公开(公告)号：US12005145B2

公开(公告)日：2024-06-11

申请号：US17695687

申请日：2022-03-15

Applicant: Applied Materials, Inc.

Inventor： Colin C. Neikirk ,  Jonathan Frankel

IPC: A61K9/50 ,  A61J3/07 ,  A61K31/405 ,  A61K31/424 ,  A61K31/43 ,  A61K31/506 ,  A61K31/519 ,  A61K31/7048 ,  A61K47/58 ,  C07K16/22 ,  C07K16/28 ,  C07K16/32 ,  C23C16/40 ,  C23C16/44 ,  C23C16/455 ,  C23C16/458

CPC classification number: A61K9/5089 ,  A61J3/07 ,  A61K9/501 ,  A61K31/405 ,  A61K31/424 ,  A61K31/43 ,  A61K31/506 ,  A61K31/519 ,  A61K31/7048 ,  A61K47/58 ,  C07K16/22 ,  C07K16/2833 ,  C07K16/32 ,  C23C16/40 ,  C23C16/403 ,  C23C16/405 ,  C23C16/4417 ,  C23C16/45525 ,  C23C16/45555 ,  C23C16/458 ,  C07K2317/24 ,  C07K2317/94 ,  A61K31/424 ,  A61K2300/00 ,  A61K31/43 ,  A61K2300/00

Abstract: A method of preparing a pharmaceutical composition having a drug-containing core enclosed by one or more metal oxide materials is provided. The method includes the sequential steps of (a) loading the particles comprising the drug into a reactor, (b) applying a vaporous or gaseous metal precursor to the particles in the reactor, (c) performing one or more pump-purge cycles of the reactor using inert gas, (d) applying a vaporous or gaseous oxidant to the particles in the reactor, and (e) performing one or more pump-purge cycles of the reactor using inert gas. The temperature of the particles does not exceed 35° C. This produces a pharmaceutical composition comprising a drug containing core enclosed by one or more metal oxide materials.

公开(公告)号：US20230347310A1

公开(公告)日：2023-11-02

申请号：US18212599

申请日：2023-06-21

Applicant: Applied Materials, Inc.

Inventor： Jonathan Frankel ,  Colin C. Neikirk ,  Pravin K. Narwankar ,  Quoc Truong ,  Govindraj Desai ,  Sekar Krishnasamy

IPC: B01J8/10 ,  C23C16/44 ,  B05D1/00 ,  B01F27/70 ,  B01F27/112

CPC classification number: B01J8/10 ,  C23C16/4417 ,  B05D1/60 ,  B01F27/70 ,  B01F27/112 ,  B01J2208/00867 ,  B01F2101/22

Abstract: A reactor for coating particles includes a stationary vacuum chamber to hold a bed of particles to be coated, a vacuum port in an upper portion of the chamber, a chemical delivery system configured to inject a reactant or precursor gas into a lower portion of the chamber, a paddle assembly, and a motor to rotate a drive shaft of the paddle assembly. The lower portion of the chamber forms a half-cylinder. The paddle assembly includes a rotatable drive shaft extending through the chamber along the axial axis of the half cylinder, and a plurality of paddles extending radially from the drive shaft such that rotation of the drive shaft by the motor orbits the plurality of paddles about the drive shaft.

公开(公告)号：US11560804B2

公开(公告)日：2023-01-24

申请号：US17832568

申请日：2022-06-03

Applicant: Applied Materials, Inc.

Inventor： Yuriy Melnik ,  Sukti Chatterjee ,  Kaushal Gangakhedkar ,  Jonathan Frankel ,  Lance A. Scudder ,  Pravin K. Narwankar ,  David Alexander Britz ,  Thomas Knisley ,  Mark Saly ,  David Thompson

IPC: F01D5/28 ,  C23C16/455 ,  C23C16/34 ,  C23C16/40 ,  C23C16/30 ,  C23C16/56 ,  F01D9/02 ,  F01D25/12 ,  F01D25/28 ,  F23R3/28 ,  C07F11/00 ,  F01D25/14

Abstract: Methods for forming protective coatings on aerospace components are provided. In one or more embodiments, the method includes exposing an aerospace component to a first precursor and a first reactant to form a first deposited layer on a surface of the aerospace component by a first deposition process (e.g., CVD or ALD), and exposing the aerospace component to a second precursor and a second reactant to form a second deposited layer on the first deposited layer by a second deposition process. The first deposited layer and the second deposited layer have different compositions from each other. The method also includes repeating the first deposition process and the second deposition process to form a nanolaminate film stack having from 2 pairs to about 1,000 pairs of the first deposited layer and the second deposited layer consecutively deposited on each other.

公开(公告)号：US12220678B2

公开(公告)日：2025-02-11

申请号：US17073111

申请日：2020-10-16

Applicant: Applied Materials, Inc

Inventor： Govindraj Desai ,  Sekar Krishnasamy ,  Sumedh Acharya ,  Dakshalkumar Patel ,  Jonathan Frankel ,  Quoc Truong ,  Mario Cambron ,  Ravindra Patil

IPC: C23C16/44 ,  B01J8/00 ,  B01J19/00 ,  B05C19/00 ,  B05C19/02 ,  B05D1/00

Abstract: A reactor for coating particles includes a stationary vacuum chamber to hold a bed of particles to be coated, a chemical delivery system, and a paddle assembly. The paddle assembly includes a rotatable drive shaft and a first plurality of paddles and a second plurality of paddles that extend radially from the drive shaft. The spacing, cross-sections, and oblique angles of the paddles are such that orbiting of the paddles causes the first plurality of paddles and the second plurality of paddles to displace substantially equal volumes in opposite directions in the lower portion of the stationary vacuum chamber.

公开(公告)号：US12161759B2

公开(公告)日：2024-12-10

申请号：US17341213

申请日：2021-06-07

Applicant: Applied Materials, Inc.

Inventor： Fei Wang ,  Miaojun Wang ,  Balaji Ganapathy ,  Jonathan Frankel ,  Shivkumar Chiruvolu ,  Pravin K. Narwankar

IPC: A61K9/50 ,  A61K31/397 ,  A61K31/4422 ,  A61K31/517

Abstract: A pharmaceutical composition containing a metal oxide coated particle comprising 1) an amorphous solid dispersion (ASD) core containing an active pharmaceutical ingredient (API) and a polymer; and 2) a metal oxide coating, and the method of making said metal oxide coated particle by atomic layer deposition (ALD). The metal oxide coated particle is useful because it prevents the ASD from crystallization and helps maintain the ASD in an amorphous form.

公开(公告)号：US20230128094A1

公开(公告)日：2023-04-27

申请号：US17971511

申请日：2022-10-21

Applicant: Applied Materials, Inc.

Inventor： Brian Hayes Burrows ,  Sekar Krishnasamy ,  Ayyanagouda Raravi ,  Monika Mudalkar ,  Govindraj Desai ,  Hemantha Kumar Raju ,  Basavaraj Pattanshetty ,  David Masayuki Ishikawa ,  Visweswaren Sivaramakrishnan ,  Shrikant Swaminathan ,  Mario Cambron ,  Robert Navasca ,  Miaojun Wang ,  Jonathan Frankel

IPC: B05C19/02 ,  B01J8/38 ,  B01J8/18

Abstract: A reactor for coating particles includes a rotatable reactor assembly includes a reactor drum configured to hold a plurality of particles to be coated, an inlet tube, and an outlet tube. The drum includes a cylindrical tube, and an inlet-side endplate secured to cover an inlet-side opening of the cylindrical tube and/or an outlet-side endplate secured to cover an outlet-side opening of the cylindrical tube. A stationary gas inlet line is coupled to the inlet tube by a rotary inlet seal, a stationary gas outlet line is coupled to the outlet tube by a rotary outlet seal, and a motor rotates the rotatable reactor assembly. The inlet tube is releasably mechanically secured to the inlet-side endplate and the outlet tube is releasably mechanically secured to the outlet-side endplate.

公开(公告)号：US20230127489A1

公开(公告)日：2023-04-27

申请号：US17971504

申请日：2022-10-21

Applicant: Applied Materials, Inc.

Inventor： Brian Hayes Burrows ,  Sekar Krishnasamy ,  Ayyanagouda Raravi ,  Monika Mudalkar ,  Govindraj Desai ,  Hemantha Kumar Raju ,  Basavaraj Pattanshetty ,  David Masayuki Ishikawa ,  Visweswaren Sivaramakrishnan ,  Shrikant Swaminathan ,  Mario Cambron ,  Robert Navasca ,  Miaojun Wang ,  Jonathan Frankel

IPC: A61K9/16 ,  B01J19/28 ,  B01J19/00

Abstract: A reactor for coating particles includes a rotatable reactor assembly including a drum configured to hold a plurality of particles to be coated, an inlet tube, and an outlet tube, a stationary gas inlet line coupled to the inlet tube by a rotary inlet seal, a stationary gas outlet line coupled to the outlet tube by a rotary outlet seal, and a motor to rotate the rotatable reactor assembly.

公开(公告)号：US20210378971A1

公开(公告)日：2021-12-09

申请号：US17341213

申请日：2021-06-07

Applicant: Applied Materials, Inc.

Inventor： Fei Wang ,  Miaojun Wang ,  Balaji Ganapathy ,  Jonathan Frankel ,  Shivkumar Chiruvolu ,  Pravin K. Narwankar

IPC: A61K9/50 ,  A61K31/397 ,  A61K31/517 ,  A61K31/4422

Abstract: A pharmaceutical composition containing a metal oxide coated particle comprising 1) an amorphous solid dispersion (ASD) core containing an active pharmaceutical ingredient (API) and a polymer; and 2) a metal oxide coating, and the method of making said metal oxide coated particle by atomic layer deposition (ALD). The metal oxide coated particle is useful because it prevents the ASD from crystallization and helps maintain the ASD in an amorphous form.

公开(公告)号：US20200340108A1

公开(公告)日：2020-10-29

申请号：US16855887

申请日：2020-04-22

Applicant: Applied Materials, Inc.

Inventor： Jonathan Frankel ,  Quoc Truong ,  Sekar Krishnasamy ,  Govindraj Desai ,  Sandip S. Desai

IPC: C23C16/44 ,  C23C16/455

Abstract: A method of coating particles includes dispensing particles into a vacuum chamber to form a particle bed in at least a lower portion of the chamber that forms a half-cylinder, evacuating the chamber through a vacuum port in an upper portion of the chamber, rotating a paddle assembly such that a plurality of paddles orbit a drive shaft to stir the particles in the particle bed, injecting a reactant or precursor gas through a plurality of channels into the lower portion of the chamber as the paddle assembly rotates to coat the particles, and injecting the reactant or precursor gas or a purge gas through the plurality of channels at a sufficiently high velocity such that the reactant or precursor a purge gas de-agglomerates particles in the particle bed.

公开(公告)号：US20200338521A1

公开(公告)日：2020-10-29

申请号：US16855871

申请日：2020-04-22

Applicant: Applied Materials, Inc.

Inventor： Jonathan Frankel ,  Colin C. Neikirk ,  Pravin K. Narwankar ,  Quoc Truong ,  Govindraj Desai ,  Sekar Krishnasamy

IPC: B01J19/18 ,  B01F7/00 ,  B01F7/04 ,  B01J19/00

Abstract: A reactor for coating particles includes a stationary vacuum chamber having a lower portion that forms a half-cylinder and an upper portion to hold a bed of particles to be coated, a vacuum port in the upper portion of the chamber, a paddle assembly, a motor to rotate a drive shaft of the paddle assembly, a chemical delivery system to deliver a first fluid, and a first gas injection assembly to receive the first fluid from the chemical delivery system and having apertures configured to inject a first reactant or precursor gas into the lower portion of the chamber and such that the first reactant or precursor gas flows substantially tangent to a curved inner surface of the half-cylinder.