公开(公告)号：US20240353430A1

公开(公告)日：2024-10-24

申请号：US18640521

申请日：2024-04-19

申请人： Worcester Polytechnic Institute

发明人： Kathryn Woodland ,  Madison Gass ,  Isabel Nearing ,  Grace Jolin ,  Ziya Isiksacan ,  Mathias Bonmarin ,  Sakthikumar Ambady ,  O. Berk Usta ,  Ahmet C. Sabuncu

IPC分类号： G01N33/72 ,  G01N21/78

CPC分类号： G01N33/726 ,  G01N21/78

摘要： A storage and monitoring device for red blood samples in storage for donation (blood bank) and research. Stored blood can be susceptible to degradation, most often from a phenomenon known as ice nucleation. Accurate detection and identification of relevant factors causing ice nucleation can determine healthy samples of stored blood, and identify storage factors that promote storage longevity. A photodetection approach directs an illumination source and photometer on opposed sides of a blood containing vessel for measuring an illuminance affected by hemoglobin released from ruptured cells. Hemoglobin released from ruptured cells reduces light passage though the sample to indicate unusable samples. An accelerometer and temperature sensor measure the physical and temperate factors correlating with the detected cell degradation to determine storage criteria for extending blood longevity.

公开(公告)号：US20240319210A1

公开(公告)日：2024-09-26

申请号：US18267469

申请日：2021-12-20

申请人： HUMAN METABOLOMICS INSTITUTE, INC.

发明人： Wei Jia ,  Guoxiang Xie ,  Kejun Zhou

IPC分类号： G01N33/72 ,  G01N30/02 ,  G01N30/72 ,  G01N30/88

CPC分类号： G01N33/728 ,  G01N30/7266 ,  G01N2030/027 ,  G01N2030/8822 ,  G01N2333/9108 ,  G01N2333/96419 ,  G01N2800/085

摘要： Disclosed in the present invention is an application of conjugated bilirubin as a biomarker in preparation of a diagnosis device for evaluating a risk of neonatal biliary atresia. Also disclosed in the present invention are a bilirubin content measurement method, a stable quantitative detection reagent for bilirubin, and an application of the quantitative detection reagent for bilirubin in preparation of a kit for measuring a content of the bilirubin and evaluating a risk of biliary atresia of a subject, infant hepatitis syndrome, α1 antitrypsin deficiency disease or Alagille syndrome. Also disclosed in the present invention are a kit for measuring the content of the bilirubin or evaluating the risk of neonatal biliary atresia, an application of the kit, a method for evaluating the risk of neonatal biliary atresia, and a device for predicting the risk of neonatal biliary atresia by using an expression level of the conjugated bilirubin. The present invention has the advantages of being simple and rapid, flexible in sample preparation, low in limit of detection, good in repeatability and high in sensitivity; and the sample preparation and detection method is simple and easy to implement, low in cost and suitable for popularization and use.

公开(公告)号：US20240310465A1

公开(公告)日：2024-09-19

申请号：US18608144

申请日：2024-03-18

申请人： Texas Tech University System

发明人： David P. Cistola

IPC分类号： G01N33/72

CPC分类号： G01R33/50 ,  G01N33/4925 ,  G01N33/726 ,  G01R33/465

摘要： Embodiments of the present disclosure pertain to methods of detecting hypoxemia in a subject by: (1) receiving a blood sample from the subject; (2) measuring the T2 relaxation time constant of the blood cell (e.g., blood cell pellet) of the blood sample (T2P value); and (3) correlating the measured T2P value to hypoxemia. In some embodiments, the methods of the present disclosure also include a step of correlating the measured T2P value to the subject's susceptibility to one or more hypoxemia-related conditions. Further embodiments of the present disclosure pertain to systems for detecting hypoxemia in a subject in accordance with the methods of the present disclosure.

公开(公告)号：US12085529B2

公开(公告)日：2024-09-10

申请号：US17056684

申请日：2019-05-17

申请人： PROVIGATE INC.

发明人： Narushi Ito ,  Mitsumi Nishi ,  Norikazu Katayama ,  Yuuya Miyazawa

IPC分类号： G01N27/327 ,  C12Q1/26 ,  G01N33/483 ,  G01N33/72

CPC分类号： G01N27/327 ,  C12Q1/26 ,  G01N33/483 ,  G01N33/72

摘要： Provided is a glycated protein sensor provided with: immobilized protease; immobilized ketoamine oxidase; and a hydrogen peroxide detection section.

公开(公告)号：US20240277666A1

公开(公告)日：2024-08-22

申请号：US18569263

申请日：2022-06-14

申请人： Scandion Oncology A/S

发明人： Peter Michael Vestlev ,  Nicklas Lindland Roest

IPC分类号： A61K31/41 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/519 ,  A61P35/00 ,  G01N33/72

CPC分类号： A61K31/41 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/519 ,  A61P35/00 ,  G01N33/728 ,  G01N2800/52

摘要： The present invention relates to treatment of subgroups of cancer patients, methods for identifying treatment and dosage regimens, as well as methods for identifying these subgroups of cancer patients.

公开(公告)号：US20240192232A1

公开(公告)日：2024-06-13

申请号：US18443138

申请日：2024-02-15

申请人： Instrumentation Laboratory Co.

发明人： Vitaly Dobromyslin ,  Shankar Balasubramanian

IPC分类号： G01N33/72 ,  B01L3/00 ,  G06T7/00

CPC分类号： G01N33/726 ,  B01L3/502715 ,  G06T7/0012 ,  G06T7/97 ,  B01L2300/0663 ,  G06T2207/30072 ,  G06T2207/30168

摘要： Technology described herein includes a method that includes obtaining an image of a fluid of a microfluidic analysis system. The microfluidic analysis system includes or receives a container that contains the fluid for measurement of analyte or quality determination. A region of interest (ROI) is identified based on the image. The ROI is a set of pixel values for use in the measurement of the analyte or the quality determination of the fluid, fluidic path, or measuring system. Identifying the ROI includes: determining an alignment of the container of the fluid with the imaging device based on the image, and identifying the ROI based on information about the measurement of the fluid or based on information about non-analyte features of the fluid. An analysis of the image of the fluid is performed using the set of pixel values of the ROI.

公开(公告)号：US11971424B2

公开(公告)日：2024-04-30

申请号：US17043354

申请日：2019-03-20

申请人： HITACHI HIGH-TECH CORPORATION ,  ROCHE DIAGNOSTICS OPERATIONS, INC.

发明人： Yuichi Hirabayashi ,  Dai Inagi ,  Satoshi Yokotsuka ,  Youichi Aruga ,  Mohamed Abouelsoud

IPC分类号： G01N33/68 ,  A01N1/02 ,  B01L3/00 ,  C07C309/65 ,  C07C309/73 ,  G01N1/40 ,  G01N21/01 ,  G01N21/31 ,  G01N21/33 ,  G01N21/64 ,  G01N27/414 ,  G01N33/52 ,  G01N33/532 ,  G01N33/543 ,  G01N33/569 ,  G01N33/72 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

CPC分类号： G01N35/025 ,  G01N35/00623 ,  G01N35/1002 ,  G01N35/1065 ,  G01N2035/00465 ,  G01N2035/00653 ,  G01N2035/00891 ,  G01N2035/0443 ,  G01N2035/0453

摘要： An automatic analyzer is provided which is easier to investigate when some troubles such as data abnormality occur in a sample analysis result as compared with an automatic analyzer according to the related art. The automatic analyzer includes: analysis units that perform analysis and quality control analysis for ensuring quality of the analysis; a storage medium that stores quality control results of the quality control analysis performed by the analysis units; a monitor that displays the quality control results; and a control PC that controls an operation of the analysis units (8, 9, and 16), executes, when an arbitrary result is selected from the quality control results stored in the storage medium, based on the selected quality control result, statistical calculation of the selected result and a quality control result performed in the past, and causes the monitor to display a statistical calculation screen as a statistical calculation result.

公开(公告)号：US20240094190A1

公开(公告)日：2024-03-21

申请号：US18013682

申请日：2021-10-19

申请人： Kristy MCKEATING ,  Herschel WATKINS ,  Google LLC

发明人： Kristy McKeating ,  Herschel Watkins

IPC分类号： G01N33/49 ,  B01L3/00 ,  G01N33/72

CPC分类号： G01N33/491 ,  B01L3/5023 ,  G01N33/726 ,  B01L2200/0652 ,  B01L2200/16 ,  B01L2300/0681 ,  B01L2400/0406

摘要： The present disclosure provides an assay device for determining a concentration of hemoglobin in a sample. The device includes a separation membrane containing a cell lysing reagent that is present on the separation membrane in an amount greater than 200 micrograms/square centimeter to less than 675 micrograms/square centimeter. Further, the device includes a downstream detection membrane configured to elicit a quantifiable response in the presence of hemoglobin. The detection membrane includes an asymmetric membrane having a first plurality of pores located towards an upstream side of the detection membrane and a second plurality of pores located towards a downstream side of the detection membrane. The first plurality of pores are larger than the second plurality of pores. The present disclosure also provides methods for using a vertical flow assay device to lyse the red blood cells in the sample to quantify the level of hemoglobin present via reflectance spectroscopy.

公开(公告)号：US11921106B2

公开(公告)日：2024-03-05

申请号：US17675759

申请日：2022-02-18

申请人： SYSMEX CORPORATION

发明人： Takaaki Nagai ,  Noriyuki Narisada ,  Daigo Fukuma ,  Masanori Imazu

IPC分类号： G01N15/12 ,  G01N15/00 ,  G01N15/14 ,  G01N33/50 ,  G01N33/72

CPC分类号： G01N33/5091 ,  G01N15/12 ,  G01N15/1459 ,  G01N33/5094 ,  G01N33/721 ,  G01N33/726 ,  G01N2015/0073 ,  G01N2015/0076 ,  G01N2015/008 ,  G01N2015/1486 ,  Y10T436/11 ,  Y10T436/113332

摘要： A sample analyzer prepares a measurement sample from a blood sample or a body fluid sample which differs from the blood sample; measures the prepared measurement sample; obtains characteristic information representing characteristics of the components in the measurement sample; sets either a blood measurement mode for measuring the blood sample, or a body fluid measurement mode for measuring the body fluid sample as an operating mode; and measures the measurement sample prepared from the blood sample by executing operations in the blood measurement mode when the blood measurement mode has been set, and measuring the measurement sample prepared from the body fluid sample by executing operations in the body fluid measurement mode that differs from the operations in the blood measurement mode when the body fluid measurement mode has been set, is disclosed. A computer program product is also disclosed.

公开(公告)号：US11896681B2

公开(公告)日：2024-02-13

申请号：US16343043

申请日：2018-05-14

申请人： BILIX CO., LTD.

发明人： Sang Yong Jon ,  Dong Yun Lee ,  Yong Hyun Lee ,  Do Hyun Yoo ,  Won Sik Jung

IPC分类号： A61K49/00 ,  A61K49/10 ,  A61K33/243 ,  A61K33/242 ,  A61K33/26 ,  A61K47/22 ,  G01N33/72

CPC分类号： A61K49/106 ,  A61K33/242 ,  A61K33/243 ,  A61K33/26 ,  A61K47/22 ,  G01N33/728

摘要： The present invention provides hydrophilic bilirubin derivative particles containing a metal, a use thereof, and a preparation method therefor. The bilirubin derivative particles of the present invention form coordinate bonds with various metals, and thus can be used in MR diagnosis, CT diagnosis, photo-acoustic diagnosis, PET diagnosis, or optical diagnosis. The bilirubin derivative particles of the present invention can release an anticancer drug encapsulated therein to the outside by the combination with a platinum-based anticancer drug and the degradation by a stimulation of light/reactive oxygen species, and exhibit anti-inflammatory and anticancer activities, and thus the bilirubin derivative particles of the present invention have a concept of theranostics in which the bilirubin derivative particles can be for therapeutic uses as well as diagnostic uses.