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    DEVICE FOR COUNTING PARTICLES
    1.
    发明申请
    DEVICE FOR COUNTING PARTICLES 审中-公开

    公开(公告)号：US20180088020A1

    公开(公告)日：2018-03-29

    申请号：US15563427

    申请日：2016-04-01

    申请人： HORIBA ABAX SAS

    发明人： Guilhem COUDERC

    IPC分类号： G01N15/12

    CPC分类号： G01N15/1227 ,  G01N2015/1062

    摘要： A device for counting particles comprises a detector arranged to produce an electrical measurement signal in response to the passage of one or more particles, and a comparator arranged to compare the measurement signal with a threshold signal and to increment a counting value when the measurement signal exceeds the threshold signal, characterized in that it furthermore comprises a threshold-adjusting circuit that applies a lowpass filter to the measurement signal, and that is connected to the comparator in order to use the resulting signal as threshold signal.

    Device and method for detecting bioelectric signals from electrophysiologically active regions in spheroids
    5.
    发明申请
    Device and method for detecting bioelectric signals from electrophysiologically active regions in spheroids 失效
    用于检测球状体中电生理活性区域的生物电信号的装置和方法

    公开(公告)号：US20040209351A1

    公开(公告)日：2004-10-21

    申请号：US10487711

    申请日：2004-02-26

    发明人： Hagen Thielecke ,  Andres Robitzki

    IPC分类号： C12M001/34

    CPC分类号： G01N15/1475 ,  C12M41/46 ,  G01N15/1227 ,  G01N2015/1254 ,  G01N2015/1263

    摘要： Disclosed is a device for detecting bioelectric signals from spheroids comprising a measuring chamber having a measuring chamber wall which encloses a volume, which is open at least at one side, is composed of an electrically non-conducting material, and has, in at least one measuring region, an inner cross section, which corresponds as far as possible to the largest cross section of a spheroid, comprising at least a number of electrodes which are disposed in a common plane inside said measuring chamber wall and each electrode has a freely accessible electrode surface which is oriented towards the measuring region, and comprising an impedance measuring arrangement which is connected to the electrodes. The device and the method can be used to test substances in 3D biological in-vitro (three-dimensional) cell aggregates.

    摘要翻译： 公开了一种用于检测来自球体的生物电信号的装置，包括具有测量室壁的测量室，所述测量室围绕至少在一侧开放的体积，该体积由不导电材料构成，并且在至少一个 测量区域，尽可能对应于球状体的最大横截面的内部横截面，包括至少多个电极，所述至少一些电极设置在所述测量室壁内部的公共平面中，并且每个电极具有可自由访问的电极 表面朝向测量区域定向，并且包括连接到电极的阻抗测量装置。 该装置和方法可用于测试3D生物体外（三维）细胞聚集体中的物质。

    Duet jfet rf oscillator-detector for flow cytometer
    6.
    发明授权
    Duet jfet rf oscillator-detector for flow cytometer 有权
    用于流式细胞仪的Duet jfet rf振荡器检测器

    公开(公告)号：US06452372B1

    公开(公告)日：2002-09-17

    申请号：US09952701

    申请日：2001-09-14

    申请人： Frederick K. Husher ,  Gerard Schneider ,  Lazaro Ramirez

    发明人： Frederick K. Husher ,  Gerard Schneider ,  Lazaro Ramirez

    IPC分类号： G01N2700

    CPC分类号： G01N15/1227 ,  H03B5/1206 ,  H03B5/1231 ,  H03B5/124 ,  H03B2200/0038

    摘要： A junction field effect transistor (JFET) RF oscillator-detector circuit generates an RF signal for an apparatus for conducting electrical measurements of particles contained in a carrier fluid passing through an aperture in a cytometer flow cell. The JFET oscillator includes a plurality of parallel-coupled JFETs having respectively different VDS vs. IDS characteristics, that are biased to operate at square law detection regions of their respective VDS vs. IDS characteristics. One JFET operates in Class C mode, while the other operates in Class AB mode. An RF resonant circuit is electrically coupled to the JFETs and to the measurement cell, and is operative to establish the frequency of an RF field applied to the measurement cell. An RF load change detection circuit is coupled to the RF resonator circuit and is operative to detect an RF load change associated with a modification of the RF field as a result of a particle within the measurement cell aperture.

    摘要翻译： 结型场效应晶体管（JFET）RF振荡器检测器电路产生RF信号，用于对包含在通过细胞仪流通池中的孔的载体流体中的颗粒进行电测量的装置。 JFET振荡器包括分别具有不同的VDS与IDS特性的多个并联耦合的JFET，其被偏置以在它们各自的VDS与IDS特性的平方律检测区域操作。 一个JFET工作在C类模式，另一个工作在AB类模式。 RF谐振电路电耦合到JFET和测量单元，并且可操作地建立施加到测量单元的RF场的频率。 RF负载变化检测电路耦合到RF谐振器电路，并且可操作以由于测量单元孔径内的颗粒的结果来检测与RF场的修改相关联的RF负载变化。

    Method of and apparatus for determining a property of a sample
    7.
    发明授权
    Method of and apparatus for determining a property of a sample 失效
    用于确定样品性质的方法和装置

    公开(公告)号：US5691633A

    公开(公告)日：1997-11-25

    申请号：US374659

    申请日：1995-04-07

    申请人： Ying Liu ,  Eric William Abel ,  Jill Janette Freda Belch ,  Richard John Tweedie

    发明人： Ying Liu ,  Eric William Abel ,  Jill Janette Freda Belch ,  Richard John Tweedie

    IPC分类号： G01N33/49 ,  G01N15/12 ,  G01N27/02 ,  G01N33/487 ,  G01N33/48

    CPC分类号： G01N15/12 ,  G01N15/1218 ,  G01N15/1227

    摘要： An apparatus and method for determining a property of a sample, derived from a response obtained from the sample after an electrical pulse has been applied to it. Blood cells are subjected to an electrical pulse, a response is obtained using data retrieval means and a Fourier Transform is applied to the response. As the pulse applied is of very short duration (ideally a Dirac pulse) the Fourier transform yields information across a very broad bandwidth, typically several MHz, and accordingly a wide range of frequency response data is obtained. Certain cellular defects can be deduced from the transformed data. A detector is provided to detect precisely the presence of a cell as it passes through a particular region of an oriface. This is then used to trigger the pulse at a precisely controlled instant. This reduces the effect of random dispersion and can be adapted to ignore noise peaks which inevitably occur. The invention may be operated continuously and provides information across a bandwidth which is wider than was previously possible.

    摘要翻译： PCT No.PCT / GB93 / 01544 Sec。 371日期：1995年4月7日 102（e）1995年4月7日PCT PCT 1993年7月22日PCT公布。 公开号WO94 / 02846 日期1994年2月3日一种用于确定样品性质的装置和方法，其来自在施加电脉冲之后从样品获得的响应。 对血细胞进行电脉冲，使用数据检索装置获得响应，并且对响应应用傅里叶变换。 当施加的脉冲持续时间非常短（理想地是狄拉克脉冲）时，傅立叶变换通过非常宽的带宽（通常为几MHz）产生信息，因此获得宽范围的频率响应数据。 某些细胞缺陷可以从转化的数据中推导出来。 提供了一种检测器，用于精确检测细胞在通过一个特定区域时的存在。 然后将其用于在精确控制的瞬间触发脉冲。 这减少了随机色散的影响，并且可以适应于忽略不可避免地发生的噪声峰值。 本发明可以连续地操作，并且跨越比以前更宽的带宽提供信息。

    Particle analyzer for measuring the resistance and reactance of a particle
    9.
    发明授权
    Particle analyzer for measuring the resistance and reactance of a particle 失效
    用于测量颗粒的电阻和电抗的粒子分析仪

    公开(公告)号：US4791355A

    公开(公告)日：1988-12-13

    申请号：US921654

    申请日：1986-10-21

    申请人： Wallace H. Coulter ,  Carlos M. Rodriguez

    发明人： Wallace H. Coulter ,  Carlos M. Rodriguez

    IPC分类号： G01N15/12 ,  G01N33/48 ,  G01N27/00

    CPC分类号： G01N15/1227 ,  G01N2015/129

    摘要： A circuit, which is useful to provide data needed to measure the electrical opacity of a particle, for instance a blood cell, passing through a Coulter type transducer, includes a current source for providing a conventional d.c. current through the sensing aperture of the transducer, as well as an oscillator for providing a high frequency current through the aperture. The oscillator includes an active device and a resonant circuit, and the aperture is coupled in parallel with the resonant circuit of the oscillator. The oscillator can be any type of oscillator, such as a Hartley oscillator. As a particle passes through the aperture, the resistance of the aperture increases, which in turn, increases the Q of the oscillator circuit, whereby the oscillator output signal is amplitude modulated in accordance with the increased Q. This amplitude modulated signal can be detected to provide a value based on the high frequency reactance of the particle being detected. The change in d.c. resistance due to a particle passing through the aperture is detected in a conventional manner. The detected amplitudes of the a.c. and d.c. signals then can be compared to determine the opacity of each particle. Multiple oscillators of different frequencies can be coupled in parallel with the transducer through a coupling circuit, which connects each oscillator to the transducer through a low impedance path and isolates each oscillator from signals having frequencies of the other oscillators.

    摘要翻译： 用于提供测量通过Coulter型换能器的颗粒（例如血细胞）的电气不透明度所需的数据的电路包括用于提供常规直流电流的电流源。 通过传感器的感测孔径的电流，以及用于提供通过孔径的高频电流的振荡器。 振荡器包括有源器件和谐振电路，并且该孔与振荡器的谐振电路并联耦合。 振荡器可以是任何类型的振荡器，例如Hartley振荡器。 当颗粒通过孔径时，孔径的电阻增加，这又增加了振荡器电路的Q，由此根据增加的Q对振荡器输出信号进行幅度调制。该幅度调制信号可以被检测为 提供基于所检测的粒子的高频电抗的值。 d.c.的变化 以常规方式检测通过孔径的颗粒的电阻。 检测到的a.c.的振幅。 和d.c. 然后可以比较信号来确定每个粒子的不透明度。 不同频率的多个振荡器可以通过耦合电路与传感器并联耦合，该耦合电路通过低阻抗路径将每个振荡器连接到换能器，并将每个振荡器与具有其他振荡器频率的信号隔离开来。

    Tandem sensing zones for improved signal-to-noise ratio in particle analyzer
    10.
    发明授权
    Tandem sensing zones for improved signal-to-noise ratio in particle analyzer 失效
    串联检测区，可提高粒子分析仪的信噪比

    公开(公告)号：US4438390A

    公开(公告)日：1984-03-20

    申请号：US246755

    申请日：1981-03-23

    申请人： Walter R. Hogg

    发明人： Walter R. Hogg

    IPC分类号： G01N15/12 ,  G01N27/00

    CPC分类号： G01N15/1227 ,  G01N15/1218 ,  G01N15/1245

    摘要： A tandem arrangement of sensing zones is established by alternately arranged electrodes and dielectric plates, each sensing zone has a particle sensing aperture, through which microscopic particles in an electrolyte suspension pass and electric current flows. The apertures are aligned. This tandem sensing zone arrangement improves the signal-to-noise ratio of a particle analyzing apparatus in which it is employed.

    摘要翻译： 通过交替布置的电极和电介质板建立感测区的串联布置，每个感测区具有粒子感测孔，电解质悬浮液中的微小颗粒通过该孔传播并且电流流动。 孔对齐。 该串联感测区域布置改善了使用它的粒子分析装置的信噪比。