公开(公告)号：US20240252653A1

公开(公告)日：2024-08-01

申请号：US18441882

申请日：2024-02-14

Applicant: ALNYLAM PHARMACEUTICALS, INC.

Inventor： Jayaprakash K. NAIR ,  Alexander V. KEL'IN ,  Pachamuthu KANDASAMY ,  Kallanthottathil G. RAJEEV ,  Muthiah MANOHARAN

IPC: A61K47/54 ,  A61K31/7088 ,  C07C231/14 ,  C07D207/12 ,  C07H1/00 ,  C07H15/26 ,  C12N15/113

CPC classification number: A61K47/549 ,  A61K31/7088 ,  C07C231/14 ,  C07D207/12 ,  C07H1/00 ,  C07H15/26 ,  C12N15/113 ,  C12N2310/351 ,  C12N2320/32

Abstract: This disclosure relates to an improved process for the preparation of carbohydrate conjugates. The disclosure also relates to carbohydrate conjugated iRNA agents comprising these carbohydrate conjugates, which have improved purity and are advantageous for the in vivo delivery of the iRNA agents.

公开(公告)号：US12037541B2

公开(公告)日：2024-07-16

申请号：US17451086

申请日：2021-10-15

Applicant: CHINA PETROLEUM & CHEMICAL CORPORATION ,  SHANGHAI RESEARCH INSTITUTE OF PETROCHEMICAL TECHNOLOGY, SINOPEC

Inventor： Yingcheng Li ,  Songyuan Gu ,  Weidong Zhang ,  Xinning Bao ,  Ou Sha ,  Zhiqin Shen ,  Yiqing Yang ,  Xiaodong Zhai

IPC: C09K8/584 ,  C07C213/06 ,  C07C217/08 ,  C07C231/14 ,  C07C233/05 ,  C07C233/09 ,  C07C233/36 ,  C07C237/08 ,  C07C237/40 ,  C07C303/22 ,  C07C309/10 ,  C09K8/60

CPC classification number: C09K8/584 ,  C07C213/06 ,  C07C217/08 ,  C07C231/14 ,  C07C233/05 ,  C07C233/09 ,  C07C233/36 ,  C07C237/08 ,  C07C237/40 ,  C07C303/22 ,  C07C309/10 ,  C09K8/602

Abstract: An anionic-cationic-nonionic surfactant represented by the formula (I)




exhibits significantly improved interfacial activity and stability as compared with the prior art. With the present anionic-cationic-nonionic surfactant, a flooding fluid composition for tertiary oil recovery with improved oil displacement efficiency and oil washing capability as compared with the prior art could be produced.

公开(公告)号：US20240174597A1

公开(公告)日：2024-05-30

申请号：US18514650

申请日：2023-11-20

Applicant: Boston Scientific Scimed, Inc.

Inventor： Yen-Hao Hsu

IPC: C07C231/14 ,  C08G64/02

CPC classification number: C07C231/14 ,  C08G64/0233

Abstract: In some embodiments, the present disclosure provides iodinated polyamino compounds having a plurality of primary amine groups, all of which are the same, as well as methods for forming the same. In some embodiments, the present disclosure pertains to systems for forming hydrogels, which systems comprise such an iodinated polyamino compound and a polymer that that forms crosslinks with the iodinated polyamino compound. In some embodiments, the present disclosure pertains to hydrogels that are formed using such systems.

公开(公告)号：US20230364048A1

公开(公告)日：2023-11-16

申请号：US18359271

申请日：2023-07-26

Applicant: MBI Distributing

Inventor： Ned L. Jensen

IPC: A61K31/22 ,  A61K31/4045 ,  A61K47/24 ,  A61K47/10 ,  A61K47/14 ,  A61P25/06 ,  C07C231/14 ,  A61P15/00 ,  A61P25/22 ,  A61P25/28 ,  A61P25/20 ,  A61K9/127

CPC classification number: A61K31/22 ,  A61K31/4045 ,  A61K47/24 ,  A61K47/10 ,  A61K47/14 ,  A61P25/06 ,  C07C231/14 ,  A61P15/00 ,  A61P25/22 ,  A61P25/28 ,  A61P25/20 ,  A61K9/127

Abstract: The present invention is directed to compositions comprising N-Acetyl Methyl GABA, methods of preparing N-Acetyl Methyl GABA and compositions including N-Acetyl Methyl GABA, and methods of using N-Acetyl Methyl GABA for instance to improve sleep and control anxiety.

公开(公告)号：US20230339870A1

公开(公告)日：2023-10-26

申请号：US17773349

申请日：2020-10-28

Applicant: KYUNGSUNG UNIVERSITY INDUSTRY COOPERATION FOUNDATION ,  PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION

Inventor： Jae-Hwan KWAK ,  Young-Suk JUNG ,  Doyoung KWON ,  Min Woo KIM ,  Sou Hyun KIM

IPC: C07D261/08 ,  C07C235/34 ,  C07C231/14

CPC classification number: C07D261/08 ,  C07C235/34 ,  C07C231/14

Abstract: The present disclosure relates to a pharmaceutical composition containing a cinnamic amide derivative that activates FXR or an isomer, solvate, or pharmaceutically acceptable salt thereof, and a method for preparing the same.

公开(公告)号：US11724982B2

公开(公告)日：2023-08-15

申请号：US16868343

申请日：2020-05-06

Applicant: Ming-Yu Ngai ,  Katarzyna N. Hojczyk

Inventor： Ming-Yu Ngai ,  Katarzyna N. Hojczyk

IPC: C07C233/25 ,  C07C259/06 ,  C07C259/10 ,  C07C269/06 ,  C07C273/18 ,  C07C231/14 ,  C07C253/30 ,  C07D213/75 ,  C07D213/76 ,  C07D347/00 ,  C07D239/47 ,  C07D239/91 ,  C07D473/40 ,  C07D263/57 ,  C07D209/08 ,  C07D215/40 ,  C07D401/04 ,  C07D471/04 ,  C07J43/00 ,  C07D417/04 ,  C07D405/04 ,  C07C231/12 ,  C07C233/33 ,  C07C233/54 ,  C07C233/80 ,  C07C233/81 ,  C07C255/60 ,  C07C255/58 ,  C07C271/38 ,  C07C275/34

CPC classification number: C07C233/25 ,  C07C231/12 ,  C07C231/14 ,  C07C233/33 ,  C07C233/54 ,  C07C233/80 ,  C07C233/81 ,  C07C253/30 ,  C07C255/58 ,  C07C255/60 ,  C07C259/06 ,  C07C259/10 ,  C07C269/06 ,  C07C271/38 ,  C07C273/1809 ,  C07C273/1854 ,  C07C275/34 ,  C07D209/08 ,  C07D213/75 ,  C07D213/76 ,  C07D215/40 ,  C07D239/47 ,  C07D239/91 ,  C07D263/57 ,  C07D347/00 ,  C07D401/04 ,  C07D405/04 ,  C07D417/04 ,  C07D471/04 ,  C07D473/40 ,  C07J43/003 ,  C07C273/1854 ,  C07C275/64 ,  C07C269/06 ,  C07C271/38 ,  C07C231/14 ,  C07C233/25 ,  C07C253/30 ,  C07C255/60 ,  C07C253/30 ,  C07C255/58 ,  C07C273/1809 ,  C07C275/34

Abstract: The present invention provides a process of producing a trifluoromcthoxylated aryl or trifluoromothoxylated heteroaryl having the structure:




wherein

A is an aryl or heteroaryl, each with or without substitution; and

R1 is —H, -(alkyl), -(alkenyl), -(alkynyl), -(aryl), -(heteroaryl), -(alkylaryl), -(alkylheteroaryl), —NH-(alkyl), —N(alkyl)2, —NH-(alkenyl), —NH-(alkynyl) —NH-(aryl), —NH-(heteroaryl), —O-(alkyl), —O-(alkenyl), —O-(alkynyl), —O-(aryl), —O-(heteroaryl), —S-(alkyl), —S-(alkenyl), —S-(alkynyl), —S-(aryl), or —S-(heteroaryl), comprising:

(a) reacting a compound having the structure:





with a trifluoromethylating agent in the presence of a base in a first suitable solvent under conditions to produce a compound having the structure:





and

(b) maintaining the compound produced in step (a) in a second suitable solvent under conditions sufficient to produce the trifluoromethoxylated aryl or trifluormethoxylated heteroaryl having the structure:

公开(公告)号：US11697634B2

公开(公告)日：2023-07-11

申请号：US17322798

申请日：2021-05-17

Applicant: National Tsing Hua University

Inventor： Chien-Chung Han ,  Suman Alishetty

IPC: C07C231/14 ,  C07D307/68 ,  C07C253/02 ,  C07C249/04 ,  C07C233/57

CPC classification number: C07C231/14 ,  C07C233/57 ,  C07C249/04 ,  C07C253/02 ,  C07D307/68

Abstract: A method for producing a homocyclic or heterocyclic compound includes reacting a compound of formula (I) with a compound of formula (II) in presence of a base:

R1—B-G  (I)





In formula (I), B is an unsaturated moiety selected from substituted or unsubstituted vinylene, ethynylene, aryleneethynylene, substituted or unsubstituted arylenevinylene, and a combination thereof, the vinylene or arylenevinylene has n (=0, 1 or 2) substituent(s) R2, G is an electron-withdrawing group, R1 is hydrogen or a substituent, and two of R1, R2 and G may joint together to form a ring. In formula (II), R3 and R4 are independently hydrogen or a substituent, R5 is an electron-withdrawing group, and two of R3, R4 and R5 may joint together to form a ring. The conjugate acid of the base has a pKa in the range of 1 to 15.

公开(公告)号：US11673862B2

公开(公告)日：2023-06-13

申请号：US16256596

申请日：2019-01-24

Applicant: SUZHOU PENGXU PHARMATECH CO. LTD.

Inventor： Peng Wang ,  Pixu Li ,  Qiang Wei ,  Yuanhua Liu

IPC: C07D207/27 ,  A61K31/4015 ,  C07C53/19 ,  C07C53/50 ,  C07C67/307 ,  C07C69/63 ,  C07C71/00 ,  C07C209/08 ,  C07C231/14 ,  C07C233/05 ,  C07C237/06

CPC classification number: C07D207/27 ,  A61K31/4015 ,  C07C53/19 ,  C07C53/50 ,  C07C67/307 ,  C07C69/63 ,  C07C71/00 ,  C07C209/08 ,  C07C231/14 ,  C07C233/05 ,  C07C237/06

Abstract: The present invention provides a scalable synthesis of enantiomerically pure brivaracetam, and related derivatives.

公开(公告)号：US20230159421A1

公开(公告)日：2023-05-25

申请号：US17788698

申请日：2020-12-23

Applicant: Kynan Duke IP, LLC

Inventor： Colin Charles Duke ,  Rujee Kyokajee DUKE ,  Van Hoan TRAN

IPC: C07C43/23 ,  C07C41/26 ,  C07C51/367 ,  C07C201/12 ,  C07C209/04 ,  C07C303/40 ,  C07C231/12 ,  C07C231/14 ,  C07C277/08 ,  C07D235/26 ,  C07D263/58 ,  A61P35/00 ,  A61P17/06 ,  A61P17/00 ,  A61P29/00 ,  C07C217/80 ,  C07C65/28 ,  C07C217/82 ,  C07C311/08 ,  C07C233/01 ,  C07C237/04 ,  C07C225/06 ,  C07C235/74 ,  C07C279/18

CPC classification number: C07C43/23 ,  C07C41/26 ,  C07C51/367 ,  C07C201/12 ,  C07C209/04 ,  C07C303/40 ,  C07C231/12 ,  C07C231/14 ,  C07C277/08 ,  C07D235/26 ,  C07D263/58 ,  A61P35/00 ,  A61P17/06 ,  A61P17/00 ,  A61P29/00 ,  C07C217/80 ,  C07C65/28 ,  C07C217/82 ,  C07C311/08 ,  C07C233/01 ,  C07C237/04 ,  C07C225/06 ,  C07C235/74 ,  C07C279/18

Abstract: The present disclosure relates to substituted hydroxystilbene compounds and derivatives, specifically 2-substituted hydroxystilbene compounds and derivatives, the synthesis of such compounds and their use in therapy.

公开(公告)号：US20180370904A1

公开(公告)日：2018-12-27

申请号：US15779852

申请日：2016-02-29

Applicant: HYBIO PHARMACEUTICAL CO., LTD.

Inventor： Youjin CHEN ,  Pengcheng MI ,  Anjin TAO ,  Jiancheng YUAN

IPC: C07C231/14 ,  C07C237/22 ,  B01J31/02

CPC classification number: C07C231/14 ,  B01J31/0247 ,  B01J2231/49 ,  C07B41/12 ,  C07B43/06 ,  C07B2200/07 ,  C07C231/02 ,  C07C231/12 ,  C07C235/08 ,  C07C237/22 ,  C07C269/06 ,  Y02P20/55 ,  C07C271/16 ,  C07C237/08 ,  C07C237/12

Abstract: The present invention relates to a preparation method of a long-chain compound, which includes the following steps: (1) carrying out condensation reaction on H—R2 and R5N-Glu(OR4)—OR3, wherein, R3 is a carboxyl protecting group, R4 is a carboxyl activating group, and R5 is an amino protecting group; obtaining a compound of formula II; (2) removing carboxyl protecting group R3 and amino protecting group R5 of the compound shown in formula II to obtain a compound of formula III; (3) carrying out condensation reaction on the compound shown in formula III and to obtain a compound shown in formula I. The method reduces the time of deprotection, and all the reactions can be carried out in a solvent with low boiling point. The post-processing requires only simple washing and recrystallization to obtain the product with higher purity, so the method is suitable for large-scale production.