-
公开(公告)号：US20240361345A1
公开(公告)日：2024-10-31
申请号：US18766388
申请日：2024-07-08
发明人： Peter Stroot
CPC分类号： G01N33/84 , G01N2021/6439 , G01N21/78 , G01N2800/7009
摘要： The present application describes methods and systems for measuring and controlling oxidative stress in animals and humans. The degree of oxidative stress can be measured directly by inducing all of the blood cells to produce excessive reactive oxygen species (ROS) by exposure to an elevated concentration sulfide or other ROS inducing chemical and measuring the fluorescence intensity of a fluorescent dye or color intensity of dye that reacts with ROS. Oxidative stress can be reduced by reducing dietary sulfur, consumption of a methanogenic probiotic, or apheresis methods to replace ROS-positive blood cells with normal blood cells. Plasma oxidative stress can be compared in venous and arterial blood samples to evaluate small vessel disease. Oxidative stress can be increased by increasing dietary sulfur or the use of an intravenous method that exposes blood cells to an elevated blood concentration of sulfide or other ROS inducing chemical.
-
公开(公告)号：US20240337650A1
公开(公告)日：2024-10-10
申请号：US18574424
申请日：2022-06-27
发明人： Xinting Zheng , Laura Sutarlie , Yong Yu , Xiaodi Su
CPC分类号： G01N33/523 , G01N33/5308 , G01N33/84 , G01N2800/202
摘要： There is provided herein a paper-based sensor for simultaneously determining a plurality of biomarkers present in a biological sample comprising a plurality of detection zones in fluid communication with a sampling zone, wherein said plurality of detection zones comprises sensing material specific to each of said plurality of biomarkers. There is also provided herein a method of manufacturing the paper-based sensor, a use of a paper-based sensor for wound diagnosis, a kit comprising the paper-based sensor and a method of diagnosing wound health.
-
公开(公告)号：US20240302387A1
公开(公告)日：2024-09-12
申请号：US18403891
申请日：2024-01-04
发明人： William C.K. Pomerantz , Jiaqian Li
IPC分类号： G01N33/84 , C07C317/14 , C07C321/28 , C07C321/30
CPC分类号： G01N33/84 , C07C317/14 , C07C321/28 , C07C321/30
摘要： The invention provides compounds of Formula I useful for the measurement of temperature by 19F magnetic resonance imaging.
-
公开(公告)号：US20240254540A1
公开(公告)日：2024-08-01
申请号：US18433029
申请日：2024-02-05
发明人： Yamuna Krishnan , Saheli Halder
IPC分类号： C12Q1/6809 , C12N15/11 , C12N15/113 , C12Q1/00 , C12Q1/02 , C12Q1/6816 , C12Q1/6825 , C12Q1/6876 , G01N33/84
CPC分类号： C12Q1/6809 , C12N15/111 , C12N15/113 , C12Q1/005 , C12Q1/025 , C12Q1/6816 , C12Q1/6825 , C12Q1/6876 , G01N33/84 , C12N2310/14 , C12N2310/3517
摘要： Described herein are nucleic acid molecules and complexes useful as i-switch pH reporters that have increased sensitivities as a pH reporter and have alternate pH reporting capacity ranges. Aspects of the disclosure relate to a method for determining pH comprising providing a nucleic acid complex comprising: a first single-stranded nucleic acid molecule comprising the sequence CnXCnYCnZCn (SEQ ID NO. 6) wherein C is cytosine; X, Y and Z are each one or more of adenine, thymine, guanine, or combinations thereof; and n is greater than or equal to 2; and wherein at least 2 cytosine residues of the first single-stranded nucleic acid molecule are modified; and a second single-stranded nucleic acid molecule that is partially or fully complementary to the first single-stranded molecule, wherein a first label is conjugated to the first single-stranded nucleic acid molecule or the second single-stranded nucleic acid molecule; and wherein the first label is capable of producing a signal, wherein the intensity of the signal varies as a function of the conformation of the nucleic acid complex; and measuring the intensity of the signal and determining the pH from the measured signal.
-
公开(公告)号：US12050226B2
公开(公告)日：2024-07-30
申请号：US17465303
申请日：2021-09-02
发明人： James A. Ball , Jonathan Schultz
IPC分类号： B01J19/00 , C12Q1/6869 , G01N33/84
CPC分类号： G01N33/84 , B01J19/0086 , C12Q1/6869 , C12Q1/6869 , C12Q2527/119 , C12Q2527/125 , C12Q2565/607
摘要： A buffered suspension includes a surfactant and a solid buffer particulate having a point of zero charge at least 1.2 pH units different that the pH of the buffered suspension. The buffered suspension can be prepared by mixing a stock solution with the solid buffer particulate and titrating. A method of preforming a pH sensitive process includes drawing the buffered suspension from a reservoir, filtering the solid buffer particulate from the buffered suspension, and applying the filtered solution to a sensor.
-
公开(公告)号：US12007399B2
公开(公告)日：2024-06-11
申请号：US17942396
申请日：2022-09-12
IPC分类号： A61K33/00 , A61K9/00 , C12Q1/6883 , G01N33/497 , G01N33/84
CPC分类号： G01N33/84 , A61K9/007 , A61K33/00 , C12Q1/6883 , G01N33/497 , C12Q2600/106 , C12Q2600/156 , G01N2800/12
摘要： Methods for identifying premature infants at risk for developing bronchopulmonary dysplasia and/or most likely to benefit from administration of inhaled nitric oxide for prevention of bronchopulmonary dysplasia (BPD). Methods for treating premature infants identified as at risk and/or likely to benefit are provided. also provided are methods for identifying premature infants that are not at risk for developing bronchopulmonary dysplasia and/or unlikely to benefit from administration of inhaled nitric oxide for prevention of bronchopulmonary dysplasia, and methods for avoiding risks of toxicity and undesirable side effects associated with inhaled nitric oxide therapy comprising administering only non-iNO treatment modalities to these infants.
-
公开(公告)号：US20240158693A1
公开(公告)日：2024-05-16
申请号：US18267088
申请日：2021-11-11
发明人： Jong Seok LEE , Dan-Bi SUNG , Yeon-Ju LEE , Jihoon LEE , Hyi Seung LEE , Hee Jae SHIN
CPC分类号： C09K11/06 , C09B57/00 , C09B67/0065 , G01N21/6428 , G01N33/84 , C09K2211/1007 , C09K2211/1014 , C09K2211/1018 , G01N2021/6439
摘要： The probe for hydrogen sulfide detection according to the present invention is represented by chemical formula 1 below.
-
公开(公告)号：US20240042063A1
公开(公告)日：2024-02-08
申请号：US18331904
申请日：2023-06-08
CPC分类号： A61K49/0056 , G01N33/84 , C07K7/06 , A61K47/65 , A61K47/42 , A61B5/0071 , A61K47/64 , C07K14/00 , G01N2033/0003
摘要： Provided herein are, inter alia, pH-triggered compounds and compositions comprising one or more peptides that are capable of inserting into a lipid bilayer below a certain pH. Treatment, imaging, diagnostic, and other uses of such compounds and compositions are also provided.
-
公开(公告)号：US11859007B2
公开(公告)日：2024-01-02
申请号：US17031297
申请日：2020-09-24
IPC分类号： C07K16/28 , A61K39/00 , G01N33/573 , G01N33/84 , A61P35/00
CPC分类号： C07K16/2896 , A61P35/00 , G01N33/573 , G01N33/84 , C07K2317/24 , C07K2317/52 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92 , G01N2333/916
摘要： Provided herein are, inter alia, humanized 1E9 antibodies capable of binding CD73. The humanized antibodies are useful for the treatment of cancer. Further provided are nucleic acids encoding humanized 1E9 antibodies and methods of inhibiting cell proliferation using the humanized antibodies provided herein.
-
公开(公告)号：US20230416320A1
公开(公告)日：2023-12-28
申请号：US18330459
申请日：2023-06-07
CPC分类号： C07K14/4728 , G01N33/582 , G01N33/84 , G01N21/77 , A61K49/0004 , A61K49/0041 , A61K49/0056 , C07K2319/20 , C07K2319/60 , G01N2333/4727 , G01N2021/7786
摘要： A chemigenetic calcium indicator and a method of measuring calcium are provided. The chemigenetic calcium indicator includes a calcium-binding protein domain attached to a ligand binding protein domain. The method of measuring calcium includes administering a chemigenetic calcium indicator to a subject and determining changes in fluorescence, the chemigenetic calcium indicator including a ligand binding protein domain having a calcium-binding protein domain and a dye-ligand conjugate attached thereto.
-
-
-
-
-
-
-
-
-
搜索结果
1310 条记录 (耗时 0.024 秒)
