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公开(公告)号：US20230034284A1
公开(公告)日：2023-02-02
申请号：US17842135
申请日：2022-06-16
Applicant: Hongene Biotech Corporation
Inventor： Xiaoyang Guan , David Yu , Ruiming Zou , Xiaoling Zheng , John Liu , Aldrich N.K. Lau , Wing C. Poon , Gang Zhao , Gengyu Du , Yun-Chiao Yao
Abstract: Embodiments of the present application relate to N-acetylgalactosamine-conjugated nucleosides. In particular, the N-acetylgalactosamine is installed on the nucleobase of the nucleosides through a wide variety of linkers. Methods of making N-acetylgalactosamine-conjugated nucleosides are also disclosed herein. N-acetylgalactosamine is a well-defined liver-targeted moiety and N-acetylgalactosamine-conjugated nucleosides may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
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公开(公告)号：US11649260B2
公开(公告)日：2023-05-16
申请号：US17842135
申请日：2022-06-16
Applicant: Hongene Biotech Corporation
Inventor： Xiaoyang Guan , David Yu , Ruiming Zou , Xiaoling Zheng , John Liu , Aldrich N. K. Lau , Wing C. Poon , Gang Zhao , Gengyu Du , Yun-Chiao Yao
CPC classification number: C07H19/06 , A61K47/549 , A61K48/0033 , C07H1/00 , C07H19/14
Abstract: Embodiments of the present application relate to N-acetylgalactosamine-conjugated nucleosides. In particular, the N-acetylgalactosamine is installed on the nucleobase of the nucleosides through a wide variety of linkers. Methods of making N-acetylgalactosamine-conjugated nucleosides are also disclosed herein. N-acetylgalactosamine is a well-defined liver-targeted moiety and N-acetylgalactosamine-conjugated nucleosides may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
