公开(公告)号：US20210000087A1

公开(公告)日：2021-01-07

申请号：US16916492

申请日：2020-06-30

Applicant: TRIANNI, INC.

Inventor： Bao DUONG ,  Peter Daniel BURROWS ,  Werner MUELLER ,  Gloria ESPOSITO ,  Matthias WABL

IPC: A01K67/027 ,  C12N5/0781 ,  C12N5/16 ,  C07K16/46

Abstract: Transgenic mammals that express canine-based immunoglobulins are described herein, including transgenic rodents that express canine-based immunoglobulins for the development of canine therapeutic antibodies.

公开(公告)号：US20240215556A1

公开(公告)日：2024-07-04

申请号：US18557414

申请日：2022-05-04

Applicant: TRIANNI, INC.

Inventor： Werner MUELLER ,  Peter BURROWS ,  Bao DUONG ,  Matthias WABL

IPC: A01K67/0275 ,  C07K16/46 ,  C12N15/85

CPC classification number: A01K67/0275 ,  C07K16/462 ,  C12N15/8509 ,  A01K2217/072 ,  A01K2227/105 ,  A01K2267/01 ,  C07K2317/24

Abstract: Described herein are transgenic mammals that express immunoglobulins with equine variable domains, including transgenic rodents that express immunoglobulins with equine variable domains for the development of therapeutic equine antibodies.

公开(公告)号：US20240175049A1

公开(公告)日：2024-05-30

申请号：US18440340

申请日：2024-02-13

Applicant: TRIANNI, INC.

Inventor： Matthias WABL ,  Werner MUELLER ,  Peter BURROWS ,  Gloria ESPOSITO ,  Bao DUONG

IPC: C12N15/85 ,  A01K67/0278 ,  C07K16/18 ,  C12N5/074 ,  C12N15/10 ,  C12N15/62 ,  C40B40/10

CPC classification number: C12N15/8509 ,  A01K67/0278 ,  C07K16/18 ,  C12N5/0696 ,  C12N15/1072 ,  C12N15/62 ,  C40B40/10 ,  A01K2207/15 ,  A01K2217/054 ,  A01K2217/072 ,  A01K2227/105 ,  A01K2267/01 ,  A01K2267/03 ,  C12N2015/8518 ,  C12N2015/8527

Abstract: The invention relates to a long DH (LDH) cassette comprising a recombinant DH construct comprising at least two DH gene segments encoding at least 10 amino acids of the HCDR3 amino acid sequence, wherein at least one of the DH gene segments is a heterologous DH gene segment; an immunoglobulin heavy chain locus and a transgenic non-human animal comprising the same; and their use in producing an immunoglobulin library with long HCDR3 regions.

公开(公告)号：US20210000089A1

公开(公告)日：2021-01-07

申请号：US17030057

申请日：2020-09-23

Applicant: TRIANNI, INC.

Inventor： Matthias WABL ,  Bao DUONG ,  Werner MUELLER

IPC: A01K67/027 ,  C07K16/00 ,  C12N15/85 ,  C12N5/12 ,  C12N15/11

Abstract: The invention provides compositions and methods for enhanced production of immunoglobulin diversity. Specifically, the invention provides compositions and methods for making accessible a B cell receptor repertoire that has not been culled by developmental tolerance mechanisms. The invention also provides transgenic animals, cells, and antibodies resulting from these compositions and methods.

公开(公告)号：US20240156071A1

公开(公告)日：2024-05-16

申请号：US18394651

申请日：2023-12-22

Applicant: TRIANNI, INC.

Inventor： Matthias WABL ,  Bao DUONG ,  Werner MUELLER

IPC: A01K67/0278 ,  C07K16/00 ,  C12N5/12 ,  C12N15/11 ,  C12N15/85

CPC classification number: A01K67/0278 ,  C07K16/00 ,  C12N5/12 ,  C12N15/11 ,  C12N15/85 ,  A01K2217/072 ,  A01K2227/105 ,  A01K2267/01 ,  A01K2267/03 ,  C07K2317/52 ,  C07K2317/60

Abstract: The invention provides compositions and methods for enhanced production of immunoglobulin diversity. Specifically, the invention provides compositions and methods for making accessible a B cell receptor repertoire that has not been culled by developmental tolerance mechanisms. The invention also provides transgenic animals, cells, and antibodies resulting from these compositions and methods.

公开(公告)号：US20220369609A1

公开(公告)日：2022-11-24

申请号：US17624084

申请日：2020-06-30

Applicant: TRIANNI, INC.

Inventor： Bao DUONG ,  Werner MUELLER ,  Peter Daniel BURROWS ,  Gloria ESPOSITO ,  Matthias WABL

IPC: A01K67/027

Abstract: Transgenic mammals that express bovine-based immunoglobulins are described herein, including transgenic rodents that express bovine-based immunoglobulins for the development of bovine therapeutic antibodies.

公开(公告)号：US20210292378A1

公开(公告)日：2021-09-23

申请号：US17338408

申请日：2021-06-03

Applicant: TRIANNI, INC.

Inventor： Nigel KILLEEN ,  Christoph HASENHINDL ,  Bao DUONG

IPC: C07K14/315 ,  C07K16/00 ,  C07K14/705 ,  C07K14/73 ,  C07K14/74 ,  C12N5/0781 ,  C12N5/12 ,  C12N5/16 ,  A01K67/027 ,  C07K16/42

Abstract: The present invention provides methods and compositions for generating transgenic animals, including transgenic mammals, as well as plasma cells that allow for cell surface capture of secreted immunoglobulin molecules produced endogenously in the plasma cells.