公开(公告)号：US20250064469A1

公开(公告)日：2025-02-27

申请号：US18763211

申请日：2024-07-03

Applicant: NORTH CAROLINA STATE UNIVERSITY ,  THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

Inventor： Xiaoning Jiang ,  Jinwook Kim ,  Jianguo Ma ,  Xuming Dai

IPC: A61B17/22 ,  A61B18/00 ,  A61B18/22 ,  A61B18/26

Abstract: A catheter-implemented transducer device for intravascular thrombolysis, is described herein. Such a transducer device includes a catheter defining a longitudinal axis and having opposed proximal and distal ends. At least one ultrasonic transducer arrangement is disposed about the distal end. The ultrasonic transducer arrangement is oriented with acoustic waves propagating parallel or perpendicular to the longitudinal axis. Optionally, the ultrasonic transducer arrangement is configured as a multi-layer stacked structure of ultrasonic transducer elements. Optionally, the ultrasonic transducer arrangement is a laser ultrasonic transducer arrangement. Optionally, the ultrasonic transducer arrangement is configured to operate in a lateral mode.

公开(公告)号：US12234377B2

公开(公告)日：2025-02-25

申请号：US17048114

申请日：2019-05-15

Applicant: The University of North Carolina at Chapel Hill

Inventor： John Michael Ramsey ,  William Hampton Henley

IPC: C09D183/08 ,  B01L3/00 ,  C09D5/00 ,  C09D7/20

Abstract: Described herein are compositions, devices, and methods for improving a surface property of a substrate. In some embodiments, the hydrophobicity and/or fluorocarbon-phobicity of the surface is increased. Some embodiments include compositions, devices and methods for improving bead loading and/or immiscible oil sealing of microwell array reactions on plastic microfluidic devices.

公开(公告)号：US12209251B2

公开(公告)日：2025-01-28

申请号：US17307117

申请日：2021-05-04

Applicant: The University of North Carolina at Chapel Hill

Inventor： Xiao Xiao ,  Randolph Qian ,  Juan Li

IPC: C12N15/86 ,  A61K48/00 ,  C07K14/005 ,  C12N7/00

Abstract: The present invention provides mutant adeno-associated virus serotype 5 (AAV5) that exhibit altered capsid properties, e. g., increased infectivity in human liver cells and/or minimal binding to human neutralizing antibodies. The present invention further provides libraries of mutant AAV5 comprising one or more mutations in a capsid gene. The present invention further provides methods of generating the mutant AAV5 and mutant AAV5 libraries, and compositions comprising the mutant AAV5. The present invention further provides recombinant AAV5 (rAAV5) virions that comprise a mutant capsid protein. The present invention further provides nucleic acids comprising nucleotide sequences that encode mutant capsid proteins.

公开(公告)号：US20250027139A1

公开(公告)日：2025-01-23

申请号：US18784114

申请日：2024-07-25

Applicant: The University of North Carolina at Chapel Hill

Inventor： John Michael Ramsey ,  William Henley ,  Emily Oblath

IPC: C12Q1/6823 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/6853 ,  C12Q1/686 ,  G01N35/00

Abstract: A microfluidic device includes a plurality of reaction wells; and a plurality of solid supports, and each of the solid supports has a reagent attached thereto. The reagent is attached to the solid support via a labile reagent/support bond such that the reagent is configured to be cleaved from the support via a cleaving operation.

公开(公告)号：US12201697B2

公开(公告)日：2025-01-21

申请号：US17407718

申请日：2021-08-20

Applicant: The University of North Carolina at Chapel Hill

Inventor： Matthew Louis Hirsch ,  Richard Jude Samulski

IPC: A61K48/00 ,  A61K9/00 ,  A61K35/76 ,  A61P27/00 ,  C07K14/00 ,  C12N9/24 ,  C12N9/26 ,  C12N15/86

Abstract: This invention relates to viral vectors for delivery of alpha-L-iduronidase to the cornea of a subject and methods of using the same for treatment and prevention of corneal clouding and blindness in a subject due to mucopolysaccharidosis I.

公开(公告)号：US20250018003A1

公开(公告)日：2025-01-16

申请号：US18615134

申请日：2024-03-25

Applicant: The University of North Carolina at Chapel Hill

Inventor： Roland R. Arnold ,  David C. Henke

IPC: A61K38/06 ,  A01N1/02 ,  A61K9/00 ,  A61K31/198 ,  A61K31/375 ,  A61K33/00 ,  A61K33/04 ,  A61K33/10 ,  A61K38/40 ,  A61K38/44 ,  A61K45/06

Abstract: The present invention provides compositions and formulations comprising glutathione with or without thiocyanate and methods of use thereof to treat diseases and disorders in mucosal/epithelial tissue.

公开(公告)号：US12195806B2

公开(公告)日：2025-01-14

申请号：US17046514

申请日：2019-04-12

Applicant: The University of North Carolina at Chapel Hill

Inventor： Wesley Hunter Stepp ,  Travis Parke Schrank

IPC: C07H21/02 ,  C12Q1/6886 ,  C12Q1/70

Abstract: Described herein are assays and methods to detect and/or treat a non-responsive or treatment resistant p16 positive tumor in a subject in need thereof. The disclosed method can also involve determining if the subject is HPV positive or negative, whether the HPV is integrated or episomal, and selecting a suitable treatment based on these determinations. Also disclosed herein is a method of treating an oropharyngeal squamous cell carcinoma in a subject using the arrays and methods disclosed herein.

公开(公告)号：US20250002644A1

公开(公告)日：2025-01-02

申请号：US18703878

申请日：2022-11-07

Applicant: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

Inventor： Aleksandr V. Zhukhovitskiy ,  Rachael A.J. Ditzler

IPC: C08G63/91 ,  C08F8/48 ,  C08G61/08 ,  C08G63/08 ,  C08G63/78

Abstract: The present disclosure relates to polymers, methods for polymer synthesis, and methods of modifying the backbone of said polymers. Modification of the polymer backbone via a sigmatropic rearrangement allows facile entry into new, highly ordered polymers.

公开(公告)号：US20250002539A1

公开(公告)日：2025-01-02

申请号：US18292199

申请日：2022-07-25

Applicant: The University of North Carolina at Chapel Hill

Inventor： Ralph Steven Baric ,  Lisa Chon Lindesmith

IPC: C07K14/005 ,  A61K39/00 ,  A61P31/14

Abstract: The present invention is directed to methods and compositions for GII.3/GII.4 chimeric norovirus capsid proteins comprising one or more amino acid substitutions. Additionally provided are synthetic backbone molecules, norovirus P particles, synthetic nanoparticles, scaffold immunogens, nucleic acids, mimitopes, polypeptides, virus replicon particles (VRPs), virus like particles (VLPs), vectors, cells, and compositions comprising the same.

公开(公告)号：US12173051B2

公开(公告)日：2024-12-24

申请号：US16890380

申请日：2020-06-02

Applicant: Duke University ,  MacroGenics, Inc. ,  The University of North Carolina at Chapel Hill

Inventor： Barton F. Haynes ,  Guido Ferrari ,  Scott Koenig ,  Leslie S. Johnson ,  Chia-Ying Kao Lam ,  Julia A. Sung ,  David M. Margolis ,  Liqin Liu ,  Jeffrey Lee Nordstrom

IPC: C07K16/10 ,  A61K39/395 ,  A61K39/42 ,  A61K45/06 ,  C07K16/28 ,  C07K16/44 ,  C07K16/46 ,  A61K39/00

Abstract: The invention is directed to bispecific molecules comprising an HIV-1 envelope targeting arm and an arm targeting an effector cell, compositions comprising these bispecific molecule and methods of use. In certain aspects, the bispecific molecules of the present invention can bind to two different targets or epitopes on two different cells within the first epitope is expressed on a different cell type than the second epitope, such that the bispecific molecules can bring the two cells together. In certain aspects, the bispecific molecules of the present invention can bind to two different cells, wherein the bispecific molecules comprises an arm with the binding specificity of A32, 7B2, CH27, CH28 or CH44.