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    Device and method for detecting bioelectric signals from electrophysiologically active regions in spheroids
    1.
    发明授权
    Device and method for detecting bioelectric signals from electrophysiologically active regions in spheroids 失效
    用于检测球状体中电生理活性区域的生物电信号的装置和方法

    公开(公告)号：US07709246B2

    公开(公告)日：2010-05-04

    申请号：US10487711

    申请日：2002-08-20

    Applicant: Hagen Thielecke ,  Andrea Robitzki

    Inventor： Hagen Thielecke ,  Andrea Robitzki

    IPC: C12M1/34 ,  C12Q1/00

    CPC classification number: G01N15/1475 ,  C12M41/46 ,  G01N15/1227 ,  G01N2015/1254 ,  G01N2015/1263

    Abstract: Disclosed is a device for detecting bioelectric signals from spheroids comprising a measuring chamber having a measuring chamber wall which encloses a volume, which is open at least at one side, is composed of an electrically non-conducting material, and has, in at least one measuring region, an inner cross section, which corresponds as far as possible to the largest cross section of a spheroid, comprising at least a number of electrodes which are disposed in a common plane inside said measuring chamber wall and each electrode has a freely accessible electrode surface which is oriented towards the measuring region, and comprising an impedance measuring arrangement which is connected to the electrodes. The device and the method can be used to test substances in 3D biological in-vitro (three-dimensional) cell aggregates.

    Abstract translation: 公开了一种用于检测来自球体的生物电信号的装置，包括具有测量室壁的测量室，所述测量室围绕至少在一侧开放的体积，该体积由不导电材料构成，并且在至少一个 测量区域，尽可能对应于球状体的最大横截面的内部横截面，包括至少多个电极，所述至少一些电极设置在所述测量室壁内部的公共平面中，并且每个电极具有可自由访问的电极 表面朝向测量区域定向，并且包括连接到电极的阻抗测量装置。 该装置和方法可用于测试3D生物体外（三维）细胞聚集体中的物质。

    BLOOD MEASURING APPARATUS
    3.
    发明申请
    BLOOD MEASURING APPARATUS 有权
    血液测量装置

    公开(公告)号：US20150020613A1

    公开(公告)日：2015-01-22

    申请号：US14336587

    申请日：2014-07-21

    Applicant: NIHON KOHDEN CORPORATION

    Inventor： Yoshihiro Niiyama ,  Satoshi Suzuki ,  Koji Masuda

    IPC: G01N1/28 ,  G01N33/49

    CPC classification number: G01N1/28 ,  G01N15/12 ,  G01N15/1404 ,  G01N33/49 ,  G01N2015/1006 ,  G01N2015/1236 ,  G01N2015/1263 ,  G01N2015/1411

    Abstract: A blood measuring apparatus includes: a liquid supply source storing a sheath liquid and applying a pressure to supply the sheath liquid to first and second chambers, pressures of the sheath liquids to be supplied to the first and second chambers different from each other; a sheath flow generator sending a blood sample supplied to the first chamber, to the aperture while causing the blood sample to be converged by a sheath flow due to the sheath liquid supplied from the liquid supply source; and a swirling flow generator causing the blood sample in the second chamber, to be converged by a swirling flow due to the sheath liquid supplied from the liquid supply source, thereby allowing the blood sample to flow in a direction separating from the aperture.

    Abstract translation: 血液测量装置包括：液体供应源，其存储鞘液，并施加压力以将鞘液供应到第一和第二腔室;供应给第一和第二腔室的鞘液的压力彼此不同; 将供给到第一室的血液试样送到孔的鞘流发生器，同时由于从液体供给源供给的皮肤液体，使血液样品被鞘流收敛; 并且使由第二腔室中的血液样本引起的旋流产生器由于从液体供给源供给的鞘液而由旋转流会聚，从而允许血液样本沿与孔径分离的方向流动。

    FLOW CHANNEL DEVICE, PARTICLE SORTING APPARATUS, PARTICLE OUTFLOW METHOD, AND PARTICLE SORTING METHOD
    4.
    发明申请
    FLOW CHANNEL DEVICE, PARTICLE SORTING APPARATUS, PARTICLE OUTFLOW METHOD, AND PARTICLE SORTING METHOD 有权
    流通道装置，颗粒分选装置，颗粒流出方法和粒子分选方法

    公开(公告)号：US20140261757A1

    公开(公告)日：2014-09-18

    申请号：US14184904

    申请日：2014-02-20

    Applicant: Sony Corporation

    Inventor： Yoichi Katsumoto

    IPC: F17D1/00

    CPC classification number: F17D1/00 ,  B01L2200/0652 ,  B01L2300/0864 ,  B07C5/342 ,  G01N15/1245 ,  G01N15/1404 ,  G01N2015/1006 ,  G01N2015/1236 ,  G01N2015/1263 ,  G01N2015/1413 ,  G01N2015/149 ,  Y10T137/4891

    Abstract: A flow channel device includes an inflow unit into which a transfer fluid that transfers particles is caused to flow, a first outflow unit including an inflow port into which a part of the transfer fluid caused to flow from the inflow unit is caused to flow, a holding unit that is connected to the inflow port and holds particles, and a particle outflow port from which the particles held in the holding unit are caused to flow out to a predetermined flow channel area by the transfer fluid caused to flow from the inflow port, and a second outflow unit including a peripheral outflow channel through which another part of the transfer fluid caused to flow from the inflow unit is caused to flow out to a peripheral flow channel area that surrounds the predetermined flow channel area, the peripheral outflow channel surrounding at least the particle outflow port.

    Abstract translation: 流动通道装置包括：流入单元，使流过粒子的输送流体流入该流入单元;第一流出单元，具有流入所述流入单元流入的输送流体的一部分的流入口， 保持单元，其连接到流入口并保持颗粒;以及颗粒流出端口，通过所述输送流体从所述流入口流出，保持在所述保持单元中的颗粒从所述颗粒流出端口流出到预定的流路区域， 以及第二流出单元，其包括周边流出通道，使来自流入单元的流体的另一部分通过该流出通道流出到围绕预定流路区域的周边流动通道区域，周边流出通道围绕在 最少颗粒流出口。

    Flow channel device, particle sorting apparatus, particle outflow method, and particle sorting method
    6.
    发明授权
    Flow channel device, particle sorting apparatus, particle outflow method, and particle sorting method 有权
    流道装置，粒子分选装置，粒子流出法，粒子分选法等

    公开(公告)号：US09429276B2

    公开(公告)日：2016-08-30

    申请号：US14184904

    申请日：2014-02-20

    Applicant: Sony Corporation

    Inventor： Yoichi Katsumoto

    IPC: B07C5/34 ,  F17D1/00 ,  G01N15/12 ,  B07C5/342 ,  G01N15/10 ,  G01N15/14

    CPC classification number: F17D1/00 ,  B01L2200/0652 ,  B01L2300/0864 ,  B07C5/342 ,  G01N15/1245 ,  G01N15/1404 ,  G01N2015/1006 ,  G01N2015/1236 ,  G01N2015/1263 ,  G01N2015/1413 ,  G01N2015/149 ,  Y10T137/4891

    Abstract: A flow channel device includes an inflow unit into which a transfer fluid that transfers particles is caused to flow, a first outflow unit including an inflow port into which a part of the transfer fluid caused to flow from the inflow unit is caused to flow, a holding unit that is connected to the inflow port and holds particles, and a particle outflow port from which the particles held in the holding unit are caused to flow out to a predetermined flow channel area by the transfer fluid caused to flow from the inflow port, and a second outflow unit including a peripheral outflow channel through which another part of the transfer fluid caused to flow from the inflow unit is caused to flow out to a peripheral flow channel area that surrounds the predetermined flow channel area, the peripheral outflow channel surrounding at least the particle outflow port.

    Abstract translation: 流动通道装置包括：流入单元，使流过粒子的输送流体流入该流入单元;第一流出单元，具有流入所述流入单元流入的输送流体的一部分的流入口， 保持单元，其连接到流入口并保持颗粒;以及颗粒流出端口，通过所述输送流体从所述流入口流出，保持在所述保持单元中的颗粒从所述颗粒流出端口流出到预定的流路区域， 以及第二流出单元，其包括周边流出通道，使来自流入单元的流体的另一部分通过该流出通道流出到围绕预定流路区域的周边流动通道区域，周边流出通道围绕在 最少颗粒流出口。

    Microfluidic System and Method for Isolating and Quantifying at Least One Sub-Population of Cells From a Population of Cells
    7.
    发明申请
    Microfluidic System and Method for Isolating and Quantifying at Least One Sub-Population of Cells From a Population of Cells 审中-公开
    微流体系统和从细胞群体中分离和定量至少一个细胞群的方法

    公开(公告)号：US20160187336A1

    公开(公告)日：2016-06-30

    申请号：US14907540

    申请日：2014-07-25

    Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

    Inventor： Anne-Marie Gue ,  Karine Reybier ,  Jan Sudor ,  Sébastien Cargou ,  Armelle Montrose

    IPC: G01N33/569 ,  B01L3/00 ,  G01N15/14

    CPC classification number: G01N33/56972 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0867 ,  B01L2400/043 ,  G01N15/1429 ,  G01N15/1459 ,  G01N15/1484 ,  G01N33/54326 ,  G01N33/5438 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1263 ,  G01N2015/1486 ,  G01N2015/149 ,  G01N2333/70535 ,  G01N2333/70596

    Abstract: Disclosed are a microfluidic system (1) configured to receive cell populations and further configured to simultaneously isolate and quantify at least one sub-population of cells for each cell population, and related methods of using the system. The system comprises a substrate having networks of microchannels comprising a first sorting unit configured to isolate, by magnetic attraction, cells of interest in the population in at least one first sorting microchannel. The network comprises a second unit for simultaneous sorting and counting comprising at least one second sorting microchannel defined by a closed wall having an inner face provided with at least one functionalised electrode configured to trap a sub-population. The second unit further comprising means for counting the sub-population by impedance spectroscopy. The second sorting microchannel can have at least one pair of opposing functionalised electrodes and at least one pair of second micro-coils for trapping the cells of interest arranged in the wall facing the electrodes and controlling successive attraction/release cycles that alternate between the micro-coils.

    Abstract translation: 公开了一种微流体系统（1），其被配置为接收细胞群体并进一步被配置为同时分离和定量每个细胞群体的至少一个细胞群，以及使用该系统的相关方法。 该系统包括具有微通道网络的衬底，其包括第一分类单元，其被配置为通过磁吸引将至少一个第一分类微通道中的群体中的感兴趣细胞分离。 网络包括用于同时分类和计数的第二单元，其包括由封闭壁限定的至少一个第二排序微通道，所述第二排序微通道具有设置有至少一个功能化电极的内表面，该功能化电极被配置为捕获子群体。 第二单元还包括用于通过阻抗光谱法对子群进行计数的装置。 第二分选微通道可以具有至少一对相对的功能化电极和至少一对第二微型线圈，用于捕获布置在面向电极的壁中的感兴趣的细胞，并且控制连续的吸引/释放循环， 线圈

    PARTICLE INSPECTION UNIT AND PARTICLE INSPECTION SYSTEM
    9.
    发明申请
    PARTICLE INSPECTION UNIT AND PARTICLE INSPECTION SYSTEM 审中-公开
    颗粒检查单元和颗粒检查系统

    公开(公告)号：US20160320286A1

    公开(公告)日：2016-11-03

    申请号：US15205691

    申请日：2016-07-08

    Applicant: KABUSHIKI KAISHA TOSHIBA

    Inventor： Hiroko MIKI ,  Michihiko NISHIGAKI ,  Kentaro KOBAYASHI ,  Naofumi NAKAMURA

    IPC: G01N15/12 ,  G01N27/447 ,  G01N21/78

    CPC classification number: G01N15/12 ,  B01L3/502761 ,  G01N15/1031 ,  G01N21/78 ,  G01N27/44791 ,  G01N2015/1006 ,  G01N2015/1263

    Abstract: According to one embodiment, a particle inspection system includes an inspection module and a determination module. The inspection module includes a particle inspection chip includes electrodes for detecting existence of particles in a sample liquid by a change in an electrical signal, and a memory element which is provided separately from the electrodes and configured to store whether the inspection chip is a used chip or not. The determination module includes a determination circuit configured to determine the existence of the particles based on a detection signal of the inspection chip, and a control circuit configured to control an operation of the determination circuit from information in the memory element.

    Abstract translation: 根据一个实施例，颗粒检查系统包括检查模块和确定模块。 检查模块包括：粒子检查芯片，包括用于通过电信号的变化来检测样品液体中的颗粒的存在的电极;以及与电极分开设置的存储元件，其被配置为存储检查芯片是否是使用的芯片 或不。 确定模块包括确定电路，其被配置为基于检查芯片的检测信号确定颗粒的存在;以及控制电路，被配置为根据存储元件中的信息控制确定电路的操作。

    Device and method for detecting bioelectric signals from electrophysiologically active regions in spheroids
    10.
    发明申请
    Device and method for detecting bioelectric signals from electrophysiologically active regions in spheroids 失效
    用于检测球状体中电生理活性区域的生物电信号的装置和方法

    公开(公告)号：US20040209351A1

    公开(公告)日：2004-10-21

    申请号：US10487711

    申请日：2004-02-26

    Inventor： Hagen Thielecke ,  Andres Robitzki

    IPC: C12M001/34

    CPC classification number: G01N15/1475 ,  C12M41/46 ,  G01N15/1227 ,  G01N2015/1254 ,  G01N2015/1263

    Abstract: Disclosed is a device for detecting bioelectric signals from spheroids comprising a measuring chamber having a measuring chamber wall which encloses a volume, which is open at least at one side, is composed of an electrically non-conducting material, and has, in at least one measuring region, an inner cross section, which corresponds as far as possible to the largest cross section of a spheroid, comprising at least a number of electrodes which are disposed in a common plane inside said measuring chamber wall and each electrode has a freely accessible electrode surface which is oriented towards the measuring region, and comprising an impedance measuring arrangement which is connected to the electrodes. The device and the method can be used to test substances in 3D biological in-vitro (three-dimensional) cell aggregates.

    Abstract translation: 公开了一种用于检测来自球体的生物电信号的装置，包括具有测量室壁的测量室，所述测量室围绕至少在一侧开放的体积，该体积由不导电材料构成，并且在至少一个 测量区域，尽可能对应于球状体的最大横截面的内部横截面，包括至少多个电极，所述至少一些电极设置在所述测量室壁内部的公共平面中，并且每个电极具有可自由访问的电极 表面朝向测量区域定向，并且包括连接到电极的阻抗测量装置。 该装置和方法可用于测试3D生物体外（三维）细胞聚集体中的物质。

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