公开(公告)号：US12180544B2

公开(公告)日：2024-12-31

申请号：US17560928

申请日：2021-12-23

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Jingyue Ju ,  Huanyan Cao ,  Zengmin Li ,  Qinglin Meng ,  Jia Guo ,  Shenglong Zhang ,  Lin Yu

IPC: C12Q1/68 ,  C07H19/06 ,  C07H19/10 ,  C07H19/14 ,  C07H19/16 ,  C07H19/20 ,  C12Q1/6869

Abstract: This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.

公开(公告)号：US12145960B2

公开(公告)日：2024-11-19

申请号：US17287255

申请日：2019-10-24

Applicant: Singular Genomics Systems, Inc.

Inventor： Ronald Graham ,  Olga Adelfinskaya ,  Megha Cila ,  Rodrigo Rodriguez ,  Abrehet Abdu ,  Eli N. Glezer

IPC: C07H19/14 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/68 ,  C12Q1/6869 ,  C12Q1/6876

Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.

公开(公告)号：US12071662B2

公开(公告)日：2024-08-27

申请号：US18313227

申请日：2023-05-05

Applicant: Illumina Cambridge Limited

Inventor： Elena Cressina ,  Antoine Francais ,  Xiaohai Liu

IPC: C12Q1/68 ,  C07H19/06 ,  C07H19/073 ,  C07H19/10 ,  C07H19/14 ,  C07H19/16 ,  C07H19/20 ,  C07H21/00 ,  C07H21/04 ,  C12Q1/6809 ,  C12Q1/6816 ,  C12Q1/6869

CPC classification number: C12Q1/6869 ,  C07H19/06 ,  C07H19/073 ,  C07H19/10 ,  C07H19/14 ,  C07H19/16 ,  C07H19/20 ,  C07H21/00 ,  C07H21/04 ,  C12Q1/6809 ,  C12Q1/6816 ,  C12Q1/6869 ,  C12Q2525/117 ,  C12Q2535/122

Abstract: The present disclosure relates to new nucleotide and oligonucleotide compounds and their use in nucleic acid sequencing applications.

公开(公告)号：US20240174709A1

公开(公告)日：2024-05-30

申请号：US18522886

申请日：2023-11-29

Applicant: Singular Genomics Systems, Inc.

Inventor： Ronald Graham ,  Olga Adelfinskaya ,  Megha Cila ,  Rodrigo Rodriguez ,  Abrehet Abdu ,  Eli N. Glezer

IPC: C07H19/14 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6869 ,  C12Q1/6876

CPC classification number: C07H19/14 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6869 ,  C12Q1/6876

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.

公开(公告)号：US11958877B2

公开(公告)日：2024-04-16

申请号：US18178802

申请日：2023-03-06

Applicant: Singular Genomics Systems, Inc.

Inventor： Ronald Graham ,  Olga Adelfinskaya ,  Megha Cila ,  Rodrigo Rodriguez ,  Abrehet Abdu ,  Eli N. Glezer

IPC: C07H19/14 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6869 ,  C12Q1/6876

CPC classification number: C07H19/14 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6869 ,  C12Q1/6876

Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.

公开(公告)号：US20230257908A1

公开(公告)日：2023-08-17

申请号：US17913458

申请日：2021-03-25

Applicant: TECHNISCHE UNIVERSITAET DORTMUND

Inventor： Andreas BRUNSCHWEIGER ,  Mateja KLIKA SKOPIC ,  Marco POTOWSKI ,  Verena Barbara Katharina KUNIG

IPC: C40B40/06 ,  C07H19/052 ,  C07H19/14 ,  C07H19/167 ,  C07H21/04

CPC classification number: C40B40/06 ,  C07H19/14 ,  C07H19/052 ,  C07H19/167 ,  C07H21/04

Abstract: A compound library may include a plurality of conjugate molecules, said conjugates comprising a small organic molecule covalently coupled to a nucleic acid moiety. The nucleic acid moiety may include or consist of 7-deazapurines and/or 7-deaza-8-azapurines, and, optionally, modified pyrimidine nucleotides and/or unmodified pyrimidine nucleotides. Further, a library for screening compounds binding to a target molecule and methods of synthesizing said library is also disclosed.

公开(公告)号：US11649260B2

公开(公告)日：2023-05-16

申请号：US17842135

申请日：2022-06-16

Applicant: Hongene Biotech Corporation

Inventor： Xiaoyang Guan ,  David Yu ,  Ruiming Zou ,  Xiaoling Zheng ,  John Liu ,  Aldrich N. K. Lau ,  Wing C. Poon ,  Gang Zhao ,  Gengyu Du ,  Yun-Chiao Yao

IPC: C07H19/06 ,  C07H1/00 ,  C07H19/14 ,  A61K48/00 ,  A61K47/54

CPC classification number: C07H19/06 ,  A61K47/549 ,  A61K48/0033 ,  C07H1/00 ,  C07H19/14

Abstract: Embodiments of the present application relate to N-acetylgalactosamine-conjugated nucleosides. In particular, the N-acetylgalactosamine is installed on the nucleobase of the nucleosides through a wide variety of linkers. Methods of making N-acetylgalactosamine-conjugated nucleosides are also disclosed herein. N-acetylgalactosamine is a well-defined liver-targeted moiety and N-acetylgalactosamine-conjugated nucleosides may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.

公开(公告)号：US20230025669A1

公开(公告)日：2023-01-26

申请号：US17856441

申请日：2022-07-01

Applicant: Illumina Cambridge Limited

Inventor： Nikolai Nikolaevich ROMANOV ,  Patrick MCCAULEY ,  Carole ANASTASI ,  Xiaolin WU ,  Niall HYNES

IPC: C07D417/04 ,  C07D405/04 ,  C07D413/04 ,  C07H19/10 ,  C07H19/14 ,  C12Q1/6876

Abstract: The present application relates to secondary amine-substituted coumarin compounds and their uses as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.

公开(公告)号：US20220411860A1

公开(公告)日：2022-12-29

申请号：US17373295

申请日：2021-07-12

Applicant: Jingyue Ju ,  Xiaoxu Li ,  Xin Chen ,  Zengmin Li ,  Shiv Kumar ,  Shundi Shi ,  Cheng Guo ,  Jianyi Ren ,  Min-Kang Hsieh ,  Minchen Chien ,  Chuanjuan Tao ,  Ece Erturk ,  Sergey Kalachikov ,  James J. Russo

Inventor： Jingyue Ju ,  Xiaoxu Li ,  Xin Chen ,  Zengmin Li ,  Shiv Kumar ,  Shundi Shi ,  Cheng Guo ,  Jianyi Ren ,  Min-Kang Hsieh ,  Minchen Chien ,  Chuanjuan Tao ,  Ece Erturk ,  Sergey Kalachikov ,  James J. Russo

IPC: C12Q1/6869 ,  C07H19/10 ,  C07H19/14 ,  C07H19/20

Abstract: Disclosed herein, inter alfa, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

公开(公告)号：US20220233566A1

公开(公告)日：2022-07-28

申请号：US17619379

申请日：2020-06-17

Applicant: TAIHO PHARMACEUTICAL CO., LTD.

Inventor： Hitoshi MIYAKOSHI ,  Nozomu TANAKA ,  Yu KOBAYAKAWA

IPC: A61K31/7064 ,  C07H19/14 ,  A61P35/00 ,  A61K31/495 ,  A61N5/10

Abstract: There is provided a novel carbonate compound of a nucleoside having a pyrrolopyrimidine skeleton having an excellent antitumor effect, or a pharmaceutically acceptable salt thereof and a method for preventing and/or treating a tumor in combination with an alkylating agent and/or a radiation therapy. According to one aspect of the present invention, there is provided a compound represented by the following general formula (1): or a pharmaceutically acceptable salt thereof, and a method for preventing and/or treating a tumor in combination with an alkylating agent and/or a radiation therapy.