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公开(公告)号:US12072274B2
公开(公告)日:2024-08-27
申请号:US17276717
申请日:2019-09-16
IPC分类号: G01N15/12 , C12Q1/18 , G01N15/02 , G01N15/0227 , G01N15/10 , G01N15/1031
CPC分类号: G01N15/12 , C12Q1/18 , G01N15/0227 , G01N15/1023 , G01N15/1031 , G01N2015/0294 , G01N2015/1006 , G01N2015/1029 , G01N2015/103
摘要: A method of antimicrobial susceptibility testing comprises: preparing samples of microorganisms suspended in an electrolyte, comprising a first sample of the microorganisms unexposed to antimicrobial agents and a second sample of the microorganisms exposed to an antimicrobial agent; passing the first sample through an impedance flow cytometer to obtain a first impedance signal representing one or more components of impedance values of the unexposed microorganisms; passing the second sample through the impedance flow cytometer to obtain a second impedance signal representing one or more components of the impedance values of the exposed microorganisms; comparing the first impedance signal and the second impedance signal; and determining a susceptibility of the microorganisms to the antimicrobial agent based on any differences between the first impedance signal and second impedance signal.
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公开(公告)号:US12053774B2
公开(公告)日:2024-08-06
申请号:US17185177
申请日:2021-02-25
IPC分类号: G01N1/00 , B01L3/00 , G01N15/01 , G01N15/10 , G01N15/12 , G01N15/14 , G01N15/1434 , G01N21/01 , G01N21/359 , G01N21/53 , G01N21/64 , G01N21/78 , G01N35/00
CPC分类号: B01L3/502715 , B01L3/50273 , B01L3/502738 , G01N15/1434 , G01N21/01 , G01N21/359 , G01N21/532 , G01N21/6486 , G01N21/78 , G01N35/00029 , G01N35/00871 , B01L2200/027 , B01L2200/028 , B01L2200/0689 , B01L2300/0627 , B01L2300/0816 , B01L2300/0832 , B01L2300/0861 , B01L2400/0487 , G01N15/01 , G01N2015/1006 , G01N15/12 , G01N15/1459 , G01N2021/6493 , G01N2035/00158 , G01N2035/00326 , G01N2035/00356 , G01N2035/00881 , G01N2201/024 , G01N2201/06113 , G01N2201/062
摘要: A modular analytic system includes a base, at least one fluid sample processing module configured to be removably attached to the base, at least one fluid sample analysis module configured to be removably attached to the base, a fluid actuation module positioned on the base, a fluidic network comprising multiple fluidic channels, in which the fluid actuation module is arranged to control transport of a fluid sample between the at least one sample processing module and the at least one sample analysis module through the fluidic network, and an electronic processor, in which the electronic processor is configured to control operation of the fluid actuation module and receive measurement data from the at least one fluid sample analysis module.
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公开(公告)号:US20180188236A1
公开(公告)日:2018-07-05
申请号:US15908339
申请日:2018-02-28
申请人: SYSMEX CORPORATION
发明人: Takaaki Nagai , Noriyuki Narisada , Daigo Fukuma , Masanori Imazu
CPC分类号: G01N33/5091 , G01N15/12 , G01N15/1459 , G01N33/5094 , G01N33/721 , G01N33/726 , G01N2015/0073 , G01N2015/0076 , G01N2015/008 , G01N2015/1486 , Y10T436/11 , Y10T436/113332
摘要: A sample analyzer prepares a measurement sample from a blood sample or a body fluid sample which differs from the blood sample; measures the prepared measurement sample; obtains characteristic information representing characteristics of the components in the measurement sample; sets either a blood measurement mode for measuring the blood sample, or a body fluid measurement mode for measuring the body fluid sample as an operating mode; and measures the measurement sample prepared from the blood sample by executing operations in the blood measurement mode when the blood measurement mode has been set, and measuring the measurement sample prepared from the body fluid sample by executing operations in the body fluid measurement mode that differs from the operations in the blood measurement mode when the body fluid measurement mode has been set, is disclosed. A computer program product is also disclosed.
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公开(公告)号:US20170276642A1
公开(公告)日:2017-09-28
申请号:US15603384
申请日:2017-05-23
发明人: Tao Shen , Huilin Shi , Jin Teng , Wenheng Guo
IPC分类号: G01N27/416
CPC分类号: G01N27/4163 , G01N15/12 , G01N2015/1272 , G01N2015/1281
摘要: The present disclosure provides a particle analyzer and a particle test control method and device thereof. A method comprises, after acquiring a diluted sample, preserving a part of the diluted sample, and monitoring whether a pore blocking event occurs during a counting process; when the pore blocking event occurs, suspending the test of the sample, and performing an unblocking operation; and after the unblocking operation is completed, controlling a liquid addition system to again acquire the preserved part of the sample from a reaction cell or a tube of the liquid addition system and inject it into a counting cell, and then re-counting the sample in the counting cell by an impedance method. The method makes full use of the residual diluted sample for a second test to eliminate the impact of pore blocking that occurs in the first measurement of the sample on the test result, and there is no need to be place the sample tube again at test position for re-acquisition and re-dilution, thereby reducing the probability of pore blocking.
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公开(公告)号:US09588102B2
公开(公告)日:2017-03-07
申请号:US14812088
申请日:2015-07-29
IPC分类号: G01N33/00 , G01N31/00 , G01N33/49 , C12Q1/06 , G06F19/00 , G01N27/02 , G01N15/00 , G01N21/49 , G01N21/59 , G01N35/08 , G01N15/12 , G01N15/10 , G01N15/14
CPC分类号: G01N33/49 , C12Q1/06 , G01N15/00 , G01N15/12 , G01N15/14 , G01N15/1456 , G01N15/1459 , G01N21/49 , G01N21/59 , G01N27/02 , G01N33/4915 , G01N35/08 , G01N2015/0065 , G01N2015/0073 , G01N2015/008 , G01N2015/1006 , G01N2015/1037 , G01N2015/1402 , G01N2015/1413 , G01N2015/1486 , G06F19/00 , G16H50/20
摘要: Embodiments of the present invention encompass automated systems and methods for analyzing white blood cell parameters in an individual based on a biological sample obtained from blood of the individual. Exemplary techniques involve correlating aspects of direct current (DC) impedance, radiofrequency (RF) conductivity, and/or light measurement data obtained from the biological sample with an evaluation of white blood cell conditions in the individual.
摘要翻译: 本发明的实施方案包括基于从个体的血液获得的生物样品来分析个体中的白细胞参数的自动化系统和方法。 示例性技术涉及将来自生物样品的直流(DC)阻抗,射频(RF)电导率和/或光测量数据的方面与个体中的白细胞状况的评估相关联。
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公开(公告)号:US20160282377A1
公开(公告)日:2016-09-29
申请号:US15081175
申请日:2016-03-25
申请人: Sysmex Corporation
发明人: Takaaki NAGAI , Akio TOYODA
CPC分类号: G01N35/00663 , G01N1/38 , G01N15/12 , G01N15/1459 , G01N21/31 , G01N27/08 , G01N33/726 , G01N33/80 , G01N35/1004 , G01N35/1095 , G01N2015/0073 , G01N2015/1006 , G01N2015/1037 , G01N2015/1272 , G01N2015/1486 , G01N2035/00673 , G01N2333/805
摘要: A blood measuring device comprises a reagent preparation unit and a measurement unit and a controller. The controller is configured to control the fluid supplying part to wash the sites least affecting the measurement results of the measurement sample using pure water, and wash the sites affecting the measurement results of the measurement sample using the reagent, when the measurement unit performs the washing operation.
摘要翻译: 血液测量装置包括试剂调制单元和测量单元以及控制器。 控制器被配置为控制流体供应部分,以使用纯净水清洗最少影响测量样品的测量结果的部位,并且当测量单元进行洗涤时,使用试剂洗涤影响测量样品测量结果的部位 操作。
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公开(公告)号:US20160282254A1
公开(公告)日:2016-09-29
申请号:US15006332
申请日:2016-01-26
申请人: E. I. SPECTRA, LLC
发明人: Harold E. Ayliffe
CPC分类号: G01N15/1404 , B01L3/502715 , B01L3/502761 , B01L99/00 , B01L2300/0645 , B01L2300/0874 , B01L2300/0887 , B01L2400/0487 , G01N15/1056 , G01N15/12 , G01N15/1209 , G01N15/1456 , G01N15/1463 , G01N27/00 , G01N33/49 , G01N35/00 , G01N2015/1037 , G01N2015/1062 , G01N2015/1087 , G01N2035/00306 , G06F17/40 , G06F19/00 , H01J49/0013 , H01J49/0022
摘要: A portable, stand-alone microfluidic interrogation device including a microprocessor and a touch-screen display. The touch screen display can receive one or more user input to select a particular particle interrogation procedure, and subsequently show interrogation results. A microfluidic path extending through the interrogation device, includes alignment structure that defines an interrogation zone in which particles carried in a fluid are urged toward single-file travel. Operable alignment structure may define sheath-, or non-sheath fluid flow. Desirably, a portion of the alignment structure is removable from the. device in a tool-free procedure, The device may operate under the Coulter principle, and/or detect Stokes' shift phenomena, and/or other optically-based signal(s).
摘要翻译: 一种便携式,独立的微流体询问装置,其包括微处理器和触摸屏显示器。 触摸屏显示器可以接收一个或多个用户输入以选择特定的粒子询问过程,并随后显示询问结果。 延伸穿过询问装置的微流体路径包括对准结构,该对准结构限定了询问区域,其中流体中携带的颗粒被推向单文件传送。 可操作的对准结构可以限定鞘或非鞘液流。 期望地,对准结构的一部分可从该可移除的位置移除。 该设备可以在库尔特原理下操作,和/或检测斯托克斯的移位现象和/或其他基于光学的信号。
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公开(公告)号:US20160187335A1
公开(公告)日:2016-06-30
申请号:US14959133
申请日:2015-12-04
发明人: Sadato HONGO , Hirohisa MIYAMOTO
IPC分类号: G01N33/561 , G01N27/40 , G01N27/447
CPC分类号: G01N27/40 , B82Y5/00 , B82Y15/00 , G01N15/12 , G01N33/48728 , G01N33/54346 , G01N33/54366 , G01N2015/1236
摘要: According to one embodiment, a method for detecting a sample includes preparing a device for detecting a sample, the device including a measurement cassette, a first chamber formed by partitioning the cassette with a partition wall, a through-hole provided in the partition wall, a first electrode provided in the cassette, and a second electrode provided in the cassette, introducing a reagent and a sample containing a measuring object substance into the first chamber, introducing a conductive liquid into the second chamber, supplying current to the through-hole, allowing the measuring object substance whose surface is bound to and is covered by the tag particles via the capture substance in the first chamber to pass through the through-hole, and detecting presence of the measuring object substance.
摘要翻译: 根据一个实施例,一种用于检测样品的方法包括制备用于检测样品的装置,所述装置包括测量盒,通过用隔板分隔盒形成的第一室,设置在分隔壁中的通孔, 设置在盒中的第一电极和设置在盒中的第二电极,将试剂和含有测量对象物质的样品引入到第一室中,将导电液体引入第二室,向通孔提供电流, 允许表面被第一室中的捕获物质结合并被标签颗粒覆盖的测量对象物质通过通孔,并检测测量对象物质的存在。
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公开(公告)号:US09322820B2
公开(公告)日:2016-04-26
申请号:US13828230
申请日:2013-03-14
发明人: Robert H. Blick , Eric James Stava
IPC分类号: G01N27/00 , G01N33/487 , G01N15/12
CPC分类号: G01N33/48721 , C12Q1/6869 , G01N15/12 , G01N15/1218 , G01N15/1227
摘要: A piezoelectric substrate having a nanopore opening that separates two reservoirs of conductive fluid may provide for sensitive biological measurements by allowing control of the size of the nanopore according to piezoelectric stimulation of the substrate. Multiple embodiments are provided of monolithic piezoelectric substrates and nanopores for this purpose as well as a control system for controlling the nanopore dimensions electrically using AC or DC waveforms.
摘要翻译: 具有分离两个导电流体储存器的纳米孔开口的压电基片可以通过根据基底的压电刺激来控制纳米孔的尺寸来提供灵敏的生物学测量。 提供了用于此目的的单片压电基片和纳米孔的多个实施例,以及用AC或DC波形电控制纳米孔尺寸的控制系统。
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公开(公告)号:US09316576B2
公开(公告)日:2016-04-19
申请号:US14011666
申请日:2013-08-27
发明人: Sadato Hongo , Kentaro Kobayashi , Hideto Furuyama
IPC分类号: G01N15/12 , G01N33/53 , G01N33/543 , G01N33/58 , G01N15/10
CPC分类号: G01N15/12 , G01N15/1031 , G01N33/53 , G01N33/5438 , G01N33/587 , G01N2015/1087 , G01N2015/1093
摘要: According to one embodiment, a sample detection apparatus including an insulating partition to divide a first and a second region, a pore formed in the partition, a first electrode arranged in the first region, a second electrode arranged in the second region, a power source configured to apply electrical current between the first and second electrode in a state in which a reagent containing a capture substance to be bound to a target and a tag particle bound to the capture substance is introduced into the first region together with a sample, and an electrolyte solution is introduced into the second region, a measurement unit configured to observe a change in a conductive state, and a detection unit to detect presence/absence of the target in the sample based on an observation result.
摘要翻译: 根据一个实施例,一种样本检测装置,包括分隔第一和第二区域的绝缘隔板,形成在隔板中的孔,布置在第一区域中的第一电极,布置在第二区域中的第二电极,电源 被配置为在所述第一和第二电极之间以与待结合的捕获物质的试剂和与所述捕获物质结合的标签颗粒与试样一起被引入到所述第一区域的状态,在所述第一和第二电极之间施加电流, 电解质溶液被引入到第二区域中,测量单元被配置为观察导电状态的变化,以及检测单元,其基于观察结果来检测样品中的目标的存在/不存在。
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