公开(公告)号：US20230025583A1

公开(公告)日：2023-01-26

申请号：US17780846

申请日：2020-11-27

Applicant: SEKISUI MEDICAL CO., LTD.

Inventor： Tomohide ASAI ,  Yoshihiro TANAKA ,  Ikumi SUZUKI ,  Satoko SEO ,  Tomoyuki USUI ,  Tomo SHIMIZU ,  Osamu MIYAZAKI

IPC: G01N33/543 ,  C07K16/18

Abstract: A problem to be solved by the invention is to improve the sensitivity of measurement of an analyte in a sample by a sandwich immunoassay. The sensitivity can be improved significantly in a sandwich immunoassay using a first antibody and a second antibody when one or both of the first antibody and the second antibody are a mixture of a monoclonal antibody recognizing a linear epitope and a monoclonal antibody recognizing a conformational epitope.

公开(公告)号：US20220113327A1

公开(公告)日：2022-04-14

申请号：US17560263

申请日：2021-12-23

Applicant: SEKISUI MEDICAL CO., LTD.

Inventor： Seiichiro ISHIOKA ,  Yasuo MINAMI ,  Tomohide ASAI ,  Kyoichi IWAHASHI

IPC: G01N35/04

Abstract: There is provided an automated analysis device capable of transferring a rack to a predetermined instrument extraction position efficiently and rapidly, the rack being loaded with instruments to be used for an analysis process. An automated analysis device of the invention includes a conveyance unit to raise and lower a plurality of racks in a vertically stacked state to convey the racks into an analyte processing space, the racks being loaded with instruments to be used for analyte processing. The conveyance unit includes a movement mechanism to move an uppermost rack from a rack standby position to an extraction position with guidance of a protrusion and a recess while maintaining a state of slidable protrusion and recess engagement between the uppermost rack and a rack below the uppermost rack.

公开(公告)号：US20240255505A1

公开(公告)日：2024-08-01

申请号：US18290089

申请日：2022-06-16

Applicant: SEKISUI MEDICAL CO., LTD.

Inventor： Jiro HIROTA ,  Satoru UNO ,  Yasushi OCHIAI ,  Shizuka ITO ,  Keisuke WATANABE ,  Shinya OKUYAMA ,  Tomohide ASAI

IPC: G01N33/569 ,  C07K14/005 ,  C07K16/10

CPC classification number: G01N33/56983 ,  C07K14/005 ,  C07K16/1002 ,  C07K2317/565 ,  C12N2770/20022 ,  G01N2333/165

Abstract: The present invention provides an immunoassay method for assaying SARS-CoV-2 in a biological sample, including using two types of monoclonal antibodies or antibody fragments thereof that bind to a peptide fragment having 30 or less consecutive amino acids in a nucleocapsid protein of SARS-CoV-2, wherein the two types of monoclonal antibodies or antibody fragments thereof recognize different epitopes

公开(公告)号：US20220146529A1

公开(公告)日：2022-05-12

申请号：US17427209

申请日：2020-01-30

Applicant: Toru MIYAZAKI ,  SEKISUI MEDICAL CO., LTD. ,  SOCIAL WELFARE ORGANIZATION "SAISEIKAI" IMPERIAL GIFT FOUNDATION INC.

Inventor： Toru MIYAZAKI ,  Tomoko YAMAZAKI ,  Takeshi OKANOUE ,  Tomohide ASAI ,  Yuka KANETSUKI ,  Jiro HIROTA

IPC: G01N33/68

Abstract: A problem to be solved is to detect only free AIM in a biological sample containing complex AIM and free AIM.
The problem can be solved by an immunoassay method for free AIM in a biological sample using an anti-AIM monoclonal antibody having a property of reacting with free AIM and not reacting with complex AIM, wherein the anti-AIM monoclonal antibody is an antibody binding to an epitope in the SRCR2 domain of human AIM.

公开(公告)号：US20220113329A1

公开(公告)日：2022-04-14

申请号：US17561538

申请日：2021-12-23

Applicant: SEKISUI MEDICAL CO., LTD.

Inventor： Seiichiro ISHIOKA ,  Yasuo MINAMI ,  Tomohide ASAI ,  Kyoichi IWAHASHI

IPC: G01N35/10

Abstract: There is provided an automated analysis device capable of transferring a reagent for reagent dispensing efficiently and rapidly. An automated analysis device of the invention includes a reagent transfer unit to transfer a reagent suction nozzle between a reaction unit and a reagent supply unit. In a region of an analyte processing space where a tip supply unit, the reagent supply unit, a tip disposal unit, and the reaction unit are lined up along a straight line, the reagent transfer unit forms a uniaxial transfer line where the reagent suction nozzle is moved only in a uniaxial direction along the straight line for a reagent transfer.

公开(公告)号：US20250035618A1

公开(公告)日：2025-01-30

申请号：US18709250

申请日：2022-12-27

Applicant: SEKISUI MEDICAL CO., LTD.

Inventor： Daisuke YAMADA ,  Ikumi SUZUKI ,  Kengo FUJIMURA ,  Tomohide ASAI ,  Osamu MIYAZAKI

IPC: G01N33/543 ,  G01N33/53 ,  G01N33/536

Abstract: It is an object of the present invention to provide a method for suppressing non-specific reactions using a highly versatile method without affecting specific reactions. The present invention provides a detection method for detecting a target antigen in a sample using a specific antibody that specifically binds to the antigen, the method comprising: a) a step of bringing the sample into contact with a modified antibody; and b) a step of bringing the sample into contact with the specific antibody simultaneously with or after the step a), which is a highly versatile method that can suppress non-specific reactions.

公开(公告)号：US20240369543A1

公开(公告)日：2024-11-07

申请号：US18688434

申请日：2022-10-18

Applicant: SEKISUI MEDICAL CO., LTD.

Inventor： Tomo SHIMIZU ,  Tomohide ASAI

IPC: G01N33/53 ,  C07K16/18 ,  G01N33/68

Abstract: A measurement reagent for a cross-linked N-telopeptide of type I collagen containing uric acid or its salt. This reagent is easier to handle and enables NTx measurement with higher accuracy.

公开(公告)号：US20220120762A1

公开(公告)日：2022-04-21

申请号：US17427294

申请日：2020-01-30

Applicant: Toru MIYAZAKI ,  SEKISUI MEDICAL CO., LTD. ,  SOCIAL WELFARE ORGANIZATION "SAISEIKAI" IMPERIAL GIFT FOUNDATION INC.

Inventor： Toru MIYAZAKI ,  Takeshi OKANOUE ,  Tomohide ASAI ,  Yuka KANETSUKI ,  Jiro HIROTA

IPC: G01N33/68 ,  G01N33/53

Abstract: A problem to be solved is to further improve the specificity for free AIM of an antibody specifically reacting with free AIM and to diagnose NASH without imposing a burden on patients and medical staffs.
The problem can be solved by an immunoassay method for free AIM in a biological sample containing complex AIM and free AIM, and the method comprises bringing the biological sample into contact with an antibody specifically reacting with free AIM in a presence of an anti-IgM antibody.

公开(公告)号：US20220107318A1

公开(公告)日：2022-04-07

申请号：US17427559

申请日：2020-01-30

Applicant: Toru MIYAZAKI ,  SEKISUI MEDICAL CO., LTD. ,  SOCIAL WELFARE ORGANIZATION "SAISEIKAI" IMPERIALGIFT FOUNDATION INC.

Inventor： Toru MIYAZAKI ,  Takeshi OKANOUE ,  Tomohide ASAI ,  Yuka KANETSUKI ,  Jiro HIROTA

IPC: G01N33/577 ,  G01N33/53

Abstract: A problem to be solved is to improve the specificity of an anti-AIM antibody for free AIM in a biological sample containing complex AIM and free AIM.
The problem can be solved by an immunoassay method for measuring an amount of free AIM in a biological sample containing complex AIM and free AIM, and the method comprises bringing the biological sample into contact with an anti-AIM antibody in the presence of an anti-IgM antibody.

公开(公告)号：US20240241120A1

公开(公告)日：2024-07-18

申请号：US18290077

申请日：2022-06-16

Applicant: SEKISUI MEDICAL CO., LTD.

Inventor： Jiro HIROTA ,  Satoru UNO ,  Yasushi OCHIAI ,  Shohei YAJI ,  Christopher Kenta HEWSON ,  Keigo KOHNO ,  Tomohide ASAI

IPC: G01N33/569 ,  C07K16/10

CPC classification number: G01N33/56983 ,  C07K16/1003 ,  C07K2317/34 ,  G01N2333/165

Abstract: The present invention provides an immunoassay method for assaying SARS-CoV-2, including a step of contacting a biological sample with a monoclonal antibody or an antibody fragment thereof that binds to a nucleocapsid protein of SARS-COV-2, wherein the monoclonal antibody or the antibody fragment thereof binds to the SARS-CoV-2 treated with a serine protease.