 , C07C271/22 , C07C271/12 , C07C247/04 , C07C235/06 , C07C271/16 , C07C275/20
CPC分类号： C07C323/58 , C07C235/06 , C07C247/04 , C07C271/12 , C07C271/16 , C07C271/20 , C07C271/22 , C07C275/10 , C07C275/14 , C07C275/16 , C07C275/20 , C07K16/32 , C07K2317/24 , C07K2317/40 , C07K2317/526
摘要： There are provided pyrrolysine analogues of the formulae (X), (I), (II), (V), (VI), (VII) and (VIII), in which the a, b, d, X, Y, Z, FG, R, R1, R2 and R3 are as defined in the claims, which are useful in bioconjugation processes and mutant proteins containing them.
摘要翻译： 提供式（X），（I），（II），（V），（VI），（VII）和（VIII）的吡咯赖氨酸类似物，其中a，b，d，X，Y，Z ，FG，R，R 1，R 2和R 3如权利要求中所定义，其可用于生物缀合过程和含有它们的突变蛋白。
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公开(公告)号：US20170306381A1
公开(公告)日：2017-10-26
申请号：US15611116
申请日：2017-06-01
申请人： MEDIMMUNE LIMITED
发明人： Kenneth H. Grabstein , Michael Van Brunt , Marcello Marelli , William Brady , Jeffrey C. Johnson
IPC分类号： C12P21/02 , C07C233/56 , C07C235/74 , C07C247/04 , C07C271/12 , C07C271/20 , C07C233/49 , C12N9/00 , C07K17/08 , C07K16/46 , C07K16/40 , C07K16/32 , C07K16/28 , C07K16/24 , C07K14/435 , C07C271/22 , C12N15/85
CPC分类号： C12P21/02 , A61K47/6851 , C07C233/49 , C07C233/56 , C07C235/74 , C07C247/04 , C07C271/12 , C07C271/20 , C07C271/22 , C07K14/43595 , C07K16/244 , C07K16/248 , C07K16/2863 , C07K16/32 , C07K16/40 , C07K16/46 , C07K17/08 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/40 , C07K2317/51 , C12N9/93 , C12N15/85 , C12Y301/01025 , C12Y601/01 , C12Y601/01025
摘要： There is provided inter alia a process for stabilizing a eukaryotic cell line which expresses PylRS and tRNAPyl and which is suitable for incorporation of a gene encoding a target protein containing one or more non-natural amino acids encoded by a nonsense codon which comprises culturing said cell line under conditions in which the adverse effect of tRNAPyl expression on cell viability and/or cell growth is reduced or eliminated.
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公开(公告)号：US20170306380A1
公开(公告)日：2017-10-26
申请号：US15610931
申请日：2017-06-01
申请人： MEDIMMUNE LIMITED
IPC分类号： C12P21/02 , C07C233/49 , C12N9/00 , C07C233/56 , C07C235/74 , C07C247/04 , C07C271/12 , C07K17/08 , C07K16/46 , C07K16/40 , C07K16/32 , C07K16/28 , C07K16/24 , C07K14/435 , C07C271/22 , C07C271/20 , C12N15/85
CPC分类号： C12P21/02 , A61K47/6851 , C07C233/49 , C07C233/56 , C07C235/74 , C07C247/04 , C07C271/12 , C07C271/20 , C07C271/22 , C07K14/43595 , C07K16/244 , C07K16/248 , C07K16/2863 , C07K16/32 , C07K16/40 , C07K16/46 , C07K17/08 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/40 , C07K2317/51 , C12N9/93 , C12N15/85 , C12Y301/01025 , C12Y601/01 , C12Y601/01025
摘要： There are provided amino acid derivatives of formula V and VI as defined herein which are pyrrolysine analogs for use in bioconjugation processes.
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公开(公告)号：US09670521B2
公开(公告)日：2017-06-06
申请号：US14430412
申请日：2013-09-24
申请人： MEDIMMUNE LIMITED
IPC分类号： C07C233/49 , C07C233/56 , C07C235/74 , C07C247/04 , C07C271/12 , C07C271/20 , C07C271/22 , C07K16/24 , C07K16/32 , C07K16/46 , C07K17/08 , C07K16/40 , C12N9/00 , C12N15/85 , C12P21/02 , A61K47/48 , C07K14/435 , C07K16/28
CPC分类号： C12P21/02 , A61K47/6851 , C07C233/49 , C07C233/56 , C07C235/74 , C07C247/04 , C07C271/12 , C07C271/20 , C07C271/22 , C07K14/43595 , C07K16/244 , C07K16/248 , C07K16/2863 , C07K16/32 , C07K16/40 , C07K16/46 , C07K17/08 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/40 , C07K2317/51 , C12N9/93 , C12N15/85 , C12Y301/01025 , C12Y601/01 , C12Y601/01025
摘要： There are provided amino acid derivatives of formula V and VI as defined herein which are pyrrolysine analogs for use in bioconjugation processes.
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