公开(公告)号：US12162839B1

公开(公告)日：2024-12-10

申请号：US18668552

申请日：2024-05-20

Applicant: KING FAISAL UNIVERSITY

Inventor： Mai Mostafa Khalaf Ali ,  Hany Mohamed Abd El-Lateef Ahmed ,  Antar Ahmed Abdelhamid Ahmed

IPC: C07D233/64 ,  A61P31/04 ,  A61P31/10

Abstract: An 4,5-bis(4-bromophenyl)-2-(4-bromophenyl)-1-hexyl-1H-imidazole compound, its synthesis, and its use as an antimicrobial agent.

公开(公告)号：US12139472B2

公开(公告)日：2024-11-12

申请号：US17164817

申请日：2021-02-01

Applicant: PRAETEGO INC

Inventor： Raja G. Khalifah

IPC: C07D401/14 ,  C07D213/38 ,  C07D233/64 ,  C07D401/04

Abstract: The present disclosure provides compounds of the formula pharmaceutical compositions, and methods for treating or inhibiting development of AGE- and/or ALE-associated complications in subjects in need thereof.

公开(公告)号：US12129320B2

公开(公告)日：2024-10-29

申请号：US17410480

申请日：2021-08-24

Applicant: The Board of Trustees of the University of Alabama

Inventor： Jason Edward Bara ,  Steven Thomas Weinman

IPC: C08F26/06 ,  B01D71/28 ,  B01D71/44 ,  B01D71/72 ,  C07D233/64 ,  C07D235/10 ,  C08F212/08 ,  C08F226/06 ,  B01D71/74

CPC classification number: C08F226/06 ,  B01D71/28 ,  B01D71/72 ,  C07D233/64 ,  C07D235/10 ,  C08F212/08 ,  B01D71/74 ,  C08F26/06

Abstract: Imidazole-containing polymer membranes and resins are described herein. Methods of their preparation and use are also described herein. The methods of using the membranes and resins include reducing acids from liquid phases.

公开(公告)号：US12116443B2

公开(公告)日：2024-10-15

申请号：US17317287

申请日：2021-05-11

Applicant: Johnson & Johnson Vision Care, Inc.

Inventor： Shivkumar Mahadevan ,  Dola Sinha ,  Yong Zhang ,  Ghulam Maharvi

IPC: C08F283/12 ,  A61F2/16 ,  C07C237/22 ,  C07C279/14 ,  C07C309/15 ,  C07C323/58 ,  C07D233/64 ,  G02B1/04

CPC classification number: C08F283/12 ,  A61F2/16 ,  C07C237/22 ,  C07C279/14 ,  C07C309/15 ,  C07C323/58 ,  C07D233/64 ,  G02B1/043

Abstract: Provided are amino acid based polymerizable compounds and their applications in ophthalmic devices. The amino acid based polymerizable compounds are of formula I:




wherein R, R1, and R2 are as described herein.

公开(公告)号：US20240327377A1

公开(公告)日：2024-10-03

申请号：US18743634

申请日：2024-06-14

Applicant: NIPPON SODA CO., LTD.

Inventor： Keita SAKANISHI ,  Hikaru AOYAMA ,  Daisuke USHIJIMA ,  Takao IWASA ,  Norifumi SAKIYAMA ,  Maki MATSUI

IPC: C07D401/04 ,  A01N43/50 ,  A01N43/54 ,  A01N43/653 ,  C07D233/64 ,  C07D401/14

CPC classification number: C07D401/04 ,  A01N43/50 ,  A01N43/54 ,  A01N43/653 ,  C07D233/64 ,  C07D401/14

Abstract: An object of the present invention is to provide a heteroaryl azole compound that is excellent in pest control activity, particularly, insecticidal activity and/or miticidal activity, is excellent in safety, and may be industrially advantageously synthesized. The heteroaryl azole compound of the present invention is a compound of the following formula (II), an N-oxide compound, stereoisomer, tautomer or hydrate thereof, or a salt of any of these compounds. Here, in the formula (II), R1 represents a substituted or unsubstituted C1-6 alkylthio group or the like; B1 represents a nitrogen atom or CR2; R2 represents a hydrogen atom, a substituted or unsubstituted C1-6 alkyl group or the like; R3 represents a hydrogen atom, a substituted or unsubstituted C1-6 alkyl group or the like; R represents a substituted or unsubstituted C1-6 alkyl group or the like; A represents a carbon atom or a nitrogen atom; X represents a substituted or unsubstituted C1-6 alkyl group or the like; n represents a number of chemically acceptable X, and is an integer of 0 to 2; and X is the same or different when n is 2.

公开(公告)号：US12102720B2

公开(公告)日：2024-10-01

申请号：US17556316

申请日：2021-12-20

Applicant: Translate Bio, Inc.

Inventor： Braydon Charles Guild ,  Michael Heartlein ,  Frank DeRosa ,  Jerry Chi Zhang

IPC: A61K9/19 ,  A61K9/127 ,  A61K31/7088 ,  A61K38/45 ,  A61K38/46 ,  A61K38/47 ,  A61K38/50 ,  C07C323/25 ,  C07C323/27 ,  C07C323/44 ,  C07D233/64 ,  C07J41/00 ,  C07J43/00 ,  C12N15/88 ,  A61K9/51

CPC classification number: A61K9/19 ,  A61K9/1271 ,  A61K9/1272 ,  A61K31/7088 ,  A61K38/45 ,  A61K38/465 ,  A61K38/47 ,  A61K38/50 ,  C07C323/25 ,  C07C323/27 ,  C07C323/44 ,  C07D233/64 ,  C07J41/0055 ,  C07J43/003 ,  C12N15/88 ,  A61K9/5123 ,  C12Y201/03003 ,  C12Y203/01 ,  C12Y207/08015 ,  C12Y301/06 ,  C12Y302/01022 ,  C12Y302/01035 ,  C12Y302/01046 ,  C12Y302/01076 ,  C12Y305/03001

Abstract: Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.

公开(公告)号：US20240254079A1

公开(公告)日：2024-08-01

申请号：US18239892

申请日：2023-08-30

Applicant: ARCUS BIOSCIENCES, INC.

Inventor： Joel Worley BEATTY ,  Samuel Lawrie DREW ,  Matthew EPPLIN ,  Jeremy Thomas Andre FOURNIER ,  Balint GAL ,  Tezcan GUNEY ,  Karl T. HAELSIG ,  Clayton HARDMAN ,  Steven Donald JACOB ,  Jenna Leigh JEFFREY ,  Jaroslaw KALISIAK ,  Kenneth Victor LAWSON ,  Manmohan Reddy LELETI ,  Erick Allen LINDSEY ,  Artur Karenovich MAILYAN ,  Debashis MANDAL ,  Guillaume MATA ,  Hyunyoung MOON ,  Jay Patrick POWERS ,  Brandon Reid ROSEN ,  Yongli SU ,  Anh Thu TRAN ,  Zhang WANG ,  Xuelei YAN ,  Kai YU

IPC: C07C317/32 ,  A61K31/10 ,  A61K31/277 ,  A61K31/343 ,  A61K31/353 ,  A61K31/365 ,  A61K31/381 ,  A61K31/404 ,  A61K31/415 ,  A61K31/416 ,  A61K31/4174 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/423 ,  A61K31/426 ,  A61K31/428 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4412 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/472 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/5025 ,  A61K31/505 ,  A61K31/519 ,  A61K31/538 ,  A61K39/395 ,  A61K45/06 ,  C07C255/53 ,  C07C317/22 ,  C07C317/36 ,  C07D209/34 ,  C07D211/86 ,  C07D213/57 ,  C07D213/71 ,  C07D213/73 ,  C07D213/74 ,  C07D213/84 ,  C07D215/48 ,  C07D217/04 ,  C07D231/12 ,  C07D231/56 ,  C07D233/64 ,  C07D237/20 ,  C07D239/42 ,  C07D241/12 ,  C07D249/06 ,  C07D249/08 ,  C07D263/32 ,  C07D263/57 ,  C07D265/36 ,  C07D277/30 ,  C07D277/56 ,  C07D277/64 ,  C07D307/83 ,  C07D311/22 ,  C07D333/64 ,  C07D401/04 ,  C07D401/10 ,  C07D409/10 ,  C07D413/10 ,  C07D471/04 ,  C07D487/04

CPC classification number: C07C317/32 ,  A61K31/10 ,  A61K31/277 ,  A61K31/343 ,  A61K31/353 ,  A61K31/365 ,  A61K31/381 ,  A61K31/404 ,  A61K31/415 ,  A61K31/416 ,  A61K31/4174 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/423 ,  A61K31/426 ,  A61K31/428 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4412 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/472 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/5025 ,  A61K31/505 ,  A61K31/519 ,  A61K31/538 ,  A61K39/3955 ,  A61K45/06 ,  C07C255/53 ,  C07C317/22 ,  C07C317/36 ,  C07D209/34 ,  C07D211/86 ,  C07D213/57 ,  C07D213/71 ,  C07D213/73 ,  C07D213/74 ,  C07D213/84 ,  C07D215/48 ,  C07D217/04 ,  C07D231/12 ,  C07D231/56 ,  C07D233/64 ,  C07D237/20 ,  C07D239/42 ,  C07D241/12 ,  C07D249/06 ,  C07D249/08 ,  C07D263/32 ,  C07D263/57 ,  C07D265/36 ,  C07D277/30 ,  C07D277/56 ,  C07D277/64 ,  C07D307/83 ,  C07D311/22 ,  C07D333/64 ,  C07D401/04 ,  C07D401/10 ,  C07D409/10 ,  C07D413/10 ,  C07D471/04 ,  C07D487/04 ,  C07C2602/08 ,  C07C2602/10

Abstract: Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2α.

公开(公告)号：US12037326B2

公开(公告)日：2024-07-16

申请号：US17500866

申请日：2021-10-13

Applicant: Nippon Soda Co., Ltd.

Inventor： Keita Sakanishi ,  Takao Iwasa ,  Hikaru Aoyama ,  Norifumi Sakiyama ,  Daisuke Ushijima ,  Maki Matsui ,  Tomomi Kobayashi

IPC: C07D401/14 ,  A01N43/50 ,  A01N43/54 ,  A01N43/56 ,  A01N43/653 ,  A61K31/506 ,  A61P31/10 ,  A61P31/14 ,  C07D233/64 ,  C07D401/04 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D413/10

CPC classification number: C07D403/14 ,  A01N43/50 ,  A01N43/54 ,  A01N43/56 ,  A01N43/653 ,  A61K31/506 ,  A61P31/10 ,  A61P31/14 ,  C07D233/64 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D413/10

Abstract: A compound represented by Formula (I), or a salt thereof:




wherein, R1 represents an unsubstituted or substituted C1-6 alkylthio group, or the like; A1 represents a nitrogen atom or CH; A2 represents a nitrogen atom or CR2; R2 and R3 each independently represents a hydrogen atom, an unsubstituted or substituted C6-10 aryl group, an unsubstituted or substituted 3- to 6-membered heterocyclyl group, or the like; B1 and B2 each independently represents a nitrogen atom or CR5, with the proviso that B1 and B2 do not represent CR5 at the same time, wherein R5 represents a hydrogen atom, an unsubstituted or substituted C1-6 alkyl group, or the like; R4 represents an unsubstituted or substituted C1-6 alkyl group, or the like, and R4 binds to any one of nitrogen atoms forming an imidazole ring or a triazole ring; and Ar represents an unsubstituted or substituted C6-10 aryl group or the like.

公开(公告)号：US12006296B1

公开(公告)日：2024-06-11

申请号：US18535770

申请日：2023-12-11

Applicant: KING FAISAL UNIVERSITY

Inventor： Mai Mostafa Khalaf Ali ,  Hany Mohamed Abd El-Lateef Ahmed ,  Antar Ahmed Abdelhamid Ahmed

IPC: C07D233/64 ,  A61P31/04 ,  A61P31/10

CPC classification number: C07D233/64 ,  A61P31/04 ,  A61P31/10

Abstract: A 5-(4-methoxyphenyl)-1-hexyl-2-(4-nitrophenyl)-4-phenyl-1H-imidazole compound, its synthesis, and its use as an antimicrobial agent.

公开(公告)号：US12006295B1

公开(公告)日：2024-06-11

申请号：US18387918

申请日：2023-11-08

Applicant: KING FAISAL UNIVERSITY

Inventor： Mai Mostafa Khalaf Ali ,  Hany Mohamed Abd El-Lateef Ahmed ,  Antar Ahmed Abdelhamid Ahmed

IPC: C07D233/64 ,  A61P31/04 ,  A61P31/10

CPC classification number: C07D233/64 ,  A61P31/04 ,  A61P31/10

Abstract: An 4,5-bis(4-bromophenyl)-2-(4-bromophenyl)-1-hexyl-1H-imidazole compound, its synthesis, and its use as an antimicrobial agent.