公开(公告)号：US20240287120A1

公开(公告)日：2024-08-29

申请号：US18646230

申请日：2024-04-25

Applicant: Hongene Biotech Corporation

Inventor： Wing C. Poon ,  Xiaoyang Guan ,  David Yu ,  Ruiming Zou ,  Xiaojun Li ,  Michael Su ,  Gang Zhao ,  Gengyu Du ,  Yun-Chiao Yao ,  Aldrich N.K. Lau

IPC: C07H15/26 ,  C07H21/00

CPC classification number: C07H15/26 ,  C07H21/00

Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.

公开(公告)号：US20230279041A1

公开(公告)日：2023-09-07

申请号：US18065503

申请日：2022-12-13

Applicant: Hongene Biotech Corporation

Inventor： Wing C. Poon ,  Xiaoyang Guan ,  David Yu ,  Ruiming Zou ,  Xiaojun Li ,  Michael Su ,  Gang Zhao ,  Gengyu Du ,  Yun-Chiao Yao

IPC: C07H15/26 ,  C07H21/00

CPC classification number: C07H15/26 ,  C07H21/00

Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.

公开(公告)号：US11649260B2

公开(公告)日：2023-05-16

申请号：US17842135

申请日：2022-06-16

Applicant: Hongene Biotech Corporation

Inventor： Xiaoyang Guan ,  David Yu ,  Ruiming Zou ,  Xiaoling Zheng ,  John Liu ,  Aldrich N. K. Lau ,  Wing C. Poon ,  Gang Zhao ,  Gengyu Du ,  Yun-Chiao Yao

IPC: C07H19/06 ,  C07H1/00 ,  C07H19/14 ,  A61K48/00 ,  A61K47/54

CPC classification number: C07H19/06 ,  A61K47/549 ,  A61K48/0033 ,  C07H1/00 ,  C07H19/14

Abstract: Embodiments of the present application relate to N-acetylgalactosamine-conjugated nucleosides. In particular, the N-acetylgalactosamine is installed on the nucleobase of the nucleosides through a wide variety of linkers. Methods of making N-acetylgalactosamine-conjugated nucleosides are also disclosed herein. N-acetylgalactosamine is a well-defined liver-targeted moiety and N-acetylgalactosamine-conjugated nucleosides may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.

公开(公告)号：US11884691B2

公开(公告)日：2024-01-30

申请号：US18320118

申请日：2023-05-18

Applicant: Hongene Biotech Corporation

Inventor： Wing C. Poon ,  Gang Zhao ,  Gengyu Du ,  Yun-Chiao Yao ,  Mufa Zou ,  Xiaoyang Guan ,  Xiaoling Zheng ,  David Yu ,  Ruiming Zou ,  Aldrich N. K. Lau

IPC: C07H1/00 ,  C07H19/067 ,  C07H19/10 ,  C07H21/02

CPC classification number: C07H1/00 ,  C07H19/067 ,  C07H19/10 ,  C07H21/02

Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.

公开(公告)号：US11725073B2

公开(公告)日：2023-08-15

申请号：US17562714

申请日：2021-12-27

Applicant: Hongene Biotech Corporation

Inventor： Aldrich N. K. Lau ,  Xiaoyang Guan ,  David Yu

IPC: C07H19/00 ,  C07H21/02 ,  A61K47/54 ,  A61K47/58 ,  C08F220/22

CPC classification number: C08F220/22 ,  A61K47/549 ,  A61K47/58 ,  C07H19/00 ,  C07H21/02

Abstract: Embodiments of the present application relate to polymers for liquid phase oligonucleotide synthesis. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis, comprising dissolving a polyvalent hub having a plurality of functional groups in a solvent and contacting the polyvalent hub with one or more nucleoside analogs to form a first bioconjugate are also provided.

公开(公告)号：US11993626B2

公开(公告)日：2024-05-28

申请号：US18065503

申请日：2022-12-13

Applicant: Hongene Biotech Corporation

Inventor： Wing C. Poon ,  Xiaoyang Guan ,  David Yu ,  Ruiming Zou ,  Xiaojun Li ,  Michael Su ,  Gang Zhao ,  Gengyu Du ,  Yun-Chiao Yao ,  Aldrich N. K. Lau

IPC: C07H15/26 ,  C07H21/00

CPC classification number: C07H15/26 ,  C07H21/00

Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.

公开(公告)号：US11692001B2

公开(公告)日：2023-07-04

申请号：US17822679

申请日：2022-08-26

Applicant: Hongene Biotech Corporation

Inventor： Wing C. Poon ,  Gang Zhao ,  Gengyu Du ,  Yun-Chiao Yao ,  Mufa Zou ,  Xiaoyang Guan ,  Xiaoling Zheng ,  David Yu ,  Ruiming Zou ,  Aldrich N. K. Lau

IPC: C07H1/00 ,  C07H19/067 ,  C07H19/10 ,  C07H21/02

CPC classification number: C07H1/00 ,  C07H19/067 ,  C07H19/10 ,  C07H21/02

Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.

公开(公告)号：US20230034284A1

公开(公告)日：2023-02-02

申请号：US17842135

申请日：2022-06-16

Applicant: Hongene Biotech Corporation

Inventor： Xiaoyang Guan ,  David Yu ,  Ruiming Zou ,  Xiaoling Zheng ,  John Liu ,  Aldrich N.K. Lau ,  Wing C. Poon ,  Gang Zhao ,  Gengyu Du ,  Yun-Chiao Yao

IPC: C07H19/06 ,  C07H1/00 ,  C07H19/14 ,  A61K47/54 ,  A61K48/00

Abstract: Embodiments of the present application relate to N-acetylgalactosamine-conjugated nucleosides. In particular, the N-acetylgalactosamine is installed on the nucleobase of the nucleosides through a wide variety of linkers. Methods of making N-acetylgalactosamine-conjugated nucleosides are also disclosed herein. N-acetylgalactosamine is a well-defined liver-targeted moiety and N-acetylgalactosamine-conjugated nucleosides may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.

公开(公告)号：US20220204670A1

公开(公告)日：2022-06-30

申请号：US17562714

申请日：2021-12-27

Applicant: Hongene Biotech Corporation

Inventor： Aldrich N.K. Lau ,  Xiaoyang Guan ,  David Yu

IPC: C08F220/22 ,  A61K47/58 ,  A61K47/54

Abstract: Embodiments of the present application relate to polymers for liquid phase oligonucleotide synthesis. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis, comprising dissolving a polyvalent hub having a plurality of functional groups in a solvent and contacting the polyvalent hub with one or more nucleoside analogs to form a first bioconjugate are also provided.