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公开(公告)号：US20240299939A1
公开(公告)日：2024-09-12
申请号：US18670099
申请日：2024-05-21
CPC分类号： B01L3/50273 , F04B43/1223 , G01N35/1009 , B01L2200/027 , B01L2300/0861 , B01L2300/123
摘要： Embodiments described herein generally relate to apparatuses, cartridges, and pumps for peristaltic pumping of fluids and associated methods, systems, and devices. The pumping of fluids is, in certain cases, an important aspect of a variety of applications, such as bioanalytical applications (e.g., biological sample analysis, sequencing, identification). The inventive features described herein may, in some embodiments, provide an ability to pump fluids in ways that combine certain advantages of robotic fluid handling systems (e.g., automation, programmability, configurability, flexibility) with certain advantages of microfluidics (e.g., small fluid volumes with high fluid resolution, precision, monolithic consumables, limiting of the wetting of components to consumables).
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公开(公告)号：US20240255534A1
公开(公告)日：2024-08-01
申请号：US18431330
申请日：2024-02-02
CPC分类号： G01N35/0098 , G01N35/0099 , G01N35/10 , G01N35/1009 , Y10T436/255
摘要： The present teachings provide apparatuses and methods for automated handling of samples, e.g., biological or chemical samples. The apparatuses and the methods of the present teachings allow automated performance of various sample manipulation steps without manual intervention. In a preferred embodiment, the present teachings provide apparatuses and methods for automated enrichment of templated beads produced by PCR.
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公开(公告)号：US12011716B2
公开(公告)日：2024-06-18
申请号：US17083106
申请日：2020-10-28
IPC分类号： G01N33/68 , A01N1/02 , B01L3/00 , C07C309/65 , C07C309/73 , F04B43/12 , G01N1/40 , G01N21/33 , G01N21/64 , G01N33/52 , G01N35/10
CPC分类号： B01L3/50273 , F04B43/1223 , G01N35/1009 , B01L2200/027 , B01L2300/0861 , B01L2300/123
摘要： Embodiments described herein generally relate to apparatuses, cartridges, and pumps for peristaltic pumping of fluids and associated methods, systems, and devices. The pumping of fluids is, in certain cases, an important aspect of a variety of applications, such as bioanalytical applications (e.g., biological sample analysis, sequencing, identification). The inventive features described herein may, in some embodiments, provide an ability to pump fluids in ways that combine certain advantages of robotic fluid handling systems (e.g., automation, programmability, configurability, flexibility) with certain advantages of microfluidics (e.g., small fluid volumes with high fluid resolution, precision, monolithic consumables, limiting of the wetting of components to consumables).
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公开(公告)号：US20240192245A1
公开(公告)日：2024-06-13
申请号：US18517051
申请日：2023-11-22
发明人： Takahiro OMORI , Hideto KOJIMA , Takafumi FUJIWARA , Takeshi KINPARA , Yoshifumi YAMAGATA , Tomoaki KURANO
CPC分类号： G01N35/1009 , G01N35/00623 , G01N2035/1025
摘要： An automatic analysis device according to the present embodiment includes a processor. The processor calculates the liquid level height in a reaction tube, based on a scheduled dispensing amount of liquid to be dispensed into the reaction tube. The processor detects whether there is an abnormality in a dispensing operation in which liquid is dispensed into the reaction tube, based on a measured liquid level height in the reaction tube and a calculated liquid level height in the reaction tube.
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公开(公告)号：US20240192240A1
公开(公告)日：2024-06-13
申请号：US18531853
申请日：2023-12-07
发明人： Takeshi KINPARA , Takafumi FUJIWARA , Takahiro OMORI , Hideto KOJIMA , Yoshifumi YAMAGATA , Tomoaki KURANO
CPC分类号： G01N35/026 , G01N35/00663 , G01N35/00732 , G01N35/1002 , G01N35/1009 , G01N2035/00673 , G01N2035/1025
摘要： A transport rack according to the present embodiment comprises a holder configured to hold a storage container that stores a sample or a reagent that is reacted with the sample, a first observation window configured to enable reading of identification information on the storage container, and a second observation window configured to enable observation of the sample or the reagent stored in the storage container.
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公开(公告)号：US20240142478A1
公开(公告)日：2024-05-02
申请号：US18405912
申请日：2024-01-05
申请人： Cytiva US LLC
CPC分类号： G01N35/00732 , G01N35/1009 , B01D15/08
摘要： A buffer management system includes at least one workstation configured to support a supply of concentrated buffer solution and an inline dilution skid having a manifold and at least one workstation to support delivery of diluted (surge) buffers from the inline dilution skid. The latter workstation also serves to supply ready-made (diluted) buffers to a bioprocessing unit. The manifold is in fluid communication with the supply of concentrated buffer solution and is adapted to be placed in fluid communication with a source of water for injection (WFI). The inline dilution skid is configured to variably mix the supply of concentrated buffer solution and the source of WFI to obtain a range of diluted buffer solutions. Processes for automatically identifying the arrangement of buffer solutions in a bioprocessing application use signals from various sensors to identify the fluid connections between components of the system.
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公开(公告)号：US20240133757A1
公开(公告)日：2024-04-25
申请号：US18279448
申请日：2022-04-10
IPC分类号： G01L9/00
CPC分类号： G01L9/0054 , G01N35/1009
摘要： A pressure sensor module and a dispensing apparatus improving accuracy of pressure measurement are provided. A pressure sensor module includes: a flow channel substrate in which a flow channel and a branch channel are formed; and a distortion detection unit configured to detect a pressure. The branch channel is branched from the flow channel and is connected to the distortion detection unit at one end of the branch channel. The distortion detection unit is disposed at least partially via a bond layer to block the one end of the branch channel. A protrusion is provided to surround the one end of the branch channel.
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公开(公告)号：US20240082838A1
公开(公告)日：2024-03-14
申请号：US18136636
申请日：2023-04-19
申请人： LexaGene, Inc.
发明人： John Regan , John DePiano
IPC分类号： B01L3/00 , C12Q1/6806 , G01N1/10 , G01N1/40 , G01N35/10
CPC分类号： B01L3/502746 , B01L3/567 , C12Q1/6806 , G01N1/10 , G01N1/405 , G01N35/1009 , G01N35/1095 , B01L2200/0631 , B01L2200/10 , B01L2300/0663 , B01L2300/0681 , B01L2300/123 , B01L2400/0433 , B01L2400/0644 , B01L2400/082
摘要： Nucleic acid extraction and purification cartridges and systems are provided. The cartridges can be removable and are configured to allow for the concentration of particles of interest, followed by nucleic acid extraction and purification. The cartridges directly contact samples and provide a partial barrier between samples and the reusable components of the system, thereby reducing the probability of clogging the system's microfluidics and fouling the lines, valves, and pumps of the system. Furthermore, these cartridges are designed to purity nucleic acids by removing the majority of inhibitors for down-stream genetic testing. Embodiments may comprise one, two, or three or more channels. In an exemplary embodiment the nucleic acid extraction and purification cartridge comprises a first channel containing a filter disposed therein; and a second channel containing a nucleic acid binding matrix disposed therein, wherein a first end of the cartridge is configured to directly contact a sample comprising a biological material, and wherein a second end of the cartridge Is configured to connect in a reversible fashion to a flow-through automated Instrument that controls fluid flow through the cartridge.
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公开(公告)号：US20240036070A1
公开(公告)日：2024-02-01
申请号：US18379263
申请日：2023-10-12
申请人： TTP Plc
IPC分类号： G01N35/10
CPC分类号： G01N35/1095 , G01N35/1009
摘要： There is provided a sample ejection system for ejecting a sample from a flow of fluid, the system comprises: a fluid flow channel for receiving, in use, the flow of fluid; a fluid inlet channel connected to the flow channel and arranged to receive, in use, pressurised fluid; a fluid outlet channel connected to the flow channel at a location downstream in the flow direction of the flow of fluid and comprises an outlet. The system is arranged such that, in use, pressurised fluid is applied to the fluid flow channel via the fluid inlet channel to drive fluid from the region of the fluid flow channel between the fluid inlet and outlet channels through the fluid outlet channel and out of the outlet.
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公开(公告)号：US20240012018A1
公开(公告)日：2024-01-11
申请号：US17768288
申请日：2020-10-07
IPC分类号： G01N35/10
CPC分类号： G01N35/1004 , G01N35/1009
摘要： An automatic analyzer: includes a washing tank in which an exterior of a probe is washed with washing water, a pump to supply washing water stored in a tank to the washing tank through a first flow channel, and a flow channel switching mechanism to switch between supplying washing water to the washing tank through the first flow channel and returning washing water to the tank through a second flow channel connecting the first flow channel and the tank; and sets a washing period when washing water is supplied to the washing tank through the first flow channel and the probe is washed with washing water in a cycle constituting a sequence of the automatic analyzer; and controls the flow channel switching mechanism so as to return washing water to the tank through the second flow channel during the washing period in a cycle of not washing the probe.
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