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公开(公告)号：US20190203205A1
公开(公告)日：2019-07-04
申请号：US16236259
申请日：2018-12-28
Applicant: Adimab, LLC
Inventor： Maximiliano Vasquez , Michael Feldhaus , Tillman U. Gerngross , K. Dane Wittrup
CPC classification number: C12N15/1093 , C07K16/00 , C07K16/005 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C40B40/08
Abstract: The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system, with or without DH segments derived from other species, and are based on rational design informed by examination of publicly available databases of antibody sequences.
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公开(公告)号：US10189894B2
公开(公告)日：2019-01-29
申请号：US14150129
申请日：2014-01-08
Applicant: ADIMAB, LLC
Inventor： Maximiliano Vasquez , Michael Feldhaus , Tillman U. Gerngross , K. Dane Wittrup
Abstract: The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.
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公开(公告)号：US20230348901A1
公开(公告)日：2023-11-02
申请号：US17856679
申请日：2022-07-01
Applicant: Adimab, LLC
Inventor： Maximiliano Vasquez , Michael Feldhaus , Tillman U. Gerngross , K. Dane Wittrup
CPC classification number: C12N15/1093 , C07K16/005 , C07K16/00 , C07K2317/567 , C40B40/08 , C07K2317/565 , C07K2317/21 , C40B50/06
Abstract: The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system, with or without DH segments derived from other species, and are based on rational design informed by examination of publicly available databases of antibody sequences.
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公开(公告)号：US11008383B2
公开(公告)日：2021-05-18
申请号：US16215523
申请日：2018-12-10
Applicant: Adimab, LLC
Inventor： Maximiliano Vasquez , Michael Feldhaus , Tillman U. Gerngross , K. Dane Wittrup
Abstract: The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.
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公开(公告)号：US20140364340A1
公开(公告)日：2014-12-11
申请号：US14150129
申请日：2014-01-08
Applicant: ADIMAB, LLC
Inventor： Maximiliano Vasquez , Michael Feldhaus , Tillman U. Gerngross , K. Dane Wittrup
IPC: C07K16/18
CPC classification number: C07K16/18 , C07K16/005 , C07K16/40 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C40B40/10
Abstract: The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.
Abstract translation: 本发明克服了通过专门设计具有定向序列和长度多样性的文库来生成抗体编码多核苷酸文库的已知方法中的不足之处。 这些图书馆旨在反映由人类免疫系统自然产生的免疫缺陷文库，并且基于通过检查公开可得到的人抗体序列数据库的合理设计。
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Patent Agency Ranking
公开(公告)号：US20230399386A1
公开(公告)日：2023-12-14
申请号：US17856673
申请日：2023-08-30
Applicant: Adimab, LLC
Inventor： Maximiliano Vasquez , Michael Feldhaus , Tillman U. Gerngross , Karl Dane Wittrup
CPC classification number: C07K16/18 , C07K16/005 , C07K16/40 , C40B40/10
Abstract: The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.
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公开(公告)号：US11008568B2
公开(公告)日：2021-05-18
申请号：US16236259
申请日：2018-12-28
Applicant: Adimab, LLC
Inventor： Maximiliano Vasquez , Michael Feldhaus , Tillman U. Gerngross , K. Dane Wittrup
Abstract: The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system, with or without DH segments derived from other species, and are based on rational design informed by examination of publicly available databases of antibody sequences.
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公开(公告)号：US10196635B2
公开(公告)日：2019-02-05
申请号：US14256126
申请日：2014-04-18
Applicant: Adimab, LLC
Inventor： Maximiliano Vasquez , Michael Feldhaus , Tillman U. Gerngross , K. Dane Wittrup
Abstract: The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system, with or without DH segments derived from other species, and are based on rational design informed by examination of publicly available databases of antibody sequences.
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公开(公告)号：US20190225677A1
公开(公告)日：2019-07-25
申请号：US16215523
申请日：2018-12-10
Applicant: Adimab, LLC
Inventor： Maximiliano Vasquez , Michael Feldhaus , Tillman U. Gerngross , K. Dane Wittrup
Abstract: The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.
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公开(公告)号：US20140221250A1
公开(公告)日：2014-08-07
申请号：US14256126
申请日：2014-04-18
Applicant: Adimab, LLC
Inventor： Maximiliano Vasquez , Michael Feldhaus , Tillman U. Gerngross , K. Dane Wittrup
CPC classification number: C12N15/1093 , C07K16/00 , C07K16/005 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C40B40/08
Abstract: The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system, with or without DH segments derived from other species, and are based on rational design informed by examination of publicly available databases of antibody sequences.
Abstract translation: 本发明克服了通过专门设计具有定向序列和长度多样性的文库来生成抗体编码多核苷酸文库的已知方法中的不足之处。 图书馆旨在反映人类免疫系统自然产生的免疫缺陷病毒库，具有或不具有衍生自其他物种的DH区段，并且基于通过检查可公开获得的抗体序列数据库而得出的合理设计。
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