公开(公告)号：US12128037B2

公开(公告)日：2024-10-29

申请号：US17722244

申请日：2022-04-15

申请人： MEDAC GESELLSCHAFT FUER KLINISCHE SPEZIALPRAEPARATE MBH

发明人： Marguerite Mensonides-Harsema ,  Sebastian Bialleck

IPC分类号： A61K31/4402 ,  A61K9/00 ,  A61K45/06 ,  C07D213/76

CPC分类号： A61K31/4402 ,  A61K9/0031 ,  A61K9/0053 ,  A61K45/06 ,  C07D213/76 ,  C07B2200/13

摘要： Disclosed is a process for preparing new crystal salt forms of sulfasalazine, in particular a crystal Form A of the D(−)-N-methylglucamine (meglumine) salt of sulfasalazine, a crystal form A of the piperazine salt of sulfasalazine and a crystal Form B of the diethylamine salt of sulfasalazine, and the use thereof in the treatment of a disease or condition in which modulation of inflammatory cells is beneficial, a disease or condition concerning bones or joints and/or the gastro-intestinal tract.

公开(公告)号：US20240300889A1

公开(公告)日：2024-09-12

申请号：US18216181

申请日：2023-06-29

申请人： UNIVERSITY OF HOUSTON SYSTEM

发明人： Ognjen Miljanic ,  Alexandra Robles

IPC分类号： C07C251/86 ,  B01D53/02 ,  C02F1/26 ,  C07C249/16 ,  C07D213/76 ,  C30B29/54 ,  G21F9/02

CPC分类号： C07C251/86 ,  B01D53/02 ,  C02F1/26 ,  C07C249/16 ,  C07D213/76 ,  C30B29/54 ,  G21F9/02 ,  B01D2253/20 ,  B01D2257/202 ,  C02F2101/006 ,  C02F2101/12 ,  C02F2305/00 ,  C07B2200/13

摘要： This invention relates to materials and methods for iodine capture from a variety of sources and media, and at water/organic solvent interfaces.

公开(公告)号：US20240285772A1

公开(公告)日：2024-08-29

申请号：US18106242

申请日：2023-02-06

申请人： University of Rhode Island Board of Trustees ,  Colgate University

发明人： Fang Wang ,  Jacob M. Goldberg ,  Bradley M. Lipka ,  Daniel S. Honeycutt

IPC分类号： A61K47/54 ,  C07D213/61 ,  C07D213/64 ,  C07D213/68 ,  C07D213/71 ,  C07D213/76 ,  C07D235/24 ,  C07D235/28 ,  C07D237/12 ,  C07D239/30 ,  C07D277/62

CPC分类号： A61K47/545 ,  C07D213/61 ,  C07D213/64 ,  C07D213/68 ,  C07D213/71 ,  C07D213/76 ,  C07D235/24 ,  C07D235/28 ,  C07D237/12 ,  C07D239/30 ,  C07D277/62

摘要： Disclosed are pnictogen-containing heterocyclic compounds of Formula (I)




Each of R1, the heterocyclic ring H, A+, LG, and X− is defined herein. Also provided are methods of modifying a substrate using such a compound, conjugated biomolecules thus modified, and pharmaceutical compositions containing one of the conjugated biomolecules.

公开(公告)号：US20240246915A1

公开(公告)日：2024-07-25

申请号：US18423733

申请日：2024-01-26

申请人： Calgent Biotechnology Co., Ltd.

发明人： Yun YEN ,  Jing-ping LIOU ,  Shiow-lin PAN

IPC分类号： C07D213/75 ,  A61K31/166 ,  A61K31/167 ,  A61K31/4409 ,  A61K33/243 ,  A61P3/10 ,  A61P25/28 ,  A61P35/02 ,  A61P37/00 ,  C07D209/04 ,  C07D213/74 ,  C07D213/76 ,  C07D215/40 ,  C07D215/42 ,  C07D231/38 ,  C07D235/30 ,  C07D239/42 ,  C07D241/04 ,  C07D241/20 ,  C07D277/42 ,  C07D471/04 ,  C07D487/04 ,  A61K31/337 ,  A61K31/475 ,  A61K31/506 ,  A61K31/593 ,  A61K31/704 ,  A61K33/24

CPC分类号： C07D213/75 ,  A61K31/166 ,  A61K31/167 ,  A61K31/4409 ,  A61K33/243 ,  A61P3/10 ,  A61P25/28 ,  A61P35/02 ,  A61P37/00 ,  C07D209/04 ,  C07D213/74 ,  C07D213/76 ,  C07D215/40 ,  C07D215/42 ,  C07D231/38 ,  C07D235/30 ,  C07D239/42 ,  C07D241/04 ,  C07D241/20 ,  C07D277/42 ,  C07D471/04 ,  C07D487/04 ,  A61K31/337 ,  A61K31/475 ,  A61K31/506 ,  A61K31/593 ,  A61K31/704 ,  A61K33/24 ,  A61K2300/00

摘要： The invention relates to new compounds of formula (I)




with low cytotoxicity for blocking the ubiquitination-proteasome system in diseases. Accordingly, these compounds can be used in treatment of disorders including, but not limited to, cancers.

公开(公告)号：US20240217965A1

公开(公告)日：2024-07-04

申请号：US18221546

申请日：2023-07-13

申请人： PLEXXIKON INC.

发明人： Jack Lin ,  Jason Walters

IPC分类号： C07D471/04 ,  C07D213/76

CPC分类号： C07D471/04 ,  C07D213/76

摘要： Provided herein are intermediates and processes useful for facile synthesis of compounds of Formula 2:




wherein R1 is C(O)R2; R2 is alkyl optionally substituted with 1-5 halogens; G is phenyl or a 5-6 membered heteroaryl optionally substituted with 1-2 R3; and each R3 is independently C1-C6 alkyl, CN, C1-C6 alkyl-CN, 3-6 membered cycloalkyl, or 4-6 membered heterocycloalkyl.

公开(公告)号：US11919858B2

公开(公告)日：2024-03-05

申请号：US16740167

申请日：2020-01-10

申请人： Calgent Biotechnology Co., Ltd.

发明人： Yun Yen ,  Jing-ping Liou ,  Shiow-lin Pan

IPC分类号： A61K31/166 ,  A61K31/167 ,  A61K31/337 ,  A61K31/4409 ,  A61K31/475 ,  A61K31/506 ,  A61K31/593 ,  A61K31/704 ,  A61K33/24 ,  A61P3/10 ,  A61P25/28 ,  A61P35/02 ,  A61P37/00 ,  C07D209/04 ,  C07D213/74 ,  C07D213/75 ,  C07D213/76 ,  C07D215/40 ,  C07D215/42 ,  C07D231/38 ,  C07D235/30 ,  C07D239/42 ,  C07D241/04 ,  C07D241/20 ,  C07D277/42 ,  C07D471/04 ,  C07D487/04

CPC分类号： C07D213/75 ,  A61K31/166 ,  A61K31/167 ,  A61K31/4409 ,  A61P3/10 ,  A61P25/28 ,  A61P35/02 ,  A61P37/00 ,  C07D209/04 ,  C07D213/74 ,  C07D213/76 ,  C07D215/40 ,  C07D215/42 ,  C07D231/38 ,  C07D235/30 ,  C07D239/42 ,  C07D241/04 ,  C07D241/20 ,  C07D277/42 ,  C07D471/04 ,  C07D487/04 ,  A61K31/337 ,  A61K31/475 ,  A61K31/506 ,  A61K31/593 ,  A61K31/704 ,  A61K33/24 ,  A61K2300/00

摘要： The invention relates to compounds of formula (I)




with low cytotoxicity for blocking the ubiquitination-proteasome system in diseases. Accordingly, these compounds can be used in treatment of disorders including, but not limited to, cancers.

公开(公告)号：US20240018153A1

公开(公告)日：2024-01-18

申请号：US18253730

申请日：2021-11-18

申请人： 2692372 ONTARIO, INC. ,  DUNAD THERAPEUTICS LTD.

发明人： Patrick T. GUNNING ,  Jeff OMEARA ,  Siawash AHMAR ,  Graham L. SIMPSON ,  Peter HUNT ,  David Alexander ROSA ,  Ji Sung PARK

IPC分类号： C07D487/04 ,  C07D403/04 ,  C07D239/48 ,  C07D401/12 ,  C07D213/76 ,  C07D213/74 ,  C07C317/32 ,  C07D405/12 ,  C07K1/10

CPC分类号： C07D487/04 ,  C07D403/04 ,  C07D239/48 ,  C07D401/12 ,  C07D213/76 ,  C07D213/74 ,  C07C317/32 ,  C07D405/12 ,  C07K1/10

摘要： Provided herein are benzenesulfonamide compounds, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.

公开(公告)号：US20230139808A1

公开(公告)日：2023-05-04

申请号：US18148672

申请日：2022-12-30

申请人： OTSUKA PHARMACEUTICAL CO., LTD.

发明人： Takashi NAKAGAWA ,  Makoto SAKAMOTO ,  Kazuya YAMAGUCHI ,  Yuki TERAUCHI ,  Masamichi SHIRAKURA ,  Yasuo HARADA ,  Yutaka KOJIMA ,  Takumi SUMIDA

IPC分类号： C07D213/75 ,  C07D213/76

摘要： The present invention provides a novel compound having an excellent antitumor effect stability and metabolic stability. The compound of the present invention is represented by the following general formula (1) wherein R1 represents a halogen atom, an aryl group, an aryloxy group or a lower alkyl group optionally substituted with one or more halogen atoms; R2 represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; and; m represents an integer of 1 to 3; provided that when m represents 2 or 3, R1s are the same or different.

公开(公告)号：US20230002322A1

公开(公告)日：2023-01-05

申请号：US17776805

申请日：2020-11-09

申请人： KaNDy Therapeutics Limited

发明人： Marcel SCHLEUSNER ,  Massimo GHIZZONI ,  Ron LAWRENCE

IPC分类号： C07D213/76 ,  C07D213/75 ,  B01J23/44

摘要： The invention relates to a new process for producing compound 2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide (Compound IX) which is useful in the manufacture of compound 2-[3,5-Bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide (Compound A).

公开(公告)号：US20220401463A1

公开(公告)日：2022-12-22

申请号：US17699522

申请日：2022-03-21

申请人： HELSINN HEALTHCARE SA

发明人： Luca Fadini ,  Peter Manini ,  Claudio Pietra ,  Claudio Giuliano ,  Emanuela Lovati ,  Roberta Cannella ,  Alessio Venturini ,  Valentino J. Stella

IPC分类号： A61K31/675 ,  C07F9/6509 ,  C07D213/76 ,  A61K31/496 ,  A61K31/4178 ,  A61K31/439 ,  C07F9/02

摘要： Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK1) receptor. The compounds have the general formula (I):