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公开(公告)号：US11426407B2
公开(公告)日：2022-08-30
申请号：US16836155
申请日：2020-03-31
发明人： Mark Thomas Miller , Corey Anderson , Vijayalaksmi Arumugam , Brian Richard Bear , Hayley Marie Binch , Jeremy J. Clemens , Thomas Cleveland , Erica Conroy , Timothy Richard Coon , Bryan A. Frieman , Peter Diederik Jan Grootenhuis , Raymond Stanley Gross , Sara Sabina Hadida-Ruah , Haripada Khatuya , Pramod Virupax Joshi , Paul John Krenitsky , Chun-Chieh Lin , Gulin Erdogan Marelius , Vito Melillo , Jason McCartney , Georgia McGaughey Nicholls , Fabrice Jean Denis Pierre , Alina Silina , Andreas P. Termin , Johnny Uy , Jinglan Zhou
IPC分类号： C07D213/82 , A61K31/506 , A61K31/4418 , A61K31/444 , A61K31/44 , C07D213/84 , C07D231/14 , A61K31/415 , C07D209/42 , A61K31/404 , C07D401/12 , A61K31/4439 , C07D401/14 , C07D231/12 , A61K31/497 , C07D417/12 , C07D405/14 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/4525 , A61J1/03 , C07D403/12 , C07D413/14 , C07D213/73 , C07D231/20 , C07D401/04 , C07D235/24 , C07D403/10 , C07D239/34 , C07D407/12 , C07D209/18 , C07D209/49 , C07D213/64
摘要： The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.
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公开(公告)号：US20210047295A1
公开(公告)日：2021-02-18
申请号：US16994875
申请日：2020-08-17
发明人： Alexander Russell Abela , Timothy Alcacio , Corey Anderson , Paul Timothy Angell , Minson Baek , Jeremy J. Clemens , Thomas Cleveland , Lori Ann Ferris , Peter Diederik Jan Grootenhuis , Raymond Stanley Gross , Anton V. Gulevich , Sara Sabina Hadida Ruah , Clara Kuang-Ju Hsia , Robert M. Hughes , Pramod Virupax Joshi , Ping Kang , Ali Keshavarz-Shokri , Haripada Khatuya , Paul John Krenitsky , Jason McCartney , Mark Thomas Miller , Prasuna Paraselli , Fabrice Jean Denis Pierre , Yi Shi , Muna Shrestha , David Andrew Siesel , Kathy Stavropoulos , Andreas P. Termin , Fredrick F. Van Goor , Johnny Uy , Timothy John Young , Jinglan Zhou
IPC分类号： C07D401/14 , C07D471/14 , A61P11/00 , C07D498/14 , C07D401/04 , C07D231/20
摘要： Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.
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公开(公告)号：US10787472B2
公开(公告)日：2020-09-29
申请号：US16283904
申请日：2019-02-25
发明人： Corey Anderson , Sara Sabina Hadida Ruah , Julian Marian Charles Golec , Beili Zhang , Benjamin Joseph Littler , Ali Keshavarz-Shokri , Tim Edward Alcacio , Daniel T. Belmont
IPC分类号： C07F9/58 , C07F9/59 , C07F9/576 , A61K31/675 , A61K45/06
摘要： The invention relates to prodrug compounds of formula I: wherein R2, R3, R5, R7 and X are as defined herein. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain. The compounds of formula I possess advantageous solubility and physicochemical properties.
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公开(公告)号：US10647661B2
公开(公告)日：2020-05-12
申请号：US16032799
申请日：2018-07-11
发明人： Nadia Ahmad , Corey Anderson , Vijayalaksmi Arumugam , Iuliana Luci Asgian , Joanne Louise Camp , Lev Tyler Dewey Fanning , Sara Sabina Hadida Ruah , Dennis Hurley , Yvonne Schmidt , David Shaw , Urvi Patel , Stephen Andrew Thomson , Lidio Marx Carvalho Meireles
IPC分类号： C07D213/69 , C07D213/81 , C07D213/82 , C07D239/34 , C07D239/42 , C07D307/79 , C07D307/86 , C07D317/46 , C07D405/12 , C07C235/64 , A61K31/165 , C07C237/42 , C07D213/89
摘要： Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.
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公开(公告)号：US10570115B2
公开(公告)日：2020-02-25
申请号：US15721390
申请日：2017-09-29
发明人： Timothy Alcacio , Minson Baek , Peter Grootenhuis , Sara Sabina Hadida Ruah , Robert M. Hughes , Ali Keshavarz-Shokri , Rachel McAuley-Aoki , Jason McCartney , Mark Thomas Miller , Fredrick Van Goor , Beili Zhang , Corey Anderson , Thomas Cleveland , Bryan A. Frieman , Haripada Khatuya , Pramod Virupax Joshi , Paul John Krenitsky , Vito Melillo , Fabrice Jean Denis Pierre , Andreas P. Termin , Johnny Uy , Jinglan Zhou , Alexander Russell Abela , Brett Bradley Busch , Prasuna Paraselli , David Andrew Siesel
IPC分类号： C07D401/14 , A61K31/465 , A61K31/455 , A61K31/4155 , A61K31/4025 , C07D471/14 , C07D498/14 , C07B59/00
摘要： Compounds of Formula I: pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.
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公开(公告)号：US09783501B2
公开(公告)日：2017-10-10
申请号：US14813911
申请日：2015-07-30
发明人： Sara Sabina Hadida-Ruah , Corey Anderson , Vijayalaksmi Arumugam , Iuliana Luci Asgian , Brian Richard Bear , Andreas P. Termin , James Philip Johnson
IPC分类号： A61K31/47 , C07D215/227 , C07D215/54 , C07D403/12 , C07D401/12 , C07D413/12 , C07D241/44 , C07D417/12 , A61K31/4709 , A61K31/498
CPC分类号： C07D215/54 , A61K31/47 , A61K31/4709 , A61K31/498 , C07D241/44 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： The invention relates to compounds of formula I or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.
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公开(公告)号：US09393235B2
公开(公告)日：2016-07-19
申请号：US14699437
申请日：2015-04-29
发明人： Sara Sabina Hadida-Ruah , Corey Anderson , Vijayalaksmi Arumugam , Iuliana Luci Asgian , Brian Richard Bear , Andreas P. Termin , James Philip Johnson
IPC分类号： A61K31/04 , A61K31/4412 , C07D213/75 , C07D405/12 , C07D401/12
CPC分类号： C07D213/75 , A61K31/4412 , C07D401/12 , C07D405/12
摘要： The invention relates to pyridone amide compounds of formula I and I′ or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.
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公开(公告)号：US20160095858A1
公开(公告)日：2016-04-07
申请号：US14876525
申请日：2015-10-06
发明人： Mark Thomas Miller , Corey Anderson , Vijayalaksmi Arumugam , Brian Richard Bear , Hayley Marie Binch , Jeremy J. Clemens , Thomas Cleveland , Erica Conroy , Timothy Richard Coon , Bryan A. Frieman , Peter Diederik Jan Grootenhuis , Raymond Stanley Gross , Sara Sabina Hadida-Ruah , Khatuya Haripada , Pramod Virupax Joshi , Paul John Krenitsky , Chun-Chieh Lin , Gulin Erdgogan Marelius , Vito Melillo , Jason McCartney , Georgia McGaughey Nicholls , Fabrice Jean Denis Pierre , Alina Silina , Andreas P. Termin , Johnny Uy , Jinglan Zhou
IPC分类号： A61K31/506 , A61K31/4418 , A61K31/444 , A61K31/44 , C07D213/84 , C07D231/14 , A61K31/415 , C07D209/42 , A61K31/404 , C07D401/12 , A61K31/4439 , C07D401/14 , C07D231/12 , A61K31/497 , C07D417/12 , C07D405/14 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/4525 , A61J1/03 , C07D213/82
CPC分类号： A61K31/506 , A61J1/035 , A61K31/404 , A61K31/415 , A61K31/44 , A61K31/4418 , A61K31/4439 , A61K31/444 , A61K31/4525 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , C07D209/18 , C07D209/42 , C07D209/49 , C07D213/64 , C07D213/73 , C07D213/82 , C07D213/84 , C07D231/12 , C07D231/14 , C07D231/20 , C07D235/24 , C07D239/34 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/14 , C07D407/12 , C07D413/14 , C07D417/12
摘要： The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.
摘要翻译： 本发明的特征在于式I化合物或其药学上可接受的盐，其中R1，R2，R3，W，X，Y，Z，n，o，p和q如本文所定义，用于治疗CFTR介导 疾病如囊性纤维化。 本发明还特征在于药物组合物，治疗方法及其试剂盒。
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公开(公告)号：US11186566B2
公开(公告)日：2021-11-30
申请号：US16702891
申请日：2019-12-04
发明人： Timothy Alcacio , Minson Baek , Peter Grootenhuis , Sara Sabina Hadida Ruah , Robert M. Hughes , Ali Keshavarz-Shokri , Rachel McAuley-Aoki , Jason McCartney , Mark Thomas Miller , Fredrick Van Goor , Beili Zhang , Corey Anderson , Thomas Cleveland , Bryan A. Frieman , Haripada Khatuya , Pramod Virupax Joshi , Paul John Krenitsky , Vito Melillo , Fabrice Jean Denis Pierre , Andreas P. Termin , Johnny Uy , Jinglan Zhou , Alexander Russell Abela , Brett Bradley Busch , Prasuna Paraselli
IPC分类号： C07D401/14 , C07D471/14 , C07D498/14 , C07B59/00
摘要： Compounds of Formula I: pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.
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公开(公告)号：US10738009B2
公开(公告)日：2020-08-11
申请号：US16107109
申请日：2018-08-21
发明人： Sara Sabina Hadida Ruah , Corey Anderson , Vijayalaksmi Arumugam , Iuliana Luci Asgian , Brian Richard Bear , Andreas P. Termin , James Philip Johnson
IPC分类号： C07D213/75 , C07D405/12 , C07D401/12 , A61K31/4412
摘要： The invention relates to pyridone amide compounds of formula I and I′ or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.
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