公开(公告)号：US20240092728A1

公开(公告)日：2024-03-21

申请号：US18260420

申请日：2022-01-05

申请人： Evonik Operations GmbH

发明人： Xin LU ,  Jennifer Schild ,  Sandra Nattland ,  Marita Regina Baetsen ,  Ursula Maczkiewitz ,  Hans Henning Wenk ,  Monica Desiree van Logchem ,  Lisa Maus

IPC分类号： C07C235/08 ,  A61K8/42 ,  A61K8/49 ,  A61Q19/08 ,  B01J31/02 ,  C07C235/74 ,  C07D309/10

CPC分类号： C07C235/08 ,  A61K8/42 ,  A61K8/498 ,  A61Q19/08 ,  B01J31/0244 ,  C07C235/74 ,  C07D309/10

摘要： Hydroxy-substituted sphingolipids are useful as constituents in cosmetic formulations. A method for preparing the sphingolipids involves reacting a lysosphingolipid with a hydroxycarboxylic acid or an intramolecular cyclic ester of a hydroxycarboxylic acid. The sphingolipids can be used for therapy or prophylaxis of cell damage, including skin cell damage and cell damage induced by UV radiation.

公开(公告)号：US20230159421A1

公开(公告)日：2023-05-25

申请号：US17788698

申请日：2020-12-23

申请人： Kynan Duke IP, LLC

发明人： Colin Charles Duke ,  Rujee Kyokajee DUKE ,  Van Hoan TRAN

IPC分类号： C07C43/23 ,  C07C41/26 ,  C07C51/367 ,  C07C201/12 ,  C07C209/04 ,  C07C303/40 ,  C07C231/12 ,  C07C231/14 ,  C07C277/08 ,  C07D235/26 ,  C07D263/58 ,  A61P35/00 ,  A61P17/06 ,  A61P17/00 ,  A61P29/00 ,  C07C217/80 ,  C07C65/28 ,  C07C217/82 ,  C07C311/08 ,  C07C233/01 ,  C07C237/04 ,  C07C225/06 ,  C07C235/74 ,  C07C279/18

CPC分类号： C07C43/23 ,  C07C41/26 ,  C07C51/367 ,  C07C201/12 ,  C07C209/04 ,  C07C303/40 ,  C07C231/12 ,  C07C231/14 ,  C07C277/08 ,  C07D235/26 ,  C07D263/58 ,  A61P35/00 ,  A61P17/06 ,  A61P17/00 ,  A61P29/00 ,  C07C217/80 ,  C07C65/28 ,  C07C217/82 ,  C07C311/08 ,  C07C233/01 ,  C07C237/04 ,  C07C225/06 ,  C07C235/74 ,  C07C279/18

摘要： The present disclosure relates to substituted hydroxystilbene compounds and derivatives, specifically 2-substituted hydroxystilbene compounds and derivatives, the synthesis of such compounds and their use in therapy.

公开(公告)号：US20180297970A1

公开(公告)日：2018-10-18

申请号：US16014552

申请日：2018-06-21

申请人： Celanese International Corporation

发明人： Christoph Mollenkopf ,  Peter Groer ,  Arvind Yadav

IPC分类号： C07D291/06 ,  C07C235/74 ,  A23L27/30

CPC分类号： C07D291/06 ,  A23L27/30 ,  A23V2002/00 ,  C07C235/74

摘要： Improved processes for producing high purity acesulfame potassium. In one embodiment, the process comprises the steps of contacting a solvent, e.g., dichloromethane, and a cyclizing agent, e.g., sulfur trioxide, to form a cyclizing agent composition and reacting an acetoacetamide salt with the cyclizing agent in the composition to form a cyclic sulfur trioxide adduct. The contact time is less than 60 minutes. The process also comprises forming from the cyclic sulfur trioxide adduct composition a finished acesulfame potassium composition comprising non-chlorinated, e.g., non-chlorinated, acesulfame potassium and less than 35 wppm 5-halo acesulfame potassium, preferably less than 5 wppm.

公开(公告)号：US10079387B2

公开(公告)日：2018-09-18

申请号：US14632907

申请日：2015-02-26

申请人： Gao Liu ,  Hui Zhao

发明人： Gao Liu ,  Hui Zhao

IPC分类号： C07C235/74 ,  H01M4/62 ,  H01M4/04 ,  H01M4/134 ,  H01M4/1395 ,  H01M4/38 ,  H01M4/66 ,  C07C235/78 ,  H01M4/02 ,  H01M10/0525

CPC分类号： H01M4/622 ,  C07C235/74 ,  C07C235/78 ,  H01M4/0404 ,  H01M4/134 ,  H01M4/1395 ,  H01M4/386 ,  H01M4/387 ,  H01M4/661 ,  H01M10/0525 ,  H01M2004/027 ,  Y02E60/122

摘要： A Poly(1-pyrenemethyl methacrylate-co-dopamine methacrylamide) PPyDMA polymer binder has been designed and fabricated, and has demonstrated an excellent performance for silicon (Si), graphite and a metal alloy anode materials. The PPyDMA polymer binder demonstrates the great potential of a catechol moiety for use in a lithium-ion battery.

公开(公告)号：US09924718B2

公开(公告)日：2018-03-27

申请号：US13998326

申请日：2013-10-21

申请人： Robert H. Bedoukian

发明人： Robert H. Bedoukian

IPC分类号： C07C235/74 ,  A01N43/16 ,  A01N31/06 ,  A01N35/06 ,  A01N43/08 ,  C07C35/06 ,  C07C35/18 ,  C07C49/603 ,  C07C49/647 ,  C07D307/28 ,  C07D309/18 ,  A01N37/36 ,  A01N37/42

CPC分类号： A01N43/16 ,  A01N31/06 ,  A01N35/06 ,  A01N37/36 ,  A01N37/42 ,  A01N43/08 ,  C07C35/06 ,  C07C35/18 ,  C07C49/603 ,  C07C49/647 ,  C07C235/74 ,  C07D307/28 ,  C07D309/18

摘要： Control and repellency of biting flies, house flies, ticks, ants, fleas, biting midges, cockroaches, spiders and stink bugs is obtained by contact of the insects with at least one of the compounds of the structure (I).

公开(公告)号：US20180042871A1

公开(公告)日：2018-02-15

申请号：US15633480

申请日：2017-06-26

申请人： KALYRA PHARMACEUTICALS, INC.

发明人： Kevin Duane Bunker

IPC分类号： A61K31/16 ,  C07C217/52 ,  A61K45/06 ,  A61K31/24 ,  A61K31/221 ,  A61K9/00 ,  C07C233/63 ,  A61K31/133 ,  A61K31/14 ,  C07C211/62 ,  C07C233/41 ,  C07C233/52 ,  A61K31/13 ,  A61K31/215 ,  A61K31/216 ,  A61K31/22 ,  A61K31/235 ,  C07C233/23 ,  C07C235/74 ,  C07C233/06

CPC分类号： A61K31/16 ,  A61K9/0014 ,  A61K9/0019 ,  A61K31/13 ,  A61K31/133 ,  A61K31/14 ,  A61K31/215 ,  A61K31/216 ,  A61K31/22 ,  A61K31/221 ,  A61K31/235 ,  A61K31/24 ,  A61K45/06 ,  C07C211/62 ,  C07C217/52 ,  C07C233/06 ,  C07C233/23 ,  C07C233/41 ,  C07C233/52 ,  C07C233/63 ,  C07C235/74 ,  C07C2602/38

摘要： Analgesic compounds for treatment of pain or fever that include a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic drugs, and methods for treating pain or fever by administering a compound described herein.

公开(公告)号：US09840460B2

公开(公告)日：2017-12-12

申请号：US15600998

申请日：2017-05-22

申请人： THERAVANCE BIOPHARMA R&D IP, LLC

发明人： Erik Fenster ,  Melissa Fleury ,  Adam D. Hughes

IPC分类号： A61K31/40 ,  A61K31/42 ,  A61K31/44 ,  A61K31/197 ,  A61K31/397 ,  A61K31/5375 ,  C07D205/04 ,  C07D207/09 ,  C07D207/14 ,  C07D213/56 ,  C07C235/34 ,  C07D261/04 ,  C07D295/32 ,  C07C243/38 ,  C07D491/107 ,  C07D213/87 ,  A61K31/341 ,  A61K31/4409 ,  C07D213/86 ,  C07D213/65 ,  C07C235/80 ,  A61K31/4406 ,  A61K31/192 ,  A61K45/06 ,  A61K31/495 ,  A61K31/4015 ,  C07D307/68 ,  C07D213/61 ,  C07D211/62 ,  C07D211/60 ,  C07D211/48 ,  C07D211/46 ,  C07D211/42 ,  C07D211/38 ,  C07D211/22 ,  C07C243/32 ,  C07C243/24 ,  C07D493/10 ,  C07D207/16 ,  C07D207/12 ,  C07D207/08 ,  C07D265/30 ,  C07C235/78 ,  C07C235/74 ,  C07C235/20 ,  C07C235/12 ,  C07C233/56 ,  C07D261/02 ,  C07D239/36 ,  C07D405/06 ,  C07D401/04 ,  C07D233/06 ,  C07D309/08 ,  C07C259/04 ,  C07D213/75

CPC分类号： C07C243/38 ,  A61K31/192 ,  A61K31/197 ,  A61K31/341 ,  A61K31/397 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/42 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/495 ,  A61K31/5375 ,  A61K45/06 ,  C07C233/56 ,  C07C235/12 ,  C07C235/20 ,  C07C235/34 ,  C07C235/74 ,  C07C235/78 ,  C07C235/80 ,  C07C243/24 ,  C07C243/32 ,  C07C259/04 ,  C07C2601/08 ,  C07C2601/16 ,  C07D205/04 ,  C07D207/08 ,  C07D207/09 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D211/22 ,  C07D211/38 ,  C07D211/42 ,  C07D211/46 ,  C07D211/48 ,  C07D211/60 ,  C07D211/62 ,  C07D213/56 ,  C07D213/61 ,  C07D213/65 ,  C07D213/75 ,  C07D213/86 ,  C07D213/87 ,  C07D233/06 ,  C07D239/36 ,  C07D261/02 ,  C07D261/04 ,  C07D265/30 ,  C07D295/32 ,  C07D307/68 ,  C07D309/08 ,  C07D401/04 ,  C07D405/06 ,  C07D491/107 ,  C07D493/10

摘要： In one aspect, the invention relates to compounds having the formula: where R1-R5 and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.

公开(公告)号：US20170320814A1

公开(公告)日：2017-11-09

申请号：US15528403

申请日：2015-11-10

申请人： DAICEL CORPORATION ,  YAMAGUCHI UNIVERSITY

发明人： Yuichi SAKANISHI ,  Takashi SAEKI ,  Mami ITOH

IPC分类号： C07C235/74 ,  A61K47/18 ,  C09D7/00 ,  A23L29/20 ,  A61Q19/00 ,  A61K8/42

CPC分类号： C07C235/74 ,  A23L29/20 ,  A23V2002/00 ,  A61K8/42 ,  A61K47/18 ,  A61K2800/10 ,  A61K2800/48 ,  A61Q19/00 ,  C09D7/43 ,  C09K3/00

摘要： Provided are: a compound, a thickening/stabilizing agent including the compound, a thickened/stabilized composition including the thickening/stabilizing agent and a fluid organic substance, and a method for producing the thickened/stabilized composition, where the compound effectively thickens the fluid organic substance to a desired viscosity and effectively uniformly stabilizes the formulation of the composition containing the fluid organic substance via thickening of the fluid organic substance. The thickening/stabilizing agent according to the present invention includes a compound represented by Formula (1): (R2—HNOC)4-n—R1—(CONH—R3)n  (1) where R1 is a group resulting from removing four hydrogen atoms from the structural formula of butane; R2 and R3 are different from each other and are aliphatic hydrocarbon groups each containing 4 or more carbon atoms; and n is an integer of 1 to 3.

公开(公告)号：US09732367B2

公开(公告)日：2017-08-15

申请号：US14430542

申请日：2013-09-24

申请人： MEDIMMUNE LIMITED

发明人： Kenneth H. Grabstein ,  Michael Van Brunt ,  Marcello Marelli ,  William Brady ,  Jeffrey C. Johnson

IPC分类号： C12P21/02 ,  C07K16/40 ,  C12N15/85 ,  C07K16/46 ,  C07K17/08 ,  C07K16/32 ,  C07C271/12 ,  C07C271/20 ,  C07C271/22 ,  C07C233/49 ,  C07C233/56 ,  C07C247/04 ,  C07K16/24 ,  A61K47/48 ,  C07C235/74 ,  C07K14/435 ,  C07K16/28 ,  C12N9/00

CPC分类号： C12P21/02 ,  A61K47/6851 ,  C07C233/49 ,  C07C233/56 ,  C07C235/74 ,  C07C247/04 ,  C07C271/12 ,  C07C271/20 ,  C07C271/22 ,  C07K14/43595 ,  C07K16/244 ,  C07K16/248 ,  C07K16/2863 ,  C07K16/32 ,  C07K16/40 ,  C07K16/46 ,  C07K17/08 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/40 ,  C07K2317/51 ,  C12N9/93 ,  C12N15/85 ,  C12Y301/01025 ,  C12Y601/01 ,  C12Y601/01025

摘要： There is provided inter alia a process for stabilizing a eukaryotic cell line which expresses PylRS and tRNAPyl and which is suitable for incorporation of a gene encoding a target protein containing one or more non-natural amino acids encoded by a nonsense codon which comprises culturing said cell line under conditions in which the adverse effect of tRNAPyl expression on cell viability and/or cell growth is reduced or eliminated.

公开(公告)号：US09528045B2

公开(公告)日：2016-12-27

申请号：US14627404

申请日：2015-02-20

申请人： SAUDI ARABIAN OIL COMPANY ,  CORNELL UNIVERSITY

发明人： Mazen Y. Kanj ,  Mohammad Harunar Rashid ,  Emmanuel Giannelis

IPC分类号： C09K11/65 ,  C07C215/08 ,  C09K11/06 ,  B82Y20/00

CPC分类号： C09K11/06 ,  B82Y20/00 ,  B82Y40/00 ,  C01B32/15 ,  C07C215/08 ,  C07C227/18 ,  C07C231/02 ,  C07C235/74 ,  C07H15/04 ,  C09K9/02 ,  C09K11/65 ,  C09K2208/10 ,  C09K2211/10 ,  E21B47/1015 ,  E21B49/00 ,  E21B49/008 ,  Y10S977/773 ,  Y10S977/774 ,  Y10S977/896 ,  Y10S977/95 ,  Y10T428/2982

摘要： The present invention relates to carbon-based fluorescent nano-agent tracers for analysis of oil reservoirs. The carbon-based fluorescent nano-agents may be used in the analysis of the porosity of a formation. The nanoagents are suitable for injection into a petroleum reservoir and may be recovered from the reservoir for the determination of hydrocarbon flow rates and retention times.