公开(公告)号：US20240360084A1

公开(公告)日：2024-10-31

申请号：US18633495

申请日：2024-04-11

Applicant: REATA PHARMACEUTICALS, INC.

Inventor： Xin JIANG ,  Melean VISNICK ,  Christopher F. BENDER ,  Gary BOLTON ,  Bradley CAPRATHE ,  Chitase LEE ,  Brian KORNBERG ,  Patrick O'BRIEN ,  Martha R. HOTEMA

IPC: C07D231/54 ,  C07D235/02 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D405/04 ,  C07D409/04 ,  C07D413/10 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

CPC classification number: C07D231/54 ,  C07D235/02 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D405/04 ,  C07D409/04 ,  C07D413/10 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

Abstract: Disclosed herein are compounds of the formula:




as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to modulate the activity of IL-17 and RORγ. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or for autoimmune disorders.

公开(公告)号：US12129236B2

公开(公告)日：2024-10-29

申请号：US17204206

申请日：2021-03-17

Applicant: CANCER RESEARCH TECHNOLOGY LIMITED

Inventor： Alison E. McGonagle ,  Allan M. Jordan ,  Bohdan Waszkowycz ,  Colin P. Hutton ,  Ian D. Waddell ,  James R. Hitchin ,  Kate M. Smith ,  Niall M. Hamilton

IPC: C07D235/26 ,  A61P35/00 ,  C07D307/85 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D409/04 ,  C07D413/04 ,  C07D413/06 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D417/14

CPC classification number: C07D235/26 ,  A61P35/00 ,  C07D307/85 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D409/04 ,  C07D413/04 ,  C07D413/06 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D417/14

Abstract: The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity: wherein R1a, R1b, R1c, R1d, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.

公开(公告)号：US12116362B2

公开(公告)日：2024-10-15

申请号：US17959064

申请日：2022-10-03

Applicant: Valo Health, Inc.

Inventor： Brian Raimundo ,  Elena S. Koltun ,  John Griffin ,  Eric Stangeland

IPC: C07D417/14 ,  A61P1/16 ,  A61P3/10 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  C07D401/04 ,  C07D401/14 ,  C07D417/04 ,  C07D471/04

CPC classification number: C07D417/14 ,  A61P1/16 ,  A61P3/10 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  C07D401/04 ,  C07D401/14 ,  C07D417/04 ,  C07D471/04

Abstract: Provided herein are compounds, compositions including them, and methods of modulating GPR120 activity and treating diseases mediated by GPR120 by administering such compounds and compositions.

公开(公告)号：US20240308973A1

公开(公告)日：2024-09-19

申请号：US18598312

申请日：2024-03-07

Applicant: Zoetis Services LLC

Inventor： Richard A. EWIN ,  Michael P. CURTIS ,  Todd M. MADDUX ,  Graham M. KYNE

IPC: C07D401/04 ,  A61K31/433 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/501 ,  A61K31/506 ,  A61K31/549 ,  A61K31/55 ,  A61K45/06 ,  C07D401/14 ,  C07D403/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04

CPC classification number: C07D401/04 ,  A61K31/433 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/501 ,  A61K31/506 ,  A61K31/549 ,  A61K31/55 ,  A61K45/06 ,  C07D401/14 ,  C07D403/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04

Abstract: The invention describes novel PDE3 inhibitors for treating a cardiovascular disease including myxomatous mitral valve disease, congestive heart failure and/or asymptomatic heart failure in animals, particularly canines.

公开(公告)号：US20240287098A1

公开(公告)日：2024-08-29

申请号：US18345686

申请日：2023-06-30

Applicant: Hb Therapeutics Inc.

Inventor： Anita Bellail ,  Chunhai Hao ,  Ho Yin Lo

IPC: C07D513/04 ,  A61P35/00 ,  C07C275/40 ,  C07D217/06 ,  C07D277/64 ,  C07D277/82 ,  C07D417/04 ,  C07D417/12

CPC classification number: C07D513/04 ,  A61P35/00 ,  C07C275/40 ,  C07D217/06 ,  C07D277/64 ,  C07D277/82 ,  C07D417/04 ,  C07D417/12

Abstract: The present invention relates to the field of anti-cancer compounds. More particularly, the invention relates to a family of benzothiazolyl urea or thiorurea compound useful as such agents. The present invention also relates to methods for treating cancers using these compounds.

公开(公告)号：US12024500B2

公开(公告)日：2024-07-02

申请号：US16966704

申请日：2018-09-13

Applicant: Qingdao Kingagroot Chemical Compound Co., Ltd.

Inventor： Lei Lian ,  Yurong Zheng ,  Rongbao Hua ,  Jianfeng Wang ,  Xuegang Peng ,  Qi Cui

IPC: C07D403/04 ,  A01N43/58 ,  A01N43/82 ,  A01N43/84 ,  C07D401/14 ,  C07D403/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D417/04 ,  C07D487/04

CPC classification number: C07D403/04 ,  A01N43/58 ,  A01N43/82 ,  A01N43/84 ,  C07D401/14 ,  C07D403/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D417/04 ,  C07D487/04

Abstract: The present disclosure provides an herbicidal compound according to Formula I, which is a five-membered ring-substituted pyridazinol compound, as well as derivatives of the compound, an herbicidal composition comprising the compound, preparation methods thereof, and applications thereof.

公开(公告)号：US11999718B2

公开(公告)日：2024-06-04

申请号：US18150955

申请日：2023-01-06

Applicant: Aptabio Therapeutics Inc.

Inventor： Soo Jin Lee ,  Sung Hwan Moon ,  Sooho Ban ,  Eunsil Lee ,  Eun Jung Shin ,  Yoo-Kyung Goh

IPC: C07D401/14 ,  A61P1/16 ,  A61P11/00 ,  A61P35/00 ,  A61P39/06 ,  C07D231/54 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  C07D495/04

CPC classification number: C07D401/14 ,  A61P1/16 ,  A61P11/00 ,  A61P35/00 ,  A61P39/06 ,  C07D231/54 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  C07D495/04

Abstract: The Present invention provides a novel pyrazole derivative compound represented by Chemical formula 1, a stereoisomer thereof, a solvate thereof, an isotopic variant thereof, a tautomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same.




(In the above, A, B and R, and the like are the same as defined in the description of the invention.)

公开(公告)号：US11992531B2

公开(公告)日：2024-05-28

申请号：US17107781

申请日：2020-11-30

Applicant: C4 Therapeutics, Inc.

Inventor： Andrew J. Phillips ,  Christopher G. Nasveschuk ,  James A. Henderson ,  Yanke Liang ,  Minsheng He ,  Kiel Lazarski ,  Gesine Kerstin Veits ,  Harit U. Vora

IPC: C07D401/14 ,  A61K31/45 ,  A61K31/451 ,  A61K31/454 ,  A61K31/4545 ,  A61K47/54 ,  C07D211/86 ,  C07D211/88 ,  C07D211/90 ,  C07D221/22 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04 ,  C07D495/04 ,  C07D495/14 ,  C07D519/00 ,  C07K14/47 ,  C07K14/72

CPC classification number: A61K47/545 ,  A61K31/45 ,  A61K31/451 ,  A61K31/454 ,  A61K31/4545 ,  C07D211/86 ,  C07D211/88 ,  C07D211/90 ,  C07D221/22 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04 ,  C07D495/04 ,  C07D495/14 ,  C07D519/00 ,  C07K14/47 ,  C07K14/72

Abstract: This invention provides Degronimers that have carbon-linked E3 Ubiquitin Ligase targeting moieties (Degrons), which can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.

公开(公告)号：US20240150338A1

公开(公告)日：2024-05-09

申请号：US18261682

申请日：2022-01-14

Applicant: University of Florida Research Foundation, Incorporated ,  VOVA IDA THERAPEUTICS, INC.

Inventor： Thomas D. BANNISTER ,  Corinne LASMEZAS ,  Minghai ZHOU ,  Sultan ULLAH

IPC: C07D417/04 ,  C07D277/42

CPC classification number: C07D417/04 ,  C07D277/42

Abstract: Provided are, inter alia, compounds having a structure of Formulae (X) to (XVII), or a subordinate structure thereof, composition including the same and methods of use.

公开(公告)号：US20240150334A1

公开(公告)日：2024-05-09

申请号：US18482129

申请日：2023-10-06

Applicant: Pfizer Inc.

Inventor： Jan Antoinette Cusi Romero Adams ,  Bruce Michael Bechle ,  Jason Kenneth Dutra ,  Michelle Renee Garnsey ,  Xinjun Hou ,  Jisun Lee ,  Deane Milford Nason, II ,  Steven Victor O'Neil ,  Danica Antonia Rankic ,  Yang Wang ,  Ann Sorrentino Wright ,  Lei Zhang ,  Liying Zhang ,  David James Edmonds

IPC: C07D413/04 ,  C07D231/56 ,  C07D263/56 ,  C07D401/04 ,  C07D403/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D498/04 ,  C07D513/04

CPC classification number: C07D413/04 ,  C07D231/56 ,  C07D263/56 ,  C07D401/04 ,  C07D403/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D498/04 ,  C07D513/04

Abstract: Described herein are compounds of Formula I,




wherein the variables are defined herein, their use as HSD17B13 inhibitors and/or degraders, pharmaceutical compositions containing such compounds and their use to treat, for example, NAFLD and NASH.