公开(公告)号：US12065460B2

公开(公告)日：2024-08-20

申请号：US18505877

申请日：2023-11-09

Applicant: Hongene Biotech Corporation

Inventor： Gaomai Yang ,  Yun-Chiao Yao ,  David Yu ,  Aldrich N. K. Lau

IPC: C07H1/00 ,  C07H21/00 ,  C08F120/68 ,  C08F220/28 ,  C08F220/56 ,  C08F265/10

CPC classification number: C07H1/00 ,  C07H21/00 ,  C08F120/68 ,  C08F220/286 ,  C08F220/56 ,  C08F265/10

Abstract: Embodiments of the present application relate to polymers used as polymeric polyvalent hub for liquid phase oligonucleotide synthesis. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the polyvalent hub are also provided.

公开(公告)号：US20230212209A1

公开(公告)日：2023-07-06

申请号：US18146279

申请日：2022-12-23

Applicant: Hongene Biotech Corporation

Inventor： Gaomai Yang ,  Yun-Chiao Yao ,  David Yu ,  Aldrich N.K. Lau

IPC: C07H1/00 ,  C08F220/56 ,  C07H21/00 ,  C08F265/10 ,  C08F220/28 ,  C08F120/68

CPC classification number: C07H1/00 ,  C08F220/56 ,  C07H21/00 ,  C08F265/10 ,  C08F220/286 ,  C08F120/68

Abstract: Embodiments of the present application relate to polymers used as polymeric polyvalent hub for liquid phase oligonucleotide synthesis. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the polyvalent hub are also provided.

公开(公告)号：US20230130509A1

公开(公告)日：2023-04-27

申请号：US18048350

申请日：2022-10-20

Applicant: Hongene Biotech Corporation

Inventor： Jingshe Song ,  John Michael Cue ,  Yun-Chiao Yao ,  David Yu ,  Aldrich N.K. Lau

IPC: C08F12/32 ,  C08F2/08 ,  C08F12/22

Abstract: Embodiments of the present application relate to porous polymeric beads solid support for use in oligonucleotide synthesis and the method of producing and using the same. Further embodiments relate to porous polymeric beads and method for preparing and using the same.

公开(公告)号：US11897914B2

公开(公告)日：2024-02-13

申请号：US18059357

申请日：2022-11-28

Applicant: Hongene Biotech Corporation

Inventor： Wing C. Poon ,  Ruiming Zou ,  Aldrich N. K. Lau ,  David Yu ,  Gengyu Du ,  Yun-Chiao Yao ,  Gang Zhao

IPC: C07H21/02 ,  C07H19/10 ,  C07H19/067 ,  C07H19/167 ,  C07H19/20 ,  C07H23/00

CPC classification number: C07H21/02 ,  C07H19/067 ,  C07H19/10 ,  C07H19/167 ,  C07H19/20 ,  C07H23/00

Abstract: Embodiments of the present application relate to the preparation of 2′-O-protected nucleoside phosphoramidites and conjugation of the 2′-O-protected nucleoside to a solid support. More specifically, the present application relates to nucleosides having a hydroxy protecting group at the 2′ position that reduces migration to the 3′ position during RNA (e.g., mRNA) synthesis and can be readily removed under mild conditions without the use of toxic metal-containing reagents. Methods of using the nucleosides described herein in RNA synthesis are also disclosed.

公开(公告)号：US20240002420A1

公开(公告)日：2024-01-04

申请号：US18337233

申请日：2023-06-19

Applicant: Hongene Biotech Corporation

Inventor： Gaomai Yang ,  Jingshe Song ,  Shengdong Wang ,  Yun-Chiao Yao ,  Hongrong Yang ,  David Yu ,  Aldrich N.K. Lau

IPC: C07H1/00 ,  C08F120/68 ,  C08F220/28 ,  C08F220/56 ,  C08F265/10

CPC classification number: C07H1/00 ,  C08F120/68 ,  C08F220/286 ,  C08F220/56 ,  C08F265/10

Abstract: Embodiments of the present application relate to polymers used as polymeric polyvalent hubs for liquid phase oligonucleotide synthesis. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the polymers are also provided.

公开(公告)号：US11851454B2

公开(公告)日：2023-12-26

申请号：US18146279

申请日：2022-12-23

Applicant: Hongene Biotech Corporation

Inventor： Gaomai Yang ,  Yun-Chiao Yao ,  David Yu ,  Aldrich N. K. Lau

IPC: C07H1/00 ,  C07H21/00 ,  C08F220/56 ,  C08F265/10 ,  C08F220/28 ,  C08F120/68

CPC classification number: C07H1/00 ,  C07H21/00 ,  C08F120/68 ,  C08F220/286 ,  C08F220/56 ,  C08F265/10

Abstract: Embodiments of the present application relate to polymers used as polymeric polyvalent hub for liquid phase oligonucleotide synthesis. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the polyvalent hub are also provided.

公开(公告)号：US20230279041A1

公开(公告)日：2023-09-07

申请号：US18065503

申请日：2022-12-13

Applicant: Hongene Biotech Corporation

Inventor： Wing C. Poon ,  Xiaoyang Guan ,  David Yu ,  Ruiming Zou ,  Xiaojun Li ,  Michael Su ,  Gang Zhao ,  Gengyu Du ,  Yun-Chiao Yao

IPC: C07H15/26 ,  C07H21/00

CPC classification number: C07H15/26 ,  C07H21/00

Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.

公开(公告)号：US11649260B2

公开(公告)日：2023-05-16

申请号：US17842135

申请日：2022-06-16

Applicant: Hongene Biotech Corporation

Inventor： Xiaoyang Guan ,  David Yu ,  Ruiming Zou ,  Xiaoling Zheng ,  John Liu ,  Aldrich N. K. Lau ,  Wing C. Poon ,  Gang Zhao ,  Gengyu Du ,  Yun-Chiao Yao

IPC: C07H19/06 ,  C07H1/00 ,  C07H19/14 ,  A61K48/00 ,  A61K47/54

CPC classification number: C07H19/06 ,  A61K47/549 ,  A61K48/0033 ,  C07H1/00 ,  C07H19/14

Abstract: Embodiments of the present application relate to N-acetylgalactosamine-conjugated nucleosides. In particular, the N-acetylgalactosamine is installed on the nucleobase of the nucleosides through a wide variety of linkers. Methods of making N-acetylgalactosamine-conjugated nucleosides are also disclosed herein. N-acetylgalactosamine is a well-defined liver-targeted moiety and N-acetylgalactosamine-conjugated nucleosides may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.

公开(公告)号：US20250034192A1

公开(公告)日：2025-01-30

申请号：US18902678

申请日：2024-09-30

Applicant: Hongene Biotech Corporation

Inventor： Gaomai Yang ,  Jingshe Song ,  Shengdong Wang ,  Yun-Chiao Yao ,  Hongrong Yang ,  David Yu ,  Aldrich N.K. Lau

IPC: C07H1/00 ,  C08F120/68 ,  C08F220/28 ,  C08F220/56 ,  C08F265/10

Abstract: Embodiments of the present application relate to polymers used as polymeric polyvalent hubs for liquid phase oligonucleotide synthesis. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the polymers are also provided.

公开(公告)号：US12180140B2

公开(公告)日：2024-12-31

申请号：US18390545

申请日：2023-12-20

Applicant: Hongene Biotech Corporation

Inventor： Gaomai Yang ,  Min Xie ,  Hongrong Yang ,  Shengdong Wang ,  Aldrich N. K. Lau ,  Ruiming Zou ,  David Yu

IPC: C07C237/22 ,  C07C231/00 ,  C07C233/59 ,  C07H1/00 ,  C07H21/00

Abstract: The present disclosure relates to methods and compounds for liquid phase oligonucleotide synthesis employing the use of small molecules with lipophilic groups. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the compounds described herein are also provided.