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公开(公告)号：US12103005B2
公开(公告)日：2024-10-01
申请号：US16995555
申请日：2020-08-17
IPC分类号： B01L3/00 , B01F23/41 , B01F33/3011 , B01L3/02 , B01L7/00 , C12Q1/6806 , G01N35/00 , G01N35/08 , G01N35/10
CPC分类号： B01L3/502784 , B01F23/41 , B01F33/3011 , B01L3/502715 , B01L3/502723 , C12Q1/6806 , G01N35/085 , B01L3/0275 , B01L7/52 , B01L2200/027 , B01L2200/0689 , B01L2300/0816 , B01L2300/0829 , B01L2300/0867 , B01L2400/0487 , G01N2035/00148 , G01N2035/1034 , G01N35/1065 , Y10T29/494
摘要： A system, including method and apparatus, for generating droplets suitable for droplet-based assays. The disclosed systems may include either one-piece or multi-piece droplet generation components configured to form sample-containing droplets by merging aqueous, sample-containing fluid with a background emulsion fluid such as oil, to form an emulsion of sample-containing droplets suspended in the background fluid. In some cases, the disclosed systems may include channels or other suitable mechanisms configured to transport the sample-containing droplets to an outlet region, so that subsequent assay steps may be performed.
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公开(公告)号：US12097475B2
公开(公告)日：2024-09-24
申请号：US18412395
申请日：2024-01-12
发明人： Rustem F. Ismagilov , Bo Zheng , Cory John Gerdts
IPC分类号： B01L99/00 , B01F25/314 , B01F33/302 , B01J19/00 , B01L3/00 , B01L3/02 , C30B7/00 , C30B29/58 , G01N1/38 , G05D7/06 , B01L3/06 , G01N35/08 , G01N35/10
CPC分类号： B01F33/3021 , B01F25/314 , B01J19/0046 , B01L3/0293 , B01L3/502784 , B01L3/527 , C30B7/00 , C30B29/58 , G01N1/38 , G05D7/0694 , B01J2219/00522 , B01J2219/00585 , B01J2219/0059 , B01J2219/00599 , B01L3/06 , B01L3/502723 , B01L3/502746 , B01L2200/0673 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/0867 , B01L2400/0406 , B01L2400/0409 , B01L2400/0415 , B01L2400/0433 , B01L2400/0487 , G01N35/08 , G01N2035/1034 , Y10T137/0318 , Y10T436/12
摘要： The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale.
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3.发明公开公开(公告)号：US20240168046A1
公开(公告)日：2024-05-23
申请号：US18283367
申请日：2022-03-21
发明人： Thomas R. Covey , Chang Liu
CPC分类号： G01N35/10 , G01N2035/00386 , G01N2035/00455 , G01N2035/1034
摘要： GT Systems and methods are disclosed for controlling humidity and/or temperature during chemical analysis of a sample material. Specifically, the present application relates to microfluidics systems and methods, e.g. involving ADE, open port interface (OPI) and/or mass spectrometry (MS), for controlling humidity and/or temperature during chemical analysis of a sample material. The present systems and methods allow a user to modify the temperature of a microplate during dispensing. This allows the user to study reactions that occur at temperatures different than room temperature, e.g. at body temperature. Additionally, modifying and/or controlling the temperature of a microplate during dispensing can allow a user to maintain quality of a sample through maintaining a proper temperature, e.g. a cool temperature to prevent degradation of a sample. As part of the present invention, Applicant determined how to avoid phase changes, e.g. evaporation, that are particularly concerning because of the small amounts of sample involved.
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公开(公告)号：US20240118273A1
公开(公告)日：2024-04-11
申请号：US18368931
申请日：2023-09-15
发明人： John J. Rajasekaran , Vasanth Jayaraman , Tianhao Wang , Kang Bei , Hari Krishnan Krishnamurthy
IPC分类号： G01N33/543 , C40B40/06 , C40B40/10 , G01N35/00 , G16B20/00
CPC分类号： G01N33/54366 , C40B40/06 , C40B40/10 , G01N33/54386 , G01N35/00029 , G01N35/00069 , G01N35/0099 , G16B20/00 , G01N2035/00158 , G01N2035/00168 , G01N2035/1034
摘要： Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and methods of assuring a uniformly high quality of a microarray of features that are attached to a surface of the microarray at positionally-defined locations.
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公开(公告)号：US11872554B2
公开(公告)日：2024-01-16
申请号：US16812961
申请日：2020-03-09
发明人： Alexander Schenk zu Schweinsberg , Austin Matthew Derfus , Justin Davidson , Karthikeyan Kumaravadivelu , Maulik Vinod Patel , Olaf Piepenburg , Catherine Jean Greenwood , Oliver Nentwich
CPC分类号： B01L3/502715 , B01L3/5029 , G01N1/14 , G01N35/00069 , B01L2200/027 , B01L2200/082 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0478 , B01L2400/0655 , G01N1/38 , G01N2001/028 , G01N2035/00158 , G01N2035/1034
摘要： A microfluidic device includes an inlet port configured to receive a sample, a first reaction chamber fluidically coupled to the inlet port, a first pump fluidically coupled to the inlet port, a second pump fluidically coupled to a mixing chamber, a metering channel fluidically coupled to the first reaction chamber and to the mixing chamber, and one or more second reaction chambers fluidically coupled to the mixing chamber. The first pump is configured to move fluid from the inlet port to the first reaction chamber and from the first pump to the inlet port. The second pump is configured to move fluid from the second pump to the mixing chamber, from the first reaction chamber to the mixing chamber, and from the mixing chamber to the one or more second reaction chambers.
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6.发明公开公开(公告)号：US20230213544A1
公开(公告)日：2023-07-06
申请号：US18001157
申请日：2021-06-11
申请人： NEW YORK UNIVERSITY
发明人： Glennon W. Simmons
CPC分类号： G01N35/1009 , G01N35/00029 , B01L3/50273 , G01N2035/1034 , B01L2400/0481 , B01L2300/0636 , B01L2200/025 , B01L2200/16 , B01L2400/0406 , B01L2400/0677
摘要： The present invention provides devices and methods for generating a pulsatile fluid flow in a microchannel by means of external actuation of a thin flexible film. With the devices described herein, cycles of positive and negative actuation can be used to infuse or withdrawal fluid in a microchannel. Fluid can be recirculated over one or more microfluidic feature, such as a chemical or molecular receptor, biosensor, electrode, cell or biological material, chromatography feature, mixer, etc., in a way that would represent an advantage over the single-pass flow techniques common to most microfluidic devices. The devices and methods are particularly useful in vitro diagnostics (IVD), analytical chemistry, chromatography, and mixing applications in a variety of fields.
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公开(公告)号：US20190240653A1
公开(公告)日：2019-08-08
申请号：US16309325
申请日：2017-07-19
申请人： TECAN TRADING AG
发明人： Philipp OTT
CPC分类号： B01L3/0275 , B01L3/021 , B01L3/54 , B01L2200/0605 , B01L2200/143 , B01L2300/021 , B01L2300/0645 , B01L2400/049 , B25J9/1664 , G01D5/2417 , G01F23/263 , G01N35/00732 , G01N35/0099 , G01N35/1011 , G01N35/1016 , G01N2035/00811 , G01N2035/1013 , G01N2035/1025 , G01N2035/103 , G01N2035/1034
摘要： The present invention relates to pipette tips for connecting to a pipette tube of a pipetting device that is used for taking up and dispensing fluids. A pipette tip is shaped as a long tube that forms a pipette body with an opening on one of its ends and the other end is designed to connect to the pipette tube. The pipette tip is characterised in that it has an electrode as a volume measuring electrode of a measuring capacitor. The present invention further relates to pipetting devices with a pipette tip, methods for determining the volume of a fluid sample in such a pipette tip, methods for recognising such a pipette tip on a pipetting device, methods for producing such a pipette tip, uses for such a pipette tip and a set of pipette tips.
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公开(公告)号：US20190237167A1
公开(公告)日：2019-08-01
申请号：US16193995
申请日：2018-11-16
申请人： Xtest, Inc.
发明人： Frederick Abraham
CPC分类号： G16H10/40 , G01N1/00 , G01N35/00871 , G01N2001/002 , G01N2035/00237 , G01N2035/00881 , G01N2035/00891 , G01N2035/1034 , G06Q20/18
摘要： The present invention relates to implementing an online diagnostic system for diagnosing the sample received from a client. The system is connected with an electrode through a Bluetooth low energy communication channel to receive the sample from one or more subscribed client(s) and the system is configured to transmit the received sample for further diagnosis of the sample. Additionally, the system can be supported with a diagnostic kiosk integrated with a dual purpose chip/imbedded Microfluidic chip (MFC) to collect the test sample. Further, the transmitted sample is diagnosed in the cloud by using nano technology and through the implementation of the cloud computation technology. Further, the application is configured to send back the sample diagnosis result to the electronic device from which the client sample was collected or through a diagnostic kiosk LED display to provide a virtual medical assistance for the clients diagnosed with a disease.
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公开(公告)号：US20180296992A1
公开(公告)日：2018-10-18
申请号：US15767979
申请日：2016-10-07
发明人： Dino Di Carlo , Soroush Kahkeshani
CPC分类号： B01F3/0815 , A61K9/0009 , A61K9/0021 , A61K9/0024 , A61K9/0097 , A61M2037/0023 , B01F13/0059 , B01F13/0077 , B01L3/502761 , B01L3/502784 , B01L2200/0668 , B01L2300/0816 , B01L2300/0867 , B01L2400/043 , G01N35/1002 , G01N2035/1034
摘要： A microfluidic device for forming droplets includes at least one ferrofluid reservoir disposed in the microfluidic device and containing a ferrofluid therein. The microfluidic device includes a continuous-phase reservoir disposed in the microfluidic device and containing an oil phase therein and one or more microfluidic channels connecting between the at least one ferrofluid reservoir and the continuous-phase reservoir, the continuous-phase reservoir comprising a step region having an increased height as compared to a height of the one or more microfluidic channels. To form droplets an externally applied magnetic field is applied to the device to pull the ferrofluid into the continuous-phase reservoir, whereby droplets are formed at step region.
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公开(公告)号：US20180238864A1
公开(公告)日：2018-08-23
申请号：US15952966
申请日：2018-04-13
IPC分类号： G01N33/53 , B01L3/00 , B01L7/00 , G01N35/10 , G01N35/00 , B01J19/00 , B01L9/00 , G01N33/543 , G01N33/569 , G01N33/94 , A61B5/15 , A61B5/151 , G01N35/02 , B01L3/02 , G01N33/68 , G01N1/38 , G01N33/574 , A61B10/00 , A61B10/02
CPC分类号： G01N33/5304 , A61B5/15 , A61B5/150755 , A61B5/151 , A61B10/0038 , A61B10/0045 , A61B10/0051 , A61B10/0058 , A61B10/007 , A61B10/02 , A61B2010/0074 , A61B2010/0077 , B01J19/0046 , B01J2219/00283 , B01J2219/00292 , B01J2219/00315 , B01J2219/00369 , B01J2219/00371 , B01J2219/00385 , B01J2219/00466 , B01J2219/00495 , B01J2219/005 , B01J2219/00693 , B01J2219/00702 , B01L3/021 , B01L3/0262 , B01L3/5025 , B01L3/527 , B01L7/52 , B01L7/5255 , B01L9/543 , B01L2200/04 , B01L2200/0689 , B01L2200/141 , B01L2200/148 , B01L2300/0654 , B01L2300/0829 , B01L2300/1805 , B01L2400/043 , G01N1/38 , G01N33/5302 , G01N33/54326 , G01N33/54366 , G01N33/54386 , G01N33/56966 , G01N33/57484 , G01N33/6803 , G01N33/94 , G01N35/00732 , G01N35/00871 , G01N35/028 , G01N35/10 , G01N35/1065 , G01N35/1074 , G01N2035/00237 , G01N2035/00851 , G01N2035/00881 , G01N2035/0097 , G01N2035/1032 , G01N2035/1034 , G01N2035/1048 , G01N2333/4737 , G01N2333/475 , G01N2333/71 , G01N2333/912 , G01N2333/91205 , G01N2333/9129 , G01N2800/26 , G01N2800/60 , G16H10/40 , Y10T29/49826 , Y10T436/25375
摘要： The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.
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