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公开(公告)号：US12222351B2
公开(公告)日：2025-02-11
申请号：US17282307
申请日：2019-10-08
Applicant: SEKISUI MEDICAL CO., LTD. , NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITION
Inventor： Shigeo Takayama , Tetsuji Naka , Satoshi Serada
IPC: G01N33/545
Abstract: An object of the present invention is to provide a measurement method and a reagent for measurement which can measure LRG in a biological sample simply in a short time. The present inventors have intensively studied to achieve the object and made findings that LRG in a biological sample can be measured simply in a short time by an immunoagglutination measurement method in which the biological sample is brought into contact with insoluble carrier particles carrying a first anti-LRG monoclonal antibody and insoluble carrier particles carrying a second anti-LRG monoclonal antibody in a liquid phase, and the invention has been thus completed.
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公开(公告)号：US20240329068A1
公开(公告)日：2024-10-03
申请号：US18733844
申请日：2024-06-05
Applicant: SEKISUI MEDICAL CO., LTD.
Inventor： Toshiki KAWABE , Yumi IIJIMA , Kosuke OGASAWARA
IPC: G01N35/00
CPC classification number: G01N35/00663 , G01N35/00722 , G01N2035/00673 , G01N2035/00891
Abstract: The automatic analysis device of the invention includes a history information storage unit configured to store history information related to a previously conducted analysis, a number-of-analyses calculation unit configured to calculate a number of analyses per unit for each analysis item from the history information, a classification/storage unit configured to classify and store the number of analyses per unit by day of the week, a reagent remaining amount detection unit configured to detect a reagent remaining amount, a conversion unit configured to read each number of analyses per unit over a predetermined period corresponding to a day of a week of an analysis implementation date from the classification/storage unit and convert the read each number of analyses per unit into a reagent usage amount, and a display device configured to arrange and display information associated with the reagent usage amount and the reagent remaining amount for each reagent.
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公开(公告)号：US20240302366A1
公开(公告)日：2024-09-12
申请号：US18273153
申请日：2022-01-25
Applicant: SEKISUI MEDICAL CO., LTD.
Inventor： Kengo FUJIMURA , Daigo NOMOTO , Tomo SHIMIZU , Yuki KORA
IPC: G01N33/564 , G01N33/543
CPC classification number: G01N33/564 , G01N33/54313 , G01N2333/4716
Abstract: An object of the invention is to suppress non-specific reaction in an immunoreaction measurement method. An immunoassay method characterized by conducting immunoreaction in the presence of an anti-C3 antibody in a method for measuring an analyte in a sample immunologically is provided. Moreover, a method for suppressing non-specific reaction in a method for immunologically measuring an analyte in a sample which is characterized by conducting immunoreaction in the presence of an anti-C3 antibody is provided.
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公开(公告)号：US20240019451A1
公开(公告)日：2024-01-18
申请号：US18476326
申请日：2023-09-28
Applicant: SEKISUI MEDICAL CO., LTD.
Inventor： Yoshihiro YANO
IPC: G01N35/00
CPC classification number: G01N35/00584 , G01N2035/00346
Abstract: A temperature adjustment system includes: a temperature adjustment unit for adjusting a temperature of a liquid required for measurement to a desired temperature; a measurement unit for obtaining measurement information of a measurement object-containing liquid; a connection flow path connecting the temperature adjustment unit and the measurement unit; temperature detection units and to detect temperatures of the liquids in the temperature adjustment unit and the measurement unit; and a control unit to perform liquid temperature control to control a temperature of the temperature adjustment unit such that the temperature of the liquid in the measurement unit becomes a target temperature while considering a temperature change associated with a flow of the liquids from the temperature adjustment unit to the measurement unit through the connection flow path, based on the temperature of the liquid in the measurement unit and the temperature of the liquid in the temperature adjustment unit.
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5.发明公开
公开(公告)号：US20240011013A1
公开(公告)日：2024-01-11
申请号：US18024322
申请日：2021-09-03
Applicant: SEKISUI MEDICAL CO., LTD. , SEKISUI CHEMICAL CO., LTD.
Inventor： Sou YAMAGUCHI , Katsura UCHIDA , Tatsunori TAKAMATSU , Takamasa KOUNO , Takuya KINOSHITA
IPC: C12N15/10
CPC classification number: C12N15/1006
Abstract: Provided is a nucleic acid purification method capable of efficiently purifying a nucleic acid. The nucleic acid purification method including the steps of: mixing a nucleic acid with an antifoaming agent and a coprecipitation agent; and purifying the nucleic acid, in which the antifoaming agent is at least one of a nonionic surfactant and a silicone antifoaming agent.
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公开(公告)号：US20230393156A1
公开(公告)日：2023-12-07
申请号：US18250783
申请日：2021-10-29
Applicant: SEKISUI MEDICAL CO., LTD.
Inventor： Toshiki KAWABE , Kengo ONISHI
IPC: G01N33/86
CPC classification number: G01N33/86
Abstract: A method for detecting a blood coagulation reaction, comprising: 1) measuring a blood coagulation reaction of a subject blood specimen and acquiring a first derivative V(i) of a coagulation reaction up to a latest measurement point; 2) calculating areas under the curve (AUCs) before the peak and after the peak, wherein a top of the peak of V(i) is cVmax(k) which is a maximum value of V(i); and 3) detecting cVmax(k) as Vmax which is a true maximum value of V(i) when the pre-peak AUC and the post-peak AUC are both equal to or higher than a first threshold AUCth1 and a period L during which the pre-peak AUC and the post-peak AUC have continued to be a constant value reaches a predetermined length.
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公开(公告)号：US20230341423A1
公开(公告)日：2023-10-26
申请号：US17788869
申请日：2020-12-25
Applicant: SEKISUI MEDICAL CO., LTD.
Inventor： Toshiki KAWABE
Abstract: Provided is a blood coagulation time measurement method. In the method, reaction X(i) is acquired through smoothing and zero-point adjustment of a measured value P(i) for coagulation reaction of a blood specimen, and then an integration ratio Z(i) of the reaction X(i) is acquired. These values are used to calculate an index for coagulation time Tc calculation, and it is determined whether or not the index satisfies the criteria. The procedure is sequentially repeated until an index that satisfies the criteria is obtained.
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公开(公告)号：US20230258657A1
公开(公告)日：2023-08-17
申请号：US18015231
申请日：2021-07-09
Applicant: SEKISUI MEDICAL CO., LTD.
Inventor： Kengo FUJIMURA , Tomoyuki USUI , Yuka SUZUKI , Akiko MATSUMOTO
IPC: G01N33/68
CPC classification number: G01N33/6863
Abstract: An object of the present invention is to provide a TARC-containing composition with high storage stability. Provided is a composition including TARC (Thymus and activation-regulated chemokine) and a polymer having 2-methacryloyloxyethyl phosphorylcholine as a structural unit, and being in liquid form. The aforementioned object is achieved by the composition.
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公开(公告)号：US11668708B2
公开(公告)日：2023-06-06
申请号：US16651872
申请日：2017-09-29
Applicant: SEKISUI MEDICAL CO., LTD.
Inventor： Kengo Fujimura , Junichi Kondou , Mitsuaki Yamamoto
IPC: G01N33/53 , G01N33/543
CPC classification number: G01N33/543 , G01N2458/00
Abstract: A method for avoiding the influence of a blood sample on a measurement error in a latex agglutination immunoassay. The measurement error caused by a blood sample in a latex agglutination immunoassay can be reduced by a method which includes a step of bringing the sample into contact, in a liquid phase, with latex particles carrying a substance having a specific affinity for an analyte in the presence of imidazole.
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10.发明申请
公开(公告)号：US20230003746A1
公开(公告)日：2023-01-05
申请号：US17778647
申请日：2020-11-20
Applicant: SEKISUI MEDICAL CO., LTD.
Inventor： Mitsuaki YAMAMOTO , Mieko OTA , Tomohisa NISHIO
IPC: G01N33/82 , G01N33/544
Abstract: The present invention addresses the problem of providing a method for measuring 25-hydroxy vitamin D and a measurement reagent, the method and the reagent being based on a competitive immunoassay. The present invention provides a reagent for measuring 25-hydroxy vitamin D based on a competitive immunoassay, which includes at least the following composition: (1) a Vitamin D derivative represented by the chemical formula (I) and/or (II), (2) an anti-25 hydroxy vitamin D antibody. In addition, the present invention provides a reagent for measuring vitamin D based on a competitive latex turbidimetric immunoassay (competitive LTIA) in which, in particular, a vitamin D derivative or an anti-25-hydroxy vitamin D antibody is immobilized on latex.
