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23 条记录 (耗时 0.018 秒)

    ANALYZING PER-CELL CO-EXPRESSION OF CELLULAR CONSTITUENTS
    2.
    发明公开
    ANALYZING PER-CELL CO-EXPRESSION OF CELLULAR CONSTITUENTS 审中-公开

    公开(公告)号：US20240145035A1

    公开(公告)日：2024-05-02

    申请号：US18497763

    申请日：2023-10-30

    申请人： BioLegend, Inc.

    发明人： Santosh Putta ,  Nikil Wale ,  Wesley Jensen ,  Srikar Devakonda

    IPC分类号： G16B25/10 ,  G16B40/20 ,  G16B45/00

    CPC分类号： G16B25/10 ,  G16B40/20 ,  G16B45/00

    摘要： A data structure relating to a sample of cells is described. The data structure includes first data elements each representing one of a number of first-degree nodes. Each of the first-degree nodes corresponds to a different one of a number of cellular constituents. Each first data element includes a quantitative indication of the portion of cells of the sample in which the constituent has positive expression. The data structure also includes second data elements each representing one of a number of greater-than-first-degree nodes, which each correspond to a different subset of the constituents of size two or more. Each second data element includes a quantitative indication of the portion of cells of the sample in which the subset of constituents all have positive expression. The contents of the data structure are usable to generate a visual co-expression graph characterizing the sample.

    STABLE NANOMAGNETIC PARTICLE DISPERSIONS
    3.
    发明公开
    STABLE NANOMAGNETIC PARTICLE DISPERSIONS 审中-公开

    公开(公告)号：US20230160884A1

    公开(公告)日：2023-05-25

    申请号：US18099224

    申请日：2023-01-19

    申请人： BIOLEGEND, INC.

    发明人： DHANESH GOHEL ,  HONG ZHANG ,  JOHN RANSOM

    IPC分类号： G01N33/543 ,  G01N33/552

    CPC分类号： G01N33/54326 ,  G01N33/552

    摘要： Processes and compositions are described for preparing new, colloidally stable, coated nanomagnetic particles useful for both in-vitro and in-vivo biomedical applications, including cell targeting and capturing cells, microorganisms, and cellular organelles or entities such as exosomes. These nanomagnetic particles can also be used as imaging contrast agents due to their small size and high magnetic moment. The nanomagnetic particles include a series of sequentially added, stabilizing surface coatings rendered onto nano-sized magnetic crystal clusters (e.g., magnetite particles) to impart colloidal stability in complex biological samples with minimal leaching of the coating materials, high binding capacity, and low non-specific binding. Another benefit of this invention is the ability to utilize both external and internal magnetic field-generating separation devices to effect separation of the magnetic nanoparticles.

    Conjugated polymers and methods of use
    5.
    发明授权
    Conjugated polymers and methods of use 有权

    公开(公告)号：US11584883B2

    公开(公告)日：2023-02-21

    申请号：US16702146

    申请日：2019-12-03

    申请人： BioLegend, Inc.

    发明人： Xinshe Xu ,  Jing Wang ,  Matthew Yerou

    IPC分类号： C09K11/06 ,  C08G61/10 ,  G01N33/58

    摘要： The present disclosure provides fluorescent polyindenofluorene polymers or macromers with unique optical properties that are stable. The polymeric fluorophores are useful in various bioassays formats. The inventive polymers are useful in assays relying on fluorescence resonance energy transfer (FRET) mechanisms where two fluorophores are used.

    COMPOSITIONS AND METHODS FOR PERFORMING MAGNETIBUOYANT SEPARATIONS
    7.
    发明申请
    COMPOSITIONS AND METHODS FOR PERFORMING MAGNETIBUOYANT SEPARATIONS 审中-公开

    公开(公告)号：US20190119641A1

    公开(公告)日：2019-04-25

    申请号：US16096209

    申请日：2017-04-30

    申请人： BioLegend, Inc.

    发明人： Dhanesh GOHEL ,  Hong ZHANG ,  John RAMSOM

    IPC分类号： C12N5/0783 ,  B01J20/24 ,  B01J20/10 ,  B01J20/06 ,  B01J20/28 ,  C07K16/28

    摘要： Processes and compositions are provided for performing magnetibuoyant separations of different biomolecules (e.g., cells, organelles, etc.) in a biological sample, as well as compositions and kits for performing such methods. Compositions containing the separated biomolecules, and methods for using the same for in-vitro and in-vivo biomedical applications, are also provided. The magnetibuoyant methods of the invention employ targeted magnetic particles, preferably targeted nanomagnetic particles, and targeted buoyant particles such as buoyant microparticles and microbubbles. Among the benefits of the invention is the ability to combine targeted magnetic particles with differentially targeted buoyant particles to achieve separation of two or more specifically cell targeted populations during the same work flow.

    Stable nanomagnetic particle dispersions
    9.
    发明授权
    Stable nanomagnetic particle dispersions 有权

    公开(公告)号：US11630104B2

    公开(公告)日：2023-04-18

    申请号：US16719337

    申请日：2019-12-18

    申请人： BIOLEGEND, INC.

    发明人： Dhanesh Gohel ,  Hong Zhang ,  John Ransom

    IPC分类号： G01N33/543 ,  G01N33/552

    摘要： Processes and compositions are described for preparing new, colloidally stable, coated nanomagnetic particles useful for both in-vitro and in-vivo biomedical applications, including cell targeting and capturing cells, microorganisms, and cellular organelles or entities such as exosomes. These nanomagnetic particles can also be used as imaging contrast agents due to their small size and high magnetic moment. The nanomagnetic particles include a series of sequentially added, stabilizing surface coatings rendered onto nano-sized magnetic crystal clusters (e.g., magnetite particles) to impart colloidal stability in complex biological samples with minimal leaching of the coating materials, high binding capacity, and low non-specific binding. Another benefit of this invention is the ability to utilize both external and internal magnetic field-generating separation devices to effect separation of the magnetic nanoparticles.