-
公开(公告)号：US20240182570A1
公开(公告)日：2024-06-06
申请号：US18486086
申请日：2023-10-12
Applicant: Arcus Biosciences, Inc.
CPC classification number: C07K16/2809 , A61P35/00 , A61K2039/505 , C07K2317/565 , C07K2317/734 , C07K2317/92
Abstract: The present disclosure provides antibodies that specifically bind to TIGIT. The antibodies have the capacity for substantial activation of T cells and natural killer cells by inhibiting binding of TIGIT to CD155. The antibodies can be used for treatment of cancer and infectious disease, among other applications.
-
公开(公告)号：US11993584B2
公开(公告)日：2024-05-28
申请号：US17260847
申请日：2019-07-17
Applicant: ARCUS BIOSCIENCES, INC.
IPC: C07D401/14 , A61K45/06 , C07K16/28
CPC classification number: C07D401/14 , A61K45/06 , C07K16/2818 , C07K16/2827 , C07B2200/13
Abstract: The present invention provides solid forms, solvates and hydrates of 3-[2-amino-6-(1-{[6-(2-hydroxypropan-2-yl)pyridin-2-yl]methyl}-1H-1,2,3-triazol-4-yl)pyrimidin-4-yl]-2-methylbenzonitrile (Compound I),
and methods of making and using the same.-
公开(公告)号：US20240124490A1
公开(公告)日：2024-04-18
申请号：US18219046
申请日：2023-07-06
Applicant: Arcus Biosciences, Inc.
Inventor： Joshua R. Corbin , Sandeep Dhanju , Corinne Nicole Foley , Jeremy Fournier , Padmanabha V. Kattamuri , Manmohan Reddy Leleti , Pradeep Nareddy , Jay Patrick Powers , Ehesan Ul Sharif , Joice Thomas
IPC: C07D519/00 , C07D513/04
CPC classification number: C07D519/00 , C07D513/04
Abstract: Disclosed herein are compounds that are Hematopoietic Progenitor Kinase 1 (HPK1) inhibitors having a structure according to Formula I, and compositions containing those compounds. Methods of preparing the compounds, and methods of using the compounds for the treatment of diseases, disorders, or conditions are also described.
-
公开(公告)号：US20240034803A1
公开(公告)日：2024-02-01
申请号：US18177729
申请日：2023-03-02
Applicant: ARCUS BIOSCIENCES, INC. , WUXI BIOLOGICS IRELAND LIMITED
Inventor： Christine Elizabeth Bowman , Ada Pei Xian Chen , Ester Fernandez-Salas , Nigel Pelham Clinton Walker , Xiaoning Zhao , Yaohua Hu , Siwei Nie , Jijie Gu
CPC classification number: C07K16/2896 , A61P35/00 , C07K2317/21 , C07K2317/24
Abstract: Provided herein are anti-CD39 antibodies that inhibit the enzymatic activity of human CD39 and methods of using the same.
-
公开(公告)号：US20230382942A1
公开(公告)日：2023-11-30
申请号：US18297398
申请日：2023-04-07
Applicant: Arcus Biosciences, Inc.
Inventor： Andrew M. K. Pennell , Eric F. Connor , Stephen Edmund Gottschling , Jim Dimetrios Colomvakos , Mohammed Asadullah Khan
CPC classification number: C07H19/23 , A61K45/06 , C07K16/2818 , C07K16/2827 , C07B2200/13
Abstract: Crystalline forms of the compound of Formula (I), which modulates the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compound and methods for preparing the crystalline forms, are described herein. The use of such crystalline form of Formula (I) and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
-
Patent Agency Ranking
公开(公告)号：US20230024438A1
公开(公告)日：2023-01-26
申请号：US17777103
申请日：2020-12-03
Applicant: ARCUS BIOSCIENCES, INC.
Inventor： Joel Worley BEATTY , Samuel Lawrie DREW , Jeremy Thomas Andre FOURNIER , Tezcan GUNEY , Steven Donald JACOB , Kenneth Victor LAWSON , Manmohan Reddy LELETI , Erick Allen LINDSEY , Debashis MANDAL , Guillaume MATA , Jay Patrick POWERS , Brandon Reid ROSEN , Yongli SU , Anh Thu TRAN , Xuelei YAN
IPC: C07D231/56 , C07D401/12 , C07D403/12 , A61K39/395 , A61K31/497 , A61K31/4439 , A61K31/416 , C07D471/04 , C07D487/04 , C07D401/04 , A61K31/4709 , A61K31/437 , A61K31/519
Abstract: Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2α.
-
公开(公告)号：US20230021476A1
公开(公告)日：2023-01-26
申请号：US17835559
申请日：2022-06-08
Applicant: ARCUS BIOSCIENCES, INC.
Inventor： Joel Worley BEATTY , Samuel Lawrie DREW , Matthew EPPLIN , Jeremy Thomas Andre FOURNIER , Balint GAL , Tezcan GUNEY , Karl T. HAELSIG , Clayton HARDMAN , Steven Donald JACOB , Jenna Leigh JEFFREY , Jaroslaw KALISIAK , Kenneth Victor LAWSON , Manmohan Reddy LELETI , Erick Allen LINDSEY , Artur Karenovich MAILYAN , Debashis MANDAL , Guillaume MATA , Hyunyoung MOON , Jay Patrick POWERS , Brandon Reid ROSEN , Yongli SU , Anh Thu TRAN , Zhang WANG , Xuelei YAN , Kai YU
IPC: C07C317/32 , A61K31/10 , A61K31/277 , A61K31/343 , A61K31/353 , A61K31/365 , A61K31/381 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/4174 , A61K31/4192 , A61K31/4196 , A61K31/421 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/437 , A61K31/44 , A61K31/4412 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4965 , A61K31/50 , A61K31/5025 , A61K31/505 , A61K31/519 , A61K31/538 , A61K39/395 , A61K45/06 , C07C255/53 , C07C317/22 , C07C317/36 , C07D209/34 , C07D211/86 , C07D213/57 , C07D213/71 , C07D213/73 , C07D213/74 , C07D213/84 , C07D215/48 , C07D217/04 , C07D231/12 , C07D231/56 , C07D233/64 , C07D237/20 , C07D239/42 , C07D241/12 , C07D249/06 , C07D249/08 , C07D263/32 , C07D263/57 , C07D265/36 , C07D277/30 , C07D277/56 , C07D277/64 , C07D307/83 , C07D311/22 , C07D333/64 , C07D401/04 , C07D401/10 , C07D409/10 , C07D413/10 , C07D471/04 , C07D487/04
Abstract: Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2α.
-
公开(公告)号：US20210346353A1
公开(公告)日：2021-11-11
申请号：US17271795
申请日：2019-08-26
Applicant: ARCUS BIOSCIENCES, INC.
Inventor： Joel BEATTY , Laurent Pierre Paul DEBIEN , Samuel Lawrie DREW , Jeremy FOURNIER , Rebecca Louise GRANGE , Steven Donald JACOB , Jenna Leigh JEFFREY , Kenneth V. LAWSON , Manmohan Reddy LELETI , Erick Allen LINDSEY , Debashis MANDAL , Jay Patrick POWERS , Anh Thu TRAN , Rhiannon THOMAS-TRAN , Xuelei YAN
IPC: A61K31/4192 , A61K39/395 , A61K33/243 , A61K31/282 , A61K31/704 , A61K31/519 , C07D403/04 , C07D403/14 , C07D401/14 , C07D405/14 , C07D471/04 , C07D413/14 , A61K31/4439 , A61K31/437 , A61K31/423 , A61K31/422 , A61K31/4985 , C07D487/04
Abstract: Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
-
公开(公告)号：US11058704B2
公开(公告)日：2021-07-13
申请号：US16338975
申请日：2017-10-02
Applicant: ARCUS BIOSCIENCES, INC.
Inventor： Laurent Pierre Paul Debien , Jaroslaw Kalisiak , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Dillon Harding Miles , Eric Newcomb , Jay Patrick Powers , Brandon Reid Rosen , Ehesan Ul Sharif
IPC: A01N43/04 , A61K31/70 , A61K31/7076 , A61K31/706 , A61K31/7064 , A61K39/395 , C07H19/20 , C07H19/207 , C07H19/23
Abstract: Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
-
公开(公告)号：US10239912B2
公开(公告)日：2019-03-26
申请号：US15400748
申请日：2017-01-06
Applicant: ARCUS BIOSCIENCES, INC.
Inventor： Laurent Pierre Paul Debien , Juan Carlos Jaen , Jaroslaw Kalisiak , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Dillon Harding Miles , Eric Newcomb , Jay Patrick Powers , Brandon Reid Rosen , Ehesan Ul Sharif
IPC: A61K31/70 , A01N43/04 , C07H19/23 , A61K31/7052 , A61K31/7076 , C07H19/16 , C07H19/20 , C07H19/207 , A61K31/7064 , C07H19/14 , C07F9/6561 , C07H19/04
Abstract: Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
-
-
-
-
-
-
-
-
-
Search Results
71
records
(took 0.024 seconds)
