MICROREACTOR AND METHOD FOR CONTINUOUS FLOW SYNTHESIS OF 2,5-FURANDICARBOXYLIC ACID

    公开(公告)号:US20250059149A1

    公开(公告)日:2025-02-20

    申请号:US18936914

    申请日:2024-11-04

    Abstract: Disclosed is a microreactor for continuous flow synthesis of 2,5-furandicarboxylic acid, the microreactor includes a first container, a collection device, an injection pump, a first flow pump, a second flow pump, a first microreactor substrate, ion exchange resin adsorption pipes, activated carbon adsorption pipes, a second microreactor substrate, an oxygen source, a first T-connector, a second T-connector, and a third T-connector; where the first container is connected to the first T-connector via the first flow pump, the injection pump is connected to the first T-connector, the third T-connector is connected to the first T-connector and the first microreactor substrate, respectively, the first microreactor substrate is connected to the ion exchange resin adsorption pipes, the activated carbon adsorption pipes, the second T-connector, and the second microreactor substrate in sequence, and the oxygen source is connected to the second T-connector. Further disclosed is a method for continuous flow synthesis of 2,5-furandicarboxylic acid.

    Multi-stage sample recovery system

    公开(公告)号:US12228584B2

    公开(公告)日:2025-02-18

    申请号:US17506600

    申请日:2021-10-20

    Inventor: Bob Chen

    Abstract: Multi-stage sample-recovery systems, including automated 2-stage and 3-stage sample-recovery systems, are provided. Such systems enable the rapid screening and recovery of samples, including viable cell-based samples, from high-throughput screening systems, including systems utilizing large-scale arrays of microcapillaries. In specific screening systems, each microcapillary comprises a solution containing a variant protein, an immobilized target molecule, and a reporter element. Immobilized target molecules may include any molecule of interest, including proteins, nucleic acids, carbohydrates, and other biomolecules. The association of a variant protein with a molecular target is assessed by measuring a signal from the reporter element. The contents of microcapillaries identified in the assays as containing variant proteins of interest can be identified and recovered using the multi-stage systems disclosed herein.

    FURNACE AND MANUFACTURING APPARATUS FOR GLASS PARTICLE DEPOSIT INCLUDING THE SAME

    公开(公告)号:US20250050302A1

    公开(公告)日:2025-02-13

    申请号:US18721982

    申请日:2022-12-21

    Inventor: Tomomi MORIYA

    Abstract: The present disclosure relates to a furnace for manufacturing a glass particle deposit by depositing glass particles generated from a glass raw material. The furnace includes two or more portions that are not fixed to each other in an upper-lower direction which is an axial direction of the glass particle deposit. The two or more portions include a first portion and a second portion which are independently formed, and the two or more portions have a structure in which the first portion and the second portion do not interfere with each other when the first portion is deformed by thermal expansion.

    SPATIAL BARCODES BY HYDROGEL LITHOGRAPHY

    公开(公告)号:US20250050301A1

    公开(公告)日:2025-02-13

    申请号:US18908638

    申请日:2024-10-07

    Abstract: The invention is directed to methods and systems for producing a surface coated with a plurality of spatial barcodes. In one aspect, beads carrying barcode oligonucleotides are disposed on a surface after which hydrogel chambers are synthesized around each bead and barcode oligonucleotides are released to be captured on the surface in the interiors of the chambers. Captured oligonucleotide barcodes are amplified and optionally sequenced to form a coating of spatial barcodes.

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