公开(公告)号：US20230357191A1

公开(公告)日：2023-11-09

申请号：US17880720

申请日：2022-08-04

申请人： Vertex Pharmaceuticals Incorporated

发明人： Alexander Russell Abela ,  Timothy Alcacio ,  Corey Anderson ,  Paul Timothy Angell ,  Minson Baek ,  Jeremy J. Clemens ,  Thomas Cleveland ,  Lori Ann Ferris ,  Peter Diederik Jan Grootenhuis ,  Raymond Stanley Gross ,  Anton V. Gulevich ,  Sara Sabina Hadida Ruah ,  Clara Kuang-Ju Hsia ,  Robert M. Hughes ,  Pramod Virupax Joshi ,  Ping Kang ,  Ali Keshavarz-Shokri ,  Haripada Khatuya ,  Paul John Krenitsky ,  Jason McCartney ,  Mark Thomas Miller ,  Prasuna Paraselli ,  Fabrice Jean Denis Pierre ,  Yi Shi ,  Muna Shrestha ,  David Andrew Siesel ,  Kathy Stavropoulos ,  Andreas P. Termin ,  Fredrick F. Van Goor ,  Johnny Uy ,  Timothy John Young ,  Jinglan Zhou

IPC分类号： C07D401/14 ,  C07D471/14 ,  A61P11/00 ,  C07D498/14 ,  C07D401/04 ,  C07D231/20

CPC分类号： C07D401/14 ,  A61P11/00 ,  C07D231/20 ,  C07D401/04 ,  C07D471/14 ,  C07D498/14 ,  C07B2200/13

摘要： Compounds of Formula (I):





pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

公开(公告)号：US10793547B2

公开(公告)日：2020-10-06

申请号：US15836627

申请日：2017-12-08

申请人： Vertex Pharmaceuticals Incorporated

发明人： Alexander Russell Abela ,  Timothy Alcacio ,  Corey Anderson ,  Paul Timothy Angell ,  Minson Baek ,  Jeremy J. Clemens ,  Thomas Cleveland ,  Lori Ann Ferris ,  Peter Diederik Jan Grootenhuis ,  Raymond Stanley Gross ,  Anton V. Gulevich ,  Sara Sabina Hadida Ruah ,  Clara Kuang-Ju Hsia ,  Robert M. Hughes ,  Pramod Virupax Joshi ,  Ping Kang ,  Ali Keshavarz-Shokri ,  Haripada Khatuya ,  Paul John Krenitsky ,  Jason McCartney ,  Mark Thomas Miller ,  Prasuna Paraselli ,  Fabrice Jean Denis Pierre ,  Yi Shi ,  Muna Shrestha ,  David Andrew Siesel ,  Kathy Stavropoulos ,  Andreas P. Termin ,  Fredrick F. Van Goor ,  Johnny Uy ,  Timothy John Young ,  Jinglan Zhou

IPC分类号： C07D401/14 ,  C07D471/14 ,  A61P11/00 ,  C07D498/14 ,  C07D401/04 ,  C07D231/20

摘要： Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

公开(公告)号：US11453655B2

公开(公告)日：2022-09-27

申请号：US16994875

申请日：2020-08-17

申请人： Vertex Pharmaceuticals Incorporated

发明人： Alexander Russell Abela ,  Timothy Alcacio ,  Corey Anderson ,  Paul Timothy Angell ,  Minson Baek ,  Jeremy J. Clemens ,  Thomas Cleveland ,  Lori Ann Ferris ,  Peter Diederik Jan Grootenhuis ,  Raymond Stanley Gross ,  Anton V. Gulevich ,  Sara Sabina Hadida Ruah ,  Clara Kuang-Ju Hsia ,  Robert M. Hughes ,  Pramod Virupax Joshi ,  Ping Kang ,  Ali Keshavarz-Shokri ,  Haripada Khatuya ,  Paul John Krenitsky ,  Jason McCartney ,  Mark Thomas Miller ,  Prasuna Paraselli ,  Fabrice Jean Denis Pierre ,  Yi Shi ,  Muna Shrestha ,  David Andrew Siesel ,  Kathy Stavropoulos ,  Andreas P. Termin ,  Fredrick F. Van Goor ,  Johnny Uy ,  Timothy John Young ,  Jinglan Zhou

IPC分类号： C07D401/04 ,  C07D401/14 ,  C07D471/14 ,  A61P11/00 ,  C07D498/14 ,  C07D231/20

摘要： Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

公开(公告)号：US20220106331A1

公开(公告)日：2022-04-07

申请号：US17323267

申请日：2021-05-18

申请人： Vertex Pharmaceuticals Incorporated

发明人： Jeremy J. Clemens ,  Alexander Russell Abela ,  Corey Don Anderson ,  Brett B. Busch ,  Weichao George Chen ,  Thomas Cleveland ,  Timothy Richard Coon ,  Bryan Frieman ,  Senait G. Ghirmai ,  Peter Grootenhuis ,  Anton V. Gulevich ,  Sara Sabina Hadida Ruah ,  Clara Kuang-Ju Hsia ,  Ping Kang ,  Haripada Khatuya ,  Jason McCartney ,  Mark Thomas Miller ,  Prasuna Paraselli ,  Fabrice Pierre ,  Sara E. Swift ,  Andreas Termin ,  Johnny Uy ,  Carl V. Vogel ,  Jinglan Zhou

IPC分类号： C07D513/22 ,  A61K31/439 ,  A61K31/404 ,  A61K31/47 ,  A61P11/00 ,  C07D515/22

摘要： Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

公开(公告)号：US20180162839A1

公开(公告)日：2018-06-14

申请号：US15836627

申请日：2017-12-08

申请人： Vertex Pharmaceuticals Incorporated

发明人： Alexander Russell Abela ,  Timothy Alcacio ,  Corey Anderson ,  Paul Timothy Angell ,  Minson Baek ,  Jeremy J. Clemens ,  Thomas Cleveland ,  Lori Ann Ferris ,  Peter Diederik Jan Grootenhuis ,  Raymond Stanley Gross ,  Anton V. Gulevich ,  Sara Sabina Hadida Ruah ,  Clara Kuang-Ju Hsia ,  Robert M. Hughes ,  Pramod Virupax Joshi ,  Ping Kang ,  Ali Keshavarz-Shokri ,  Haripada Khatuya ,  Paul John Krenitsky ,  Jason McCartney ,  Mark Thomas Miller ,  Prasuna Paraselli ,  Fabrice Jean Denis Pierre ,  Yi Shi ,  Muna Shrestha ,  David Andrew Siesel ,  Kathy Stavropoulos ,  Andreas P. Termin ,  Fredrick F. Van Goor ,  Johnny Uy ,  Timothy John Young ,  Jinglan Zhou

IPC分类号： C07D401/14 ,  C07D471/14 ,  C07D498/14 ,  A61P11/00

摘要： Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

公开(公告)号：US11866450B2

公开(公告)日：2024-01-09

申请号：US17323267

申请日：2021-05-18

申请人： Vertex Pharmaceuticals Incorporated

发明人： Jeremy J. Clemens ,  Alexander Russell Abela ,  Corey Don Anderson ,  Brett B. Busch ,  Weichao George Chen ,  Thomas Cleveland ,  Timothy Richard Coon ,  Bryan Frieman ,  Senait G. Ghirmai ,  Peter Grootenhuis ,  Anton V. Gulevich ,  Sara Sabina Hadida Ruah ,  Clara Kuang-Ju Hsia ,  Ping Kang ,  Haripada Khatuya ,  Jason McCartney ,  Mark Thomas Miller ,  Prasuna Paraselli ,  Fabrice Pierre ,  Sara E. Swift ,  Andreas Termin ,  Johnny Uy ,  Carl V. Vogel ,  Jinglan Zhou

IPC分类号： C07D513/22 ,  A61K31/439 ,  A61P11/00 ,  A61K31/47 ,  A61K31/404 ,  C07D515/22

CPC分类号： C07D513/22 ,  A61K31/404 ,  A61K31/439 ,  A61K31/47 ,  A61P11/00 ,  C07D515/22

摘要： Compounds of Formula (I):




pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

公开(公告)号：US11066417B2

公开(公告)日：2021-07-20

申请号：US16276350

申请日：2019-02-14

申请人： Vertex Pharmaceuticals Incorporated

发明人： Jeremy J. Clemens ,  Alexander Russell Abela ,  Corey Don Anderson ,  Brett B. Busch ,  Weichao George Chen ,  Thomas Cleveland ,  Timothy Richard Coon ,  Bryan Frieman ,  Senait G. Ghirmai ,  Peter Grootenhuis ,  Anton V. Gulevich ,  Sara Sabina Hadida Ruah ,  Clara Kuang-Ju Hsia ,  Ping Kang ,  Haripada Khatuya ,  Jason McCartney ,  Mark Thomas Miller ,  Prasuna Paraselli ,  Fabrice Pierre ,  Sara E. Swift ,  Andreas Termin ,  Johnny Uy ,  Carl V. Vogel ,  Jinglan Zhou

IPC分类号： A61K31/44 ,  A61K31/435 ,  C07D513/22 ,  A61K31/439 ,  A61P11/00 ,  A61K31/47 ,  A61K31/404 ,  C07D515/22

摘要： Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

公开(公告)号：US20210047295A1

公开(公告)日：2021-02-18

申请号：US16994875

申请日：2020-08-17

申请人： Vertex Pharmaceuticals Incorporated

发明人： Alexander Russell Abela ,  Timothy Alcacio ,  Corey Anderson ,  Paul Timothy Angell ,  Minson Baek ,  Jeremy J. Clemens ,  Thomas Cleveland ,  Lori Ann Ferris ,  Peter Diederik Jan Grootenhuis ,  Raymond Stanley Gross ,  Anton V. Gulevich ,  Sara Sabina Hadida Ruah ,  Clara Kuang-Ju Hsia ,  Robert M. Hughes ,  Pramod Virupax Joshi ,  Ping Kang ,  Ali Keshavarz-Shokri ,  Haripada Khatuya ,  Paul John Krenitsky ,  Jason McCartney ,  Mark Thomas Miller ,  Prasuna Paraselli ,  Fabrice Jean Denis Pierre ,  Yi Shi ,  Muna Shrestha ,  David Andrew Siesel ,  Kathy Stavropoulos ,  Andreas P. Termin ,  Fredrick F. Van Goor ,  Johnny Uy ,  Timothy John Young ,  Jinglan Zhou

IPC分类号： C07D401/14 ,  C07D471/14 ,  A61P11/00 ,  C07D498/14 ,  C07D401/04 ,  C07D231/20

摘要： Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

公开(公告)号：US20190248809A1

公开(公告)日：2019-08-15

申请号：US16276350

申请日：2019-02-14

申请人： Vertex Pharmaceuticals Incorporated

发明人： Jeremy J. Clemens ,  Alexander Russell Abela ,  Corey Don Anderson ,  Brett B. Busch ,  Weichao George Chen ,  Thomas Cleveland ,  Timothy Richard Coon ,  Bryan Frieman ,  Senait G. Ghirmai ,  Peter Grootenhuis ,  Anton V. Gulevich ,  Sara Sabina Hadida Ruah ,  Clara Kuang-Ju Hsia ,  Ping Kang ,  Haripada Khatuya ,  Jason McCartney ,  Mark Thomas Miller ,  Prasuna Paraselli ,  Fabrice Pierre ,  Sara E. Swift ,  Andreas Termin ,  Johnny Uy ,  Carl V. Vogel ,  Jinglan Zhou

IPC分类号： C07D513/22 ,  A61K31/439 ,  A61K31/404 ,  A61K31/47 ,  A61P11/00

CPC分类号： C07D513/22 ,  A61K31/404 ,  A61K31/439 ,  A61K31/47 ,  A61P11/00 ,  C07D515/22

摘要： Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.