公开(公告)号：US12060333B2

公开(公告)日：2024-08-13

申请号：US17445989

申请日：2021-08-26

申请人： Hoffmann-La Roche Inc.

发明人： Chungen Liang ,  Hongying Yun ,  Weixing Zhang ,  Kun Miao ,  Jianguo Chen ,  Yao Wu

IPC分类号： C07D241/24 ,  C07C243/34 ,  C07C311/35 ,  C07D207/26 ,  C07D209/42 ,  C07D211/76 ,  C07D231/12 ,  C07D233/64 ,  C07D235/24 ,  C07D261/18 ,  C07D401/04 ,  C07D403/12 ,  C07D413/12

CPC分类号： C07D241/24 ,  C07C243/34 ,  C07C311/35 ,  C07D207/26 ,  C07D209/42 ,  C07D211/76 ,  C07D231/12 ,  C07D233/64 ,  C07D235/24 ,  C07D261/18 ,  C07D401/04 ,  C07D403/12 ,  C07D413/12

摘要： The present invention relates to compounds of formula (I),




wherein R1-R5 and L are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.

公开(公告)号：US12052915B2

公开(公告)日：2024-07-30

申请号：US16931273

申请日：2020-07-16

申请人： Samsung Display Co., Ltd.

发明人： Akinori Yamatani ,  Ikuo Sasaki ,  Makoto Yamamoto

IPC分类号： H10K85/60 ,  C07D235/06 ,  C07D235/18 ,  C07D235/20 ,  C07D235/24 ,  C07D235/30 ,  H10K50/11 ,  H10K50/14 ,  H10K85/40

CPC分类号： H10K85/654 ,  C07D235/06 ,  C07D235/18 ,  C07D235/20 ,  C07D235/24 ,  C07D235/30 ,  H10K50/11 ,  H10K50/14 ,  H10K85/6572 ,  H10K85/40

摘要： An organic electroluminescence device according to an embodiment of the present disclosure includes a first electrode, a second electrode facing the first electrode, and a plurality of organic layers between the first electrode and the second electrode, wherein at least one organic layer of the plurality of organic layers includes a polycyclic compound containing two aromatic 6-membered rings which are linked by a single bond, and a plurality of benzimidazole groups which are substituted at the two aromatic 6-membered rings, wherein each of the two aromatic 6-membered rings includes a carbon atom or a nitrogen atom as an atom for forming a ring.

公开(公告)号：US20230312511A1

公开(公告)日：2023-10-05

申请号：US18111241

申请日：2023-02-17

申请人： The United States of America, as represented by the Secretary, Department of Health and Human ,  The University of Kansas ,  The University of North Carolina at Chapel Hill

发明人： David R. Sibley ,  Amy Elizabeth Moritz ,  R. Benjamin Free ,  Joseph P. Steiner ,  Noel Terrence Southall ,  Marc Ferrer ,  Xin Hu ,  Warren S. Weiner ,  Jeffrey Aubé ,  Kevin Frankowski

IPC分类号： C07D401/12 ,  A61P25/28 ,  C07D209/42 ,  C07D213/65 ,  C07D213/81 ,  C07D235/24 ,  C07D295/185 ,  C07D307/85 ,  C07D317/64 ,  C07D333/70 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04

CPC分类号： C07D401/12 ,  A61P25/28 ,  C07D209/42 ,  C07D213/65 ,  C07D213/81 ,  C07D235/24 ,  C07D295/185 ,  C07D307/85 ,  C07D317/64 ,  C07D333/70 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04

摘要： The disclosure of a compound of Formula I or a pharmaceutically acceptable salt thereof




The variables W, R1, R2, R3, and R4 are defined in the disclosure. The disclosure provides a compound or salt of Formula I together with a pharmaceutically acceptable carrier. The disclosure also provides methods of treating a patient for Parkinson's disease and related syndromes, dyskinesia, especially dyskinesias secondary to treating Parkinson's disease with L-DOPA, neurodegenerative disorders such as Alzheimer's disease and dementia, Huntington's disease, restless legs syndrome, bipolar disorder and depression, schizophrenia, cognitive dysfunction, or substance use disorders, the methods comprising administering a compound of Formula I or salt thereof to the patient. The disclosure provides combination methods of treatment in which the compound of Formula I is administered to the patient together with one or more additional active agents.

公开(公告)号：US11760752B2

公开(公告)日：2023-09-19

申请号：US16825561

申请日：2020-03-20

申请人： University of Maryland, Baltimore

发明人： Steven Fletcher ,  Brandon Drennen

IPC分类号： C07D235/24 ,  C07D413/12 ,  C07D231/56 ,  C07D403/12 ,  C07D405/12 ,  C07D401/12

CPC分类号： C07D413/12 ,  C07D231/56 ,  C07D235/24 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12

摘要： Mcl-1 selective inhibitors, Bcl-2 selective inhibitors, and Mcl-1/Bcl-2 dual inhibitors and methods of using the same for the treatment of disease are disclosed.

公开(公告)号：US20230233560A1

公开(公告)日：2023-07-27

申请号：US17865220

申请日：2022-07-14

申请人： Vertex Pharmaceuticals Incorporated

发明人： Mark Thomas Miller ,  Corey Anderson ,  Vijayalaksmi Arumugam ,  Brian Richard Bear ,  Hayley Marie Binch ,  Jeremy J. Clemens ,  Thomas Cleveland ,  Erica Conroy ,  Timothy Richard Coon ,  Bryan A. Frieman ,  Peter Diederik Jan Grootenhuis ,  Raymond Stanley Gross ,  Sara Sabina Hadida-Ruah ,  Haripada Khatuya ,  Pramod Virupax Joshi ,  Paul John Krenitsky ,  Chun-Chieh Lin ,  Gulin Erdogan Marelius ,  Vito Melillo ,  Jason McCartney ,  Georgia McGaughey Nicholls ,  Fabrice Jean Denis Pierre ,  Alina Silina ,  Andreas P. Termin ,  Johnny Uy ,  Jinglan Zhou

IPC分类号： A61K31/506 ,  C07D213/82 ,  A61K31/4418 ,  A61K31/444 ,  A61K31/44 ,  C07D213/84 ,  C07D231/14 ,  A61K31/415 ,  C07D209/42 ,  A61K31/404 ,  C07D401/12 ,  A61K31/4439 ,  C07D401/14 ,  C07D231/12 ,  A61K31/497 ,  C07D417/12 ,  C07D405/14 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/4525 ,  A61J1/03 ,  C07D403/12 ,  C07D413/14 ,  C07D213/73 ,  C07D231/20 ,  C07D401/04 ,  C07D235/24 ,  C07D403/10 ,  C07D239/34 ,  C07D407/12 ,  C07D209/18 ,  C07D209/49 ,  C07D213/64

CPC分类号： A61K31/506 ,  C07D213/82 ,  A61K31/4418 ,  A61K31/444 ,  A61K31/44 ,  C07D213/84 ,  C07D231/14 ,  A61K31/415 ,  C07D209/42 ,  A61K31/404 ,  C07D401/12 ,  A61K31/4439 ,  C07D401/14 ,  C07D231/12 ,  A61K31/497 ,  C07D417/12 ,  C07D405/14 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/4525 ,  A61J1/035 ,  C07D403/12 ,  C07D413/14 ,  C07D213/73 ,  C07D231/20 ,  C07D401/04 ,  C07D235/24 ,  C07D403/10 ,  C07D239/34 ,  C07D407/12 ,  C07D209/18 ,  C07D209/49 ,  C07D213/64

摘要： The present invention features a compound of formula I:




or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

公开(公告)号：US09938243B2

公开(公告)日：2018-04-10

申请号：US15698020

申请日：2017-09-07

申请人： GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

发明人： Peter Kumpalume ,  Oliver Schon ,  Christine Patricia Donahue ,  Ghotas Evindar ,  David I. Israel ,  David Paolella ,  Letian Kuai ,  Ninad V. Prabhu

IPC分类号： C07D235/18 ,  A61K31/454 ,  C07D411/14 ,  A61K31/4545 ,  A61K31/4184 ,  C07D401/06 ,  C07D235/24 ,  C07D401/10 ,  C07D417/14

CPC分类号： C07D235/18 ,  A61K31/4184 ,  A61K31/454 ,  A61K31/4545 ,  C07D235/24 ,  C07D401/06 ,  C07D401/10 ,  C07D411/14 ,  C07D417/14

摘要： Compounds useful for affinity chromatography as presented, more particularly for use in affinity chromatography to purify serum albumin, especially human serum albumin (HSA) and fusion proteins thereof. Methods for extending the half-life of therapeutic agents are also presented, particularly therapeutic peptide agents and small molecules, such as by conjugation of compounds described herein to the therapeutic peptide or small molecule, which, upon administration, binds to HSA, thereby providing a prolonged release of the therapeutic agent.

公开(公告)号：US09809558B2

公开(公告)日：2017-11-07

申请号：US15026725

申请日：2014-10-01

申请人： GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

发明人： Peter Kumpalume ,  Oliver Schon ,  Christine Patricia Donahue ,  Ghotas Evindar ,  David I. Israel ,  David Paolella ,  Letian Kuai ,  Ninad V. Prabhu

IPC分类号： C07D235/18 ,  A61K31/4184 ,  C07D401/06 ,  C07D401/10 ,  C07D235/24 ,  C07D417/14 ,  A61K31/454 ,  A61K31/4545 ,  C07D411/14

CPC分类号： C07D235/18 ,  A61K31/4184 ,  A61K31/454 ,  A61K31/4545 ,  C07D235/24 ,  C07D401/06 ,  C07D401/10 ,  C07D411/14 ,  C07D417/14

摘要： Compounds useful for affinity chromatography as presented, more particularly for use in affinity chromatography to purify serum albumin, especially human serum albumin (HSA) and fusion proteins thereof. Methods for extending the half-life of therapeutic agents are also presented, particularly therapeutic peptide agents and small molecules, such as by conjugation of compounds described herein to the therapeutic peptide or small molecule, which upon administration, binds to HSA, thereby providing a prolonged release of the therapeutic agent.

公开(公告)号：US09802895B2

公开(公告)日：2017-10-31

申请号：US15119046

申请日：2015-02-13

申请人： BAYER CROPSCIENCE AKTIENGESELLSCHAFT

发明人： Markus Heil ,  Eike Kevin Heilmann ,  Werner Hallenbach ,  Kerstin Ilg ,  Ulrich Goergens

IPC分类号： C07D209/42 ,  C07D235/24 ,  A01N53/00

CPC分类号： C07D209/42 ,  A01N53/00 ,  C07D235/24

摘要： The present invention relates to compounds of the general formula (I), in which R1 to R6, G and n have the meanings given in the description and to a process for their preparation and to their use as insecticides and acaricides.

公开(公告)号：US20170196862A2

公开(公告)日：2017-07-13

申请号：US14876525

申请日：2015-10-06

申请人： Mark Thomas Miller ,  Corey Anderson ,  Vijayalaksmi Arumugam ,  Brian Richard Bear ,  Hayley Marie Binch ,  Jeremy J. Ciemens ,  Thomas Cleveland ,  Erica Conroy ,  Timothy Richard Coon ,  Bryan A. Frieman ,  Peter Diederik Jan Grootenhuis ,  Raymond Stanley Gross ,  Sara Sabina Hadida-Ruah ,  Haripada Khatuya ,  Pramod Virupax Joshi ,  Paul John Krenitsky ,  Chun-Chieh Lin ,  Gulin Erdogan Marelius ,  Vito Melillo ,  Jason McCartney ,  Georgia McGaughey Nicholls ,  Fabrice Jean Denis Pierre ,  Alina Silina ,  Andreas P. Termin ,  Johnny Uy ,  Jinglan Zhou

发明人： Mark Thomas Miller ,  Corey Anderson ,  Vijayalaksmi Arumugam ,  Brian Richard Bear ,  Hayley Marie Binch ,  Jeremy J. Ciemens ,  Thomas Cleveland ,  Erica Conroy ,  Timothy Richard Coon ,  Bryan A. Frieman ,  Peter Diederik Jan Grootenhuis ,  Raymond Stanley Gross ,  Sara Sabina Hadida-Ruah ,  Haripada Khatuya ,  Pramod Virupax Joshi ,  Paul John Krenitsky ,  Chun-Chieh Lin ,  Gulin Erdogan Marelius ,  Vito Melillo ,  Jason McCartney ,  Georgia McGaughey Nicholls ,  Fabrice Jean Denis Pierre ,  Alina Silina ,  Andreas P. Termin ,  Johnny Uy ,  Jinglan Zhou

IPC分类号： A61K31/506 ,  A61K31/4418 ,  A61K31/444 ,  A61K31/44 ,  C07D213/84 ,  C07D231/14 ,  A61K31/415 ,  C07D209/42 ,  A61K31/404 ,  C07D401/12 ,  A61K31/4439 ,  C07D401/14 ,  C07D231/12 ,  A61K31/497 ,  C07D417/12 ,  C07D405/14 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/4525 ,  A61J1/03 ,  C07D213/82

CPC分类号： A61K31/506 ,  A61J1/035 ,  A61K31/404 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4525 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  C07D209/18 ,  C07D209/42 ,  C07D209/49 ,  C07D213/64 ,  C07D213/73 ,  C07D213/82 ,  C07D213/84 ,  C07D231/12 ,  C07D231/14 ,  C07D231/20 ,  C07D235/24 ,  C07D239/34 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D405/14 ,  C07D407/12 ,  C07D413/14 ,  C07D417/12

摘要： The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

公开(公告)号：US20160168127A1

公开(公告)日：2016-06-16

申请号：US14968763

申请日：2015-12-14

申请人： Janssen Pharmaceutica NV

发明人： Frances Meredith Hocutt ,  Barry Eastman Leonard ,  Hillary M. Peltier ,  Victor K. Phuong ,  Michael H. Rabinowitz ,  Mark D. Rosen ,  Kyle T. Tarantino ,  Hariharan Venkatesan ,  Lucy Xiumin Zhao

IPC分类号： C07D403/04

CPC分类号： C07D403/04 ,  C07D235/24 ,  C07D403/14 ,  C07D471/04 ,  C07D473/40 ,  C07D487/04 ,  C07D513/04

摘要： The present invention is directed to benzoimidazole compounds of the formula: and enantiomers, diastereomers, racemates, and pharmaceutically acceptable salts thereof. Compounds of the present invention are useful in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions modulated by prolyl hydroxylase activity.

摘要翻译： 本发明涉及下式的苯并咪唑化合物及其对映异构体，非对映体，外消旋体及其药学上可接受的盐。 本发明的化合物可用于治疗由脯氨酰羟化酶活性调节的疾病状态，病症和状况的药物组合物和方法。