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    Methods and systems for single cell protein analysis
    2.
    发明授权
    Methods and systems for single cell protein analysis 有权

    公开(公告)号：US12235262B1

    公开(公告)日：2025-02-25

    申请号：US17014909

    申请日：2020-09-08

    Applicant: 10X GENOMICS, INC.

    Inventor： Paul Giresi

    IPC: G01N33/543 ,  G01N33/68

    Abstract: Provided herein are methods identifying protein-protein interactions in a single cell context. In some cases, the methods may be used to measure the abundance of protein-protein interactions in a single cell context. In some cases, the methods may be used to map relationships (e.g., spatial relationships) between proteins in a single cell context. Generally, the methods employ the use of proximity probes coupled with splint oligonucleotides to link information about the relationship of proteins within a single cell context, which may then be read in a downstream process (e.g., a sequencing reaction).

    Particle-drop structures and methods for making and using the same
    3.
    发明授权
    Particle-drop structures and methods for making and using the same 有权

    公开(公告)号：US12233407B2

    公开(公告)日：2025-02-25

    申请号：US18161322

    申请日：2023-01-30

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： Dino Di Carlo ,  Chueh-Yu Wu

    IPC: B01L3/02 ,  B01L3/00 ,  C12N1/04 ,  C12N5/071 ,  C12N5/0783 ,  C12Q1/6806 ,  G01N33/543

    Abstract: Sub-millimeter scale three-dimensional (3D) structures are disclosed with customizable chemical properties and/or functionality. The 3D structures are referred to as drop-carrier particles. The drop-carrier particles allow the selective association of one solution (i.e., a dispersed phased) with an interior portion of each of the drop-carrier particles, while a second non-miscible solution (i.e., a continuous phase) associates with an exterior portion of each of the drop-carrier particles due to the specific chemical and/or physical properties of the interior and exterior regions of the drop-carrier particles. The combined drop-carrier particle with the dispersed phase contained therein is referred to as a particle-drop. The selective association results in compartmentalization of the dispersed phase solution into sub-microliter-sized volumes contained in the drop-carrier particles. The compartmentalized volumes can be used for single-molecule assays as well as single-cell, and other single-entity assays.

    Multi-stage sample recovery system
    5.
    发明授权
    Multi-stage sample recovery system 有权

    公开(公告)号：US12228584B2

    公开(公告)日：2025-02-18

    申请号：US17506600

    申请日：2021-10-20

    Applicant: XCella Biosciences, Inc.

    Inventor： Bob Chen

    IPC: G01N35/10 ,  B01J19/00 ,  B01L3/00 ,  B01L9/00 ,  C12N15/10 ,  C12Q1/6851 ,  C40B60/02 ,  G01N15/14 ,  G01N15/1433 ,  G01N21/75 ,  G01N33/543 ,  G01N15/10 ,  G01N21/03 ,  G01N21/64 ,  G01N21/77 ,  G01N35/00

    Abstract: Multi-stage sample-recovery systems, including automated 2-stage and 3-stage sample-recovery systems, are provided. Such systems enable the rapid screening and recovery of samples, including viable cell-based samples, from high-throughput screening systems, including systems utilizing large-scale arrays of microcapillaries. In specific screening systems, each microcapillary comprises a solution containing a variant protein, an immobilized target molecule, and a reporter element. Immobilized target molecules may include any molecule of interest, including proteins, nucleic acids, carbohydrates, and other biomolecules. The association of a variant protein with a molecular target is assessed by measuring a signal from the reporter element. The contents of microcapillaries identified in the assays as containing variant proteins of interest can be identified and recovered using the multi-stage systems disclosed herein.

    Magnetic separation of biological entities from fluid sample
    7.
    发明授权
    Magnetic separation of biological entities from fluid sample 有权

    公开(公告)号：US12216116B2

    公开(公告)日：2025-02-04

    申请号：US17579528

    申请日：2022-01-19

    Applicant: CORNELL UNIVERSITY

    Inventor： Sasank Vemulapati ,  David Erickson

    IPC: G01N33/543 ,  G01N1/40 ,  G01N33/569

    Abstract: The present disclosure relates to, inter alia, devices, systems, and methods for use in the magnetic separation of biological entities from fluid samples. This device includes a magnetic separation chamber configured to receive a fluid sample for magnetic separation, where the magnetic separation chamber includes at least two magnets mounted on the surface or in the wall of the magnetic separation chamber. The device also includes a force provider configured to move the magnetic separation chamber in a side-to-side motion to mix and/or magnetize the fluid sample. In one embodiment, the magnetic separation chamber is in a form of a sleeve and comprises a substantially central channel for loading a vessel containing the fluid sample therein. The systems and methods of the present disclosure involve the use of this device to separate biological entities from fluid samples.

    Developer solution vial
    8.
    发明授权
    Developer solution vial 有权

    公开(公告)号：US12214351B2

    公开(公告)日：2025-02-04

    申请号：US17546440

    申请日：2021-12-09

    Applicant: ORASURE TECHNOLOGIES, INC.

    Inventor： Mark Fischl ,  Keith Kardos ,  Attila Nemeth ,  Mark Emrick

    IPC: B01L3/00 ,  G01N33/543

    Abstract: The invention provides a developer solution vial and methods of its use to diagnose diseases using a sampling and/or assay device, for example, for use with a lateral flow assay (LFA) device. The developer solution vial may include any container that is capable of holding developer solution. The developer solution vial is keyed to the sampling and/or assay device. The developer solution vial minimizes the amount of developer solution required for accurate fluid flow assay testing.

    DETECTION METHOD AND DETECTION REAGENT
    10.
    发明申请
    DETECTION METHOD AND DETECTION REAGENT 有权

    公开(公告)号：US20250035618A1

    公开(公告)日：2025-01-30

    申请号：US18709250

    申请日：2022-12-27

    Applicant: SEKISUI MEDICAL CO., LTD.

    Inventor： Daisuke YAMADA ,  Ikumi SUZUKI ,  Kengo FUJIMURA ,  Tomohide ASAI ,  Osamu MIYAZAKI

    IPC: G01N33/543 ,  G01N33/53 ,  G01N33/536

    Abstract: It is an object of the present invention to provide a method for suppressing non-specific reactions using a highly versatile method without affecting specific reactions. The present invention provides a detection method for detecting a target antigen in a sample using a specific antibody that specifically binds to the antigen, the method comprising: a) a step of bringing the sample into contact with a modified antibody; and b) a step of bringing the sample into contact with the specific antibody simultaneously with or after the step a), which is a highly versatile method that can suppress non-specific reactions.

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