公开(公告)号：US20240360228A1

公开(公告)日：2024-10-31

申请号：US18289993

申请日：2022-05-11

Applicant: BIOLEGEND, INC.

Inventor： JUAN MOYRON-QUIROZ ,  TAKATOKU OIDA

IPC: C07K16/28 ,  A61K49/00 ,  G01N33/68

CPC classification number: C07K16/2866 ,  A61K49/0058 ,  G01N33/6863 ,  C07K2317/24 ,  C07K2317/76

Abstract: Compositions and methods for making and using anti-CCR8 antibodies, antigen-binding fragments thereof, or agents, for example, monoclonal antibodies, CCR8-binding antibody fragments, and derivatives are described, as are kits, nucleic acids encoding such molecules, diagnostic reagents and kits that include anti-CCR8 antibodies, antigen-binding fragments thereof, or agents, and methods of making and using the same.

公开(公告)号：US20240360213A1

公开(公告)日：2024-10-31

申请号：US18769116

申请日：2024-07-10

Applicant: Children's Hospital Medical Center

Inventor： Sonata Jodele

IPC: C07K16/24 ,  A61K39/00 ,  A61P7/02 ,  C07K16/18 ,  C12Q1/6883

CPC classification number: C07K16/249 ,  A61P7/02 ,  C07K16/18 ,  C12Q1/6883 ,  A61K2039/507 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/76 ,  C12Q2600/158

Abstract: Disclosed are compositions that may include one or more inhibitors of interferon activity for the treatment of a disease state, for example, a disorder associated with increased interferon levels such as thrombotic microangiopathy (“TMA”). Also disclosed are methods of treating an individual having a disease state such as thrombotic microangiopathy. Further disclosed are methods of diagnosing an individual with TMA.

公开(公告)号：US20240360201A1

公开(公告)日：2024-10-31

申请号：US18643334

申请日：2024-04-23

Applicant: Biocytogen Pharmaceuticals (Beijing) Co., Ltd.

Inventor： Yuan Guo ,  Baihong Liu ,  Yi Yang ,  Yuelei Shen

IPC: C07K16/00 ,  C07K14/52

CPC classification number: C07K16/00 ,  C07K14/52 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/622 ,  C07K2319/00

Abstract: This disclosure relates to modified immunoglobulins.

公开(公告)号：US20240358707A1

公开(公告)日：2024-10-31

申请号：US18543878

申请日：2023-12-18

Applicant: Pharmacyclics LLC

Inventor： Lee Honigberg ,  Erik J. Verner ,  Zhengying Pan

IPC: A61K31/52 ,  A61K9/48 ,  A61K31/00 ,  A61K31/519 ,  A61K39/395 ,  A61K45/06 ,  C07D487/04 ,  C07K16/28

CPC classification number: A61K31/52 ,  A61K9/4825 ,  A61K31/00 ,  A61K31/519 ,  A61K39/3955 ,  A61K45/06 ,  C07D487/04 ,  C07K16/2887 ,  A61K2300/00 ,  C07K2317/24

Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

公开(公告)号：US12129309B2

公开(公告)日：2024-10-29

申请号：US17736475

申请日：2022-05-04

Applicant: Xencor, Inc.

Inventor： Matthew Bernett ,  Gregory Moore ,  John Desjarlais ,  Seung Chu ,  Rumana Rashid ,  Umesh Muchhal

IPC: C07K16/40 ,  C07K16/18 ,  C07K16/28 ,  C07K16/30 ,  A61K39/00

CPC classification number: C07K16/40 ,  C07K16/18 ,  C07K16/2809 ,  C07K16/2896 ,  C07K16/3061 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/73 ,  C07K2317/92

Abstract: The present invention is directed to heterodimeric antibodies that bind CD3 and CD38.

公开(公告)号：US12129303B2

公开(公告)日：2024-10-29

申请号：US18590853

申请日：2024-02-28

Applicant: Lassen Therapeutics 1, Inc.

Inventor： Robert A. Horlick ,  Helen Toni Jun ,  David J. King

IPC: C07K16/28 ,  A61P11/00

CPC classification number: C07K16/2866 ,  A61P11/00 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: Provided are antibodies and antigen binding fragments thereof that bind to human interleukin-11 receptor subunit α (IL-11Rα) and related compositions, which may be used in any of a variety of therapeutic or diagnostic methods, including the treatment or diagnosis of cancers, inflammatory diseases, autoimmune diseases, and others.

公开(公告)号：US12129302B2

公开(公告)日：2024-10-29

申请号：US17821295

申请日：2022-08-22

Applicant: iBio, Inc.

Inventor： Dillon Phan ,  Martin Brenner ,  Brian Berquist ,  Peter Kipp ,  Tam Phuong ,  Kevin Babilonia ,  Tom Hsu ,  Lufei Hu ,  James Talmage Taylor, Jr. ,  Cory Schwartz

IPC: C07K16/28 ,  A61P35/00

CPC classification number: C07K16/2866 ,  A61P35/00 ,  C07K2317/24 ,  C07K2317/567 ,  C07K2317/732 ,  C07K2317/92

Abstract: Materials and methods for using polypeptides containing fragments and variants of the antibody(ies) or portion(s) thereof that bind CD25 to treat cancer alone or in combination with other anti-neoplastic agents.

公开(公告)号：US12129298B2

公开(公告)日：2024-10-29

申请号：US17254105

申请日：2019-06-20

Applicant: Daiichi Sankyo Company, Limited

Inventor： Thomas Spreter Von Kreudenstein

IPC: C07K16/28

CPC classification number: C07K16/2809 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2317/94

Abstract: The present disclosure relates generally to immunoglobulin-related compositions (e.g., antibodies or antigen binding fragments thereof) that can bind to CD3 and uses thereof.

公开(公告)号：US20240353428A1

公开(公告)日：2024-10-24

申请号：US18599751

申请日：2024-03-08

Applicant: ALZPATH, INC.

Inventor： Andreas Jeromin ,  Krish Venkat

IPC: G01N33/68 ,  C07K16/18 ,  G01N33/53

CPC classification number: G01N33/6896 ,  C07K16/18 ,  G01N33/53 ,  G01N33/6857 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/565 ,  G01N2333/4704 ,  G01N2333/4709 ,  G01N2333/96416 ,  G01N2800/2821

Abstract: Provided herein are compositions and methods relating to improved assays for establishing Alzheimer's disease. Further provided herein are compositions and methods comprising improved antibodies for assays including immunoassays.

公开(公告)号：US20240352152A1

公开(公告)日：2024-10-24

申请号：US18633379

申请日：2024-04-11

Applicant: Omeros Corporation ,  University of Leicester

Inventor： Gregory A. Demopulos ,  Hans-Wilhelm Schwaeble ,  Thomas Dudler ,  Larry W. Tjoelker

IPC: C07K16/40 ,  A61K39/00 ,  A61P27/02 ,  A61P35/04

CPC classification number: C07K16/40 ,  A61P27/02 ,  A61P35/04 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: In one aspect, the present invention provides methods for preventing, treating, reverting and/or delaying angiogenesis in a mammalian subject suffering from, or at risk for developing, an angiogenesis-dependent disease or condition, comprising administering to the subject an amount of a MASP-2 inhibitory agent effective to inhibit angiogenesis. In some embodiments of these aspects of the invention, the MASP-2 inhibitory agent is a MASP-2 antibody or fragment thereof.