公开(公告)号：US12130295B2

公开(公告)日：2024-10-29

申请号：US17508309

申请日：2021-10-22

Applicant: LipoScience, Inc.

Inventor： James D. Otvos ,  Irina Y. Shalaurova

IPC: G01N33/92 ,  A61B5/00 ,  A61B5/055 ,  G01R33/465 ,  G16H10/40 ,  G16H50/30 ,  G16H50/50 ,  G16Z99/00 ,  G16B20/00 ,  G16C20/20

CPC classification number: G01N33/92 ,  A61B5/055 ,  A61B5/7275 ,  G01R33/465 ,  G16H10/40 ,  G16H50/30 ,  G16H50/50 ,  G16Z99/00 ,  G01N2800/32 ,  G16B20/00 ,  G16C20/20

Abstract: Disclosed are methods and systems to determine a subject's metabolic vulnerability index (MVX) score using at least one defined mathematical model of risk. The methods comprise evaluating various biomarkers to distinguish various health risks. In one embodiment, the method comprises evaluating biomarkers to determine a relative risk of premature all-cause mortality. The model may include NMR-derived measurements of GlycA, S-HDLP, branched chain amino acids (BCAAs), ketone bodies, total serum protein, and citrate in at least one biosample of the subject.

公开(公告)号：US20240345102A1

公开(公告)日：2024-10-17

申请号：US18682419

申请日：2022-08-05

Applicant: Siemens Healthcare Diagnostics

Inventor： Tivadar Mach ,  Peter Paulicka ,  Ramona Seliger ,  Frederick Stelling

IPC: G01N33/72 ,  B01L3/00 ,  G01N33/80 ,  G01N33/86 ,  G01N33/92

CPC classification number: G01N33/72 ,  B01L3/502761 ,  G01N33/80 ,  G01N33/86 ,  G01N33/92 ,  B01L2200/0652 ,  B01L2300/0654 ,  B01L2400/0436

Abstract: The disclosure relates to a device and method for analyzing a blood sample, particularly including pre-analytical (qualification), analytical and post-analytical (verification) testing. More particularly the disclosure relates in certain embodiments to a device configured for collecting, imaging and lysing blood cells in a sample vessel by means of ultrasonic acoustic waves, generated in the vessel by an acoustic transducer driven at one particular excitation frequency or more particular excitation frequencies, or one range of frequency or ranges of frequencies. In some non-limiting embodiments, the ultrasonic acoustic waves are generated by a single acoustic transducer. Further on, according to certain embodiments, the device and workflow are configured for three analytical steps in single device, comprising pre-analytical (qualification), analytical and post-analytical (verification) testing.

公开(公告)号：US12097207B1

公开(公告)日：2024-09-24

申请号：US17547496

申请日：2021-12-10

Applicant: Lipocine Inc.

Inventor： Mahesh V. Patel ,  Nachiappan Chidambaram ,  Satish K. Nachaegari ,  Burke Byrne ,  Kilyoung Kim ,  Jonathan A. Baker

IPC: A61K31/568 ,  A61K31/201 ,  A61K31/355 ,  A61P1/16 ,  G01N33/92 ,  A61K45/06

CPC classification number: A61K31/568 ,  A61K31/201 ,  A61K31/355 ,  A61P1/16 ,  G01N33/92 ,  A61K45/06 ,  G01N2800/085 ,  G01N2800/52

Abstract: Methods of treating a liver disease or condition, or a symptom thereof, in a subject in need of treatment, are disclosed and described. One method comprises orally administering to a subject, a pharmaceutical composition having an amount of a testosterone, or an ester thereof, sufficient to treat the liver disease or condition, or symptom thereof.

公开(公告)号：US20240307489A1

公开(公告)日：2024-09-19

申请号：US18576006

申请日：2022-07-01

Applicant: Westlake University

Inventor： Xu Li

IPC: A61K38/17 ,  A61P35/02 ,  A61P35/04 ,  C12N15/113 ,  G01N33/50 ,  G01N33/92

CPC classification number: A61K38/177 ,  A61P35/02 ,  A61P35/04 ,  C12N15/1138 ,  G01N33/5011 ,  G01N33/92 ,  C12N2310/14

Abstract: The present invention refers to a method for treating Notch signaling-dependent disease in the subject with a LRP1 specific inhibitor. The Notch signaling-dependent disease is selected from leukemia. Also provided is a method for screening a drug treating Notch signaling-dependent disease using LRP1 as a target.

公开(公告)号：US20240280594A1

公开(公告)日：2024-08-22

申请号：US18428771

申请日：2024-01-31

Applicant: Hoffmann-La Roche Inc.

Inventor： Apolline LEFÈVRE ,  Bjoern WAGNER

IPC: G01N33/92 ,  B01L3/00

CPC classification number: G01N33/92 ,  B01L3/50853 ,  B01L2200/16 ,  B01L2300/0829 ,  G01N2405/00

Abstract: The present invention relates to a method for determining the lipophilicity of a test compound comprising the steps of:



a) providing a multiwell plate, wherein the wells comprise at the bottom a lipophilic membrane and the bottom of the multiwell plate comprises a liquid tight barrier to produce a liquid tight bottom of the multiwell plate,
b) adding a non-polar solvent to the lipophilic membranes in the wells of step a),
c) adding an aqueous solution comprising the test compound to the wells of step b, and
d) determining the quantity of the test compound in the aqueous solution after a distribution equilibrium has been reached.

公开(公告)号：US12053775B2

公开(公告)日：2024-08-06

申请号：US17663020

申请日：2022-05-12

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Tie Wei ,  Jie Li ,  Yun Yue

IPC: G01N33/92 ,  B01L3/00

CPC classification number: B01L3/502715 ,  G01N33/92 ,  B01L2200/16 ,  B01L2300/087 ,  G01N2333/92

Abstract: Methods of mitigating lipoprotein interference in in vitro diagnostic assays for target hydrophobic analytes are disclosed, as well as compositions, kits, and devices useful in said methods. A pretreatment reagent is utilized that includes at least one enzyme that digests lipoprotein.

公开(公告)号：US20240241137A1

公开(公告)日：2024-07-18

申请号：US18543232

申请日：2023-12-18

Applicant: NATIONAL HEALTH RESEARCH INSTITUTES

Inventor： Shu-Yi LIN

IPC: G01N33/68 ,  G01N33/92

CPC classification number: G01N33/6896 ,  G01N33/92 ,  G01N2500/20 ,  G01N2800/52

Abstract: The present disclosure provides a method for selecting a drug candidate for treating or preventing or delaying the onset or progression of an amyloidogenic disease, comprising: (a) contacting an analyte with amyloid peptide 1-42 (Aβ42) and an amphiphilic liposaccharide or a part thereof, wherein the amphiphilic liposaccharide or the part thereof is capable of forming a complex with Aβ42; and (b) determining if the analyte extends an oscillatory event of the complex; and the analyte is selected as the drug candidate.

公开(公告)号：US20240230687A1

公开(公告)日：2024-07-11

申请号：US18554064

申请日：2022-04-06

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： Xin YAN ,  Tingyuan YANG ,  Shuli TANG ,  Xi CHEN

IPC: G01N33/92 ,  C07D213/73 ,  C07D401/12 ,  G01N33/58

CPC classification number: G01N33/92 ,  C07D213/73 ,  C07D401/12 ,  G01N33/58 ,  G01N2560/00

Abstract: The present disclosure provides compositions comprising novel mass tags. The disclosure also provides methods utilizing mass tags, including methods of quantifying one or more individual lipids from a composition of lipids, methods of identifying a double bond position of an individual lipid, methods of identifying a biological correlation of an individual lipid, and methods of preparing a lipid derivative.

公开(公告)号：US12007391B2

公开(公告)日：2024-06-11

申请号：US17101693

申请日：2020-11-23

Applicant: TURUN YLIOPISTO

Inventor： Robert Moulder ,  Santosh Bhosale ,  David Goodlett ,  Harri Lähdesmäki ,  Olli Simell ,  Riitta Lahesmaa

IPC: G01N31/00 ,  G01N33/53 ,  G01N33/564 ,  G01N33/92

CPC classification number: G01N33/564 ,  G01N33/92 ,  G01N2333/47 ,  G01N2333/4713 ,  G01N2333/4716 ,  G01N2333/76 ,  G01N2333/775 ,  G01N2560/00 ,  G01N2570/00 ,  G01N2800/042 ,  G01N2800/50 ,  G01N2800/60

Abstract: The present invention relates to methods for predicting a risk of a subject for Type 1 diabetes (T1D) on the basis of expression levels of protein markers in a sample obtained from the subject. The present invention also relates to in vitro kits for use in said methods.

公开(公告)号：US20240159779A1

公开(公告)日：2024-05-16

申请号：US18508448

申请日：2023-11-14

Applicant: VYTELLE LLC

Inventor： Bruno Valente Sanches ,  Tasha Gruhot

IPC: G01N33/92

CPC classification number: G01N33/92 ,  G01N2405/04 ,  G01N2405/08 ,  G01N2800/36

Abstract: The present disclosure provides, inter alia, methods for assessing suitability of a bovine animal as an effective surrogate dam for embryo implantation and maintenance of pregnancy, which methods include obtaining a lipidome profile for a bovine animal, quantifying the ratios of individual lipids, in particular phospholipids, and determining whether the bovine animal exhibits a lipid ratio profile that is predictive of successful embryo implantation and, thereby, assessing the likelihood of a successful in vitro fertilization (IVF) derived embryo implantation, and pregnancy. In further aspects, the present disclosure provides methods for generating a lipidome database. Also provided are compositions and kits for use in those methods to obtain and quantify the lipidome profile of a bovine animal.