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公开(公告)号：US12108128B2
公开(公告)日：2024-10-01
申请号：US17547844
申请日：2021-12-10
发明人： Christin Baumann
CPC分类号： H04N23/16 , A61B5/0071 , A61K49/0021 , A61K49/0032 , A61K49/0034 , A61K49/0058 , H04N9/68 , H04N23/45 , H04N23/72
摘要： A device for capturing an image of an object of medical interest in remitted or reflected illumination light and for capturing an image of the object in fluorescent light generated by Cy5.5 and/or SGM-101 and for capturing an image in fluorescent light generated OTL38 and/or indocyanine green (ICG). The device includes an image sensor for detecting blue, green and red light, another image sensor for detecting fluorescent light of Cy5.5 and/or SGM-101 and OTL38 and/or ICG, a beam splitter guiding light having a wavelength smaller than a predetermined cutoff wavelength to the first sensor and guiding light having a wavelength greater than the predetermined cutoff wavelength to the second sensor, and filters upstream of the second sensor for partially, substantially or completely suppressing light having a wavelength exciting Cy5.5 and/or SGM-101 and for partially, substantially or completely suppressing light having a wavelength suitable for exciting fluorescence of OTL38 and/or ICG.
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公开(公告)号：US12104214B2
公开(公告)日：2024-10-01
申请号：US16934137
申请日：2020-07-21
发明人： Martin G. Pomper , Mark Castanares , Il Minn , Shawn Lupold
IPC分类号： C12N15/63 , A61K49/00 , A61K51/04 , C07K14/005 , C12N9/48 , C12N15/85 , C12N15/86 , C12Q1/6897 , G01N33/574
CPC分类号： C12Q1/6897 , A61K49/0021 , A61K51/0406 , A61K51/0455 , C07K14/005 , C12N9/485 , C12N15/85 , C12N15/86 , C12Y304/17021 , G01N33/57434 , G01N33/57492 , G01N33/57496 , C12N2710/10043 , C12N2710/10044 , C12N2710/10071 , C12N2710/16143 , C12N2710/16222 , C12N2830/60 , G01N2333/705 , G01N2458/00
摘要： Methods, reporter gene constructs, and kits for using prostate-specific membrane antigen (PSMA) as an imaging reporter to image a variety of cells and tissues are provided.
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公开(公告)号：US20240238198A1
公开(公告)日：2024-07-18
申请号：US18562898
申请日：2022-05-20
发明人： Kenneth Craig KENT , Lian-Wang GUO , Takuro SHIRASU , Bowen WANG , Shaoqin GONG , Nisakorn YODSANIT
IPC分类号： A61K9/107 , A61K9/51 , A61K31/436 , A61K31/7076 , A61K49/00 , A61P9/10 , B82Y5/00
CPC分类号： A61K9/1075 , A61K9/51 , A61K31/436 , A61K31/7076 , A61K49/0021 , A61P9/10 , B82Y5/00
摘要： In one aspect, the disclosure relates to unimolecular micelles having N-hydroxysuccinimide ester (NHS), sulfo-NHS terminal groups, or other adhesive terminal groups, compositions including the same, methods of making the same, and methods of treating intimal hyperplasia in a subject using the same. In some aspects, the unimolecular micelles can further include fluorescent labels or drugs for treating intimal hyperplasia. In one aspect, the unimolecular micelles and compositions comprising the same are biocompatible, non-toxic, and non-inflammatory. In another aspect, the unimolecular micelles and compositions are substantially free from hydrogel, or are completely free from hydrogel. In still another aspect, the disclosed compositions and methods can be easily and quickly deployed in the operating room. Also disclosed is a method of applying the unimolecular micelles and compositions via direct penbrush painting.
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公开(公告)号：US20240115741A1
公开(公告)日：2024-04-11
申请号：US18449675
申请日：2023-08-14
发明人： Jinming GAO , Gang HUANG , Tian ZHAO , Xinpeng MA , Yiguang WANG , Yang LI , Baran D. SUMER
IPC分类号： A61K49/00 , C08F8/30 , C08F8/32 , C08F8/34 , C08F8/42 , C09B69/10 , G01N21/64 , G01N33/58 , G01N33/84
CPC分类号： A61K49/0054 , A61K49/0021 , A61K49/0032 , A61K49/0041 , C08F8/30 , C08F8/32 , C08F8/34 , C08F8/42 , C09B69/103 , C09B69/105 , C09B69/106 , C09B69/109 , G01N21/6428 , G01N21/643 , G01N21/6456 , G01N33/582 , G01N33/84 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441
摘要： The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.
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公开(公告)号：US11939345B2
公开(公告)日：2024-03-26
申请号：US17117424
申请日：2020-12-10
CPC分类号： C07F5/022 , A61K49/0021 , C08B11/16 , C08L1/30
摘要： A physiologically stable fluorophore includes a terminal moiety including a terminal reactive site that reacts with a reactive group of a substrate; a stability linker covalently bonded to the terminal moiety; and a bridge moiety covalently bonded to the stability linker such that the stability linker is interposed through chemical bonds between the bridge moiety and the terminal moiety; and a fluorescent moiety covalently bonded to the bridge moiety of the redox moiety and including: an electron bandgap mediator that is covalently bonded to the bridge moiety; a coordinate center covalently bonded to the electron bandgap mediator and that forms a Zwitterionic member with an atom in the electron bandgap mediator; and a steric hinder bonded to the electron bandgap mediator to provide steric hindrance for protection of the coordinate center.
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公开(公告)号：US20240059697A1
公开(公告)日：2024-02-22
申请号：US18320633
申请日：2023-05-19
申请人： PROMEGA CORPORATION
IPC分类号： C07D487/04 , A61K49/00 , G01N21/76
CPC分类号： C07D487/04 , G01N21/763 , A61K49/0021
摘要： Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.
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公开(公告)号：US11904025B2
公开(公告)日：2024-02-20
申请号：US17047748
申请日：2019-04-16
CPC分类号： A61K49/0052 , A61K49/0021
摘要： Described herein are cyclophanes, compositions, and methods for live cell imaging. The cyclophanes comprise an ordered, cyclic arrangement of a chromophore, a first linker unit, a molecular strut, and a second linker unit. The compositions are capable of being taking up by cells and resist photobleaching under live-cell imaging conditions.
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8.发明公开公开(公告)号：US20230390427A1
公开(公告)日：2023-12-07
申请号：US18322417
申请日：2023-05-23
发明人： Joseph P. DUNHAM , Marcus YAFFEE
CPC分类号： A61K51/1251 , G01N33/54346 , A61K49/0093 , A61K49/0021 , G01N33/5434 , B22F1/054 , B22F1/102 , B22F1/17 , B22F9/16 , B22F2302/45 , B22F2303/20 , B22F2301/255 , B22F2301/40 , B22F2303/15 , B22F2301/30 , B22F2999/00
摘要： Nanoparticles, nanoparticle conjugates, devices for making nanoparticles and nanoparticle conjugates, and related methods of use and synthesis are described.
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公开(公告)号：US20230374006A1
公开(公告)日：2023-11-23
申请号：US18229588
申请日：2023-08-02
发明人： Ming-Kuei JANG , Paul TEMPEST
IPC分类号： C07D471/04 , A61K49/00 , A61K51/04 , C07D401/10 , C07D413/10 , C07D417/10 , C07D417/14 , C07D495/04 , G01N33/68
CPC分类号： C07D471/04 , A61K49/0021 , A61K51/0455 , C07D401/10 , C07D413/10 , C07D417/10 , C07D417/14 , C07D495/04 , G01N33/6896 , G01N2800/2821
摘要： Described herein are compounds of formula (I), and pharmaceutically acceptable salts, solvates, hydrates, isotopically labeled derivatives and radiolabeled derivative thereof, and pharmaceutical compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for detecting and imaging Tau aggregates in the brain for detection of Alzheimer's disease (AD) in a subject.
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公开(公告)号：US20230296514A1
公开(公告)日：2023-09-21
申请号：US18120783
申请日：2023-03-13
IPC分类号： G01N21/64 , C07D417/04 , C07D417/14 , G01N21/77 , G01N33/58
CPC分类号： G01N21/6428 , C07D417/04 , C07D417/14 , G01N21/77 , G01N33/582 , G01N2021/6439 , G01N2021/7786 , A61K49/0021
摘要： The compounds relate to zinc-sensitive fluorescent probes, compositions and methods utilizing the same. Such compounds provide an emission-ratiometric fluorescence response upon binding of an analyte. In some embodiments, compounds can be used for two-photon excitation microscopy or conventional fluorescence microscopy. The compounds described herein can also contain one or more functional groups to improve the emission-ratiometric fluorescence response.
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