公开(公告)号：US20240209016A1

公开(公告)日：2024-06-27

申请号：US18555180

申请日：2022-04-11

Applicant: STEALTH LABELS BIOTECH AB

Inventor： Elin ESBJÖRNER WINTERS ,  Marcus WILHELMSSON ,  Pauline PFEIFFER ,  Audrey GALLUD ,  Jesper NILSSON

IPC: C07H19/14 ,  C12N15/10

CPC classification number: C07H19/14 ,  C12N15/10

Abstract: This specification discloses novel phosphate compounds of formula (I) useful for labelling RNA in-cellulo. The phosphates are spontaneously taken up by cells and may be used as substrates for RNA synthesis once across the cell membrane. This technology therefore offers a general route to understanding the biological behaviour of RNA of interest, including RNA based drugs.

公开(公告)号：US12006540B2

公开(公告)日：2024-06-11

申请号：US17816555

申请日：2022-08-01

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Jingyue Ju ,  Xiaoxu Li ,  Xin Chen ,  Zengmin Li ,  Shiv Kumar ,  Shundi Shi ,  Cheng Guo ,  Jianyi Ren ,  Min-Kang Hsieh ,  Minchen Chien ,  Chuanjuan Tao ,  Ece Erturk ,  Sergey Kalachikov ,  James J. Russo

IPC: C12Q1/68 ,  C07H19/10 ,  C07H19/14 ,  C07H19/20 ,  C12Q1/6869

CPC classification number: C12Q1/6869 ,  C07H19/10 ,  C07H19/14 ,  C07H19/20 ,  C12Q1/6869 ,  C12Q2525/117 ,  C12Q2563/107

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

公开(公告)号：US20240150389A1

公开(公告)日：2024-05-09

申请号：US18277642

申请日：2022-02-21

Applicant: NUCLERA NUCLEICS LTD

Inventor： Gordon Ross MCINROY ,  Martin Edward FOX ,  Puneet SRIVASTAVA ,  Michal Robert MATUSZEWSKI

IPC: C07H19/14

CPC classification number: C07H19/14

Abstract: The present invention relates to a compound according to Formula (1a) or (1b):




wherein R1; R3; Y and X are defined herein, and their use in methods of nucleic acid synthesis.

公开(公告)号：US11807851B1

公开(公告)日：2023-11-07

申请号：US17176617

申请日：2021-02-16

Applicant: Ultima Genomics, Inc.

Inventor： Linda G. Lee ,  Steven Menchen

IPC: A61K31/7072 ,  A61K31/706 ,  C12N15/113 ,  C07H21/04 ,  A61K47/65 ,  A61K49/00 ,  C07H19/14 ,  C12Q1/6874 ,  C07K5/02 ,  C07H19/00

CPC classification number: C12N15/113 ,  A61K47/65 ,  A61K49/0021 ,  C07H19/14 ,  C07H21/04 ,  C07K5/0205 ,  C12Q1/6874 ,  C07H19/00 ,  C12Q1/6874 ,  C12Q2521/101 ,  C12Q2525/101

Abstract: The present disclosure provides modified substrates such as modified polynucleotides, proteins, antibodies, lipids, and cells and uses thereof. Method of generating the modified substrates, which may comprise cleavage of a cleavable group linking the substrate to a labeling moiety, are also provided herein.

公开(公告)号：US20230257414A1

公开(公告)日：2023-08-17

申请号：US18295770

申请日：2023-04-04

Applicant: Singular Genomics Systems, Inc

Inventor： Ronald Graham ,  Olga Adelfinskaya ,  Megha Cila ,  Rodrigo Rodriguez ,  Abrehet Abdu ,  Eli N. Glezer

IPC: C07H19/14 ,  C12Q1/6869 ,  C07H19/20 ,  C12Q1/6876 ,  C07H19/10

CPC classification number: C07H19/14 ,  C12Q1/6869 ,  C07H19/20 ,  C12Q1/6876 ,  C07H19/10

Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.

公开(公告)号：US20190085014A1

公开(公告)日：2019-03-21

申请号：US16149114

申请日：2018-10-01

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Jingyue Ju ,  Zengmin Li ,  John Robert Edwards ,  Yasuhiro Itagaki

IPC: C07H19/14 ,  C12Q1/6869 ,  C07H21/00 ,  C12Q1/686 ,  C12Q1/6872 ,  C12Q1/6876 ,  C07H19/10 ,  C12Q1/68 ,  C12Q1/6874 ,  C40B40/00

CPC classification number: C12Q1/6869 ,  C07B2200/11 ,  C07H19/10 ,  C07H19/14 ,  C07H21/00 ,  C12Q1/68 ,  C12Q1/686 ,  C12Q1/6872 ,  C12Q1/6874 ,  C12Q1/6876 ,  C12Q2525/117 ,  C12Q2525/186 ,  C12Q2535/101 ,  C12Q2535/122 ,  C12Q2563/107 ,  C12Q2565/501 ,  C40B40/00

Abstract: This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.

公开(公告)号：US20190031705A1

公开(公告)日：2019-01-31

申请号：US16150185

申请日：2018-10-02

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Jingyue Ju ,  Zengmin Li ,  John Robert Edwards ,  Yasuhiro Itagaki

IPC: C07H19/14 ,  C12Q1/6869 ,  C07H19/10 ,  C12Q1/6874 ,  C12Q1/6876 ,  C12Q1/6872 ,  C12Q1/68 ,  C12Q1/686

CPC classification number: C12Q1/6869 ,  C07B2200/11 ,  C07H19/10 ,  C07H19/14 ,  C07H21/00 ,  C12Q1/68 ,  C12Q1/686 ,  C12Q1/6872 ,  C12Q1/6874 ,  C12Q1/6876 ,  C12Q2525/117 ,  C12Q2525/186 ,  C12Q2535/101 ,  C12Q2535/122 ,  C12Q2563/107 ,  C12Q2565/501 ,  C40B40/00

Abstract: This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.

公开(公告)号：US10138514B2

公开(公告)日：2018-11-27

申请号：US15444826

申请日：2017-02-28

Applicant: Illumina Cambridge Limited

Inventor： Xiaohai Liu ,  Xiaolin Wu ,  Geoffrey Paul Smith

IPC: C12Q1/68 ,  C07H19/073 ,  C12Q1/6869 ,  C07H19/10 ,  C07H19/14 ,  C07H19/173 ,  C07H19/20 ,  C12Q1/6876

CPC classification number: C12Q1/6869 ,  C07H19/073 ,  C07H19/10 ,  C07H19/14 ,  C07H19/173 ,  C07H19/20 ,  C12Q1/6876 ,  Y02P20/55

Abstract: Some embodiments described herein relate to modified nucleotide and nucleoside molecules with novel 3′-hydroxy protecting groups. Also provided herein are methods to prepare such modified nucleotide and nucleoside molecules and sequencing by synthesis processes using such modified nucleotide and nucleoside molecules.

公开(公告)号：US20180201981A1

公开(公告)日：2018-07-19

申请号：US15851014

申请日：2017-12-21

Applicant: Illumina Cambridge Limited

Inventor： Nikolai Romanov

IPC: C12Q1/6816 ,  C12Q1/6876 ,  C12Q1/6869 ,  C07D491/052 ,  C07H21/00 ,  C07H19/14 ,  C07H19/10 ,  C07D491/147 ,  C09K11/06

CPC classification number: C12Q1/6816 ,  C07D491/04 ,  C07D491/052 ,  C07D491/147 ,  C07H19/10 ,  C07H19/14 ,  C07H21/00 ,  C09K11/06 ,  C09K2211/1018 ,  C12Q1/6869 ,  C12Q1/6876

Abstract: The present application relates to new coumarin compounds and their uses as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.

公开(公告)号：US20180086785A1

公开(公告)日：2018-03-29

申请号：US15645685

申请日：2017-07-10

Applicant: MILLENNIUM PHARMACEUTICALS, INC.

Inventor： Stephen CRITCHLEY ,  Thomas G. GANT ,  Steven P. LANGSTON ,  Edward J. OLHAVA ,  Stephane PELUSO

IPC: C07H19/16 ,  C07H19/23 ,  C07H19/14 ,  C07D487/04 ,  C07H19/048 ,  C07D473/00 ,  C07D471/04 ,  C07D405/04 ,  C07D473/34

CPC classification number: C07H19/16 ,  C07D405/04 ,  C07D471/04 ,  C07D473/00 ,  C07D473/34 ,  C07D487/04 ,  C07H19/048 ,  C07H19/14 ,  C07H19/23

Abstract: This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.