公开(公告)号：US20190064160A1

公开(公告)日：2019-02-28

申请号：US16095902

申请日：2017-08-08

Applicant: SEKISUI MEDICAL CO., LTD.

Inventor： Shinya OKUYAMA ,  Kanako AZUMA ,  Kazunori SAITO

IPC: G01N33/559 ,  G01N21/64 ,  G01N21/78 ,  G01N33/543 ,  G01N35/00

Abstract: An object of the present invention is to provide an immunochromatographic detection kit and detection method, in which continuous increasement of coloring intensity at a detecting portion for a long time is suppressed, capturing of a complex at a detecting portion is completed within a predetermined time, and increasement of coloring intensity is stopped, when a conjugate is mixed with a liquid sample and this mixture is supplied to a test strip. The present invention addresses the problem by retaining a free antibody against the analyte antigen and a saccharide on a sample pad, separately from antibodies of the conjugate and the detecting portion, in an immunochromatographic test strip. Further, the present invention addresses the problem by retaining a specific polymeric viscous substance on a sample pad in an immunochromatographic test strip.

公开(公告)号：US20240255505A1

公开(公告)日：2024-08-01

申请号：US18290089

申请日：2022-06-16

Applicant: SEKISUI MEDICAL CO., LTD.

Inventor： Jiro HIROTA ,  Satoru UNO ,  Yasushi OCHIAI ,  Shizuka ITO ,  Keisuke WATANABE ,  Shinya OKUYAMA ,  Tomohide ASAI

IPC: G01N33/569 ,  C07K14/005 ,  C07K16/10

CPC classification number: G01N33/56983 ,  C07K14/005 ,  C07K16/1002 ,  C07K2317/565 ,  C12N2770/20022 ,  G01N2333/165

Abstract: The present invention provides an immunoassay method for assaying SARS-CoV-2 in a biological sample, including using two types of monoclonal antibodies or antibody fragments thereof that bind to a peptide fragment having 30 or less consecutive amino acids in a nucleocapsid protein of SARS-CoV-2, wherein the two types of monoclonal antibodies or antibody fragments thereof recognize different epitopes

公开(公告)号：US20250012792A1

公开(公告)日：2025-01-09

申请号：US18708381

申请日：2022-12-09

Applicant: SEKISUI MEDICAL CO., LTD.

Inventor： Shohei YAJI ,  Shizuka ITO ,  Shinya OKUYAMA

IPC: G01N33/543 ,  G01N1/40 ,  G01N33/569

Abstract: The present invention provides an immunochromatography test strip for detecting a detection target substance, comprising: a sample supply section to which a sample potentially containing the detection target substance is supplied; a conjugate section containing a conjugate in which a label is bound to an antibody or antigen that immunologically reacts with the detection target substance; and a detector section that captures a complex containing the detection target substance and the conjugate, wherein the detection target substance is a protein with an isoelectric point of 9.5 or higher, and either or both of the sample supply section and the conjugate section are formed on a polyester fiber pad or a polyolefin fiber pad.

公开(公告)号：US20240377396A1

公开(公告)日：2024-11-14

申请号：US18574523

申请日：2022-08-09

Applicant: SEKISUI MEDICAL CO., LTD.

Inventor： Shohei YAJI ,  Shizuka ITO ,  Shinya OKUYAMA ,  Yasushi OCHIAI ,  Keigo KOHNO ,  Keisuke WATANABE ,  Christopher Kenta HEWSON ,  Shun SAKAI

IPC: G01N33/569 ,  G01N33/543 ,  G01N33/58

Abstract: The present invention provides an immunoassay method for detecting a protein with an isoelectric point of 9.5 or higher, comprising a step of bringing a sample containing the protein with an isoelectric point of 9.5 or higher into contact with a glass material in the presence of a cationic substance, and an immunochromatography kit for detecting a protein with an isoelectric point of 9.5 or higher, comprising a specimen diluent and an immunochromatography test strip.