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公开(公告)号：US20210052584A1
公开(公告)日：2021-02-25
申请号：US16836155
申请日：2020-03-31
发明人： Mark Thomas Miller , Corey Anderson , Vijayalaksmi Arumugam , Brian Richard Bear , Hayley Marie Binch , Jeremy J. Clemens , Thomas Cleveland , Erica Conroy , Timothy Richard Coon , Bryan A. Frieman , Peter Diederik Jan Grootenhuis , Raymond Stanley Gross , Sara Sabina Hadida-Ruah , Haripada Khatuya , Pramod Virupax Joshi , Paul John Krenitsky , Chun-Chieh Lin , Gulin Erdogan Marelius , Vito Melillo , Jason McCartney , Georgia McGaughey Nicholls , Fabrice Jean Denis Pierre , Alina Silina , Andreas P. Termin , Johnny Uy , Jinglan Zhou
IPC分类号： A61K31/506 , C07D213/82 , A61K31/4418 , A61K31/444 , A61K31/44 , C07D213/84 , C07D231/14 , A61K31/415 , C07D209/42 , A61K31/404 , C07D401/12 , A61K31/4439 , C07D401/14 , C07D231/12 , A61K31/497 , C07D417/12 , C07D405/14 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/4525 , A61J1/03 , C07D403/12 , C07D413/14 , C07D213/73 , C07D231/20 , C07D401/04 , C07D235/24 , C07D403/10 , C07D239/34 , C07D407/12 , C07D209/18 , C07D209/49 , C07D213/64
摘要： The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.
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公开(公告)号：US20190055220A1
公开(公告)日：2019-02-21
申请号：US16089703
申请日：2017-03-31
发明人： Brian Bear , Jeremy Clemens , Thomas Cleveland , Timothy Richard Coon , Peter Diederik Jan Grootenhuis , Bryan A. Frieman , Sara S. Hadida Ruah , Haripada Khatuya , Paul J. Krenitsky , Mark Thomas Miller , Alina Silina , Johnny Uy , Jinglan Zhou
IPC分类号： C07D401/14 , C07D401/12 , C07D471/04 , A61P11/00
CPC分类号： C07D401/14 , A61P11/00 , C07D213/82 , C07D401/12 , C07D471/04
摘要： The present disclosure features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, W, X, Z, n, p, and Rings A and B are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present disclosure also features pharmaceutical compositions, method of treating, and kits thereof.
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公开(公告)号：US20180185364A1
公开(公告)日：2018-07-05
申请号：US15675000
申请日：2017-08-11
发明人： Mark Thomas Miller , Corey Anderson , Vijayalaksmi Arumugam , Brian Richard Bear , Hayley Marie Binch , Jeremy J. Clemens , Thomas Cleveland , Erica Conroy , Timothy Richard Coon , Bryan A. Frieman , Peter Diederik Jan Grootenhuis , Raymond Stanley Gross , Sara Sabina Hadida-Ruah , Haripada Khatuya , Pramod Virupax Joshi , Paul John Krenitsky , Chun-Chieh Lin , Gulin Erdogan Marelius , Vito Melillo , Jason McCartney , Georgia McGaughey Nicholls , Fabrice Jean Denis Pierre , Alina Silina , Andreas P. Termin , Johnny Uy , Jinglan Zhou
IPC分类号： A61K31/506 , C07D417/12 , C07D405/14 , C07D401/14 , C07D401/12 , C07D231/14 , C07D231/12 , C07D213/84 , C07D213/82 , C07D209/42 , A61K31/497 , A61K31/496 , A61K31/4709 , A61K31/4545 , A61K31/4525 , A61K31/444 , A61K31/4439 , A61K31/4418 , A61K31/44 , A61K31/415 , A61K31/404 , A61J1/03
CPC分类号： A61K31/506 , A61J1/035 , A61K31/404 , A61K31/415 , A61K31/44 , A61K31/4418 , A61K31/4439 , A61K31/444 , A61K31/4525 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , C07D209/18 , C07D209/42 , C07D209/49 , C07D213/64 , C07D213/73 , C07D213/82 , C07D213/84 , C07D231/12 , C07D231/14 , C07D231/20 , C07D235/24 , C07D239/34 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/14 , C07D407/12 , C07D413/14 , C07D417/12
摘要： The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.
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公开(公告)号：US09782408B2
公开(公告)日：2017-10-10
申请号：US14876525
申请日：2015-10-06
发明人： Mark Thomas Miller , Corey Anderson , Vijayalaksmi Arumugam , Brian Richard Bear , Hayley Marie Binch , Jeremy J. Clemens , Thomas Cleveland , Erica Conroy , Timothy Richard Coon , Bryan A. Frieman , Peter Diederik Jan Grootenhuis , Raymond Stanley Gross , Sara Sabina Hadida Ruah , Haripada Khatuya , Pramod Virupax Joshi , Paul John Krenitsky , Chun-Chieh Lin , Gulin Erdogan Marelius , Vito Melillo , Jason McCartney , Georgia McGaughey Nicholls , Fabrice Jean Denis Pierre , Alina Silina , Andreas P. Termin , Johnny Uy , Jinglan Zhou
IPC分类号： A61K31/506 , C07D213/82 , A61K31/4418 , A61K31/444 , A61K31/44 , C07D213/84 , C07D231/14 , A61K31/415 , C07D209/42 , A61K31/404 , C07D401/12 , A61K31/4439 , C07D401/14 , C07D231/12 , A61K31/497 , C07D417/12 , C07D405/14 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/4525 , A61J1/03
CPC分类号： A61K31/506 , A61J1/035 , A61K31/404 , A61K31/415 , A61K31/44 , A61K31/4418 , A61K31/4439 , A61K31/444 , A61K31/4525 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , C07D209/18 , C07D209/42 , C07D209/49 , C07D213/64 , C07D213/73 , C07D213/82 , C07D213/84 , C07D231/12 , C07D231/14 , C07D231/20 , C07D235/24 , C07D239/34 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/14 , C07D407/12 , C07D413/14 , C07D417/12
摘要： The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.
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公开(公告)号：US11866450B2
公开(公告)日：2024-01-09
申请号：US17323267
申请日：2021-05-18
发明人： Jeremy J. Clemens , Alexander Russell Abela , Corey Don Anderson , Brett B. Busch , Weichao George Chen , Thomas Cleveland , Timothy Richard Coon , Bryan Frieman , Senait G. Ghirmai , Peter Grootenhuis , Anton V. Gulevich , Sara Sabina Hadida Ruah , Clara Kuang-Ju Hsia , Ping Kang , Haripada Khatuya , Jason McCartney , Mark Thomas Miller , Prasuna Paraselli , Fabrice Pierre , Sara E. Swift , Andreas Termin , Johnny Uy , Carl V. Vogel , Jinglan Zhou
IPC分类号： C07D513/22 , A61K31/439 , A61P11/00 , A61K31/47 , A61K31/404 , C07D515/22
CPC分类号： C07D513/22 , A61K31/404 , A61K31/439 , A61K31/47 , A61P11/00 , C07D515/22
摘要： Compounds of Formula (I):
pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.-
公开(公告)号：US11426407B2
公开(公告)日：2022-08-30
申请号：US16836155
申请日：2020-03-31
发明人： Mark Thomas Miller , Corey Anderson , Vijayalaksmi Arumugam , Brian Richard Bear , Hayley Marie Binch , Jeremy J. Clemens , Thomas Cleveland , Erica Conroy , Timothy Richard Coon , Bryan A. Frieman , Peter Diederik Jan Grootenhuis , Raymond Stanley Gross , Sara Sabina Hadida-Ruah , Haripada Khatuya , Pramod Virupax Joshi , Paul John Krenitsky , Chun-Chieh Lin , Gulin Erdogan Marelius , Vito Melillo , Jason McCartney , Georgia McGaughey Nicholls , Fabrice Jean Denis Pierre , Alina Silina , Andreas P. Termin , Johnny Uy , Jinglan Zhou
IPC分类号： C07D213/82 , A61K31/506 , A61K31/4418 , A61K31/444 , A61K31/44 , C07D213/84 , C07D231/14 , A61K31/415 , C07D209/42 , A61K31/404 , C07D401/12 , A61K31/4439 , C07D401/14 , C07D231/12 , A61K31/497 , C07D417/12 , C07D405/14 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/4525 , A61J1/03 , C07D403/12 , C07D413/14 , C07D213/73 , C07D231/20 , C07D401/04 , C07D235/24 , C07D403/10 , C07D239/34 , C07D407/12 , C07D209/18 , C07D209/49 , C07D213/64
摘要： The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.
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公开(公告)号：US11066417B2
公开(公告)日：2021-07-20
申请号：US16276350
申请日：2019-02-14
发明人： Jeremy J. Clemens , Alexander Russell Abela , Corey Don Anderson , Brett B. Busch , Weichao George Chen , Thomas Cleveland , Timothy Richard Coon , Bryan Frieman , Senait G. Ghirmai , Peter Grootenhuis , Anton V. Gulevich , Sara Sabina Hadida Ruah , Clara Kuang-Ju Hsia , Ping Kang , Haripada Khatuya , Jason McCartney , Mark Thomas Miller , Prasuna Paraselli , Fabrice Pierre , Sara E. Swift , Andreas Termin , Johnny Uy , Carl V. Vogel , Jinglan Zhou
IPC分类号： A61K31/44 , A61K31/435 , C07D513/22 , A61K31/439 , A61P11/00 , A61K31/47 , A61K31/404 , C07D515/22
摘要： Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.
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公开(公告)号：US20190248809A1
公开(公告)日：2019-08-15
申请号：US16276350
申请日：2019-02-14
发明人： Jeremy J. Clemens , Alexander Russell Abela , Corey Don Anderson , Brett B. Busch , Weichao George Chen , Thomas Cleveland , Timothy Richard Coon , Bryan Frieman , Senait G. Ghirmai , Peter Grootenhuis , Anton V. Gulevich , Sara Sabina Hadida Ruah , Clara Kuang-Ju Hsia , Ping Kang , Haripada Khatuya , Jason McCartney , Mark Thomas Miller , Prasuna Paraselli , Fabrice Pierre , Sara E. Swift , Andreas Termin , Johnny Uy , Carl V. Vogel , Jinglan Zhou
IPC分类号： C07D513/22 , A61K31/439 , A61K31/404 , A61K31/47 , A61P11/00
CPC分类号： C07D513/22 , A61K31/404 , A61K31/439 , A61K31/47 , A61P11/00 , C07D515/22
摘要： Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.
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公开(公告)号：US20160095858A1
公开(公告)日：2016-04-07
申请号：US14876525
申请日：2015-10-06
发明人： Mark Thomas Miller , Corey Anderson , Vijayalaksmi Arumugam , Brian Richard Bear , Hayley Marie Binch , Jeremy J. Clemens , Thomas Cleveland , Erica Conroy , Timothy Richard Coon , Bryan A. Frieman , Peter Diederik Jan Grootenhuis , Raymond Stanley Gross , Sara Sabina Hadida-Ruah , Khatuya Haripada , Pramod Virupax Joshi , Paul John Krenitsky , Chun-Chieh Lin , Gulin Erdgogan Marelius , Vito Melillo , Jason McCartney , Georgia McGaughey Nicholls , Fabrice Jean Denis Pierre , Alina Silina , Andreas P. Termin , Johnny Uy , Jinglan Zhou
IPC分类号： A61K31/506 , A61K31/4418 , A61K31/444 , A61K31/44 , C07D213/84 , C07D231/14 , A61K31/415 , C07D209/42 , A61K31/404 , C07D401/12 , A61K31/4439 , C07D401/14 , C07D231/12 , A61K31/497 , C07D417/12 , C07D405/14 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/4525 , A61J1/03 , C07D213/82
CPC分类号： A61K31/506 , A61J1/035 , A61K31/404 , A61K31/415 , A61K31/44 , A61K31/4418 , A61K31/4439 , A61K31/444 , A61K31/4525 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , C07D209/18 , C07D209/42 , C07D209/49 , C07D213/64 , C07D213/73 , C07D213/82 , C07D213/84 , C07D231/12 , C07D231/14 , C07D231/20 , C07D235/24 , C07D239/34 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/14 , C07D407/12 , C07D413/14 , C07D417/12
摘要： The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.
摘要翻译： 本发明的特征在于式I化合物或其药学上可接受的盐，其中R1，R2，R3，W，X，Y，Z，n，o，p和q如本文所定义，用于治疗CFTR介导 疾病如囊性纤维化。 本发明还特征在于药物组合物，治疗方法及其试剂盒。
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公开(公告)号：US12122788B2
公开(公告)日：2024-10-22
申请号：US18093142
申请日：2023-01-04
发明人： Paul Angell , John E. Cochran , Benjamin J. Littler , David Siesel , Armando Urbina , Corey Don Anderson , Jeremy J. Clemens , Thomas Cleveland , Timothy Richard Coon , Bryan Frieman , Peter Grootenhuis , Sara Sabina Hadida Ruah , Jason McCartney , Mark Thomas Miller , Prasuna Paraselli , Fabrice Pierre , Sara E. Swift , Jinglan Zhou
IPC分类号： C07D513/22 , C07D207/08 , C07D213/71 , C07D213/82 , C07D231/20 , C07D401/04 , C07D401/14
CPC分类号： C07D513/22 , C07D207/08 , C07D213/71 , C07D213/82 , C07D231/20 , C07D401/04 , C07D401/14
摘要： The disclosure provides processes for synthesizing Compound I, and pharmaceutically acceptable salts thereof.
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