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公开(公告)号：US20220144808A1
公开(公告)日：2022-05-12
申请号：US17507921
申请日：2021-10-22
Applicant: ARCUS BIOSCIENCES, INC.
Inventor： Joel BEATTY , Laurent DEBIEN , Jenna JEFFREY , Manmohan Reddy LELETI , Debashis MANDAL , Dillon MILES , Jay POWERS , Brandon ROSEN , Ehesan SHARIF , Rhiannon THOMAS-TRAN
IPC: C07D401/14 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14
Abstract: Compound that is an inhibitor of at least one of the A2A and A2B adenosine receptors, and compositions containing the compound and methods for synthesizing the compound, are described herein. The use of such compound and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by the adenosine A2A receptor and/or the adenosine A2B receptor.
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公开(公告)号：US20230024438A1
公开(公告)日：2023-01-26
申请号：US17777103
申请日：2020-12-03
Applicant: ARCUS BIOSCIENCES, INC.
Inventor： Joel Worley BEATTY , Samuel Lawrie DREW , Jeremy Thomas Andre FOURNIER , Tezcan GUNEY , Steven Donald JACOB , Kenneth Victor LAWSON , Manmohan Reddy LELETI , Erick Allen LINDSEY , Debashis MANDAL , Guillaume MATA , Jay Patrick POWERS , Brandon Reid ROSEN , Yongli SU , Anh Thu TRAN , Xuelei YAN
IPC: C07D231/56 , C07D401/12 , C07D403/12 , A61K39/395 , A61K31/497 , A61K31/4439 , A61K31/416 , C07D471/04 , C07D487/04 , C07D401/04 , A61K31/4709 , A61K31/437 , A61K31/519
Abstract: Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2α.
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公开(公告)号：US20230021476A1
公开(公告)日：2023-01-26
申请号：US17835559
申请日：2022-06-08
Applicant: ARCUS BIOSCIENCES, INC.
Inventor： Joel Worley BEATTY , Samuel Lawrie DREW , Matthew EPPLIN , Jeremy Thomas Andre FOURNIER , Balint GAL , Tezcan GUNEY , Karl T. HAELSIG , Clayton HARDMAN , Steven Donald JACOB , Jenna Leigh JEFFREY , Jaroslaw KALISIAK , Kenneth Victor LAWSON , Manmohan Reddy LELETI , Erick Allen LINDSEY , Artur Karenovich MAILYAN , Debashis MANDAL , Guillaume MATA , Hyunyoung MOON , Jay Patrick POWERS , Brandon Reid ROSEN , Yongli SU , Anh Thu TRAN , Zhang WANG , Xuelei YAN , Kai YU
IPC: C07C317/32 , A61K31/10 , A61K31/277 , A61K31/343 , A61K31/353 , A61K31/365 , A61K31/381 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/4174 , A61K31/4192 , A61K31/4196 , A61K31/421 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/437 , A61K31/44 , A61K31/4412 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4965 , A61K31/50 , A61K31/5025 , A61K31/505 , A61K31/519 , A61K31/538 , A61K39/395 , A61K45/06 , C07C255/53 , C07C317/22 , C07C317/36 , C07D209/34 , C07D211/86 , C07D213/57 , C07D213/71 , C07D213/73 , C07D213/74 , C07D213/84 , C07D215/48 , C07D217/04 , C07D231/12 , C07D231/56 , C07D233/64 , C07D237/20 , C07D239/42 , C07D241/12 , C07D249/06 , C07D249/08 , C07D263/32 , C07D263/57 , C07D265/36 , C07D277/30 , C07D277/56 , C07D277/64 , C07D307/83 , C07D311/22 , C07D333/64 , C07D401/04 , C07D401/10 , C07D409/10 , C07D413/10 , C07D471/04 , C07D487/04
Abstract: Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2α.
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公开(公告)号：US20210346353A1
公开(公告)日：2021-11-11
申请号：US17271795
申请日：2019-08-26
Applicant: ARCUS BIOSCIENCES, INC.
Inventor： Joel BEATTY , Laurent Pierre Paul DEBIEN , Samuel Lawrie DREW , Jeremy FOURNIER , Rebecca Louise GRANGE , Steven Donald JACOB , Jenna Leigh JEFFREY , Kenneth V. LAWSON , Manmohan Reddy LELETI , Erick Allen LINDSEY , Debashis MANDAL , Jay Patrick POWERS , Anh Thu TRAN , Rhiannon THOMAS-TRAN , Xuelei YAN
IPC: A61K31/4192 , A61K39/395 , A61K33/243 , A61K31/282 , A61K31/704 , A61K31/519 , C07D403/04 , C07D403/14 , C07D401/14 , C07D405/14 , C07D471/04 , C07D413/14 , A61K31/4439 , A61K31/437 , A61K31/423 , A61K31/422 , A61K31/4985 , C07D487/04
Abstract: Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
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公开(公告)号：US20180215730A1
公开(公告)日：2018-08-02
申请号：US15875106
申请日：2018-01-19
Applicant: ARCUS BIOSCIENCES, INC.
Inventor： Joel BEATTY , Laurent DEBIEN , Jenna JEFFREY , Manmohan Reddy LELETI , Debashis MANDAL , Dillon MILES , Jay POWERS , Brandon ROSEN , Ehesan SHARIF , Rhiannon THOMAS-TRAN
IPC: C07D401/14 , A61K31/506 , C07D405/14 , C07D413/14 , C07D417/14 , A61K31/5377 , C07D403/04 , C07D403/14 , A61K45/06
CPC classification number: C07D401/14 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , A61K2300/00
Abstract: Compound that is an inhibitor of at least one of the A2A and A2B adenosine receptors, and compositions containing the compound and methods for synthesizing the compound, are described herein. The use of such compound and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by the adenosine A2A receptor and/or the adenosine A2B receptor.
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Patent Agency Ranking
公开(公告)号：US20210317079A1
公开(公告)日：2021-10-14
申请号：US17205273
申请日：2021-03-18
Applicant: ARCUS BIOSCIENCES, INC.
Inventor： Joel Worley BEATTY , Samuel Lawrie DREW , Matthew EPPLIN , Jeremy Thomas Andre FOURNIER , Balint GAL , Tezcan GUNEY , Karl T. HAELSIG , Clayton HARDMAN , Steven Donald JACOB , Jenna Leigh JEFFREY , Jaroslaw KALISIAK , Kenneth Victor LAWSON , Manmohan Reddy LELETI , Erick Allen LINDSEY , Artur Karenovich MAILYAN , Debashis MANDAL , Guillaume MATA , Hyunyoung MOON , Jay Patrick POWERS , Brandon Reid ROSEN , Yongli SU , Anh Thu TRAN , Zhang WANG , Xuelei YAN , Kai YU
IPC: C07C317/32 , A61K45/06 , C07C317/22 , C07D311/22 , C07D215/48 , C07D401/04 , A61K31/277 , A61K31/10 , A61K31/353 , A61K31/47 , A61K31/4709 , A61K31/538 , C07D265/36 , C07D217/04 , A61K31/472 , C07D413/10 , C07D409/10 , C07D401/10 , C07D333/64 , A61K31/381 , A61K31/343 , C07D307/83 , C07D231/12 , C07C255/53 , C07D213/57 , A61K31/44 , A61K31/365 , A61K31/415 , A61K31/4192 , C07D249/06 , C07D263/32 , A61K31/421 , C07D213/84 , C07D213/73 , C07D277/30 , A61K31/426 , A61K31/4412 , C07D211/86 , C07D209/34 , A61K31/404 , A61K31/505 , C07D239/42 , C07D249/08 , A61K31/4196 , A61K31/4965 , C07D241/12 , C07D237/20 , A61K31/50 , C07D277/56 , C07D231/56 , A61K31/416 , A61K31/428 , C07D277/64 , C07D213/71 , C07D213/74 , C07D233/64 , A61K31/4174 , C07C317/36 , C07D263/57 , A61K31/423 , C07D471/04 , A61K31/437 , C07D487/04 , A61K31/519 , A61K31/5025 , A61K39/395
Abstract: Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2α.
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公开(公告)号：US20210161898A1
公开(公告)日：2021-06-03
申请号：US17263016
申请日：2019-07-26
Applicant: ARCUS BIOSCIENCES, INC.
Inventor： Manmohan Reddy LELETI , Debashis MANDAL , Dillon Harding MILES , Jay Patrick POWERS , Brandon Reid ROSEN , Ehesan Ul SHARIF
IPC: A61K31/517 , A61K45/06 , A61K33/243 , A61K31/282 , A61K31/704 , A61K31/519 , C07D401/14 , C07D405/14
Abstract: Compound that inhibit at least one of the A2A and A2B adenosine receptors, and compositions containing the compound and methods for synthesizing the compound, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by the adenosine A2A receptor and/or the adenosine A2B receptor.
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公开(公告)号：US20240254079A1
公开(公告)日：2024-08-01
申请号：US18239892
申请日：2023-08-30
Applicant: ARCUS BIOSCIENCES, INC.
Inventor： Joel Worley BEATTY , Samuel Lawrie DREW , Matthew EPPLIN , Jeremy Thomas Andre FOURNIER , Balint GAL , Tezcan GUNEY , Karl T. HAELSIG , Clayton HARDMAN , Steven Donald JACOB , Jenna Leigh JEFFREY , Jaroslaw KALISIAK , Kenneth Victor LAWSON , Manmohan Reddy LELETI , Erick Allen LINDSEY , Artur Karenovich MAILYAN , Debashis MANDAL , Guillaume MATA , Hyunyoung MOON , Jay Patrick POWERS , Brandon Reid ROSEN , Yongli SU , Anh Thu TRAN , Zhang WANG , Xuelei YAN , Kai YU
IPC: C07C317/32 , A61K31/10 , A61K31/277 , A61K31/343 , A61K31/353 , A61K31/365 , A61K31/381 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/4174 , A61K31/4192 , A61K31/4196 , A61K31/421 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/437 , A61K31/44 , A61K31/4412 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4965 , A61K31/50 , A61K31/5025 , A61K31/505 , A61K31/519 , A61K31/538 , A61K39/395 , A61K45/06 , C07C255/53 , C07C317/22 , C07C317/36 , C07D209/34 , C07D211/86 , C07D213/57 , C07D213/71 , C07D213/73 , C07D213/74 , C07D213/84 , C07D215/48 , C07D217/04 , C07D231/12 , C07D231/56 , C07D233/64 , C07D237/20 , C07D239/42 , C07D241/12 , C07D249/06 , C07D249/08 , C07D263/32 , C07D263/57 , C07D265/36 , C07D277/30 , C07D277/56 , C07D277/64 , C07D307/83 , C07D311/22 , C07D333/64 , C07D401/04 , C07D401/10 , C07D409/10 , C07D413/10 , C07D471/04 , C07D487/04
CPC classification number: C07C317/32 , A61K31/10 , A61K31/277 , A61K31/343 , A61K31/353 , A61K31/365 , A61K31/381 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/4174 , A61K31/4192 , A61K31/4196 , A61K31/421 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/437 , A61K31/44 , A61K31/4412 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4965 , A61K31/50 , A61K31/5025 , A61K31/505 , A61K31/519 , A61K31/538 , A61K39/3955 , A61K45/06 , C07C255/53 , C07C317/22 , C07C317/36 , C07D209/34 , C07D211/86 , C07D213/57 , C07D213/71 , C07D213/73 , C07D213/74 , C07D213/84 , C07D215/48 , C07D217/04 , C07D231/12 , C07D231/56 , C07D233/64 , C07D237/20 , C07D239/42 , C07D241/12 , C07D249/06 , C07D249/08 , C07D263/32 , C07D263/57 , C07D265/36 , C07D277/30 , C07D277/56 , C07D277/64 , C07D307/83 , C07D311/22 , C07D333/64 , C07D401/04 , C07D401/10 , C07D409/10 , C07D413/10 , C07D471/04 , C07D487/04 , C07C2602/08 , C07C2602/10
Abstract: Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2α.
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公开(公告)号：US20220016143A1
公开(公告)日：2022-01-20
申请号：US17294353
申请日：2019-11-15
Applicant: Arcus Biosciences, Inc.
Inventor： Joel BEATTY , Eric Thomas NEWCOMB , Jay Patrick POWERS , Brandon Reid ROSEN , Yongli SU , Anh Thu TRAN , Corinne Nicole FOLEY , Rebecca Louise GRANGE , Tezcan GUNEY , Steven Donald JACOB , Jaroslaw KALISIAK , Manmohan Reddy LELETI , Erick Allen LINDSEY , Debashis MANDAL
IPC: A61K31/69 , C07F5/02 , A61K39/395 , A61K31/282 , A61K33/243 , A61K31/704
Abstract: Compounds that are inhibitors of at least one of ARG1 and ARG2, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by ARG1 and ARG2 are also described herein.
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公开(公告)号：US20210101880A1
公开(公告)日：2021-04-08
申请号：US16460263
申请日：2019-07-02
Applicant: ARCUS BIOSCIENCES, INC.
Inventor： Joel BEATTY , Laurent DEBIEN , Jenna JEFFREY , Manmohan Reddy LELETI , Debashis MANDAL , Dillon MILES , Jay POWERS , Brandon ROSEN , Ehesan SHARIF , Rhiannon THOMAS-TRAN
IPC: C07D401/14 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14
Abstract: Compound that is an inhibitor of at least one of the A2A and A2B adenosine receptors, and compositions containing the compound and methods for synthesizing the compound, are described herein. The use of such compound and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by the adenosine A2A receptor and/or the adenosine A2B receptor.
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