公开(公告)号：US20240255412A1

公开(公告)日：2024-08-01

申请号：US18633224

申请日：2024-04-11

申请人： Bio-Rad Laboratories, Inc.

发明人： Kalyan Handique ,  Austin Payne ,  Vishal Sharma ,  Kyle Gleason ,  Priyadarshini Gogoi ,  Karthik Ganesan ,  Brian Boniface ,  William Chow

IPC分类号： G01N15/14 ,  B01L3/00 ,  B01L3/02 ,  C12M1/00 ,  G01N1/20 ,  G01N1/28 ,  G01N1/40 ,  G01N15/01 ,  G01N15/10 ,  G01N15/1433 ,  G01N15/149 ,  G01N35/00 ,  G01N35/10 ,  G06V10/141 ,  G06V10/145 ,  G06V10/147 ,  G06V20/69

CPC分类号： G01N15/1484 ,  B01L3/502715 ,  B01L3/502761 ,  C12M47/04 ,  G01N1/20 ,  G01N1/28 ,  G01N1/40 ,  G01N1/405 ,  G01N1/4077 ,  G01N15/1433 ,  G01N35/00029 ,  G01N35/1011 ,  G06V10/141 ,  G06V10/145 ,  G06V10/147 ,  G06V20/69 ,  B01L3/021 ,  B01L3/502746 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0672 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0848 ,  B01L2300/0877 ,  B01L2300/168 ,  B01L2400/086 ,  G01N15/01 ,  G01N2015/1006 ,  G01N15/149 ,  G01N2035/00158 ,  G01N2035/1039

摘要： A system and method for isolating and analyzing single cells, including: a substrate having a broad surface; a set of wells defined at the broad surface of the substrate, and a set of channels, defined by the wall, that fluidly couple each well to at least one adjacent well in the set of wells; and fluid delivery module defining an inlet and comprising a plate, removably coupled to the substrate, the plate defining a recessed region fluidly connected to the inlet and facing the broad surface of the substrate, the fluid delivery module comprising a cell capture mode.

公开(公告)号：US11774463B2

公开(公告)日：2023-10-03

申请号：US16770198

申请日：2018-01-26

申请人： HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

发明人： Dennis R. Esterberg ,  Christie Dudenhoefer

IPC分类号： G01N35/10 ,  G01N35/00 ,  B01L9/00

CPC分类号： G01N35/109 ,  B01L9/52 ,  G01N35/00029 ,  G01N35/1011 ,  B01L9/523 ,  B01L9/527 ,  B01L2200/025 ,  B01L2300/0816 ,  B01L2300/0822 ,  B01L2300/0829 ,  G01N2035/00138 ,  G01N2035/1039

摘要： In one example, dispenser stages described herein may include a dispenser platform comprising: a stage coupled to a rail system to move the stage in a first plane and a second plane, an alignment feature coupled to the stage to align a substrate nest coupled to the stage with a dispenser positioned above the stage, and a releasable fastener to couple the substrate nest to the stage.

公开(公告)号：US20180217171A1

公开(公告)日：2018-08-02

申请号：US15880705

申请日：2018-01-26

申请人： SYSMEX CORPORATION

发明人： Yuto SASAKI

IPC分类号： G01N35/00 ,  C12Q1/6806 ,  G01N35/10

CPC分类号： G01N35/0098 ,  B03C1/01 ,  B03C1/0332 ,  B03C1/288 ,  B03C1/30 ,  B03C2201/18 ,  B03C2201/26 ,  C12Q1/6806 ,  G01N35/1011 ,  G01N2035/1039 ,  G01N2035/1053 ,  G01N2035/1058

摘要： A sample processing method may include: removing a liquid component in a container housing a suspension containing a magnetic particle bound with an analyte, while causing magnetic adhesion of the magnetic particle in the container; discharging an elution liquid for releasing the analyte from the magnetic particle from a pipette into the container from which the liquid component has been removed so as to mix the magnetic particle and the elution liquid; moving, after discharging the elution liquid into the container, the pipette relative to and close to an inner wall of the container so as to collect a droplet attached to the inner wall onto an outer surface of the pipette; and moving a tip of the pipette to an accumulation area in which the elution liquid accumulates in the container so as to move the droplet collected on the outer surface of the pipette to the accumulation area.

公开(公告)号：US20180106822A1

公开(公告)日：2018-04-19

申请号：US15424918

申请日：2017-02-06

申请人： King Yuan Electronics Co., Ltd.

发明人： Kuang-Hsiang LIU ,  Chieh-Wen LU ,  His-Hua CHOU ,  Shih-Chan CHINE

IPC分类号： G01N35/10

CPC分类号： G01N35/1065 ,  B01L3/0293 ,  B01L2300/0645 ,  B01L2300/0819 ,  G01N35/1011 ,  G01N35/109 ,  G01N2035/1039

摘要： A titration module of biochip includes a base, a plurality of titration units, a plurality of pipelines, a transfer unit, and a control unit. The plural titration units and the plural pipelines are arranged above the base, and that the titration units each is provided, at its lower end, a needle element and a reservoir which are communicated with each other. The transfer unit is arranged on the base, and includes at least one driving device for driving, selectively, the plural titration units and the plural pipelines in a lateral direction (leftward and rightward), a longitudinal direction (frontward and rearward) and a vertical direction (upward and downward), respectively. The control unit is electrically connected with the transfer unit, and controls the same for switching, selectively, the plural titration units and the plural pipelines.

公开(公告)号：US20170192002A1

公开(公告)日：2017-07-06

申请号：US15465342

申请日：2017-03-21

申请人： Gold Standard Diagnostics

发明人： Peter Van Praet ,  Jennifer Roth ,  John Griffiths

IPC分类号： G01N33/571 ,  G06T7/60 ,  G01N35/00 ,  G01N21/77 ,  G01N33/53 ,  G01N35/10

CPC分类号： G01N33/571 ,  G01N21/253 ,  G01N21/82 ,  G01N2015/0092 ,  G01N2021/825 ,  G01N2035/00524 ,  G01N2035/0418 ,  G01N2035/1039 ,  G06T7/60

摘要： The machine is configured to perform an automated rapid plasma reagent (RPR) agglutination test or other agglutination test. The machine includes a sample rack with multiple sample locations thereon and a reagent rack for storing of reagent. A shaker assembly supports at least one microtiter plate or other well supporting structure thereon with a plurality of wells in the plate. An automated pipette accesses samples and reagent and deposits them within wells of the microtiter plate. The shaker assembly shakes multiple samples within the wells of the microtiter plate. Finally, a camera photographs the wells of the plate, preferably from above with a light source below and the plate at least partially transparent. The image is then analyzed in an automated fashion to determine whether a ring of contrast material has remained smooth indicative of a non-reactive sample or has agglutinated/clumped together indicative of a reactive sample.

公开(公告)号：US20160202275A1

公开(公告)日：2016-07-14

申请号：US14392339

申请日：2014-05-23

申请人： INFOPIA CO., LTD.

发明人： Byeong Woo BAE ,  Chan Hee CHON ,  Hyo Jeong KIM

IPC分类号： G01N33/72 ,  B01L3/00

CPC分类号： G01N33/726 ,  B01F7/00225 ,  B01F7/005 ,  B01F7/00725 ,  B01F7/161 ,  B01L3/0289 ,  B01L3/508 ,  B01L3/523 ,  B01L2200/14 ,  B01L2200/16 ,  B01L2300/0627 ,  B01L2300/0832 ,  B01L2300/0848 ,  B01L2300/0867 ,  G01N1/12 ,  G01N1/38 ,  G01N33/49 ,  G01N33/723 ,  G01N35/10 ,  G01N2001/1463 ,  G01N2035/1039 ,  G01N2035/1058

摘要： A specimen containing unit according to one embodiment of the present invention relates to a structure for dipping a specimen into a reagent so as to react with the reagent, and the specimen containment unit comprises: a body portion rotatable by external force; an extension portion formed to be extended from one surface of the body portion at a predetermined length along a longitudinal direction; and a specimen containment portion provided to an end portion of the extension portion and including a containment hole formed to be penetrated while maintaining at a predetermined angle in the longitudinal direction so as to contain a specimen by a capillary phenomenon.

摘要翻译： 根据本发明的一个实施方案的样本容纳单元涉及将样本浸入试剂中以与试剂反应的结构，并且样本容纳单元包括：通过外力可旋转的主体部分; 延伸部，其形成为沿着长度方向以预定长度从所述主体部的一个表面延伸; 以及设置在所述延伸部的端部的试样容纳部，并且包括形成为贯通的容纳孔，同时在长度方向上保持预定角度，以便通过毛细管现象容纳样本。

公开(公告)号：US20150323518A1

公开(公告)日：2015-11-12

申请号：US14712816

申请日：2015-05-14

申请人： BIONANO GENOMICS, INC.

发明人： Han Cao ,  Parikshit A. Deshpande ,  Michael David Austin ,  Michael Boyce-Jacino

IPC分类号： G01N33/487 ,  G01N27/447 ,  C12Q1/68

CPC分类号： B82Y30/00 ,  B01L3/502761 ,  B01L2200/0663 ,  B01L2200/12 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0822 ,  B01L2300/0896 ,  B01L2400/0415 ,  B01L2400/0487 ,  C12Q1/6869 ,  G01N27/447 ,  G01N33/48721 ,  G01N2035/1039 ,  Y10T436/143333 ,  Y10T436/2575 ,  C12Q2565/631

摘要： Constricted nanochannel devices suitable for use in analysis of macromolecular structure, including DNA sequencing, are disclosed. Also disclosed are methods for fabricating such devices and for analyzing macromolecules using such devices.

摘要翻译： 公开了适用于分析大分子结构（包括DNA测序）的约束纳米通道装置。 还公开了制造这种装置和使用这种装置分析大分子的方法。

公开(公告)号：US09007574B2

公开(公告)日：2015-04-14

申请号：US14026358

申请日：2013-09-13

申请人： Beckman Coulter, Inc.

发明人： Robert Retter ,  Yagang Liu ,  Patty Pang ,  Brian Peterson

IPC分类号： G01N21/01 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10

CPC分类号： G01N21/03 ,  G01N21/01 ,  G01N21/59 ,  G01N35/0099 ,  G01N35/04 ,  G01N35/10 ,  G01N2021/0346 ,  G01N2035/0465 ,  G01N2035/1039 ,  G01N2035/1062 ,  G01N2201/02 ,  G01N2201/062

摘要： An analytical system is disclosed. The analytical system includes a storage container configured to store a plurality of capillaries. It also includes a gripper configured to receive at least one of the plurality of capillaries, and move the at least one capillary so that an end of the capillary contacts a sample in a sample container and draws the sample in the capillary. The system also includes a reader configured to detect a signal from the sample in the capillary.

摘要翻译： 公开了一种分析系统。 分析系统包括被配置为存储多个毛细管的存储容器。 它还包括构造成容纳多个毛细管中的至少一个毛细管并且移动至少一个毛细管的夹持器，使得毛细管的一端与样品容器中的样品接触并将样品抽吸在毛细管中。 该系统还包括被配置为检测来自毛细管中的样品的信号的读取器。

公开(公告)号：US20140323358A1

公开(公告)日：2014-10-30

申请号：US14326243

申请日：2014-07-08

申请人： APPLIED BIOSYSTEMS, LLC

发明人： Mark F. Oldham ,  Adrian Fawcett

IPC分类号： C12Q1/68

CPC分类号： B01L3/5085 ,  B01L3/0293 ,  B01L3/5025 ,  B01L3/5027 ,  B01L3/50851 ,  B01L3/50853 ,  B01L3/545 ,  B01L7/52 ,  B01L9/50 ,  B01L9/523 ,  B01L2200/021 ,  B01L2200/025 ,  B01L2200/0605 ,  B01L2200/0642 ,  B01L2200/0689 ,  B01L2200/14 ,  B01L2200/142 ,  B01L2300/021 ,  B01L2300/022 ,  B01L2300/044 ,  B01L2300/046 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/0864 ,  B01L2300/1883 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0487 ,  C12Q1/686 ,  G01N21/274 ,  G01N21/6452 ,  G01N21/6486 ,  G01N35/0099 ,  G01N35/028 ,  G01N35/1002 ,  G01N35/1074 ,  G01N2035/00287 ,  G01N2035/00366 ,  G01N2035/0405 ,  G01N2035/0425 ,  G01N2035/1039

摘要： A vacuum assist apparatus can comprise a microplate. The microplate can comprise a first surface and an opposing second surface. A plurality of wells can be formed in the first surface of the microplate. Each of the plurality of wells can be sized to receive an assay therein. A support base can comprise a fluid passage. The microplate can be positioned adjacent and in contact with the support base. A pressure device, in fluid communication with the fluid passage, can exert a vacuum within the fluid passage to actively retain the microplate in the contact with the support base.

摘要翻译： 真空辅助装置可以包括微孔板。 微板可以包括第一表面和相对的第二表面。 可以在微板的第一表面中形成多个孔。 可以将多个孔中的每一个的尺寸设定为在其中接受测定。 支撑基座可以包括流体通道。 微板可以定位成与支撑基座相邻并与支撑基座接触。 与流体通道流体连通的压力装置可以在流体通道内施加真空以主动地保持微板与支撑基座的接触。

公开(公告)号：US20130323138A1

公开(公告)日：2013-12-05

申请号：US13907520

申请日：2013-05-31

申请人： Biolytic Lab Performance, Inc.

发明人： Thomas J. Demmitt

IPC分类号： B01J19/00

CPC分类号： B01J19/0053 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/0036 ,  B01J2219/00369 ,  B01J2219/00376 ,  B01J2219/00466 ,  B01J2219/00509 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00691 ,  B01J2219/00722 ,  B01J2219/00759 ,  B01L3/0293 ,  B01L3/563 ,  B01L9/523 ,  B01L2200/0605 ,  G01N1/405 ,  G01N35/028 ,  G01N35/04 ,  G01N35/1011 ,  G01N35/1016 ,  G01N35/1065 ,  G01N35/1074 ,  G01N2030/009 ,  G01N2035/00237 ,  G01N2035/1034 ,  G01N2035/1039

摘要： The invention provides an improved instrument for automation of solid phase extraction chemistries typically used in biotechnology labs. The instrument includes a mechanism for transferring samples dissolved in a liquid from initial containers to reaction columns that are used to perform solid phase extractions. Samples, reaction columns and collection containers are in microtiter plate format or tubes that are on 18 millimeter centers. The transfer system is automatically cleaned after use in preparation for the next use. A dispense manifold is used to dispense various reagents into the reaction columns. Pressure differential is used to move reagents through reaction columns. A sliding cover is used to divert the reagent exiting reaction columns to waste or allowing collection of sample as it exits outlets of reaction columns. Samples are automatically collected in microtiter plates or in individual tubes or vials.

摘要翻译： 本发明提供了用于生物技术实验室中通常使用的固相萃取化学物质的自动化改进的仪器。 该仪器包括用于将溶解在液体中的样品从初始容器转移到用于进行固相萃取的反应塔的机构。 样品，反应塔和收集容器是在18毫米中心的微量滴定板形式或管。 转移系统在使用后自动清洁，以备下次使用。 分配歧管用于将各种试剂分配到反应塔中。 压差用于通过反应柱移动试剂。 使用滑动盖将离开反应塔的试剂转移到废物或允许样品在离开反应塔出口时收集。 样品自动收集在微量滴定板或单独的管或小瓶中。