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1705 条记录 (耗时 0.031 秒)

    Method for introducing liquid samples into sample processing device
    4.
    发明授权
    Method for introducing liquid samples into sample processing device 有权

    公开(公告)号：US11921027B2

    公开(公告)日：2024-03-05

    申请号：US17277755

    申请日：2019-09-24

    申请人： KYOCERA Corporation

    发明人： Masashi Yoneta

    IPC分类号： G01N15/14 ,  G01N15/00

    CPC分类号： G01N15/1404 ,  G01N2015/0065 ,  G01N2015/149

    摘要： A specimen introduction method for improving a measurement accuracy and efficiency includes a preparation step, first step, second step, and third step. The preparation step uses a switching member to connect a first feeder to a first inlet-and-outlet, a second inlet-and-outlet to a discharge container, a third inlet-and-outlet to a first inflow port, and a second feeder to a second inflow port. The first step includes filling a path from the second feeder to the switching member through the second inflow port, a specimen treatment device, and the first inflow port with a second liquid. The second step includes filling a path from the first feeder to the switching member with a first liquid. The third step includes subsequently introducing the first liquid into the first inflow port from the first feeder through the switching member, and introducing the second liquid into the second inflow port from the second feeder.

    SYSTEMS AND METHODS FOR THE AMPLIFIED DETECTION OF MOLECULES ON MICROPARTICLES
    7.
    发明公开
    SYSTEMS AND METHODS FOR THE AMPLIFIED DETECTION OF MOLECULES ON MICROPARTICLES 审中-公开

    公开(公告)号：US20230333114A1

    公开(公告)日：2023-10-19

    申请号：US18044371

    申请日：2021-09-08

    申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    发明人： Dino Di Carlo ,  Yilian Wang ,  Vishwesh Nilesh Shah

    IPC分类号： G01N33/58 ,  G01N33/543 ,  G01N15/14

    CPC分类号： G01N33/581 ,  G01N33/582 ,  G01N33/54313 ,  G01N15/1459 ,  G01N2333/908 ,  G01N2015/149

    摘要： A particle-based assay system is disclosed that uses hydrogel microparticles that capture analytes of interest from a sample which are subsequently bound with catalytic reporter complexes. Catalytic reporter complexes bound to the hydrogel microparticles generate signals that are accumulated in the vicinity of the hydrogel microparticle at high concentration (or on or within the hydrogel microparticles). In some circumstances, the reporter complex-bound hydrogel microparticles are encapsulated in an emulsion. Preferably, the emulsion is substantially uniform and contains one hydrogel microparticle per droplet. The accumulated signal generated by the catalytic reporter complexes is contained inside the emulsion, and/or optionally immobilized onto or inside the hydrogel microparticle. Signals are read and analyzed using optical instruments such as flow cytometers. Breaking the emulsion prior to signal analysis is optional. In some embodiments, a sample is introduced to hydrogel microparticles in a dried state to concentrate analytes of interest.

    Methods for determining detector gain in a flow cytometer
    9.
    发明授权
    Methods for determining detector gain in a flow cytometer 有权

    公开(公告)号：US11781964B2

    公开(公告)日：2023-10-10

    申请号：US17225347

    申请日：2021-04-08

    申请人： Becton, Dickinson and Company

    发明人： Shreyas Bhaban ,  Peter Mage

    IPC分类号： G01N15/14 ,  G01J1/08 ,  G01N15/10

    CPC分类号： G01N15/1429 ,  G01J1/08 ,  G01N15/1012 ,  G01N15/1425 ,  G01N15/1459 ,  G01N2015/1402 ,  G01N2015/149

    摘要： Aspects of the present disclosure include methods for adjusting sensitivity of a photodiode in a light detection system. Methods according to certain embodiments include determining a background data signal from a photodetector at a plurality of detector gains, irradiating the photodetector with a light source at a plurality of different light intensities, generating data signals from the photodetector for the plurality of light intensities at each detector gain and adjusting the photodetector to the detector gain that corresponds to the lowest light irradiation intensity that generates a data signal resolvable from the background data signal. Systems (e.g., particle analyzers) having a light source and a light detection system that includes a photodetector for practicing the subject methods are also described. Non-transitory computer readable storage medium are also provided.

    SORTING OF CELLULAR BODIES BASED ON FORCE SPECTROSCOPY
    10.
    发明公开
    SORTING OF CELLULAR BODIES BASED ON FORCE SPECTROSCOPY 审中-公开

    公开(公告)号：US20230314297A1

    公开(公告)日：2023-10-05

    申请号：US18023292

    申请日：2021-09-01

    申请人： LUMICKS CA HOLDING B.V.

    发明人： Rogier Martijn Reijmers ,  Gerrit Sitters

    IPC分类号： G01N15/14

    CPC分类号： G01N15/14 ,  G01N2015/149

    摘要： A method of sorting cellular bodies comprises receiving images representing manipulation of first cellular bodies in a holding space of a flow cell including or connected to a sorting device, the manipulation including: allowing some of the first cellular bodies to contact a functionalized wall of the holding space; applying a force to the contacted first cellular bodies for detaching some of the first cellular bodies; and, transporting the cellular bodies to the sorting device; and, processing the sequence of images of the first cellular bodies and controlling the sorting device based on the image processing by detecting detachments of first cellular bodies in the images; determining for each detected detached first cell a detachment force; tracking the location of detached first cellular bodies during the transport of the cellular bodies to the sorting device; and, sorting the cellular bodies by controlling the sorting device based on the detachment force.