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公开(公告)号：US12161759B2
公开(公告)日：2024-12-10
申请号：US17341213
申请日：2021-06-07
Applicant: Applied Materials, Inc.
Inventor： Fei Wang , Miaojun Wang , Balaji Ganapathy , Jonathan Frankel , Shivkumar Chiruvolu , Pravin K. Narwankar
IPC: A61K9/50 , A61K31/397 , A61K31/4422 , A61K31/517
Abstract: A pharmaceutical composition containing a metal oxide coated particle comprising 1) an amorphous solid dispersion (ASD) core containing an active pharmaceutical ingredient (API) and a polymer; and 2) a metal oxide coating, and the method of making said metal oxide coated particle by atomic layer deposition (ALD). The metal oxide coated particle is useful because it prevents the ASD from crystallization and helps maintain the ASD in an amorphous form.
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公开(公告)号：US20210378971A1
公开(公告)日：2021-12-09
申请号：US17341213
申请日：2021-06-07
Applicant: Applied Materials, Inc.
Inventor： Fei Wang , Miaojun Wang , Balaji Ganapathy , Jonathan Frankel , Shivkumar Chiruvolu , Pravin K. Narwankar
IPC: A61K9/50 , A61K31/397 , A61K31/517 , A61K31/4422
Abstract: A pharmaceutical composition containing a metal oxide coated particle comprising 1) an amorphous solid dispersion (ASD) core containing an active pharmaceutical ingredient (API) and a polymer; and 2) a metal oxide coating, and the method of making said metal oxide coated particle by atomic layer deposition (ALD). The metal oxide coated particle is useful because it prevents the ASD from crystallization and helps maintain the ASD in an amorphous form.
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公开(公告)号：US20250009671A1
公开(公告)日：2025-01-09
申请号：US18737814
申请日：2024-06-07
Applicant: Applied Materials, Inc.
Inventor： Fei Wang , Miaojun Wang , Balaji Ganapathy , Jonathan Frankel , Shivkumar Chiruvolu , Pravin K. Narwankar
IPC: A61K9/50 , A61K31/397 , A61K31/4422 , A61K31/517
Abstract: A pharmaceutical composition containing a metal oxide coated particle comprising 1) an amorphous solid dispersion (ASD) core containing an active pharmaceutical ingredient (API) and a polymer; and 2) a metal oxide coating, and the method of making said metal oxide coated particle by atomic layer deposition (ALD). The metal oxide coated particle is useful because it prevents the ASD from crystallization and helps maintain the ASD in an amorphous form.
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公开(公告)号：US20230364023A1
公开(公告)日：2023-11-16
申请号：US18199614
申请日：2023-05-19
Applicant: Applied Materials, Inc.
Inventor： Miaojun Wang , Jonathan Frankel , Pravin K. Narwankar , Suneel Kumar Rastogi , Shivkumar Chiruvolu , Fei Wang , Balaji Ganapathy , Shrikant Swaminathan
IPC: A61K9/50
CPC classification number: A61K9/501 , A61K9/5089
Abstract: Methods for providing an inorganic oxide coating to high aspect ratio particles containing an active pharmaceutical ingredient are described as are compositions containing such coated particles.
