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    METHODS FOR PREPARING ANALYTES AND RELATED KITS
    2.
    发明公开
    METHODS FOR PREPARING ANALYTES AND RELATED KITS 审中-公开

    公开(公告)号：US20230279386A1

    公开(公告)日：2023-09-07

    申请号：US18190001

    申请日：2023-03-24

    Applicant: Encodia, Inc.

    Inventor： Mark S. CHEE ,  Kevin L. Gunderson ,  Norihito Muranaka ,  Brian Tate Weinert

    IPC: C12N15/10

    CPC classification number: C12N15/1065

    Abstract: Provided herein are methods for preparing and treating an analyte (e.g., a macromolecule or a plurality of macromolecules, peptides, polypeptides, and proteins) for analysis. In some embodiments, the analyte is prepared and treated in a method that includes the use of bait and capture nucleic acids, solid supports, and reaction mixtures including the bait and capture nucleic acids. In some embodiments, the analyte is coupled to a solid support. Also provided are kits containing components for performing the provided methods for preparing the analytes. In some embodiments, the methods are for preparing an analyte for sequencing.

    Methods for preparing analytes and related kits
    4.
    发明授权
    Methods for preparing analytes and related kits 有权

    公开(公告)号：US11634709B2

    公开(公告)日：2023-04-25

    申请号：US17458199

    申请日：2021-08-26

    Applicant: Encodia, Inc.

    Inventor： Mark S. Chee ,  Kevin L. Gunderson ,  Norihito Muranaka ,  Brian Tate Weinert

    IPC: C12N15/10

    Abstract: Provided herein are methods for preparing and treating an analyte (e.g., a macromolecule or a plurality of macromolecules, peptides, polypeptides, and proteins) for analysis. In some embodiments, the analyte is prepared and treated in a method that includes the use of bait and capture nucleic acids, solid supports, and reaction mixtures including the bait and capture nucleic acids. In some embodiments, the analyte is coupled to a solid support. Also provided are kits containing components for performing the provided methods for preparing the analytes. In some embodiments, the methods are for preparing an analyte for sequencing. Provided herein are methods for preparing and treating an analyte (e.g., a macromolecule or a plurality of macromolecules, peptides, polypeptides, and proteins) for analysis. In some embodiments, the analyte is prepared and treated in a method that includes the use of bait and capture nucleic acids, solid supports, and reaction mixtures including the bait and capture nucleic acids. In some embodiments, the analyte is coupled to a solid support. Also provided are kits containing components for performing the provided methods for preparing the analytes. In some embodiments, the methods are for preparing an analyte for sequencing.

    Kits for analysis using nucleic acid encoding and/or label
    10.
    发明授权
    Kits for analysis using nucleic acid encoding and/or label 有权

    公开(公告)号：US12130291B2

    公开(公告)日：2024-10-29

    申请号：US17819263

    申请日：2022-08-11

    Applicant: Encodia, Inc.

    Inventor： Mark S. Chee ,  John M. Beierle ,  Norihito Muranaka ,  Kevin L. Gunderson ,  Michael Phillip Weiner ,  Lei Shi ,  Robert C. James ,  Luca Monfregola

    IPC: G01N33/68 ,  C40B40/10 ,  C40B70/00

    CPC classification number: G01N33/6842 ,  C40B40/10 ,  C40B70/00 ,  G01N33/6845

    Abstract: Kits and methods of using the kits for analyzing macromolecules, including peptides, polypeptides, and proteins, employing nucleic acid encoding are disclosed. The sample analysis kits employ nucleic acid encoding and/or nucleic acid recording of a molecular interaction and/or reaction, such as recognition events (e.g., between an antigen and an antibody, between a modified terminal amino acid residue, or between a small molecule or peptide therapeutic and a target, etc.). Additional barcoding reagents, such as those for cycle-specific barcoding (e.g., “clocking”), compartment barcoding, combinatorial barcoding, spatial barcoding, or any combination thereof, may be included in the kits. The sample may comprise macromolecules, including peptides, polypeptides, and proteins, and the recording may generate molecular interaction and/or reaction information, and/or polypeptide sequence information. The kits may be used in high-throughput, multiplexed, and/or automated analysis, and are suitable for analysis of a proteome or subset thereof.

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