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1.发明公开公开(公告)号：US20240309557A1
公开(公告)日：2024-09-19
申请号：US18274323
申请日：2022-01-26
Applicant: UNM Rainforest Innovations
Inventor： Brian Aaron Gold , Pavel Yamanushkin , Mark Aldren M. Feliciano
Abstract: Pyrazole-containing peptides and pyrazoline containing peptides. The pyrazole-containing peptides and/or the pyrazoline containing peptides may include one or more cyclic peptides. Methods for making pyrazole-containing peptides and pyrazoline containing peptides. The method includes reacting a diazo functionalized amino acid with an alkyne or an alkene functionalized amino acid. Amino acids may be functionalized on the N-terminus and/or the C-terminus.
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公开(公告)号：US20240302382A1
公开(公告)日：2024-09-12
申请号：US18660053
申请日：2024-05-09
Applicant: Encodia, Inc.
Inventor： Mark S. Chee , Kevin L. Gunderson , Michael Phillip Weiner
CPC classification number: G01N33/6824 , C40B40/10 , C40B70/00 , G01N33/6803 , G01N33/6842 , G01N33/6845 , G01N2458/00 , G01N2458/10
Abstract: A method for analyzing macromolecules, including peptides, polypeptides, and proteins, employing nucleic acid encoding is disclosed.
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公开(公告)号：US12060654B2
公开(公告)日：2024-08-13
申请号：US16463218
申请日：2017-11-28
Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA
Inventor： Tomoyuki Igawa , Hiroyuki Ishikawa
CPC classification number: C40B40/10 , C07K16/244 , C07K16/2818 , C07K16/2866 , A61K2039/505
Abstract: The present invention relates to a ligand binding molecule whose ligand binding activity is attenuated by the cleavage of a cleavage site and a method for producing the same, a complex formed by the ligand binding molecule and a ligand, a fusion protein comprising the ligand binding molecule and a ligand, and a pharmaceutical composition comprising the ligand binding molecule or a fusion protein of the ligand binding molecule and a ligand.
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公开(公告)号：US20240240360A1
公开(公告)日：2024-07-18
申请号：US18592456
申请日：2024-02-29
Applicant: RULES-BASED MEDICINE INC.
Inventor： Andrew Raymon Morton BRADBURY , Michael Frank ERASMUS , Andre TEIXEIRA
CPC classification number: C40B40/10 , C12N15/1037 , C12N15/81 , C40B40/08 , C40B50/06
Abstract: Antibody libraries comprising a plurality of heavy chain variable domains and/or a plurality of light chain variable domains, which comprise complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members. Further, the antibody libraries comprise members having heavy chain and/or light chain CDRs not found in the same naturally-occurring human antibody.
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公开(公告)号：US20240175049A1
公开(公告)日：2024-05-30
申请号：US18440340
申请日：2024-02-13
Applicant: TRIANNI, INC.
Inventor： Matthias WABL , Werner MUELLER , Peter BURROWS , Gloria ESPOSITO , Bao DUONG
CPC classification number: C12N15/8509 , A01K67/0278 , C07K16/18 , C12N5/0696 , C12N15/1072 , C12N15/62 , C40B40/10 , A01K2207/15 , A01K2217/054 , A01K2217/072 , A01K2227/105 , A01K2267/01 , A01K2267/03 , C12N2015/8518 , C12N2015/8527
Abstract: The invention relates to a long DH (LDH) cassette comprising a recombinant DH construct comprising at least two DH gene segments encoding at least 10 amino acids of the HCDR3 amino acid sequence, wherein at least one of the DH gene segments is a heterologous DH gene segment; an immunoglobulin heavy chain locus and a transgenic non-human animal comprising the same; and their use in producing an immunoglobulin library with long HCDR3 regions.
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Patent Agency Ranking
公开(公告)号：US11946063B2
公开(公告)日：2024-04-02
申请号：US16165018
申请日：2018-10-19
Applicant: TRIANNI, INC.
Inventor： Matthias Wabl , Werner Mueller , Peter Burrows , Gloria Esposito , Bao Duong
IPC: C12N15/85 , A01K67/027 , A01K67/0278 , C07K16/18 , C12N5/074 , C12N15/10 , C12N15/62 , C40B40/10
CPC classification number: C12N15/8509 , A01K67/0278 , C07K16/18 , C12N5/0696 , C12N15/1072 , C12N15/62 , C40B40/10 , A01K2207/15 , A01K2217/054 , A01K2217/072 , A01K2227/105 , A01K2267/01 , A01K2267/03 , C12N2015/8518 , C12N2015/8527
Abstract: The invention relates to a long DH (LDH) cassette comprising a recombinant DH construct comprising at least two DH gene segments encoding at least 10 amino acids of the HCDR3 amino acid sequence, wherein at least one of the DH gene segments is a heterologous DH gene segment; an immunoglobulin heavy chain locus and a transgenic non-human animal comprising the same; and their use in producing an immunoglobulin library with long HCDR3 regions.
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公开(公告)号：US20240025964A1
公开(公告)日：2024-01-25
申请号：US18100732
申请日：2023-01-24
Applicant: Cue Biopharma, Inc.
Inventor： Ronald D. Seidel, III , Rodolfo J. Chaparro
CPC classification number: C07K14/70539 , C07K16/2833 , C40B40/10 , A61K38/00
Abstract: The present disclosure provides T-cell modulatory multimeric polypeptides that comprise an immunomodulatory polypeptide that exhibits reduced binding affinity to a cognate co-immunomodulatory polypeptide. A T-cell modulatory multimeric polypeptide is useful for modulating the activity of a T cell, and for modulating an immune response in an individual.
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公开(公告)号：US20240003056A1
公开(公告)日：2024-01-04
申请号：US18354037
申请日：2023-07-18
Applicant: ALLOGENE THERAPEUTICS, INC.
Inventor： Thomas Charles PERTEL , Barbra Johnson SASU
CPC classification number: C40B40/10 , C07K16/40 , C12N15/63 , C07K2317/565
Abstract: The present disclosure provides, among other things, antibodies for detecting TALENs and/or FokI nucleases in a sample and methods of using the same.
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公开(公告)号：US20230399386A1
公开(公告)日：2023-12-14
申请号：US17856673
申请日：2023-08-30
Applicant: Adimab, LLC
Inventor： Maximiliano Vasquez , Michael Feldhaus , Tillman U. Gerngross , Karl Dane Wittrup
CPC classification number: C07K16/18 , C07K16/005 , C07K16/40 , C40B40/10
Abstract: The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.
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公开(公告)号：US20230364601A1
公开(公告)日：2023-11-16
申请号：US18225981
申请日：2023-07-25
Applicant: UNIVERSITY OF PUERTO RICO
Inventor： Jose Lasalde-Dominicci , Orestes Quesada-Gonzalez , Josue Rodriguez-Cordero , Carlos Baez-Pagan , Martin MONTOYA-ZAVALA
CPC classification number: B01L3/06 , C30B7/12 , C40B40/10 , B01L3/5085 , C07K1/306 , C30B29/58 , B01J19/0046 , B01J19/1893 , B01J2219/00725 , B01J2219/00522 , B01J2219/00756 , B01J2219/00317 , B01J2219/00639 , B01L2300/069 , B01J2219/00585 , B01J2219/00745
Abstract: The invention is a high-throughput voltage screening crystallographic device and methodology that uses multiple micro wells and electric circuits capable of assaying different crystallization condition for the same or different proteins of interest at the same of different voltages under a humidity and temperature controlled environment. The protein is solubilized in a lipid matrix similar to the lipid composition of the protein in the native environment to ensure stability of the protein during crystallization. The invention provides a system and method where the protein is transferred to a lipid matrix that holds a resting membrane potential, which reduces the degree of conformational freedom of the protein. The invention overcomes the majority of the difficulties associated with vapor diffusion techniques and essentially reconstitutes the protein in its native lipid environment under “cuasi” physiological conditions.
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