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    SYSTEM AND METHOD FOR ISOLATING AND ANALYZING CELLS
    2.
    发明申请
    SYSTEM AND METHOD FOR ISOLATING AND ANALYZING CELLS 有权

    公开(公告)号：US20210283608A1

    公开(公告)日：2021-09-16

    申请号：US17333142

    申请日：2021-05-28

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Kalyan Handique ,  Vishal Sharma ,  Priyadarshini Gogoi ,  William Chow ,  Austin Payne ,  Kyle Gleason ,  Brian Boniface ,  John Connolly ,  Sam Tuck

    IPC: B01L3/00 ,  C12M1/00 ,  G01N33/574 ,  C12Q1/6816 ,  G01N33/543 ,  G01N33/569 ,  G01N15/14

    Abstract: A system and method for isolating and analyzing single cells, wherein the system includes: an array of wells defined at a substrate, each well including an open surface and a well cavity configured to capture cells in one of a single-cell format and single-cluster format, and a fluid delivery module including a fluid reservoir superior to the array of wells through which fluid flow is controlled along a fluid path in a direction parallel to the broad face of the substrate; and wherein the method includes: capturing a population of non-cell particles into the array of wells in single-particle format; releasing, from the non-cell particles, a set of probes into the array of wells; capturing a population of cells into the array of wells in single-cell format; releasing biomolecules from each captured cell into the array of wells; and generating a set of genetic complexes comprising the biomolecules associated with a single captured cell and a subset of probes within individual wells of the array of wells.

    System for imaging captured cells
    3.
    发明授权
    System for imaging captured cells 有权

    公开(公告)号：US12222345B2

    公开(公告)日：2025-02-11

    申请号：US15931928

    申请日：2020-05-14

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Kalyan Handique ,  Kyle Gleason ,  Christopher Siemer ,  Priyadarshini Gogoi ,  Saedeh Sepehri Javdani ,  Gene Parunak ,  Aaron Kehrer ,  Jon Meines

    IPC: G01N33/483 ,  G01N21/25 ,  G01N21/64 ,  G01N21/76 ,  G01N33/487 ,  G02B21/06 ,  G02B21/26 ,  A61B5/00

    Abstract: A system for imaging captured cells comprising: an illumination module configured to illuminate a target object; a platform configured to position the target object in relation to the illumination module; a filter module configured to filter light transmitted to the target object and/or to filter light received from the target object, an optical sensor configured to receive light from the target object and to generate image data; and a focusing and optics module configured to manipulate light transmitted to the optical sensor. The system can further comprise one or more of: a control system configured to control at least one of the illumination module, the platform, the focusing and optics module, the filter module, and the optical sensor; a tag identifying system configured to identify and communicate tag information from system elements; a thermal control module configured to adjust temperature parameters of the system; and an image stabilization module.

    SYSTEM AND METHOD FOR ISOLATING AND ANALYZING CELLS
    5.
    发明申请
    SYSTEM AND METHOD FOR ISOLATING AND ANALYZING CELLS 有权

    公开(公告)号：US20230037836A1

    公开(公告)日：2023-02-09

    申请号：US17965495

    申请日：2022-10-13

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Kalyan Handique ,  Vishal Sharma ,  Priyadarshini Gogoi ,  William Chow ,  Austin Payne ,  Kyle Gleason ,  Brian Boniface ,  John Connolly ,  Sam Tuck

    IPC: B01L3/00 ,  C12M1/00 ,  G01N33/574 ,  C12Q1/6816 ,  G01N33/543 ,  G01N33/569 ,  G01N15/14

    Abstract: A system and method for isolating and analyzing single cells, wherein the system includes: an array of wells defined at a substrate, each well including an open surface and a well cavity configured to capture cells in one of a single-cell format and single-cluster format, and a fluid delivery module including a fluid reservoir superior to the array of wells through which fluid flow is controlled along a fluid path in a direction parallel to the broad face of the substrate; and wherein the method includes: capturing a population of non-cell particles into the array of wells in single-particle format; releasing, from the non-cell particles, a set of probes into the array of wells; capturing a population of cells into the array of wells in single-cell format; releasing biomolecules from each captured cell into the array of wells; and generating a set of genetic complexes comprising the biomolecules associated with a single captured cell and a subset of probes within individual wells of the array of wells.

    SYSTEM FOR IMAGING CAPTURED CELLS
    8.
    发明申请
    SYSTEM FOR IMAGING CAPTURED CELLS 审中-公开

    公开(公告)号：US20200271637A1

    公开(公告)日：2020-08-27

    申请号：US15931928

    申请日：2020-05-14

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Kalyan Handique ,  Kyle Gleason ,  Christopher Siemer ,  Priyadarshini Gogoi ,  Saedeh Sepehri Javdani ,  Gene Parunak ,  Aaron Kehrer ,  Jon Meines

    IPC: G01N33/483 ,  G01N21/64

    Abstract: A system for imaging captured cells comprising: an illumination module configured to illuminate a target object; a platform configured to position the target object in relation to the illumination module; a filter module configured to filter light transmitted to the target object and/or to filter light received from the target object, an optical sensor configured to receive light from the target object and to generate image data; and a focusing and optics module configured to manipulate light transmitted to the optical sensor. The system can further comprise one or more of: a control system configured to control at least one of the illumination module, the platform, the focusing and optics module, the filter module, and the optical sensor; a tag identifying system configured to identify and communicate tag information from system elements; a thermal control module configured to adjust temperature parameters of the system; and an image stabilization module.

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